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Epithelial-Mesenchymal Transition, human (Scheel, 2011): : averaged replicates

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Results for GATA6

Z-value: 0.32

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Transcription factors associated with GATA6

Gene Symbol Gene ID Gene Info
GATA6
ENSG00000141448.4 GATA6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GATA6hg19_v2_chr18_+_19749386_197494040.667.6e-02Click!

Activity profile of GATA6 motif

Sorted Z-values of GATA6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA6

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr10_-_129691195 0.68 ENST00000368671.3
 CLRN3
 clarin 3
chr18_+_19749386 0.62 ENST00000269216.3
 GATA6
 GATA binding protein 6
chr19_-_51522955 0.51 ENST00000358789.3
 KLK10
 kallikrein-related peptidase 10
chr6_+_12290586 0.39 ENST00000379375.5
 EDN1
 endothelin 1
chr19_-_51523275 0.32 ENST00000309958.3
 KLK10
 kallikrein-related peptidase 10
chr1_-_226187013 0.31 ENST00000272091.7
 SDE2
 SDE2 telomere maintenance homolog (S. pombe)
chr3_+_148583043 0.27 ENST00000296046.3
 CPA3
 carboxypeptidase A3 (mast cell)
chr1_-_94050668 0.24 ENST00000539242.1
 BCAR3
 breast cancer anti-estrogen resistance 3
chr9_-_117692697 0.23 ENST00000223795.2
 TNFSF8
 tumor necrosis factor (ligand) superfamily, member 8
chr1_-_24469602 0.23 ENST00000270800.1
 IL22RA1
 interleukin 22 receptor, alpha 1
chr11_-_116708302 0.23 ENST00000375320.1
ENST00000359492.2
ENST00000375329.2
ENST00000375323.1
 APOA1
 apolipoprotein A-I
chr17_+_74381343 0.22 ENST00000392496.3
 SPHK1
 sphingosine kinase 1
chr5_+_131409476 0.22 ENST00000296871.2
 CSF2
 colony stimulating factor 2 (granulocyte-macrophage)
chr22_-_20231207 0.20 ENST00000425986.1
 RTN4R
 reticulon 4 receptor
chr13_-_46716969 0.19 ENST00000435666.2
 LCP1
 lymphocyte cytosolic protein 1 (L-plastin)
chr8_-_20040601 0.19 ENST00000265808.7
ENST00000522513.1
 SLC18A1
 solute carrier family 18 (vesicular monoamine transporter), member 1
chr12_-_120765565 0.18 ENST00000423423.3
ENST00000308366.4
 PLA2G1B
 phospholipase A2, group IB (pancreas)
chr18_-_28742813 0.18 ENST00000257197.3
ENST00000257198.5
 DSC1
 desmocollin 1
chr6_+_31674639 0.16 ENST00000556581.1
ENST00000375832.4
ENST00000503322.1
 LY6G6F
MEGT1
 lymphocyte antigen 6 complex, locus G6F
HCG43720, isoform CRA_a; Lymphocyte antigen 6 complex locus protein G6f; Megakaryocyte-enhanced gene transcript 1 protein; Uncharacterized protein
chr4_-_103266355 0.16 ENST00000424970.2
 SLC39A8
 solute carrier family 39 (zinc transporter), member 8
chr20_+_43935474 0.15 ENST00000372743.1
ENST00000372741.3
ENST00000343694.3
 RBPJL
 recombination signal binding protein for immunoglobulin kappa J region-like
chr8_-_20040638 0.15 ENST00000519026.1
ENST00000276373.5
ENST00000440926.1
ENST00000437980.1
 SLC18A1
 solute carrier family 18 (vesicular monoamine transporter), member 1
chr6_+_130339710 0.14 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
 L3MBTL3
 l(3)mbt-like 3 (Drosophila)
chr4_+_15376165 0.13 ENST00000382383.3
ENST00000429690.1
 C1QTNF7
 C1q and tumor necrosis factor related protein 7
chr8_-_38008783 0.13 ENST00000276449.4
 STAR
 steroidogenic acute regulatory protein
chrX_+_107288239 0.12 ENST00000217957.5
 VSIG1
 V-set and immunoglobulin domain containing 1
chr10_+_24755416 0.12 ENST00000396446.1
ENST00000396445.1
ENST00000376451.2
 KIAA1217
 KIAA1217
chr4_-_103266219 0.11 ENST00000394833.2
 SLC39A8
 solute carrier family 39 (zinc transporter), member 8
chr2_+_169757750 0.11 ENST00000375363.3
ENST00000429379.2
ENST00000421979.1
 G6PC2
 glucose-6-phosphatase, catalytic, 2
chr19_+_10397648 0.09 ENST00000340992.4
ENST00000393717.2
 ICAM4
 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr19_+_10397621 0.09 ENST00000380770.3
 ICAM4
 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr20_-_54967187 0.09 ENST00000422322.1
ENST00000371356.2
ENST00000451915.1
ENST00000347343.2
ENST00000395911.1
ENST00000395907.1
ENST00000441357.1
ENST00000456249.1
ENST00000420474.1
ENST00000395909.4
ENST00000395914.1
ENST00000312783.6
ENST00000395915.3
ENST00000395913.3
 AURKA
 aurora kinase A
chr11_-_1036706 0.09 ENST00000421673.2
 MUC6
 mucin 6, oligomeric mucus/gel-forming
chr12_+_122880045 0.09 ENST00000539034.1
ENST00000535976.1
 RP11-450K4.1
 RP11-450K4.1
chr17_-_38938786 0.08 ENST00000301656.3
 KRT27
 keratin 27
chr12_-_10151773 0.08 ENST00000298527.6
ENST00000348658.4
 CLEC1B
 C-type lectin domain family 1, member B
chr2_-_69098566 0.08 ENST00000295379.1
 BMP10
 bone morphogenetic protein 10
chr22_-_29784519 0.08 ENST00000357586.2
ENST00000356015.2
ENST00000432560.2
ENST00000317368.7
 AP1B1
 adaptor-related protein complex 1, beta 1 subunit
chr19_-_13213662 0.08 ENST00000264824.4
 LYL1
 lymphoblastic leukemia derived sequence 1
chr14_-_23285069 0.07 ENST00000554758.1
ENST00000397528.4
 SLC7A7
 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr14_-_23285011 0.07 ENST00000397532.3
 SLC7A7
 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr15_-_64126084 0.07 ENST00000560316.1
ENST00000443617.2
ENST00000560462.1
ENST00000558532.1
ENST00000561400.1
 HERC1
 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
chr7_+_155090271 0.07 ENST00000476756.1
 INSIG1
 insulin induced gene 1
chr16_+_4475806 0.07 ENST00000262375.6
ENST00000355296.4
ENST00000431375.2
ENST00000574895.1
 DNAJA3
 DnaJ (Hsp40) homolog, subfamily A, member 3
chr9_-_114937465 0.07 ENST00000355396.3
 SUSD1
 sushi domain containing 1
chr6_-_46048116 0.06 ENST00000185206.6
 CLIC5
 chloride intracellular channel 5
chr9_+_125796806 0.06 ENST00000373642.1
 GPR21
 G protein-coupled receptor 21
chrX_+_107288197 0.06 ENST00000415430.3
 VSIG1
 V-set and immunoglobulin domain containing 1
chr15_-_43513187 0.06 ENST00000540029.1
ENST00000441366.2
 EPB42
 erythrocyte membrane protein band 4.2
chr20_+_31669333 0.06 ENST00000375483.3
 BPIFB4
 BPI fold containing family B, member 4
chr5_-_33984786 0.06 ENST00000296589.4
 SLC45A2
 solute carrier family 45, member 2
chr8_-_95449155 0.06 ENST00000481490.2
 FSBP
 fibrinogen silencer binding protein
chr11_+_10326612 0.06 ENST00000534464.1
ENST00000530439.1
ENST00000524948.1
ENST00000528655.1
ENST00000526492.1
ENST00000525063.1
 ADM
 adrenomedullin
chr7_+_130020180 0.06 ENST00000481342.1
ENST00000011292.3
ENST00000604896.1
 CPA1
 carboxypeptidase A1 (pancreatic)
chr16_+_71560154 0.06 ENST00000539698.3
 CHST4
 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
chr5_-_33984741 0.05 ENST00000382102.3
ENST00000509381.1
ENST00000342059.3
ENST00000345083.5
 SLC45A2
 solute carrier family 45, member 2
chr2_-_40739501 0.05 ENST00000403092.1
ENST00000402441.1
ENST00000448531.1
 SLC8A1
 solute carrier family 8 (sodium/calcium exchanger), member 1
chr11_-_59612969 0.05 ENST00000541311.1
ENST00000257248.2
 GIF
 gastric intrinsic factor (vitamin B synthesis)
chr19_+_14138960 0.05 ENST00000431365.2
ENST00000585987.1
 RLN3
 relaxin 3
chr14_+_22966642 0.05 ENST00000390496.1
 TRAJ41
 T cell receptor alpha joining 41
chr16_+_71560023 0.05 ENST00000572450.1
 CHST4
 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
chr5_-_135290705 0.05 ENST00000274507.1
 LECT2
 leukocyte cell-derived chemotaxin 2
chr1_+_174846570 0.05 ENST00000392064.2
 RABGAP1L
 RAB GTPase activating protein 1-like
chr9_-_114937676 0.05 ENST00000374270.3
 SUSD1
 sushi domain containing 1
chr1_+_12524965 0.05 ENST00000471923.1
 VPS13D
 vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr9_-_114937543 0.04 ENST00000374264.2
ENST00000374263.3
 SUSD1
 sushi domain containing 1
chr22_+_35462129 0.04 ENST00000404699.2
ENST00000308700.6
 ISX
 intestine-specific homeobox
chr1_-_27240455 0.04 ENST00000254227.3
 NR0B2
 nuclear receptor subfamily 0, group B, member 2
chr17_+_4835580 0.04 ENST00000329125.5
 GP1BA
 glycoprotein Ib (platelet), alpha polypeptide
chr2_+_102927962 0.04 ENST00000233954.1
ENST00000393393.3
ENST00000410040.1
 IL1RL1
IL18R1
 interleukin 1 receptor-like 1
interleukin 18 receptor 1
chr20_+_54967409 0.04 ENST00000415828.1
ENST00000217109.4
ENST00000428552.1
 CSTF1
 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
chr11_+_118958689 0.04 ENST00000535253.1
ENST00000392841.1
 HMBS
 hydroxymethylbilane synthase
chr2_+_87565634 0.03 ENST00000421835.2
 IGKV3OR2-268
 immunoglobulin kappa variable 3/OR2-268 (non-functional)
chr2_-_90538397 0.03 ENST00000443397.3
 RP11-685N3.1
 Uncharacterized protein
chr5_+_131892603 0.03 ENST00000378823.3
ENST00000265335.6
 RAD50
 RAD50 homolog (S. cerevisiae)
chr17_-_4806369 0.03 ENST00000293780.4
 CHRNE
 cholinergic receptor, nicotinic, epsilon (muscle)
chr20_+_51588873 0.03 ENST00000371497.5
 TSHZ2
 teashirt zinc finger homeobox 2
chr14_+_53173890 0.03 ENST00000445930.2
 PSMC6
 proteasome (prosome, macropain) 26S subunit, ATPase, 6
chr12_-_6233828 0.02 ENST00000572068.1
ENST00000261405.5
 VWF
 von Willebrand factor
chrX_-_10851762 0.02 ENST00000380785.1
ENST00000380787.1
 MID1
 midline 1 (Opitz/BBB syndrome)
chr14_+_53173910 0.02 ENST00000606149.1
ENST00000555339.1
ENST00000556813.1
 PSMC6
 proteasome (prosome, macropain) 26S subunit, ATPase, 6
chr10_-_99531709 0.02 ENST00000266066.3
 SFRP5
 secreted frizzled-related protein 5
chr6_-_86099898 0.02 ENST00000455071.1
 RP11-30P6.6
 RP11-30P6.6
chr1_+_25598989 0.02 ENST00000454452.2
 RHD
 Rh blood group, D antigen
chr16_+_616995 0.02 ENST00000293874.2
ENST00000409527.2
ENST00000424439.2
ENST00000540585.1
 PIGQ
NHLRC4
 phosphatidylinositol glycan anchor biosynthesis, class Q
NHL repeat containing 4
chr1_-_167487758 0.02 ENST00000362089.5
 CD247
 CD247 molecule
chr2_+_138722028 0.02 ENST00000280096.5
 HNMT
 histamine N-methyltransferase
chr19_-_55549624 0.02 ENST00000417454.1
ENST00000310373.3
ENST00000333884.2
 GP6
 glycoprotein VI (platelet)
chr17_+_19314505 0.02 ENST00000461366.1
 RNF112
 ring finger protein 112
chr15_+_59279851 0.01 ENST00000348370.4
ENST00000434298.1
ENST00000559160.1
 RNF111
 ring finger protein 111
chr21_-_39870339 0.01 ENST00000429727.2
ENST00000398905.1
ENST00000398907.1
ENST00000453032.2
ENST00000288319.7
 ERG
 v-ets avian erythroblastosis virus E26 oncogene homolog
chr2_+_3642545 0.01 ENST00000382062.2
ENST00000236693.7
ENST00000349077.4
 COLEC11
 collectin sub-family member 11
chr10_+_118350468 0.01 ENST00000358834.4
ENST00000528052.1
ENST00000442761.1
 PNLIPRP1
 pancreatic lipase-related protein 1
chr10_+_118350522 0.01 ENST00000530319.1
ENST00000527980.1
ENST00000471549.1
ENST00000534537.1
 PNLIPRP1
 pancreatic lipase-related protein 1
chr15_+_49715293 0.01 ENST00000267843.4
ENST00000560270.1
 FGF7
 fibroblast growth factor 7
chr1_-_167487808 0.01 ENST00000392122.3
 CD247
 CD247 molecule
chr14_+_75988851 0.01 ENST00000555504.1
 BATF
 basic leucine zipper transcription factor, ATF-like
chr7_+_128379346 0.01 ENST00000535011.2
ENST00000542996.2
ENST00000535623.1
ENST00000538546.1
ENST00000249364.4
ENST00000449187.2
 CALU
 calumenin
chr2_-_152830441 0.00 ENST00000534999.1
ENST00000397327.2
 CACNB4
 calcium channel, voltage-dependent, beta 4 subunit
chr19_-_11494975 0.00 ENST00000222139.6
ENST00000592375.2
 EPOR
 erythropoietin receptor
chr12_-_122879969 0.00 ENST00000540304.1
 CLIP1
 CAP-GLY domain containing linker protein 1
chr2_-_152830479 0.00 ENST00000360283.6
 CACNB4
 calcium channel, voltage-dependent, beta 4 subunit
chr5_+_159848807 0.00 ENST00000352433.5
 PTTG1
 pituitary tumor-transforming 1
chr8_+_21823726 0.00 ENST00000433566.4
 XPO7
 exportin 7
chr5_+_1201703 0.00 ENST00000304460.10
 SLC6A19
 solute carrier family 6 (neutral amino acid transporter), member 19

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0032911 negative regulation of transforming growth factor beta1 production(GO:0032911)
0.1 0.4 GO:0060585 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.1 0.2 GO:0046521 sphingoid catabolic process(GO:0046521)
0.1 0.2 GO:0010903 negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903)
0.1 0.3 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.0 0.2 GO:0045918 positive regulation of interleukin-23 production(GO:0032747) negative regulation of cytolysis(GO:0045918)
0.0 0.1 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894) positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253)
0.0 0.1 GO:0015770 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0 0.2 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.0 0.1 GO:1900195 spindle assembly involved in female meiosis I(GO:0007057) positive regulation of oocyte maturation(GO:1900195)
0.0 0.3 GO:0015691 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0 0.1 GO:0000821 regulation of arginine metabolic process(GO:0000821) basic amino acid transmembrane transport(GO:1990822)
0.0 0.1 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.0 0.3 GO:0002003 angiotensin maturation(GO:0002003)
0.0 0.2 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.3 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.1 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.0 0.2 GO:0023041 neuronal signal transduction(GO:0023041)
0.0 0.2 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.1 GO:0006477 protein sulfation(GO:0006477)
0.0 0.1 GO:0043249 erythrocyte maturation(GO:0043249)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.1 0.2 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.0 0.3 GO:0070081 clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.0 0.1 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.1 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.1 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.2 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.1 0.4 GO:0031708 endothelin B receptor binding(GO:0031708)
0.1 0.2 GO:0038131 neuregulin receptor activity(GO:0038131)
0.1 0.2 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.0 0.2 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.1 GO:0015157 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0 0.2 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.0 0.1 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.2 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.1 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.0 0.1 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0 0.6 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.3 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters