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Epithelial-Mesenchymal Transition, human (Scheel, 2011): : averaged replicates

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Results for GRHL1

Z-value: 1.53

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Transcription factors associated with GRHL1

Gene Symbol Gene ID Gene Info
GRHL1
ENSG00000134317.13 GRHL1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GRHL1hg19_v2_chr2_+_10091815_10091864,
hg19_v2_chr2_+_10091783_10091811		0.363.7e-01Click!

Activity profile of GRHL1 motif

Sorted Z-values of GRHL1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GRHL1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr13_-_20806440 2.25 ENST00000400066.3
ENST00000400065.3
ENST00000356192.6
 GJB6
 gap junction protein, beta 6, 30kDa
chr1_-_201368707 1.90 ENST00000391967.2
 LAD1
 ladinin 1
chr1_+_35247859 1.88 ENST00000373362.3
 GJB3
 gap junction protein, beta 3, 31kDa
chr1_-_201368653 1.71 ENST00000367313.3
 LAD1
 ladinin 1
chr19_-_291133 1.48 ENST00000327790.3
 PPAP2C
 phosphatidic acid phosphatase type 2C
chr2_+_95940186 1.25 ENST00000403131.2
ENST00000317668.4
ENST00000317620.9
 PROM2
 prominin 2
chr3_-_172241250 1.11 ENST00000420541.2
ENST00000241261.2
 TNFSF10
 tumor necrosis factor (ligand) superfamily, member 10
chr19_+_45312347 1.10 ENST00000270233.6
ENST00000591520.1
 BCAM
 basal cell adhesion molecule (Lutheran blood group)
chr20_-_18038521 1.09 ENST00000278780.6
 OVOL2
 ovo-like zinc finger 2
chr2_+_95940220 0.70 ENST00000542147.1
 PROM2
 prominin 2
chr8_-_130799134 0.65 ENST00000276708.4
 GSDMC
 gasdermin C
chr1_-_24469602 0.64 ENST00000270800.1
 IL22RA1
 interleukin 22 receptor, alpha 1
chr1_-_153113927 0.45 ENST00000368752.4
 SPRR2B
 small proline-rich protein 2B
chr9_+_5450503 0.40 ENST00000381573.4
ENST00000381577.3
 CD274
 CD274 molecule
chr1_+_155023757 0.36 ENST00000356955.2
ENST00000449910.2
ENST00000359280.4
ENST00000360674.4
ENST00000368412.3
ENST00000355956.2
ENST00000368410.2
ENST00000271836.6
ENST00000368413.1
ENST00000531455.1
ENST00000447332.3
 ADAM15
 ADAM metallopeptidase domain 15
chr1_+_44440575 0.35 ENST00000532642.1
ENST00000236067.4
ENST00000471859.2
 ATP6V0B
 ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
chr19_-_15590306 0.34 ENST00000292609.4
 PGLYRP2
 peptidoglycan recognition protein 2
chr19_-_35981358 0.33 ENST00000484218.2
ENST00000338897.3
 KRTDAP
 keratinocyte differentiation-associated protein
chr6_+_32121218 0.31 ENST00000414204.1
ENST00000361568.2
ENST00000395523.1
 PPT2
 palmitoyl-protein thioesterase 2
chr19_+_1491144 0.30 ENST00000233596.3
 REEP6
 receptor accessory protein 6
chr1_-_16539094 0.29 ENST00000270747.3
 ARHGEF19
 Rho guanine nucleotide exchange factor (GEF) 19
chr11_+_706595 0.28 ENST00000531348.1
ENST00000530636.1
 EPS8L2
 EPS8-like 2
chr19_-_17356697 0.26 ENST00000291442.3
 NR2F6
 nuclear receptor subfamily 2, group F, member 6
chr19_+_19496728 0.26 ENST00000537887.1
ENST00000417582.2
 GATAD2A
 GATA zinc finger domain containing 2A
chr7_-_80551671 0.24 ENST00000419255.2
ENST00000544525.1
 SEMA3C
 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr19_+_58038683 0.24 ENST00000240719.3
ENST00000376233.3
ENST00000594943.1
ENST00000602149.1
 ZNF549
 zinc finger protein 549
chr13_+_48807334 0.21 ENST00000378549.5
 ITM2B
 integral membrane protein 2B
chr9_+_130565487 0.21 ENST00000373225.3
ENST00000431857.1
 FPGS
 folylpolyglutamate synthase
chr6_+_168227611 0.21 ENST00000344191.4
ENST00000351017.4
ENST00000392108.3
ENST00000366806.2
ENST00000392112.1
ENST00000400824.4
ENST00000447894.2
ENST00000400822.3
 MLLT4
 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
chr17_+_9728828 0.20 ENST00000262441.5
 GLP2R
 glucagon-like peptide 2 receptor
chr2_+_113816215 0.19 ENST00000346807.3
 IL36RN
 interleukin 36 receptor antagonist
chr16_-_23568651 0.19 ENST00000563232.1
ENST00000563459.1
ENST00000449606.1
 EARS2
 glutamyl-tRNA synthetase 2, mitochondrial
chr2_+_113299990 0.18 ENST00000537335.1
ENST00000417433.2
 POLR1B
 polymerase (RNA) I polypeptide B, 128kDa
chr3_-_49142504 0.18 ENST00000306125.6
ENST00000420147.2
 QARS
 glutaminyl-tRNA synthetase
chr18_-_35145593 0.18 ENST00000334919.5
ENST00000591282.1
ENST00000588597.1
 CELF4
 CUGBP, Elav-like family member 4
chr13_+_48807288 0.17 ENST00000378565.5
 ITM2B
 integral membrane protein 2B
chr3_-_49142178 0.16 ENST00000452739.1
ENST00000414533.1
ENST00000417025.1
 QARS
 glutaminyl-tRNA synthetase
chr12_+_49687425 0.16 ENST00000257860.4
 PRPH
 peripherin
chr18_+_9475001 0.16 ENST00000019317.4
 RALBP1
 ralA binding protein 1
chr18_-_35145728 0.15 ENST00000361795.5
ENST00000603232.1
 CELF4
 CUGBP, Elav-like family member 4
chr20_-_54967187 0.15 ENST00000422322.1
ENST00000371356.2
ENST00000451915.1
ENST00000347343.2
ENST00000395911.1
ENST00000395907.1
ENST00000441357.1
ENST00000456249.1
ENST00000420474.1
ENST00000395909.4
ENST00000395914.1
ENST00000312783.6
ENST00000395915.3
ENST00000395913.3
 AURKA
 aurora kinase A
chr1_-_28384598 0.15 ENST00000373864.1
 EYA3
 eyes absent homolog 3 (Drosophila)
chr4_-_99850243 0.14 ENST00000280892.6
ENST00000511644.1
ENST00000504432.1
ENST00000505992.1
 EIF4E
 eukaryotic translation initiation factor 4E
chrX_+_146993449 0.13 ENST00000218200.8
ENST00000370471.3
ENST00000370477.1
 FMR1
 fragile X mental retardation 1
chr18_-_35145689 0.13 ENST00000591287.1
ENST00000601019.1
ENST00000601392.1
 CELF4
 CUGBP, Elav-like family member 4
chr1_+_244515930 0.12 ENST00000366537.1
ENST00000308105.4
 C1orf100
 chromosome 1 open reading frame 100
chr16_+_2564254 0.11 ENST00000565223.1
 ATP6V0C
 ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
chr11_+_119039414 0.11 ENST00000409991.1
ENST00000292199.2
ENST00000409265.4
ENST00000409109.1
 NLRX1
 NLR family member X1
chr20_-_61002584 0.11 ENST00000252998.1
 RBBP8NL
 RBBP8 N-terminal like
chr1_-_234667504 0.11 ENST00000421207.1
ENST00000435574.1
 RP5-855F14.1
 RP5-855F14.1
chr14_+_23938891 0.10 ENST00000408901.3
ENST00000397154.3
ENST00000555128.1
 NGDN
 neuroguidin, EIF4E binding protein
chr11_-_67442079 0.10 ENST00000349015.3
 ALDH3B2
 aldehyde dehydrogenase 3 family, member B2
chr22_+_18560675 0.08 ENST00000329627.7
 PEX26
 peroxisomal biogenesis factor 26
chr19_+_19496624 0.08 ENST00000494516.2
ENST00000360315.3
ENST00000252577.5
 GATAD2A
 GATA zinc finger domain containing 2A
chr18_-_35145981 0.08 ENST00000420428.2
ENST00000412753.1
 CELF4
 CUGBP, Elav-like family member 4
chr17_-_60883993 0.07 ENST00000583803.1
ENST00000456609.2
 MARCH10
 membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
chr6_-_46889694 0.07 ENST00000283296.7
ENST00000362015.4
ENST00000456426.2
 GPR116
 G protein-coupled receptor 116
chr3_-_113415441 0.07 ENST00000491165.1
ENST00000316407.4
 KIAA2018
 KIAA2018
chr4_+_110736659 0.05 ENST00000394631.3
ENST00000226796.6
 GAR1
 GAR1 ribonucleoprotein
chr19_+_10736183 0.05 ENST00000590857.1
ENST00000588688.1
ENST00000586078.1
 SLC44A2
 solute carrier family 44 (choline transporter), member 2
chr8_+_27950619 0.05 ENST00000542181.1
ENST00000524103.1
ENST00000537665.1
ENST00000380353.4
ENST00000520288.1
 ELP3
 elongator acetyltransferase complex subunit 3
chr19_+_12035913 0.04 ENST00000591944.1
 ZNF763
 Uncharacterized protein; Zinc finger protein 763
chr1_+_40723779 0.04 ENST00000372759.3
 ZMPSTE24
 zinc metallopeptidase STE24
chrX_-_119603138 0.04 ENST00000200639.4
ENST00000371335.4
ENST00000538785.1
ENST00000434600.2
 LAMP2
 lysosomal-associated membrane protein 2
chr3_-_3152031 0.03 ENST00000383846.1
ENST00000427088.1
ENST00000446632.2
ENST00000438560.1
 IL5RA
 interleukin 5 receptor, alpha
chr12_+_118814185 0.03 ENST00000543473.1
 SUDS3
 suppressor of defective silencing 3 homolog (S. cerevisiae)
chr11_-_67442196 0.03 ENST00000525827.1
 ALDH3B2
 aldehyde dehydrogenase 3 family, member B2
chr5_+_125758813 0.01 ENST00000285689.3
ENST00000515200.1
 GRAMD3
 GRAM domain containing 3
chr21_+_33671264 0.00 ENST00000339944.4
 MRAP
 melanocortin 2 receptor accessory protein
chr4_+_156588249 0.00 ENST00000393832.3
 GUCY1A3
 guanylate cyclase 1, soluble, alpha 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:2001287 negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.2 1.1 GO:0060214 endocardium formation(GO:0060214)
0.1 0.3 GO:0006425 glutaminyl-tRNA aminoacylation(GO:0006425)
0.1 0.3 GO:0032826 natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827)
0.1 0.2 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.1 0.2 GO:0006424 glutamyl-tRNA aminoacylation(GO:0006424)
0.1 0.4 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.1 0.5 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.1 0.2 GO:1900195 spindle assembly involved in female meiosis I(GO:0007057) positive regulation of oocyte maturation(GO:1900195)
0.0 0.4 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.0 1.1 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.0 0.2 GO:0003350 pulmonary myocardium development(GO:0003350)
0.0 2.2 GO:0051602 response to electrical stimulus(GO:0051602)
0.0 0.3 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.0 0.2 GO:1902714 negative regulation of interferon-gamma secretion(GO:1902714)
0.0 0.1 GO:2000301 regulation of intracellular transport of viral material(GO:1901252) negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.3 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.0 0.4 GO:1900121 negative regulation of receptor binding(GO:1900121)
0.0 0.1 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.0 1.9 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.2 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.5 GO:0007035 vacuolar acidification(GO:0007035)
0.0 0.3 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.0 GO:0030327 prenylated protein catabolic process(GO:0030327)
0.0 0.0 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043)
0.0 0.1 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.0 0.2 GO:0016576 histone dephosphorylation(GO:0016576)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.0 GO:0044393 microspike(GO:0044393)
0.2 4.1 GO:0005922 connexon complex(GO:0005922)
0.1 0.5 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 0.2 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.1 GO:0019034 viral replication complex(GO:0019034)
0.0 3.6 GO:0005604 basement membrane(GO:0005604)
0.0 0.3 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.3 GO:0042599 lamellar body(GO:0042599)
0.0 0.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0004819 glutamine-tRNA ligase activity(GO:0004819)
0.1 0.6 GO:0042015 interleukin-20 binding(GO:0042015)
0.1 1.9 GO:0005243 gap junction channel activity(GO:0005243)
0.1 0.5 GO:0042835 BRE binding(GO:0042835)
0.1 0.3 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.1 0.2 GO:0004967 glucagon receptor activity(GO:0004967)
0.1 0.2 GO:0004818 glutamate-tRNA ligase activity(GO:0004818)
0.0 0.2 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.0 0.3 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 2.0 GO:0015485 cholesterol binding(GO:0015485)
0.0 1.1 GO:0043236 laminin binding(GO:0043236)
0.0 1.1 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.1 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.3 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 0.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.2 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 0.5 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.1 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.0 GO:0004914 interleukin-5 receptor activity(GO:0004914)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 PID TRAIL PATHWAY TRAIL signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.1 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 1.1 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 1.5 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.5 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.5 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.4 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling