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Epithelial-Mesenchymal Transition, human (Scheel, 2011): : averaged replicates

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Results for LEF1

Z-value: 2.41

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Transcription factors associated with LEF1

Gene Symbol Gene ID Gene Info
LEF1
ENSG00000138795.5 LEF1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LEF1hg19_v2_chr4_-_109087872_109087881,
hg19_v2_chr4_-_109088940_109089037		-0.088.5e-01Click!

Activity profile of LEF1 motif

Sorted Z-values of LEF1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of LEF1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr18_+_29027696 3.62 ENST00000257189.4
 DSG3
 desmoglein 3
chr16_+_68679193 2.83 ENST00000581171.1
 CDH3
 cadherin 3, type 1, P-cadherin (placental)
chr16_+_68678892 2.54 ENST00000429102.2
 CDH3
 cadherin 3, type 1, P-cadherin (placental)
chr9_-_23825956 2.41 ENST00000397312.2
 ELAVL2
 ELAV like neuron-specific RNA binding protein 2
chr16_+_68678739 2.34 ENST00000264012.4
 CDH3
 cadherin 3, type 1, P-cadherin (placental)
chr8_-_42234745 2.13 ENST00000220812.2
 DKK4
 dickkopf WNT signaling pathway inhibitor 4
chr15_+_43885252 2.11 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
 CKMT1B
 creatine kinase, mitochondrial 1B
chr1_+_82266053 2.11 ENST00000370715.1
ENST00000370713.1
ENST00000319517.6
ENST00000370717.2
ENST00000394879.1
ENST00000271029.4
ENST00000335786.5
 LPHN2
 latrophilin 2
chr15_+_43985725 2.06 ENST00000413453.2
 CKMT1A
 creatine kinase, mitochondrial 1A
chr5_+_66124590 2.05 ENST00000490016.2
ENST00000403666.1
ENST00000450827.1
 MAST4
 microtubule associated serine/threonine kinase family member 4
chr15_+_43985084 2.04 ENST00000434505.1
ENST00000411750.1
 CKMT1A
 creatine kinase, mitochondrial 1A
chr7_-_41742697 1.83 ENST00000242208.4
 INHBA
 inhibin, beta A
chr2_-_161056802 1.75 ENST00000283249.2
ENST00000409872.1
 ITGB6
 integrin, beta 6
chr2_-_161056762 1.75 ENST00000428609.2
ENST00000409967.2
 ITGB6
 integrin, beta 6
chr14_-_23624511 1.68 ENST00000529705.2
 SLC7A8
 solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr9_-_23826298 1.64 ENST00000380117.1
 ELAVL2
 ELAV like neuron-specific RNA binding protein 2
chr3_+_189349162 1.63 ENST00000264731.3
ENST00000382063.4
ENST00000418709.2
ENST00000320472.5
ENST00000392460.3
ENST00000440651.2
 TP63
 tumor protein p63
chrX_-_32173579 1.61 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
 DMD
 dystrophin
chr2_-_165424973 1.51 ENST00000543549.1
 GRB14
 growth factor receptor-bound protein 14
chr19_-_6690723 1.48 ENST00000601008.1
 C3
 complement component 3
chr7_+_69064300 1.45 ENST00000342771.4
 AUTS2
 autism susceptibility candidate 2
chr6_-_11807277 1.39 ENST00000379415.2
 ADTRP
 androgen-dependent TFPI-regulating protein
chr15_+_41136216 1.29 ENST00000562057.1
ENST00000344051.4
 SPINT1
 serine peptidase inhibitor, Kunitz type 1
chr11_-_87908600 1.27 ENST00000531138.1
ENST00000526372.1
ENST00000243662.6
 RAB38
 RAB38, member RAS oncogene family
chr6_+_37137939 1.27 ENST00000373509.5
 PIM1
 pim-1 oncogene
chr5_+_145317356 1.24 ENST00000511217.1
 SH3RF2
 SH3 domain containing ring finger 2
chr8_-_15095832 1.24 ENST00000382080.1
 SGCZ
 sarcoglycan, zeta
chr19_+_751122 1.18 ENST00000215582.6
 MISP
 mitotic spindle positioning
chr8_-_21988558 1.14 ENST00000312841.8
 HR
 hair growth associated
chr6_-_11779403 1.13 ENST00000414691.3
 ADTRP
 androgen-dependent TFPI-regulating protein
chr5_-_175964366 1.13 ENST00000274811.4
 RNF44
 ring finger protein 44
chr1_-_116383322 1.13 ENST00000429731.1
 NHLH2
 nescient helix loop helix 2
chr12_-_31477072 1.12 ENST00000454658.2
 FAM60A
 family with sequence similarity 60, member A
chr7_-_22233442 1.11 ENST00000401957.2
 RAPGEF5
 Rap guanine nucleotide exchange factor (GEF) 5
chr2_+_85360499 1.09 ENST00000282111.3
 TCF7L1
 transcription factor 7-like 1 (T-cell specific, HMG-box)
chr6_-_11779174 1.08 ENST00000379413.2
 ADTRP
 androgen-dependent TFPI-regulating protein
chr17_-_39507064 1.08 ENST00000007735.3
 KRT33A
 keratin 33A
chr12_-_67072714 1.05 ENST00000545666.1
ENST00000398016.3
ENST00000359742.4
ENST00000286445.7
ENST00000538211.1
 GRIP1
 glutamate receptor interacting protein 1
chr16_+_57673430 1.04 ENST00000540164.2
ENST00000568531.1
 GPR56
 G protein-coupled receptor 56
chr7_+_16793160 1.03 ENST00000262067.4
 TSPAN13
 tetraspanin 13
chr8_-_80993010 1.03 ENST00000537855.1
ENST00000520527.1
ENST00000517427.1
ENST00000448733.2
ENST00000379097.3
 TPD52
 tumor protein D52
chr7_+_20370300 1.01 ENST00000537992.1
 ITGB8
 integrin, beta 8
chr3_-_56809685 0.99 ENST00000413728.2
 ARHGEF3
 Rho guanine nucleotide exchange factor (GEF) 3
chr10_-_116164450 0.98 ENST00000369271.3
 AFAP1L2
 actin filament associated protein 1-like 2
chr18_-_53089723 0.98 ENST00000561992.1
ENST00000562512.2
 TCF4
 transcription factor 4
chr1_-_116383738 0.97 ENST00000320238.3
 NHLH2
 nescient helix loop helix 2
chr7_+_20370746 0.96 ENST00000222573.4
 ITGB8
 integrin, beta 8
chr5_+_140248518 0.95 ENST00000398640.2
 PCDHA11
 protocadherin alpha 11
chr10_-_116164239 0.95 ENST00000419268.1
ENST00000304129.4
ENST00000545353.1
 AFAP1L2
 actin filament associated protein 1-like 2
chr9_+_133971909 0.94 ENST00000247291.3
ENST00000372302.1
ENST00000372300.1
ENST00000372298.1
 AIF1L
 allograft inflammatory factor 1-like
chr9_+_133971863 0.91 ENST00000372309.3
 AIF1L
 allograft inflammatory factor 1-like
chr9_-_117150243 0.90 ENST00000374088.3
 AKNA
 AT-hook transcription factor
chr18_-_52989217 0.90 ENST00000570287.2
 TCF4
 transcription factor 4
chr12_-_95611149 0.89 ENST00000549499.1
ENST00000343958.4
ENST00000546711.1
 FGD6
 FYVE, RhoGEF and PH domain containing 6
chr2_+_171571827 0.88 ENST00000375281.3
 SP5
 Sp5 transcription factor
chr16_+_57673207 0.88 ENST00000564783.1
ENST00000564729.1
ENST00000565976.1
ENST00000566508.1
ENST00000544297.1
 GPR56
 G protein-coupled receptor 56
chr6_-_11779840 0.85 ENST00000506810.1
 ADTRP
 androgen-dependent TFPI-regulating protein
chr18_+_55888767 0.85 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
 NEDD4L
 neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr10_-_116444371 0.84 ENST00000533213.2
ENST00000369252.4
 ABLIM1
 actin binding LIM protein 1
chr5_+_147258266 0.82 ENST00000296694.4
 SCGB3A2
 secretoglobin, family 3A, member 2
chr18_-_74207146 0.79 ENST00000443185.2
 ZNF516
 zinc finger protein 516
chr14_+_75746781 0.79 ENST00000555347.1
 FOS
 FBJ murine osteosarcoma viral oncogene homolog
chr2_+_18059906 0.78 ENST00000304101.4
 KCNS3
 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
chr8_-_17579726 0.78 ENST00000381861.3
 MTUS1
 microtubule associated tumor suppressor 1
chr1_-_32801825 0.78 ENST00000329421.7
 MARCKSL1
 MARCKS-like 1
chr5_+_145316120 0.76 ENST00000359120.4
 SH3RF2
 SH3 domain containing ring finger 2
chr11_-_94965667 0.73 ENST00000542176.1
ENST00000278499.2
 SESN3
 sestrin 3
chr3_+_57875711 0.72 ENST00000442599.2
 SLMAP
 sarcolemma associated protein
chr11_-_119234876 0.72 ENST00000525735.1
 USP2
 ubiquitin specific peptidase 2
chr17_-_39646116 0.70 ENST00000328119.6
 KRT36
 keratin 36
chr4_+_146403912 0.69 ENST00000507367.1
ENST00000394092.2
ENST00000515385.1
 SMAD1
 SMAD family member 1
chr3_+_111260856 0.69 ENST00000352690.4
 CD96
 CD96 molecule
chr7_-_25268104 0.68 ENST00000222674.2
 NPVF
 neuropeptide VF precursor
chr3_-_141747950 0.67 ENST00000497579.1
 TFDP2
 transcription factor Dp-2 (E2F dimerization partner 2)
chr2_+_27665232 0.67 ENST00000543753.1
ENST00000288873.3
 KRTCAP3
 keratinocyte associated protein 3
chr17_+_55163075 0.65 ENST00000571629.1
ENST00000570423.1
ENST00000575186.1
ENST00000573085.1
ENST00000572814.1
 AKAP1
 A kinase (PRKA) anchor protein 1
chr4_+_20255123 0.65 ENST00000504154.1
ENST00000273739.5
 SLIT2
 slit homolog 2 (Drosophila)
chr2_+_27665289 0.64 ENST00000407293.1
 KRTCAP3
 keratinocyte associated protein 3
chr3_+_111260954 0.64 ENST00000283285.5
 CD96
 CD96 molecule
chr11_-_34535297 0.63 ENST00000532417.1
 ELF5
 E74-like factor 5 (ets domain transcription factor)
chr17_-_41623691 0.63 ENST00000545954.1
 ETV4
 ets variant 4
chr4_+_95972822 0.62 ENST00000509540.1
ENST00000440890.2
 BMPR1B
 bone morphogenetic protein receptor, type IB
chr6_+_13925318 0.62 ENST00000423553.2
ENST00000537388.1
 RNF182
 ring finger protein 182
chr11_+_120039685 0.62 ENST00000530303.1
ENST00000319763.1
 AP000679.2
 Uncharacterized protein
chr10_+_71561649 0.61 ENST00000398978.3
ENST00000354547.3
ENST00000357811.3
 COL13A1
 collagen, type XIII, alpha 1
chrX_-_128788914 0.61 ENST00000429967.1
ENST00000307484.6
 APLN
 apelin
chr1_+_84630367 0.60 ENST00000370680.1
 PRKACB
 protein kinase, cAMP-dependent, catalytic, beta
chrX_+_56259316 0.59 ENST00000468660.1
 KLF8
 Kruppel-like factor 8
chr7_+_73245193 0.59 ENST00000340958.2
 CLDN4
 claudin 4
chr7_-_16505440 0.59 ENST00000307068.4
 SOSTDC1
 sclerostin domain containing 1
chr10_+_71561630 0.59 ENST00000398974.3
ENST00000398971.3
ENST00000398968.3
ENST00000398966.3
ENST00000398964.3
ENST00000398969.3
ENST00000356340.3
ENST00000398972.3
ENST00000398973.3
 COL13A1
 collagen, type XIII, alpha 1
chr3_+_186648307 0.58 ENST00000457772.2
ENST00000455441.1
ENST00000427315.1
 ST6GAL1
 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr3_+_186648274 0.57 ENST00000169298.3
 ST6GAL1
 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr19_-_49864746 0.57 ENST00000598810.1
 TEAD2
 TEA domain family member 2
chr17_-_41623716 0.57 ENST00000319349.5
 ETV4
 ets variant 4
chr7_-_25702669 0.56 ENST00000446840.1
 AC003090.1
 AC003090.1
chr3_+_57875738 0.56 ENST00000417128.1
ENST00000438794.1
 SLMAP
 sarcolemma associated protein
chr2_+_162272605 0.56 ENST00000389554.3
 TBR1
 T-box, brain, 1
chr9_+_116638562 0.55 ENST00000374126.5
ENST00000288466.7
 ZNF618
 zinc finger protein 618
chr9_+_504674 0.55 ENST00000382297.2
 KANK1
 KN motif and ankyrin repeat domains 1
chr10_+_24497704 0.53 ENST00000376456.4
ENST00000458595.1
 KIAA1217
 KIAA1217
chr1_+_100111479 0.53 ENST00000263174.4
 PALMD
 palmdelphin
chr10_+_24498060 0.53 ENST00000376454.3
ENST00000376452.3
 KIAA1217
 KIAA1217
chr18_-_24237339 0.53 ENST00000580191.1
 KCTD1
 potassium channel tetramerization domain containing 1
chrX_-_24665208 0.53 ENST00000356768.4
 PCYT1B
 phosphate cytidylyltransferase 1, choline, beta
chr8_-_139926236 0.53 ENST00000303045.6
ENST00000435777.1
 COL22A1
 collagen, type XXII, alpha 1
chr5_+_140235469 0.52 ENST00000506939.2
ENST00000307360.5
 PCDHA10
 protocadherin alpha 10
chr3_-_33700933 0.52 ENST00000480013.1
 CLASP2
 cytoplasmic linker associated protein 2
chr4_+_113152881 0.52 ENST00000274000.5
 AP1AR
 adaptor-related protein complex 1 associated regulatory protein
chr2_-_72375167 0.51 ENST00000001146.2
 CYP26B1
 cytochrome P450, family 26, subfamily B, polypeptide 1
chr2_+_233734994 0.51 ENST00000331342.2
 C2orf82
 chromosome 2 open reading frame 82
chr13_+_97928395 0.50 ENST00000445661.2
 MBNL2
 muscleblind-like splicing regulator 2
chrX_+_37545012 0.50 ENST00000378616.3
 XK
 X-linked Kx blood group (McLeod syndrome)
chr4_+_96012614 0.50 ENST00000264568.4
 BMPR1B
 bone morphogenetic protein receptor, type IB
chr4_+_71494461 0.50 ENST00000396073.3
 ENAM
 enamelin
chr5_+_140207536 0.50 ENST00000529310.1
ENST00000527624.1
 PCDHA6
 protocadherin alpha 6
chr5_-_16936340 0.50 ENST00000507288.1
ENST00000513610.1
 MYO10
 myosin X
chr1_-_12677714 0.49 ENST00000376223.2
 DHRS3
 dehydrogenase/reductase (SDR family) member 3
chr2_-_74780176 0.49 ENST00000409549.1
 LOXL3
 lysyl oxidase-like 3
chr7_+_39017504 0.48 ENST00000403058.1
 POU6F2
 POU class 6 homeobox 2
chr11_-_34535332 0.47 ENST00000257832.2
ENST00000429939.2
 ELF5
 E74-like factor 5 (ets domain transcription factor)
chr14_-_65409502 0.47 ENST00000389614.5
 GPX2
 glutathione peroxidase 2 (gastrointestinal)
chr16_-_4323015 0.46 ENST00000204517.6
 TFAP4
 transcription factor AP-4 (activating enhancer binding protein 4)
chr4_-_123542224 0.46 ENST00000264497.3
 IL21
 interleukin 21
chr12_-_48963829 0.46 ENST00000301046.2
ENST00000549817.1
 LALBA
 lactalbumin, alpha-
chr8_-_145642267 0.45 ENST00000301305.3
 SLC39A4
 solute carrier family 39 (zinc transporter), member 4
chr15_-_52043722 0.45 ENST00000454181.2
 LYSMD2
 LysM, putative peptidoglycan-binding, domain containing 2
chr6_+_4776580 0.45 ENST00000397588.3
 CDYL
 chromodomain protein, Y-like
chr11_-_75917569 0.44 ENST00000322563.3
 WNT11
 wingless-type MMTV integration site family, member 11
chr4_+_71458012 0.43 ENST00000449493.2
 AMBN
 ameloblastin (enamel matrix protein)
chr11_-_117747434 0.43 ENST00000529335.2
ENST00000530956.1
ENST00000260282.4
 FXYD6
 FXYD domain containing ion transport regulator 6
chr1_+_144339738 0.42 ENST00000538264.1
 AL592284.1
 Protein LOC642441
chr1_-_54303949 0.42 ENST00000234725.8
 NDC1
 NDC1 transmembrane nucleoporin
chr2_-_118943930 0.42 ENST00000449075.1
ENST00000414886.1
ENST00000449819.1
 AC093901.1
 AC093901.1
chr2_-_9143786 0.42 ENST00000462696.1
ENST00000305997.3
 MBOAT2
 membrane bound O-acyltransferase domain containing 2
chr1_-_216896780 0.42 ENST00000459955.1
ENST00000366937.1
ENST00000408911.3
ENST00000391890.3
 ESRRG
 estrogen-related receptor gamma
chr10_+_134210672 0.42 ENST00000305233.5
ENST00000368609.4
 PWWP2B
 PWWP domain containing 2B
chr4_+_30721968 0.42 ENST00000361762.2
 PCDH7
 protocadherin 7
chr5_+_161494521 0.41 ENST00000356592.3
 GABRG2
 gamma-aminobutyric acid (GABA) A receptor, gamma 2
chrX_-_24665353 0.40 ENST00000379144.2
 PCYT1B
 phosphate cytidylyltransferase 1, choline, beta
chr16_-_4987065 0.40 ENST00000590782.2
ENST00000345988.2
 PPL
 periplakin
chr18_+_28956740 0.40 ENST00000308128.4
ENST00000359747.4
 DSG4
 desmoglein 4
chr10_-_61900762 0.40 ENST00000355288.2
 ANK3
 ankyrin 3, node of Ranvier (ankyrin G)
chr17_-_27503770 0.40 ENST00000533112.1
 MYO18A
 myosin XVIIIA
chr12_+_70760056 0.40 ENST00000258111.4
 KCNMB4
 potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr20_+_20348740 0.40 ENST00000310227.1
 INSM1
 insulinoma-associated 1
chr8_-_20161466 0.40 ENST00000381569.1
 LZTS1
 leucine zipper, putative tumor suppressor 1
chr6_+_135502466 0.40 ENST00000367814.4
 MYB
 v-myb avian myeloblastosis viral oncogene homolog
chr3_+_132757215 0.39 ENST00000321871.6
ENST00000393130.3
ENST00000514894.1
ENST00000512662.1
 TMEM108
 transmembrane protein 108
chr4_+_113152978 0.38 ENST00000309703.6
 AP1AR
 adaptor-related protein complex 1 associated regulatory protein
chr17_-_41738931 0.38 ENST00000329168.3
ENST00000549132.1
 MEOX1
 mesenchyme homeobox 1
chr9_+_84304628 0.38 ENST00000437181.1
 RP11-154D17.1
 RP11-154D17.1
chr17_+_57297807 0.38 ENST00000284116.4
ENST00000581140.1
ENST00000581276.1
 GDPD1
 glycerophosphodiester phosphodiesterase domain containing 1
chr4_-_139163491 0.37 ENST00000280612.5
 SLC7A11
 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr16_-_30122717 0.37 ENST00000566613.1
 GDPD3
 glycerophosphodiester phosphodiesterase domain containing 3
chr18_-_52989525 0.37 ENST00000457482.3
 TCF4
 transcription factor 4
chr2_-_74781061 0.37 ENST00000264094.3
ENST00000393937.2
ENST00000409986.1
 LOXL3
 lysyl oxidase-like 3
chr15_+_50474385 0.37 ENST00000267842.5
 SLC27A2
 solute carrier family 27 (fatty acid transporter), member 2
chr1_-_54303934 0.37 ENST00000537333.1
 NDC1
 NDC1 transmembrane nucleoporin
chr1_+_196743912 0.37 ENST00000367425.4
 CFHR3
 complement factor H-related 3
chr11_-_47207390 0.37 ENST00000539589.1
ENST00000528462.1
 PACSIN3
 protein kinase C and casein kinase substrate in neurons 3
chr5_-_115872142 0.37 ENST00000510263.1
 SEMA6A
 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr11_-_75017734 0.37 ENST00000532525.1
 ARRB1
 arrestin, beta 1
chr15_-_65067773 0.37 ENST00000300069.4
 RBPMS2
 RNA binding protein with multiple splicing 2
chr6_+_135502408 0.36 ENST00000341911.5
ENST00000442647.2
ENST00000316528.8
 MYB
 v-myb avian myeloblastosis viral oncogene homolog
chr4_-_23891693 0.36 ENST00000264867.2
 PPARGC1A
 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr6_-_25874440 0.36 ENST00000361703.6
ENST00000397060.4
 SLC17A3
 solute carrier family 17 (organic anion transporter), member 3
chr17_-_41739283 0.36 ENST00000393661.2
ENST00000318579.4
 MEOX1
 mesenchyme homeobox 1
chr1_+_32739733 0.36 ENST00000333070.4
 LCK
 lymphocyte-specific protein tyrosine kinase
chr18_-_53069419 0.35 ENST00000570177.2
 TCF4
 transcription factor 4
chr1_+_196743943 0.35 ENST00000471440.2
ENST00000391985.3
 CFHR3
 complement factor H-related 3
chr8_-_33424636 0.34 ENST00000256257.1
 RNF122
 ring finger protein 122
chr4_-_123377880 0.34 ENST00000226730.4
 IL2
 interleukin 2
chr1_-_53793584 0.34 ENST00000354412.3
ENST00000347547.2
ENST00000306052.6
 LRP8
 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr13_-_99630233 0.34 ENST00000376460.1
ENST00000442173.1
 DOCK9
 dedicator of cytokinesis 9
chr2_+_26568965 0.34 ENST00000260585.7
ENST00000447170.1
 EPT1
 ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
chr10_+_71561704 0.34 ENST00000520267.1
 COL13A1
 collagen, type XIII, alpha 1
chr3_-_141747439 0.34 ENST00000467667.1
 TFDP2
 transcription factor Dp-2 (E2F dimerization partner 2)
chr6_-_127840021 0.34 ENST00000465909.2
 SOGA3
 SOGA family member 3
chr1_+_27668505 0.34 ENST00000318074.5
 SYTL1
 synaptotagmin-like 1
chr3_-_33686743 0.34 ENST00000333778.6
ENST00000539981.1
 CLASP2
 cytoplasmic linker associated protein 2
chr7_-_19184929 0.33 ENST00000275461.3
 FERD3L
 Fer3-like bHLH transcription factor
chr3_+_171561127 0.33 ENST00000334567.5
ENST00000450693.1
 TMEM212
 transmembrane protein 212
chr17_-_7297833 0.33 ENST00000571802.1
ENST00000576201.1
ENST00000573213.1
ENST00000324822.11
 TMEM256-PLSCR3
 TMEM256-PLSCR3 readthrough (NMD candidate)
chr1_+_93544791 0.33 ENST00000545708.1
ENST00000540243.1
ENST00000370298.4
 MTF2
 metal response element binding transcription factor 2
chr3_+_178253993 0.32 ENST00000420517.2
ENST00000452583.1
 KCNMB2
 potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr1_-_155948318 0.32 ENST00000361247.4
 ARHGEF2
 Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr14_-_23451845 0.32 ENST00000262713.2
 AJUBA
 ajuba LIM protein
chr6_+_135502501 0.32 ENST00000527615.1
ENST00000420123.2
ENST00000525369.1
ENST00000528774.1
ENST00000534121.1
ENST00000534044.1
ENST00000533624.1
 MYB
 v-myb avian myeloblastosis viral oncogene homolog
chr11_-_104769141 0.32 ENST00000508062.1
ENST00000422698.2
 CASP12
 caspase 12 (gene/pseudogene)
chr5_-_76935513 0.32 ENST00000306422.3
 OTP
 orthopedia homeobox
chr4_-_85419603 0.32 ENST00000295886.4
 NKX6-1
 NK6 homeobox 1
chr6_-_127840336 0.31 ENST00000525778.1
 SOGA3
 SOGA family member 3
chr10_+_123923205 0.31 ENST00000369004.3
ENST00000260733.3
 TACC2
 transforming, acidic coiled-coil containing protein 2
chr6_+_138483058 0.31 ENST00000251691.4
 KIAA1244
 KIAA1244
chr3_+_52813932 0.31 ENST00000537050.1
 ITIH1
 inter-alpha-trypsin inhibitor heavy chain 1
chr20_-_23066953 0.31 ENST00000246006.4
 CD93
 CD93 molecule
chr4_-_72649763 0.31 ENST00000513476.1
 GC
 group-specific component (vitamin D binding protein)
chr1_-_226496898 0.31 ENST00000481685.1
 LIN9
 lin-9 homolog (C. elegans)
chr14_-_57272366 0.31 ENST00000554788.1
ENST00000554845.1
ENST00000408990.3
 OTX2
 orthodenticle homeobox 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 7.7 GO:0032771 regulation of monophenol monooxygenase activity(GO:0032771) positive regulation of monophenol monooxygenase activity(GO:0032773) negative regulation of catagen(GO:0051796) regulation of hair cycle by canonical Wnt signaling pathway(GO:0060901) positive regulation of melanosome transport(GO:1902910)
0.6 1.8 GO:0060279 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.6 2.3 GO:0051799 negative regulation of hair follicle development(GO:0051799)
0.5 1.6 GO:0098582 innate vocalization behavior(GO:0098582)
0.5 1.5 GO:0002894 positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894)
0.5 1.4 GO:0002728 negative regulation of natural killer cell cytokine production(GO:0002728)
0.4 4.1 GO:0006600 creatine metabolic process(GO:0006600)
0.4 1.6 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
0.4 3.3 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.4 1.1 GO:0051300 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.4 1.1 GO:1990922 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.3 0.9 GO:0048203 vesicle targeting, trans-Golgi to endosome(GO:0048203)
0.3 0.9 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.3 0.8 GO:0021827 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836)
0.2 0.2 GO:0060738 epithelial-mesenchymal signaling involved in prostate gland development(GO:0060738)
0.2 1.1 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.2 0.6 GO:0043396 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397)
0.2 1.4 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.2 0.6 GO:0048691 modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
0.2 0.5 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.2 1.3 GO:1903232 melanosome assembly(GO:1903232)
0.2 0.8 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.2 1.3 GO:0001661 conditioned taste aversion(GO:0001661)
0.2 0.5 GO:0031133 regulation of axon diameter(GO:0031133)
0.2 1.1 GO:0048706 embryonic skeletal system development(GO:0048706)
0.2 0.5 GO:0005988 lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989)
0.2 0.3 GO:0060166 olfactory pit development(GO:0060166)
0.1 0.4 GO:0060775 mediolateral intercalation(GO:0060031) planar cell polarity pathway involved in gastrula mediolateral intercalation(GO:0060775)
0.1 0.7 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.1 1.6 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 0.6 GO:2000320 negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.1 0.4 GO:1901860 positive regulation of mitochondrial DNA metabolic process(GO:1901860)
0.1 0.4 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.1 0.4 GO:1903028 positive regulation of opsonization(GO:1903028)
0.1 0.4 GO:0003358 noradrenergic neuron development(GO:0003358)
0.1 0.7 GO:0061056 somite specification(GO:0001757) sclerotome development(GO:0061056)
0.1 0.5 GO:0048867 ganglion mother cell fate determination(GO:0007402) stem cell fate determination(GO:0048867)
0.1 1.3 GO:0070561 vitamin D receptor signaling pathway(GO:0070561) positive regulation of cell proliferation involved in heart morphogenesis(GO:2000138)
0.1 0.5 GO:0034224 cellular response to zinc ion starvation(GO:0034224)
0.1 0.3 GO:0021913 glandular epithelial cell maturation(GO:0002071) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913) type B pancreatic cell maturation(GO:0072560)
0.1 0.6 GO:1902730 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.1 0.3 GO:0042116 macrophage activation(GO:0042116)
0.1 0.6 GO:0001712 ectodermal cell fate commitment(GO:0001712)
0.1 0.4 GO:1900827 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 0.7 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
0.1 0.3 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.1 0.4 GO:0097089 methyl-branched fatty acid metabolic process(GO:0097089)
0.1 0.6 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.1 0.1 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.1 0.3 GO:0060061 Spemann organizer formation(GO:0060061) canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation(GO:1904954)
0.1 1.4 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.1 0.5 GO:0042488 positive regulation of odontogenesis of dentin-containing tooth(GO:0042488)
0.1 1.2 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.1 0.5 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.1 1.0 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.1 0.9 GO:0006657 CDP-choline pathway(GO:0006657)
0.1 2.0 GO:0001573 ganglioside metabolic process(GO:0001573)
0.1 2.1 GO:0044705 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.1 0.4 GO:0007068 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070)
0.1 0.2 GO:0048250 mitochondrial iron ion transport(GO:0048250)
0.1 0.3 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.1 0.5 GO:0097338 response to clozapine(GO:0097338)
0.1 0.7 GO:0002051 osteoblast fate commitment(GO:0002051)
0.1 0.9 GO:0038203 TORC2 signaling(GO:0038203)
0.1 0.3 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.1 0.2 GO:0071423 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) malate transmembrane transport(GO:0071423) oxaloacetate(2-) transmembrane transport(GO:1902356)
0.1 0.5 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.1 0.2 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.1 0.2 GO:0007538 primary sex determination(GO:0007538)
0.1 0.6 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.1 1.1 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.1 0.3 GO:0070842 aggresome assembly(GO:0070842)
0.1 0.7 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.1 0.3 GO:2000543 positive regulation of gastrulation(GO:2000543)
0.1 0.6 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.1 0.3 GO:0050830 defense response to Gram-positive bacterium(GO:0050830)
0.1 0.5 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.1 0.2 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.1 0.4 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.0 0.5 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.0 0.1 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.0 0.3 GO:0033504 floor plate development(GO:0033504)
0.0 0.1 GO:0090245 axis elongation involved in somitogenesis(GO:0090245)
0.0 0.2 GO:0035063 nuclear speck organization(GO:0035063)
0.0 0.1 GO:1990569 UDP-N-acetylglucosamine transport(GO:0015788) UDP-N-acetylglucosamine transmembrane transport(GO:1990569)
0.0 1.5 GO:0015695 organic cation transport(GO:0015695)
0.0 0.3 GO:0000436 carbon catabolite regulation of transcription from RNA polymerase II promoter(GO:0000429) regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432) carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.0 0.2 GO:0070980 biphenyl catabolic process(GO:0070980)
0.0 0.1 GO:0051086 chaperone mediated protein folding independent of cofactor(GO:0051086)
0.0 0.1 GO:1903977 positive regulation of glial cell migration(GO:1903977)
0.0 0.1 GO:0002439 chronic inflammatory response to antigenic stimulus(GO:0002439)
0.0 0.4 GO:0090240 positive regulation of histone H4 acetylation(GO:0090240)
0.0 0.6 GO:0030903 notochord development(GO:0030903)
0.0 0.6 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.0 0.4 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.0 0.4 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0 0.3 GO:0055059 asymmetric neuroblast division(GO:0055059) positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0 1.9 GO:0032757 positive regulation of interleukin-8 production(GO:0032757)
0.0 5.0 GO:0070268 cornification(GO:0070268)
0.0 0.6 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.4 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.1 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.0 0.5 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.2 GO:0060125 negative regulation of growth hormone secretion(GO:0060125)
0.0 0.1 GO:1904693 midbrain morphogenesis(GO:1904693)
0.0 0.5 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.0 0.2 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.0 0.8 GO:0046716 muscle cell cellular homeostasis(GO:0046716)
0.0 0.1 GO:0021592 midbrain-hindbrain boundary morphogenesis(GO:0021555) fourth ventricle development(GO:0021592)
0.0 0.4 GO:0035745 T-helper 2 cell cytokine production(GO:0035745)
0.0 0.3 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.3 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.0 0.3 GO:1905247 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) positive regulation of aspartic-type peptidase activity(GO:1905247)
0.0 1.4 GO:0046627 negative regulation of insulin receptor signaling pathway(GO:0046627)
0.0 0.0 GO:1990926 short-term synaptic potentiation(GO:1990926)
0.0 0.1 GO:0002678 positive regulation of chronic inflammatory response(GO:0002678)
0.0 0.3 GO:0045054 constitutive secretory pathway(GO:0045054)
0.0 0.5 GO:0061436 establishment of skin barrier(GO:0061436)
0.0 0.3 GO:0097264 self proteolysis(GO:0097264)
0.0 0.3 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.0 0.2 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.2 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0 0.1 GO:0003051 angiotensin-mediated drinking behavior(GO:0003051)
0.0 0.2 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.0 0.1 GO:0009212 dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212)
0.0 0.3 GO:2000288 positive regulation of myoblast proliferation(GO:2000288)
0.0 1.2 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.2 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 0.3 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0 0.1 GO:0003350 pulmonary myocardium development(GO:0003350)
0.0 0.2 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0 0.2 GO:0042428 serotonin metabolic process(GO:0042428)
0.0 0.3 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.3 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0 0.3 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0 0.1 GO:0033386 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.0 0.2 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 0.0 GO:2000382 positive regulation of mesoderm development(GO:2000382)
0.0 0.0 GO:1902226 regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) regulation of response to macrophage colony-stimulating factor(GO:1903969) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973)
0.0 0.1 GO:0009644 response to high light intensity(GO:0009644) cellular response to light intensity(GO:0071484)
0.0 0.1 GO:0071895 odontoblast differentiation(GO:0071895)
0.0 0.1 GO:0097151 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0 0.6 GO:0036152 phosphatidylethanolamine acyl-chain remodeling(GO:0036152)
0.0 0.4 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.1 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.0 0.0 GO:1904424 regulation of GTP binding(GO:1904424)
0.0 0.5 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 1.0 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.0 0.3 GO:0008595 tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595)
0.0 0.1 GO:1901377 mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788)
0.0 0.4 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.1 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.0 0.1 GO:0090625 mRNA cleavage involved in gene silencing by siRNA(GO:0090625)
0.0 0.4 GO:1900363 regulation of mRNA polyadenylation(GO:1900363)
0.0 0.3 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.0 0.1 GO:0014050 negative regulation of glutamate secretion(GO:0014050)
0.0 0.4 GO:0006629 lipid metabolic process(GO:0006629)
0.0 0.4 GO:0010669 epithelial structure maintenance(GO:0010669)
0.0 0.2 GO:0001865 NK T cell differentiation(GO:0001865)
0.0 0.8 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 0.2 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.0 GO:1904247 positive regulation of polynucleotide adenylyltransferase activity(GO:1904247)
0.0 0.4 GO:0071897 DNA biosynthetic process(GO:0071897)
0.0 0.3 GO:0001764 neuron migration(GO:0001764)
0.0 0.5 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 0.0 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.0 0.4 GO:0016242 negative regulation of macroautophagy(GO:0016242)
0.0 0.2 GO:1901078 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.2 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.1 GO:0021612 facial nerve structural organization(GO:0021612)
0.0 1.4 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.5 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.1 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.0 0.8 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.2 GO:0090331 negative regulation of platelet aggregation(GO:0090331)
0.0 0.2 GO:0019532 oxalate transport(GO:0019532)
0.0 0.1 GO:0030879 mammary gland development(GO:0030879)
0.0 0.2 GO:0072307 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.0 0.1 GO:0035995 skeletal muscle myosin thick filament assembly(GO:0030241) detection of muscle stretch(GO:0035995)
0.0 0.1 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.1 GO:0034626 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.0 GO:0061113 elastin metabolic process(GO:0051541) pancreas morphogenesis(GO:0061113)
0.0 0.1 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
0.0 0.3 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 0.1 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 0.1 GO:0021759 globus pallidus development(GO:0021759)
0.0 0.2 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.5 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
1.0 2.0 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.6 1.8 GO:0043512 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.4 1.8 GO:0030936 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.4 1.1 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.3 1.3 GO:0031905 early endosome lumen(GO:0031905)
0.2 1.6 GO:0016013 syntrophin complex(GO:0016013)
0.2 0.6 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.1 1.2 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 4.5 GO:0030057 desmosome(GO:0030057)
0.1 0.6 GO:0071664 beta-catenin-TCF7L2 complex(GO:0070369) catenin-TCF7L2 complex(GO:0071664)
0.1 0.8 GO:0035976 AP1 complex(GO:0035976)
0.1 0.3 GO:0018444 translation release factor complex(GO:0018444)
0.1 1.1 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 1.0 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 0.7 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.3 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.3 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.0 1.1 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.3 GO:0016589 NURF complex(GO:0016589)
0.0 0.3 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.5 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.2 GO:0031010 ISWI-type complex(GO:0031010)
0.0 0.8 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.0 0.1 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.5 GO:0032433 filopodium tip(GO:0032433)
0.0 1.3 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 0.6 GO:0071141 SMAD protein complex(GO:0071141)
0.0 0.2 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 2.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.2 GO:0032059 bleb(GO:0032059)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.5 GO:0071564 npBAF complex(GO:0071564)
0.0 0.0 GO:0036194 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.1 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.0 0.2 GO:1990909 Wnt signalosome(GO:1990909)
0.0 0.6 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.2 GO:0005915 zonula adherens(GO:0005915)
0.0 0.4 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.6 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.2 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 2.0 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.2 GO:0097413 Lewy body(GO:0097413)
0.0 0.4 GO:0097440 apical dendrite(GO:0097440)
0.0 0.1 GO:0038038 G-protein coupled receptor homodimeric complex(GO:0038038)
0.0 0.2 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 2.4 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.4 GO:0031143 pseudopodium(GO:0031143)
0.0 0.3 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.8 GO:0005771 multivesicular body(GO:0005771)
0.0 0.1 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.9 GO:0016235 aggresome(GO:0016235)
0.0 0.2 GO:0032156 septin cytoskeleton(GO:0032156)
0.0 1.3 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.4 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.3 GO:0005922 connexon complex(GO:0005922)
0.0 1.4 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 0.4 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.1 GO:0000235 astral microtubule(GO:0000235) aster(GO:0005818)
0.0 0.1 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0 0.1 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.2 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 2.2 GO:0032993 protein-DNA complex(GO:0032993)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0070699 type II activin receptor binding(GO:0070699)
0.6 4.1 GO:0004111 creatine kinase activity(GO:0004111)
0.5 2.2 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
0.3 2.0 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.3 1.1 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.2 2.6 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.2 0.9 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.2 0.9 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.2 2.0 GO:0019534 toxin transporter activity(GO:0019534)
0.1 0.4 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.1 0.5 GO:0038025 reelin receptor activity(GO:0038025)
0.1 1.6 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.1 1.1 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 0.4 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.1 0.6 GO:0098821 BMP receptor activity(GO:0098821)
0.1 0.5 GO:0004461 lactose synthase activity(GO:0004461)
0.1 2.7 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.8 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.1 0.7 GO:0043237 laminin-1 binding(GO:0043237)
0.1 1.1 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 1.1 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 0.6 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.1 0.2 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.1 0.4 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.1 0.2 GO:0004796 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.1 0.4 GO:0042610 CD8 receptor binding(GO:0042610)
0.1 1.3 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.1 0.3 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.1 0.8 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 0.2 GO:0015131 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131)
0.1 0.8 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.1 1.1 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1 0.6 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 0.4 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.1 0.4 GO:0050682 AF-2 domain binding(GO:0050682)
0.1 2.1 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 1.9 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.1 0.2 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.1 0.5 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.1 0.3 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.6 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.0 0.2 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.0 0.6 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 0.7 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.4 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.1 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.6 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.5 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.1 GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity(GO:0005462)
0.0 2.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.1 GO:0017002 activin-activated receptor activity(GO:0017002)
0.0 0.2 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.0 0.8 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 1.1 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.3 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.1 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.0 0.1 GO:0034711 inhibin binding(GO:0034711)
0.0 3.9 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.3 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.2 GO:0004522 ribonuclease A activity(GO:0004522)
0.0 0.4 GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144)
0.0 0.1 GO:0099609 microtubule lateral binding(GO:0099609)
0.0 0.3 GO:0008430 selenium binding(GO:0008430)
0.0 0.7 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.1 GO:0070905 serine binding(GO:0070905)
0.0 0.5 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
0.0 0.5 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.8 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.1 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.0 0.4 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.1 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.0 0.3 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.0 0.7 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.1 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 0.1 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.0 0.1 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0 0.3 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.4 GO:0015245 fatty acid transporter activity(GO:0015245) very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 2.4 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.1 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.3 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.3 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.7 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.3 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.0 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.2 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.8 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.1 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.0 0.1 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.0 0.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.1 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.7 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 0.2 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.6 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.3 GO:0070628 proteasome binding(GO:0070628)
0.0 0.0 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.0 0.1 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.0 0.3 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172)
0.0 0.2 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.2 GO:0005549 odorant binding(GO:0005549)
0.0 0.1 GO:0102336 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 1.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.4 GO:0017022 myosin binding(GO:0017022)
0.0 0.1 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.1 GO:0035198 miRNA binding(GO:0035198)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.2 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 1.9 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 2.6 PID ALK1 PATHWAY ALK1 signaling events
0.1 4.9 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.8 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.6 NABA COLLAGENS Genes encoding collagen proteins
0.0 1.0 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 1.2 PID BMP PATHWAY BMP receptor signaling
0.0 0.5 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.3 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.3 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 0.2 PID FGF PATHWAY FGF signaling pathway
0.0 0.2 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.5 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.6 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 1.1 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.2 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.0 0.8 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.8 PID SHP2 PATHWAY SHP2 signaling
0.0 0.6 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.7 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.2 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 1.5 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 1.2 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.3 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.4 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.4 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.2 6.3 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.8 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 1.8 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 1.3 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 2.7 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 0.8 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 2.1 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 1.9 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.4 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.6 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 5.4 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.8 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.4 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.3 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 1.8 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.3 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.2 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.9 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 6.8 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.5 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.0 0.6 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.5 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.4 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.4 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.0 0.4 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.4 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.2 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.3 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.6 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.4 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.4 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.9 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.4 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.3 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.2 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.4 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.2 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 2.1 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.4 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.8 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.0 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.5 REACTOME CGMP EFFECTS Genes involved in cGMP effects