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Epithelial-Mesenchymal Transition, human (Scheel, 2011): : averaged replicates

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Results for NR1D1

Z-value: 0.48

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Transcription factors associated with NR1D1

Gene Symbol Gene ID Gene Info
NR1D1
ENSG00000126368.5 NR1D1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NR1D1hg19_v2_chr17_-_38256973_382569900.911.9e-03Click!

Activity profile of NR1D1 motif

Sorted Z-values of NR1D1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NR1D1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr1_+_44398943 0.47 ENST00000372359.5
ENST00000414809.3
 ARTN
 artemin
chr16_+_67233412 0.36 ENST00000477898.1
 ELMO3
 engulfment and cell motility 3
chr16_+_67233007 0.36 ENST00000360833.1
ENST00000393997.2
 ELMO3
 engulfment and cell motility 3
chr17_-_3599327 0.32 ENST00000551178.1
ENST00000552276.1
ENST00000547178.1
 P2RX5
 purinergic receptor P2X, ligand-gated ion channel, 5
chr17_-_3599492 0.31 ENST00000435558.1
ENST00000345901.3
 P2RX5
 purinergic receptor P2X, ligand-gated ion channel, 5
chr15_+_26360970 0.26 ENST00000556159.1
ENST00000557523.1
 LINC00929
 long intergenic non-protein coding RNA 929
chr3_+_169755715 0.23 ENST00000355897.5
 GPR160
 G protein-coupled receptor 160
chr1_-_6557156 0.22 ENST00000537245.1
 PLEKHG5
 pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr17_-_74528128 0.21 ENST00000590175.1
 CYGB
 cytoglobin
chr1_+_20915409 0.21 ENST00000375071.3
 CDA
 cytidine deaminase
chr17_-_76128488 0.20 ENST00000322914.3
 TMC6
 transmembrane channel-like 6
chr2_-_64371546 0.19 ENST00000358912.4
 PELI1
 pellino E3 ubiquitin protein ligase 1
chrX_-_49089771 0.18 ENST00000376251.1
ENST00000323022.5
ENST00000376265.2
 CACNA1F
 calcium channel, voltage-dependent, L type, alpha 1F subunit
chr1_-_41131326 0.18 ENST00000372684.3
 RIMS3
 regulating synaptic membrane exocytosis 3
chr19_-_52035044 0.15 ENST00000359982.4
ENST00000436458.1
ENST00000425629.3
ENST00000391797.3
ENST00000343300.4
 SIGLEC6
 sialic acid binding Ig-like lectin 6
chr17_+_39405939 0.14 ENST00000334109.2
 KRTAP9-4
 keratin associated protein 9-4
chr17_-_38074842 0.14 ENST00000309481.7
 GSDMB
 gasdermin B
chr17_-_38074859 0.13 ENST00000520542.1
ENST00000418519.1
ENST00000394179.1
 GSDMB
 gasdermin B
chr10_-_103880209 0.13 ENST00000425280.1
 LDB1
 LIM domain binding 1
chr2_+_103353367 0.13 ENST00000454536.1
ENST00000409528.1
ENST00000409173.1
 TMEM182
 transmembrane protein 182
chr19_-_42927251 0.13 ENST00000597001.1
 LIPE
 lipase, hormone-sensitive
chr1_-_111991850 0.11 ENST00000411751.2
 WDR77
 WD repeat domain 77
chr1_+_2398876 0.10 ENST00000449969.1
 PLCH2
 phospholipase C, eta 2
chr17_-_56358287 0.10 ENST00000225275.3
ENST00000340482.3
 MPO
 myeloperoxidase
chr10_-_8095412 0.10 ENST00000458727.1
ENST00000355358.1
 RP11-379F12.3
GATA3-AS1
 RP11-379F12.3
GATA3 antisense RNA 1
chr2_+_220306745 0.10 ENST00000431523.1
ENST00000396698.1
ENST00000396695.2
 SPEG
 SPEG complex locus
chr2_-_73053126 0.09 ENST00000272427.6
ENST00000410104.1
 EXOC6B
 exocyst complex component 6B
chr17_+_39394250 0.09 ENST00000254072.6
 KRTAP9-8
 keratin associated protein 9-8
chr8_+_105235572 0.08 ENST00000523362.1
 RIMS2
 regulating synaptic membrane exocytosis 2
chr8_+_101162812 0.08 ENST00000353107.3
ENST00000522439.1
 POLR2K
 polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
chr17_-_38256973 0.08 ENST00000246672.3
 NR1D1
 nuclear receptor subfamily 1, group D, member 1
chr1_-_11865982 0.07 ENST00000418034.1
 MTHFR
 methylenetetrahydrofolate reductase (NAD(P)H)
chr15_-_65903574 0.07 ENST00000420799.2
ENST00000313182.2
ENST00000431261.2
ENST00000442903.3
 VWA9
 von Willebrand factor A domain containing 9
chr3_-_182703688 0.07 ENST00000466812.1
ENST00000487822.1
ENST00000460412.1
ENST00000469954.1
 DCUN1D1
 DCN1, defective in cullin neddylation 1, domain containing 1
chr7_+_97736197 0.07 ENST00000297293.5
 LMTK2
 lemur tyrosine kinase 2
chr2_+_113342011 0.06 ENST00000324913.5
 CHCHD5
 coiled-coil-helix-coiled-coil-helix domain containing 5
chr11_+_46740730 0.06 ENST00000311907.5
ENST00000530231.1
ENST00000442468.1
 F2
 coagulation factor II (thrombin)
chr17_+_6899366 0.06 ENST00000251535.6
 ALOX12
 arachidonate 12-lipoxygenase
chr9_+_101569944 0.06 ENST00000375011.3
 GALNT12
 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12)
chr2_+_113342163 0.06 ENST00000409719.1
 CHCHD5
 coiled-coil-helix-coiled-coil-helix domain containing 5
chr4_+_1873100 0.06 ENST00000508803.1
 WHSC1
 Wolf-Hirschhorn syndrome candidate 1
chr22_+_37415700 0.06 ENST00000397129.1
 MPST
 mercaptopyruvate sulfurtransferase
chr15_-_65903407 0.06 ENST00000395644.4
ENST00000567744.1
ENST00000568573.1
ENST00000562830.1
ENST00000569491.1
ENST00000561769.1
 VWA9
 von Willebrand factor A domain containing 9
chr13_+_113622810 0.05 ENST00000397030.1
 MCF2L
 MCF.2 cell line derived transforming sequence-like
chr1_-_111991908 0.05 ENST00000235090.5
 WDR77
 WD repeat domain 77
chr22_+_37415776 0.05 ENST00000341116.3
ENST00000429360.2
ENST00000404393.1
 MPST
 mercaptopyruvate sulfurtransferase
chr14_+_24540731 0.05 ENST00000558859.1
ENST00000559197.1
ENST00000560828.1
ENST00000216775.2
ENST00000560884.1
 CPNE6
 copine VI (neuronal)
chr22_+_37415728 0.05 ENST00000404802.3
 MPST
 mercaptopyruvate sulfurtransferase
chr2_+_63816295 0.05 ENST00000539945.1
ENST00000544381.1
 MDH1
 malate dehydrogenase 1, NAD (soluble)
chr7_+_45039783 0.05 ENST00000258781.6
ENST00000541586.1
ENST00000544363.1
 CCM2
 cerebral cavernous malformation 2
chr1_+_203764742 0.05 ENST00000432282.1
ENST00000453771.1
ENST00000367214.1
ENST00000367212.3
ENST00000332127.4
 ZC3H11A
 zinc finger CCCH-type containing 11A
chr2_-_89513402 0.05 ENST00000498435.1
 IGKV1-27
 immunoglobulin kappa variable 1-27
chr6_+_63921351 0.05 ENST00000370659.1
 FKBP1C
 FK506 binding protein 1C
chr21_-_28820892 0.05 ENST00000420186.2
 AP001604.3
 AP001604.3
chr11_+_125365110 0.05 ENST00000527818.1
 AP000708.1
 AP000708.1
chr1_-_147245484 0.05 ENST00000271348.2
 GJA5
 gap junction protein, alpha 5, 40kDa
chr2_+_63816087 0.05 ENST00000409908.1
ENST00000442225.1
ENST00000409476.1
ENST00000436321.1
 MDH1
 malate dehydrogenase 1, NAD (soluble)
chr7_-_142630820 0.05 ENST00000442623.1
ENST00000265310.1
 TRPV5
 transient receptor potential cation channel, subfamily V, member 5
chr1_-_156918806 0.05 ENST00000315174.8
 ARHGEF11
 Rho guanine nucleotide exchange factor (GEF) 11
chr10_+_23217006 0.04 ENST00000376528.4
ENST00000447081.1
 ARMC3
 armadillo repeat containing 3
chr22_-_37880543 0.04 ENST00000442496.1
 MFNG
 MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr4_-_147043058 0.04 ENST00000512063.1
ENST00000507726.1
 RP11-6L6.3
 long intergenic non-protein coding RNA 1095
chr19_-_14629224 0.04 ENST00000254322.2
 DNAJB1
 DnaJ (Hsp40) homolog, subfamily B, member 1
chr2_+_127656486 0.04 ENST00000568484.1
ENST00000450035.1
 AC114783.1
 Protein LOC339760
chr4_+_88529681 0.04 ENST00000399271.1
 DSPP
 dentin sialophosphoprotein
chr1_-_11865351 0.04 ENST00000413656.1
ENST00000376585.1
ENST00000423400.1
ENST00000431243.1
 MTHFR
 methylenetetrahydrofolate reductase (NAD(P)H)
chr14_+_24540046 0.04 ENST00000397016.2
ENST00000537691.1
ENST00000560356.1
ENST00000558450.1
 CPNE6
 copine VI (neuronal)
chr1_-_197169672 0.04 ENST00000367405.4
 ZBTB41
 zinc finger and BTB domain containing 41
chr10_+_23216944 0.04 ENST00000298032.5
ENST00000409983.3
ENST00000409049.3
 ARMC3
 armadillo repeat containing 3
chr19_-_4455290 0.04 ENST00000394765.3
ENST00000592515.1
 UBXN6
 UBX domain protein 6
chr11_+_46366918 0.04 ENST00000528615.1
ENST00000395574.3
 DGKZ
 diacylglycerol kinase, zeta
chrY_+_2803322 0.03 ENST00000383052.1
ENST00000155093.3
ENST00000449237.1
ENST00000443793.1
 ZFY
 zinc finger protein, Y-linked
chr6_+_31543334 0.03 ENST00000449264.2
 TNF
 tumor necrosis factor
chr17_+_39411636 0.03 ENST00000394008.1
 KRTAP9-9
 keratin associated protein 9-9
chr17_+_43922241 0.03 ENST00000329196.5
 SPPL2C
 signal peptide peptidase like 2C
chr10_-_43762329 0.03 ENST00000395810.1
 RASGEF1A
 RasGEF domain family, member 1A
chr1_-_1690014 0.03 ENST00000400922.2
ENST00000342348.5
 NADK
 NAD kinase
chrX_+_68725084 0.03 ENST00000252338.4
 FAM155B
 family with sequence similarity 155, member B
chrX_+_24167746 0.03 ENST00000428571.1
ENST00000539115.1
 ZFX
 zinc finger protein, X-linked
chrX_+_24167828 0.03 ENST00000379188.3
ENST00000419690.1
ENST00000379177.1
ENST00000304543.5
 ZFX
 zinc finger protein, X-linked
chr13_+_27844464 0.03 ENST00000241463.4
 RASL11A
 RAS-like, family 11, member A
chr1_+_159796534 0.03 ENST00000289707.5
 SLAMF8
 SLAM family member 8
chr19_+_21203481 0.03 ENST00000595401.1
 ZNF430
 zinc finger protein 430
chr6_+_167525277 0.03 ENST00000400926.2
 CCR6
 chemokine (C-C motif) receptor 6
chr1_+_111992064 0.02 ENST00000483994.1
 ATP5F1
 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
chr19_+_21324863 0.02 ENST00000598331.1
 ZNF431
 zinc finger protein 431
chr2_-_89442621 0.02 ENST00000492167.1
 IGKV3-20
 immunoglobulin kappa variable 3-20
chr4_+_169842707 0.02 ENST00000503290.1
 PALLD
 palladin, cytoskeletal associated protein
chr2_+_90153696 0.02 ENST00000417279.2
 IGKV3D-15
 immunoglobulin kappa variable 3D-15 (gene/pseudogene)
chr12_-_123755639 0.02 ENST00000535979.1
 CDK2AP1
 cyclin-dependent kinase 2 associated protein 1
chr9_-_37592561 0.02 ENST00000544379.1
ENST00000377773.5
ENST00000401811.3
ENST00000321301.6
 TOMM5
 translocase of outer mitochondrial membrane 5 homolog (yeast)
chr3_-_45957088 0.02 ENST00000539217.1
 LZTFL1
 leucine zipper transcription factor-like 1
chr2_-_103353277 0.02 ENST00000258436.5
 MFSD9
 major facilitator superfamily domain containing 9
chr11_-_64013663 0.02 ENST00000392210.2
 PPP1R14B
 protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr1_-_11866034 0.02 ENST00000376590.3
 MTHFR
 methylenetetrahydrofolate reductase (NAD(P)H)
chr6_-_31938700 0.02 ENST00000495340.1
 DXO
 decapping exoribonuclease
chr1_+_197382957 0.02 ENST00000367397.1
 CRB1
 crumbs homolog 1 (Drosophila)
chr7_+_64126503 0.02 ENST00000360117.3
 ZNF107
 zinc finger protein 107
chr8_+_11561660 0.02 ENST00000526716.1
ENST00000335135.4
ENST00000528027.1
 GATA4
 GATA binding protein 4
chr10_+_90346519 0.01 ENST00000371939.3
 LIPJ
 lipase, family member J
chr7_-_128695147 0.01 ENST00000482320.1
ENST00000393245.1
ENST00000471234.1
 TNPO3
 transportin 3
chr19_-_19932501 0.01 ENST00000540806.2
ENST00000590766.1
ENST00000587452.1
ENST00000545006.1
ENST00000590319.1
ENST00000587461.1
ENST00000450683.2
ENST00000443905.2
ENST00000590274.1
 ZNF506
CTC-559E9.4
 zinc finger protein 506
CTC-559E9.4
chr11_+_7534999 0.01 ENST00000528947.1
ENST00000299492.4
 PPFIBP2
 PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr19_-_43702231 0.01 ENST00000597374.1
ENST00000599371.1
 PSG4
 pregnancy specific beta-1-glycoprotein 4
chr11_-_327537 0.01 ENST00000602735.1
 IFITM3
 interferon induced transmembrane protein 3
chr3_+_58223228 0.00 ENST00000478253.1
ENST00000295962.4
 ABHD6
 abhydrolase domain containing 6
chr5_-_43313574 0.00 ENST00000325110.6
ENST00000433297.2
 HMGCS1
 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr19_-_12833164 0.00 ENST00000356861.5
 TNPO2
 transportin 2
chr10_-_105156198 0.00 ENST00000369815.1
ENST00000309579.3
ENST00000337003.4
 USMG5
 up-regulated during skeletal muscle growth 5 homolog (mouse)
chr1_-_11007927 0.00 ENST00000468348.1
 C1orf127
 chromosome 1 open reading frame 127
chr19_-_12833361 0.00 ENST00000592287.1
 TNPO2
 transportin 2
chr16_+_77225071 0.00 ENST00000439557.2
ENST00000545553.1
 MON1B
 MON1 secretory trafficking family member B
chr3_-_48723268 0.00 ENST00000439518.1
ENST00000416649.2
ENST00000341520.4
ENST00000294129.2
 NCKIPSD
 NCK interacting protein with SH3 domain

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0097021 Peyer's patch morphogenesis(GO:0061146) lymphocyte migration into lymphoid organs(GO:0097021)
0.1 0.2 GO:0019858 cytosine metabolic process(GO:0019858)
0.0 0.2 GO:2000490 negative regulation of hepatic stellate cell activation(GO:2000490)
0.0 0.2 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.2 GO:0009439 cyanate metabolic process(GO:0009439) cyanate catabolic process(GO:0009440)
0.0 0.0 GO:0045994 positive regulation of translational initiation by iron(GO:0045994)
0.0 0.2 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0 0.1 GO:0070829 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
0.0 0.1 GO:0070859 circadian temperature homeostasis(GO:0060086) positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253)
0.0 0.1 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.0 0.1 GO:0046985 positive regulation of hemoglobin biosynthetic process(GO:0046985)
0.0 0.1 GO:2001303 lipoxin biosynthetic process(GO:2001301) lipoxin A4 metabolic process(GO:2001302) lipoxin A4 biosynthetic process(GO:2001303)
0.0 0.6 GO:0035590 purinergic nucleotide receptor signaling pathway(GO:0035590)
0.0 0.0 GO:0010652 pulmonary valve formation(GO:0003193) regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652) foramen ovale closure(GO:0035922) regulation of bundle of His cell action potential(GO:0098905)
0.0 0.1 GO:1900738 cytolysis in other organism involved in symbiotic interaction(GO:0051801) positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.0 0.1 GO:0001878 response to yeast(GO:0001878)
0.0 0.1 GO:0098814 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 0.2 GO:0047888 fatty acid peroxidase activity(GO:0047888)
0.0 0.1 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.0 0.2 GO:0016784 3-mercaptopyruvate sulfurtransferase activity(GO:0016784)
0.0 0.2 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.1 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.0 0.1 GO:0016165 linoleate 13S-lipoxygenase activity(GO:0016165) hepoxilin-epoxide hydrolase activity(GO:0047977)
0.0 0.1 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.0 GO:0086020 gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling(GO:0086020)
0.0 0.0 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex