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Epithelial-Mesenchymal Transition, human (Scheel, 2011): : averaged replicates

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Results for SIX6

Z-value: 0.70

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Transcription factors associated with SIX6

Gene Symbol Gene ID Gene Info
SIX6
ENSG00000184302.6 SIX6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SIX6hg19_v2_chr14_+_60975644_60975673-0.235.8e-01Click!

Activity profile of SIX6 motif

Sorted Z-values of SIX6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX6

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr12_-_28123206 0.54 ENST00000542963.1
ENST00000535992.1
 PTHLH
 parathyroid hormone-like hormone
chr12_-_28122980 0.53 ENST00000395868.3
ENST00000534890.1
 PTHLH
 parathyroid hormone-like hormone
chr9_-_23821842 0.43 ENST00000544538.1
 ELAVL2
 ELAV like neuron-specific RNA binding protein 2
chr3_-_111314230 0.38 ENST00000317012.4
 ZBED2
 zinc finger, BED-type containing 2
chr14_+_21525981 0.33 ENST00000308227.2
 RNASE8
 ribonuclease, RNase A family, 8
chr8_+_101170257 0.29 ENST00000251809.3
 SPAG1
 sperm associated antigen 1
chr6_+_37012607 0.24 ENST00000423336.1
 COX6A1P2
 cytochrome c oxidase subunit VIa polypeptide 1 pseudogene 2
chr4_-_155511887 0.24 ENST00000302053.3
ENST00000403106.3
 FGA
 fibrinogen alpha chain
chr5_+_55147205 0.23 ENST00000396836.2
ENST00000396834.1
ENST00000447346.2
ENST00000359040.5
 IL31RA
 interleukin 31 receptor A
chr14_+_21510385 0.21 ENST00000298690.4
 RNASE7
 ribonuclease, RNase A family, 7
chr13_+_73629107 0.20 ENST00000539231.1
 KLF5
 Kruppel-like factor 5 (intestinal)
chr11_-_104916034 0.20 ENST00000528513.1
ENST00000375706.2
ENST00000375704.3
 CARD16
 caspase recruitment domain family, member 16
chr1_+_86934526 0.20 ENST00000394711.1
 CLCA1
 chloride channel accessory 1
chr1_+_212738676 0.19 ENST00000366981.4
ENST00000366987.2
 ATF3
 activating transcription factor 3
chr1_+_156119466 0.19 ENST00000414683.1
 SEMA4A
 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr1_+_156119798 0.19 ENST00000355014.2
 SEMA4A
 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr19_-_16008880 0.18 ENST00000011989.7
ENST00000221700.6
 CYP4F2
 cytochrome P450, family 4, subfamily F, polypeptide 2
chr2_+_177134134 0.17 ENST00000249442.6
ENST00000392529.2
ENST00000443241.1
 MTX2
 metaxin 2
chr11_-_104972158 0.16 ENST00000598974.1
ENST00000593315.1
ENST00000594519.1
ENST00000415981.2
ENST00000525374.1
ENST00000375707.1
 CASP1
CARD16
CARD17
 caspase 1, apoptosis-related cysteine peptidase
caspase recruitment domain family, member 16
caspase recruitment domain family, member 17
chr13_-_20080080 0.16 ENST00000400103.2
 TPTE2
 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
chr1_+_160709076 0.15 ENST00000359331.4
ENST00000495334.1
 SLAMF7
 SLAM family member 7
chr8_+_32579341 0.15 ENST00000519240.1
ENST00000539990.1
 NRG1
 neuregulin 1
chr8_+_1993173 0.15 ENST00000523438.1
 MYOM2
 myomesin 2
chr12_-_87232644 0.15 ENST00000549405.2
 MGAT4C
 mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr8_+_1993152 0.14 ENST00000262113.4
 MYOM2
 myomesin 2
chr19_+_3136115 0.13 ENST00000262958.3
 GNA15
 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
chr1_+_160709055 0.13 ENST00000368043.3
ENST00000368042.3
ENST00000458602.2
ENST00000458104.2
 SLAMF7
 SLAM family member 7
chr2_+_177134201 0.13 ENST00000452865.1
 MTX2
 metaxin 2
chr22_+_18721427 0.12 ENST00000342888.3
 AC008132.1
 Uncharacterized protein
chr20_+_54987305 0.12 ENST00000371336.3
ENST00000434344.1
 CASS4
 Cas scaffolding protein family member 4
chr1_-_161015752 0.11 ENST00000435396.1
ENST00000368021.3
 USF1
 upstream transcription factor 1
chr1_+_145413268 0.11 ENST00000421822.2
ENST00000336751.5
ENST00000497365.1
ENST00000475797.1
 HFE2
 hemochromatosis type 2 (juvenile)
chr1_+_31885963 0.11 ENST00000373709.3
 SERINC2
 serine incorporator 2
chr11_+_33902189 0.10 ENST00000330381.2
 AC132216.1
 HCG1785179; PRO1787; Uncharacterized protein
chrX_+_8433376 0.10 ENST00000440654.2
ENST00000381029.4
 VCX3B
 variable charge, X-linked 3B
chr1_+_234509186 0.10 ENST00000366615.4
 COA6
 cytochrome c oxidase assembly factor 6 homolog (S. cerevisiae)
chrX_-_20236970 0.10 ENST00000379548.4
 RPS6KA3
 ribosomal protein S6 kinase, 90kDa, polypeptide 3
chr20_+_54987168 0.09 ENST00000360314.3
 CASS4
 Cas scaffolding protein family member 4
chr5_+_140201183 0.09 ENST00000529619.1
ENST00000529859.1
ENST00000378126.3
 PCDHA5
 protocadherin alpha 5
chr8_-_141774467 0.08 ENST00000520151.1
ENST00000519024.1
ENST00000519465.1
 PTK2
 protein tyrosine kinase 2
chr16_+_19467772 0.08 ENST00000219821.5
ENST00000561503.1
ENST00000564959.1
 TMC5
 transmembrane channel-like 5
chr5_-_78281775 0.07 ENST00000396151.3
ENST00000565165.1
 ARSB
 arylsulfatase B
chr7_+_117251671 0.07 ENST00000468795.1
 CFTR
 cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
chr17_+_7788104 0.07 ENST00000380358.4
 CHD3
 chromodomain helicase DNA binding protein 3
chr19_-_1650666 0.07 ENST00000588136.1
 TCF3
 transcription factor 3
chr19_-_14628645 0.07 ENST00000598235.1
 DNAJB1
 DnaJ (Hsp40) homolog, subfamily B, member 1
chr17_-_42327236 0.07 ENST00000399246.2
 AC003102.1
 AC003102.1
chr1_+_234509413 0.07 ENST00000366613.1
ENST00000366612.1
 COA6
 cytochrome c oxidase assembly factor 6 homolog (S. cerevisiae)
chr4_+_74301880 0.07 ENST00000395792.2
ENST00000226359.2
 AFP
 alpha-fetoprotein
chr14_+_20937538 0.06 ENST00000361505.5
ENST00000553591.1
 PNP
 purine nucleoside phosphorylase
chr3_+_125694347 0.06 ENST00000505382.1
ENST00000511082.1
 ROPN1B
 rhophilin associated tail protein 1B
chr12_-_14849470 0.06 ENST00000261170.3
 GUCY2C
 guanylate cyclase 2C (heat stable enterotoxin receptor)
chr16_-_20364122 0.06 ENST00000396138.4
ENST00000577168.1
 UMOD
 uromodulin
chr1_+_160709029 0.06 ENST00000444090.2
ENST00000441662.2
 SLAMF7
 SLAM family member 7
chr2_-_134326009 0.06 ENST00000409261.1
ENST00000409213.1
 NCKAP5
 NCK-associated protein 5
chr2_-_77749474 0.06 ENST00000409093.1
ENST00000409088.3
 LRRTM4
 leucine rich repeat transmembrane neuronal 4
chr9_-_14910990 0.06 ENST00000380881.4
ENST00000422223.2
 FREM1
 FRAS1 related extracellular matrix 1
chr4_-_123377880 0.05 ENST00000226730.4
 IL2
 interleukin 2
chr1_-_67142710 0.05 ENST00000502413.2
 AL139147.1
 Uncharacterized protein
chr16_-_20364030 0.05 ENST00000396134.2
ENST00000573567.1
ENST00000570757.1
ENST00000424589.1
ENST00000302509.4
ENST00000571174.1
ENST00000576688.1
 UMOD
 uromodulin
chrX_-_118699325 0.05 ENST00000320339.4
ENST00000371594.4
ENST00000536133.1
 CXorf56
 chromosome X open reading frame 56
chr13_+_34392185 0.05 ENST00000380071.3
 RFC3
 replication factor C (activator 1) 3, 38kDa
chr15_+_58430567 0.05 ENST00000536493.1
 AQP9
 aquaporin 9
chr17_-_5342380 0.05 ENST00000225698.4
 C1QBP
 complement component 1, q subcomponent binding protein
chr15_-_80263506 0.05 ENST00000335661.6
 BCL2A1
 BCL2-related protein A1
chrY_-_16098393 0.05 ENST00000250825.4
 VCY
 variable charge, Y-linked
chr15_+_58430368 0.05 ENST00000558772.1
ENST00000219919.4
 AQP9
 aquaporin 9
chr5_+_40909354 0.05 ENST00000313164.9
 C7
 complement component 7
chrX_+_38660704 0.04 ENST00000378474.3
 MID1IP1
 MID1 interacting protein 1
chr1_+_63063152 0.04 ENST00000371129.3
 ANGPTL3
 angiopoietin-like 3
chr22_-_19137796 0.04 ENST00000086933.2
 GSC2
 goosecoid homeobox 2
chrY_+_16168097 0.04 ENST00000250823.4
 VCY1B
 variable charge, Y-linked 1B
chr10_+_91061712 0.04 ENST00000371826.3
 IFIT2
 interferon-induced protein with tetratricopeptide repeats 2
chr12_-_121477039 0.04 ENST00000257570.5
 OASL
 2'-5'-oligoadenylate synthetase-like
chr6_-_108145499 0.04 ENST00000369020.3
ENST00000369022.2
 SCML4
 sex comb on midleg-like 4 (Drosophila)
chr12_+_19282643 0.04 ENST00000317589.4
ENST00000355397.3
ENST00000359180.3
ENST00000309364.4
ENST00000540972.1
ENST00000429027.2
 PLEKHA5
 pleckstrin homology domain containing, family A member 5
chr2_-_239140011 0.04 ENST00000409376.1
ENST00000409070.1
ENST00000409942.1
 AC016757.3
 Protein LOC151174
chr4_-_71532339 0.03 ENST00000254801.4
 IGJ
 immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr4_+_88532028 0.03 ENST00000282478.7
 DSPP
 dentin sialophosphoprotein
chr17_-_67057114 0.03 ENST00000370732.2
 ABCA9
 ATP-binding cassette, sub-family A (ABC1), member 9
chr4_+_113739244 0.03 ENST00000503271.1
ENST00000503423.1
ENST00000506722.1
 ANK2
 ankyrin 2, neuronal
chr1_+_53308398 0.03 ENST00000371528.1
 ZYG11A
 zyg-11 family member A, cell cycle regulator
chrY_-_24038660 0.03 ENST00000382677.3
 RBMY1D
 RNA binding motif protein, Y-linked, family 1, member D
chrY_+_23698778 0.03 ENST00000303902.5
 RBMY1A1
 RNA binding motif protein, Y-linked, family 1, member A1
chr6_+_127898312 0.03 ENST00000329722.7
 C6orf58
 chromosome 6 open reading frame 58
chr12_-_121476959 0.03 ENST00000339275.5
 OASL
 2'-5'-oligoadenylate synthetase-like
chr15_+_69857515 0.03 ENST00000559477.1
 RP11-279F6.1
 RP11-279F6.1
chr6_+_52051171 0.03 ENST00000340057.1
 IL17A
 interleukin 17A
chrX_+_64708615 0.03 ENST00000338957.4
ENST00000423889.3
 ZC3H12B
 zinc finger CCCH-type containing 12B
chr12_-_122018346 0.03 ENST00000377069.4
 KDM2B
 lysine (K)-specific demethylase 2B
chr8_+_84824920 0.03 ENST00000523678.1
 RP11-120I21.2
 RP11-120I21.2
chr10_-_61720640 0.02 ENST00000521074.1
ENST00000444900.1
 C10orf40
 chromosome 10 open reading frame 40
chr7_-_44530479 0.02 ENST00000355451.7
 NUDCD3
 NudC domain containing 3
chr1_-_13673511 0.02 ENST00000344998.3
ENST00000334600.6
 PRAMEF14
 PRAME family member 14
chr4_+_74347400 0.02 ENST00000226355.3
 AFM
 afamin
chr12_-_121476750 0.02 ENST00000543677.1
 OASL
 2'-5'-oligoadenylate synthetase-like
chr9_-_21351377 0.02 ENST00000380210.1
 IFNA6
 interferon, alpha 6
chr9_-_7800067 0.02 ENST00000358227.4
 TMEM261
 transmembrane protein 261
chr17_-_67057047 0.02 ENST00000495634.1
ENST00000453985.2
ENST00000585714.1
 ABCA9
 ATP-binding cassette, sub-family A (ABC1), member 9
chr1_+_159557607 0.02 ENST00000255040.2
 APCS
 amyloid P component, serum
chr19_-_44031375 0.02 ENST00000292147.2
 ETHE1
 ethylmalonic encephalopathy 1
chr9_-_99382065 0.02 ENST00000265659.2
ENST00000375241.1
ENST00000375236.1
 CDC14B
 cell division cycle 14B
chr4_-_42154895 0.02 ENST00000502486.1
ENST00000504360.1
 BEND4
 BEN domain containing 4
chrX_+_128674213 0.02 ENST00000371113.4
ENST00000357121.5
 OCRL
 oculocerebrorenal syndrome of Lowe
chr10_+_52094298 0.02 ENST00000595931.1
 AC069547.1
 HCG1745369; PRO3073; Uncharacterized protein
chr11_+_74699942 0.02 ENST00000526068.1
ENST00000532963.1
ENST00000531619.1
ENST00000534628.1
ENST00000545272.1
 NEU3
 sialidase 3 (membrane sialidase)
chr1_+_112016414 0.01 ENST00000343534.5
ENST00000369718.3
 C1orf162
 chromosome 1 open reading frame 162
chr11_+_74699703 0.01 ENST00000529024.1
ENST00000544263.1
 NEU3
 sialidase 3 (membrane sialidase)
chr19_+_46000479 0.01 ENST00000456399.2
 PPM1N
 protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)
chrX_-_55020511 0.01 ENST00000375006.3
ENST00000374992.2
 PFKFB1
 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr2_+_210636697 0.01 ENST00000439458.1
ENST00000272845.6
 UNC80
 unc-80 homolog (C. elegans)
chr18_+_55018044 0.01 ENST00000324000.3
 ST8SIA3
 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr9_-_100684845 0.01 ENST00000375119.3
 C9orf156
 chromosome 9 open reading frame 156
chr4_-_139051839 0.01 ENST00000514600.1
ENST00000513895.1
ENST00000512536.1
 LINC00616
 long intergenic non-protein coding RNA 616
chr16_+_72090053 0.01 ENST00000576168.2
ENST00000567185.3
ENST00000567612.2
 HP
 haptoglobin
chr6_-_8102279 0.00 ENST00000488226.2
 EEF1E1
 eukaryotic translation elongation factor 1 epsilon 1
chr16_-_52119019 0.00 ENST00000561513.1
ENST00000565742.1
 LINC00919
 long intergenic non-protein coding RNA 919
chr7_-_92855762 0.00 ENST00000453812.2
ENST00000394468.2
 HEPACAM2
 HEPACAM family member 2
chr2_-_197457335 0.00 ENST00000260983.3
 HECW2
 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0061760 antifungal innate immune response(GO:0061760)
0.1 0.2 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.1 0.2 GO:0032304 negative regulation of icosanoid secretion(GO:0032304)
0.0 0.4 GO:0071494 cellular response to UV-C(GO:0071494)
0.0 0.3 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.0 1.0 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 0.2 GO:0051673 membrane disruption in other organism(GO:0051673)
0.0 0.1 GO:0061582 intestinal epithelial cell migration(GO:0061582)
0.0 0.1 GO:1902161 positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161)
0.0 0.2 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.1 GO:0072023 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.0 0.2 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.2 GO:0021842 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.0 0.1 GO:0006738 nicotinamide riboside catabolic process(GO:0006738) nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637) pyridine nucleoside catabolic process(GO:0070638)
0.0 0.1 GO:1904219 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.0 0.1 GO:0015722 canalicular bile acid transport(GO:0015722)
0.0 0.1 GO:0000432 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.0 0.1 GO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0 0.1 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.0 0.2 GO:0043031 negative regulation of macrophage activation(GO:0043031)
0.0 0.0 GO:1901165 negative regulation of MDA-5 signaling pathway(GO:0039534) positive regulation of trophoblast cell migration(GO:1901165)
0.0 0.0 GO:0036371 protein localization to T-tubule(GO:0036371)
0.0 0.4 GO:0045063 T-helper 1 cell differentiation(GO:0045063)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.1 0.4 GO:0097179 protease inhibitor complex(GO:0097179)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.1 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.2 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.1 GO:0016589 NURF complex(GO:0016589)
0.0 0.3 GO:0032982 myosin filament(GO:0032982)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0052870 tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259)
0.0 0.2 GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.0 1.1 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.2 GO:0004522 ribonuclease A activity(GO:0004522)
0.0 0.4 GO:0089720 caspase binding(GO:0089720)
0.0 0.2 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.1 GO:0003943 N-acetylgalactosamine-4-sulfatase activity(GO:0003943)
0.0 0.1 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.0 0.1 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.0 0.1 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.0 0.4 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.0 GO:0030984 kininogen binding(GO:0030984)
0.0 0.2 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.1 GO:0098821 BMP receptor activity(GO:0098821)
0.0 0.1 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.2 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 0.3 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.1 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine