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Epithelial-Mesenchymal Transition, human (Scheel, 2011): : averaged replicates

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Results for SOX1

Z-value: 0.32

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Transcription factors associated with SOX1

Gene Symbol Gene ID Gene Info
SOX1
ENSG00000182968.3 SOX1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX1hg19_v2_chr13_+_112721913_112721913-0.059.1e-01Click!

Activity profile of SOX1 motif

Sorted Z-values of SOX1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr3_-_189840223 0.68 ENST00000427335.2
 LEPREL1
 leprecan-like 1
chr3_+_136676851 0.45 ENST00000309741.5
 IL20RB
 interleukin 20 receptor beta
chr3_+_136676707 0.44 ENST00000329582.4
 IL20RB
 interleukin 20 receptor beta
chr16_+_12058961 0.40 ENST00000053243.1
 TNFRSF17
 tumor necrosis factor receptor superfamily, member 17
chr16_+_12059050 0.38 ENST00000396495.3
 TNFRSF17
 tumor necrosis factor receptor superfamily, member 17
chr1_+_152957707 0.32 ENST00000368762.1
 SPRR1A
 small proline-rich protein 1A
chr4_-_74486217 0.29 ENST00000335049.5
ENST00000307439.5
 RASSF6
 Ras association (RalGDS/AF-6) domain family member 6
chr2_+_102615416 0.27 ENST00000393414.2
 IL1R2
 interleukin 1 receptor, type II
chr17_-_39646116 0.24 ENST00000328119.6
 KRT36
 keratin 36
chr1_+_70876926 0.23 ENST00000370938.3
ENST00000346806.2
 CTH
 cystathionase (cystathionine gamma-lyase)
chr8_-_110620284 0.23 ENST00000529690.1
 SYBU
 syntabulin (syntaxin-interacting)
chr9_-_104249400 0.22 ENST00000374848.3
 TMEM246
 transmembrane protein 246
chr13_+_109248500 0.19 ENST00000356711.2
 MYO16
 myosin XVI
chr17_-_29624343 0.17 ENST00000247271.4
 OMG
 oligodendrocyte myelin glycoprotein
chr20_-_14318248 0.16 ENST00000378053.3
ENST00000341420.4
 FLRT3
 fibronectin leucine rich transmembrane protein 3
chr11_+_55029628 0.14 ENST00000417545.2
 TRIM48
 tripartite motif containing 48
chr11_-_57177586 0.13 ENST00000529411.1
 RP11-872D17.8
 Uncharacterized protein
chr8_+_145133493 0.13 ENST00000316052.5
ENST00000525936.1
 EXOSC4
 exosome component 4
chr12_+_115800817 0.13 ENST00000547948.1
 RP11-116D17.1
 HCG2038717; Uncharacterized protein
chr1_-_200379129 0.12 ENST00000367353.1
 ZNF281
 zinc finger protein 281
chr4_-_74486109 0.12 ENST00000395777.2
 RASSF6
 Ras association (RalGDS/AF-6) domain family member 6
chr9_-_95166884 0.12 ENST00000375561.5
 OGN
 osteoglycin
chr4_-_74486347 0.12 ENST00000342081.3
 RASSF6
 Ras association (RalGDS/AF-6) domain family member 6
chr9_-_95166841 0.11 ENST00000262551.4
 OGN
 osteoglycin
chr1_-_200379180 0.11 ENST00000294740.3
 ZNF281
 zinc finger protein 281
chr6_+_26183958 0.11 ENST00000356530.3
 HIST1H2BE
 histone cluster 1, H2be
chr1_+_32674675 0.10 ENST00000409358.1
 DCDC2B
 doublecortin domain containing 2B
chr1_+_46805832 0.10 ENST00000474844.1
 NSUN4
 NOP2/Sun domain family, member 4
chr1_+_152975488 0.10 ENST00000542696.1
 SPRR3
 small proline-rich protein 3
chr5_-_16916624 0.10 ENST00000513882.1
 MYO10
 myosin X
chr12_-_120763739 0.09 ENST00000549767.1
 PLA2G1B
 phospholipase A2, group IB (pancreas)
chr2_-_220083076 0.09 ENST00000295750.4
 ABCB6
 ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr11_-_133715394 0.09 ENST00000299140.3
ENST00000532889.1
 SPATA19
 spermatogenesis associated 19
chr12_-_10151773 0.09 ENST00000298527.6
ENST00000348658.4
 CLEC1B
 C-type lectin domain family 1, member B
chr3_-_33686925 0.09 ENST00000485378.2
ENST00000313350.6
ENST00000487200.1
 CLASP2
 cytoplasmic linker associated protein 2
chr8_+_110551925 0.09 ENST00000395785.2
 EBAG9
 estrogen receptor binding site associated, antigen, 9
chr2_-_163175133 0.08 ENST00000421365.2
ENST00000263642.2
 IFIH1
 interferon induced with helicase C domain 1
chr1_+_19578033 0.08 ENST00000330263.4
 MRTO4
 mRNA turnover 4 homolog (S. cerevisiae)
chr4_+_70861647 0.08 ENST00000246895.4
ENST00000381060.2
 STATH
 statherin
chr4_-_170924888 0.08 ENST00000502832.1
ENST00000393704.3
 MFAP3L
 microfibrillar-associated protein 3-like
chr1_+_240255166 0.07 ENST00000319653.9
 FMN2
 formin 2
chr14_+_22356029 0.07 ENST00000390437.2
 TRAV12-2
 T cell receptor alpha variable 12-2
chrX_+_129040122 0.07 ENST00000394422.3
ENST00000371051.5
 UTP14A
 UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
chr2_-_209054709 0.07 ENST00000449053.1
ENST00000451346.1
ENST00000341287.4
 C2orf80
 chromosome 2 open reading frame 80
chr3_+_158362299 0.07 ENST00000478576.1
ENST00000264263.5
ENST00000464732.1
 GFM1
 G elongation factor, mitochondrial 1
chr6_-_71666732 0.07 ENST00000230053.6
 B3GAT2
 beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)
chr7_-_142176790 0.07 ENST00000390369.2
 TRBV7-4
 T cell receptor beta variable 7-4 (gene/pseudogene)
chr9_-_2844058 0.07 ENST00000397885.2
 KIAA0020
 KIAA0020
chr17_-_38821373 0.06 ENST00000394052.3
 KRT222
 keratin 222
chr20_+_31805131 0.06 ENST00000375454.3
ENST00000375452.3
 BPIFA3
 BPI fold containing family A, member 3
chrX_+_129040094 0.06 ENST00000425117.2
 UTP14A
 UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
chr11_-_123756334 0.06 ENST00000528595.1
ENST00000375026.2
 TMEM225
 transmembrane protein 225
chr1_-_200379104 0.06 ENST00000367352.3
 ZNF281
 zinc finger protein 281
chr3_-_58200398 0.06 ENST00000318316.3
ENST00000460422.1
ENST00000483681.1
 DNASE1L3
 deoxyribonuclease I-like 3
chr10_+_78078088 0.05 ENST00000496424.2
 C10orf11
 chromosome 10 open reading frame 11
chr11_-_47400062 0.05 ENST00000533030.1
 SPI1
 spleen focus forming virus (SFFV) proviral integration oncogene
chr1_+_174769006 0.05 ENST00000489615.1
 RABGAP1L
 RAB GTPase activating protein 1-like
chr1_-_169455169 0.05 ENST00000367804.4
ENST00000236137.5
 SLC19A2
 solute carrier family 19 (thiamine transporter), member 2
chr11_-_5255861 0.05 ENST00000380299.3
 HBD
 hemoglobin, delta
chr1_-_19578003 0.05 ENST00000375199.3
ENST00000375208.3
ENST00000356068.2
ENST00000477853.1
 EMC1
 ER membrane protein complex subunit 1
chr8_-_86290333 0.05 ENST00000521846.1
ENST00000523022.1
ENST00000524324.1
ENST00000519991.1
ENST00000520663.1
ENST00000517590.1
ENST00000522579.1
ENST00000522814.1
ENST00000522662.1
ENST00000523858.1
ENST00000519129.1
 CA1
 carbonic anhydrase I
chr11_-_47399942 0.05 ENST00000227163.4
 SPI1
 spleen focus forming virus (SFFV) proviral integration oncogene
chr7_-_36634181 0.05 ENST00000538464.1
 AOAH
 acyloxyacyl hydrolase (neutrophil)
chr19_+_35842445 0.05 ENST00000246553.2
 FFAR1
 free fatty acid receptor 1
chr11_-_113577052 0.05 ENST00000540540.1
ENST00000545579.1
ENST00000538955.1
ENST00000299882.5
 TMPRSS5
 transmembrane protease, serine 5
chr12_-_11150474 0.05 ENST00000538986.1
 TAS2R20
 taste receptor, type 2, member 20
chr17_+_34391625 0.05 ENST00000004921.3
 CCL18
 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
chr19_+_55385682 0.04 ENST00000391726.3
 FCAR
 Fc fragment of IgA, receptor for
chr7_-_105029812 0.04 ENST00000482897.1
 SRPK2
 SRSF protein kinase 2
chr3_-_58613323 0.04 ENST00000474531.1
ENST00000465970.1
 FAM107A
 family with sequence similarity 107, member A
chr19_+_17830051 0.04 ENST00000594625.1
ENST00000324096.4
ENST00000600186.1
ENST00000597735.1
 MAP1S
 microtubule-associated protein 1S
chr11_-_47400078 0.04 ENST00000378538.3
 SPI1
 spleen focus forming virus (SFFV) proviral integration oncogene
chr19_+_49588690 0.04 ENST00000221448.5
 SNRNP70
 small nuclear ribonucleoprotein 70kDa (U1)
chr1_-_52499443 0.04 ENST00000371614.1
 KTI12
 KTI12 homolog, chromatin associated (S. cerevisiae)
chr11_-_5255696 0.04 ENST00000292901.3
ENST00000417377.1
 HBD
 hemoglobin, delta
chr2_+_171034646 0.04 ENST00000409044.3
ENST00000408978.4
 MYO3B
 myosin IIIB
chr1_-_43638168 0.04 ENST00000431635.2
 EBNA1BP2
 EBNA1 binding protein 2
chr22_-_30662828 0.04 ENST00000403463.1
ENST00000215781.2
 OSM
 oncostatin M
chr10_-_73976025 0.03 ENST00000342444.4
ENST00000533958.1
ENST00000527593.1
ENST00000394915.3
ENST00000530461.1
ENST00000317168.6
ENST00000524829.1
 ASCC1
 activating signal cointegrator 1 complex subunit 1
chr11_+_102980126 0.03 ENST00000375735.2
 DYNC2H1
 dynein, cytoplasmic 2, heavy chain 1
chr12_-_110434096 0.03 ENST00000320063.9
ENST00000457474.2
ENST00000547815.1
ENST00000361006.5
 GIT2
 G protein-coupled receptor kinase interacting ArfGAP 2
chr2_+_171036635 0.03 ENST00000484338.2
ENST00000334231.6
 MYO3B
 myosin IIIB
chr3_+_178276488 0.03 ENST00000432997.1
ENST00000455865.1
 KCNMB2
 potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr10_-_73976884 0.03 ENST00000317126.4
ENST00000545550.1
 ASCC1
 activating signal cointegrator 1 complex subunit 1
chr15_+_59903975 0.03 ENST00000560585.1
ENST00000396065.1
 GCNT3
 glucosaminyl (N-acetyl) transferase 3, mucin type
chr10_-_43892668 0.03 ENST00000544000.1
 HNRNPF
 heterogeneous nuclear ribonucleoprotein F
chr19_-_10491130 0.03 ENST00000530829.1
ENST00000529370.1
 TYK2
 tyrosine kinase 2
chr4_+_154622652 0.03 ENST00000260010.6
 TLR2
 toll-like receptor 2
chr11_-_104827425 0.03 ENST00000393150.3
 CASP4
 caspase 4, apoptosis-related cysteine peptidase
chr19_+_21324827 0.03 ENST00000600692.1
ENST00000599296.1
ENST00000594425.1
ENST00000311048.7
 ZNF431
 zinc finger protein 431
chr14_+_62462541 0.02 ENST00000430451.2
 SYT16
 synaptotagmin XVI
chr2_-_14541060 0.02 ENST00000418420.1
ENST00000417751.1
 LINC00276
 long intergenic non-protein coding RNA 276
chr1_-_212004090 0.02 ENST00000366997.4
 LPGAT1
 lysophosphatidylglycerol acyltransferase 1
chr12_+_100594557 0.02 ENST00000546902.1
ENST00000552376.1
ENST00000551617.1
 ACTR6
 ARP6 actin-related protein 6 homolog (yeast)
chr1_-_86848760 0.02 ENST00000460698.2
 ODF2L
 outer dense fiber of sperm tails 2-like
chr3_-_126327398 0.02 ENST00000383572.2
 TXNRD3NB
 thioredoxin reductase 3 neighbor
chr11_+_125496124 0.02 ENST00000533778.2
ENST00000534070.1
 CHEK1
 checkpoint kinase 1
chr11_-_113577014 0.02 ENST00000544634.1
ENST00000539732.1
ENST00000538770.1
ENST00000536856.1
ENST00000544476.1
 TMPRSS5
 transmembrane protease, serine 5
chr18_-_51751132 0.02 ENST00000256429.3
 MBD2
 methyl-CpG binding domain protein 2
chr11_-_26593677 0.02 ENST00000527569.1
 MUC15
 mucin 15, cell surface associated
chr18_+_21719018 0.02 ENST00000585037.1
ENST00000415309.2
ENST00000399481.2
ENST00000577705.1
ENST00000327201.6
 CABYR
 calcium binding tyrosine-(Y)-phosphorylation regulated
chr17_+_75181292 0.02 ENST00000431431.2
 SEC14L1
 SEC14-like 1 (S. cerevisiae)
chr6_+_27833034 0.01 ENST00000357320.2
 HIST1H2AL
 histone cluster 1, H2al
chr3_+_127770455 0.01 ENST00000464451.1
 SEC61A1
 Sec61 alpha 1 subunit (S. cerevisiae)
chr19_+_49588677 0.01 ENST00000598984.1
ENST00000598441.1
 SNRNP70
 small nuclear ribonucleoprotein 70kDa (U1)
chr1_+_50459990 0.01 ENST00000448346.1
 AL645730.2
 AL645730.2
chr19_+_3762703 0.01 ENST00000589174.1
 MRPL54
 mitochondrial ribosomal protein L54
chr4_+_156680153 0.01 ENST00000502959.1
ENST00000505764.1
ENST00000507146.1
ENST00000264424.8
ENST00000503520.1
 GUCY1B3
 guanylate cyclase 1, soluble, beta 3
chr11_+_125496400 0.01 ENST00000524737.1
 CHEK1
 checkpoint kinase 1
chr1_+_65613217 0.01 ENST00000545314.1
 AK4
 adenylate kinase 4
chr11_+_125496619 0.01 ENST00000532669.1
ENST00000278916.3
 CHEK1
 checkpoint kinase 1
chr11_-_76381029 0.00 ENST00000407242.2
ENST00000421973.1
 LRRC32
 leucine rich repeat containing 32
chr12_+_93096619 0.00 ENST00000397833.3
 C12orf74
 chromosome 12 open reading frame 74
chr3_+_132316081 0.00 ENST00000249887.2
 ACKR4
 atypical chemokine receptor 4
chr19_-_10491234 0.00 ENST00000524462.1
ENST00000531836.1
ENST00000525621.1
 TYK2
 tyrosine kinase 2
chr6_-_46048116 0.00 ENST00000185206.6
 CLIC5
 chloride intracellular channel 5
chr14_+_20811722 0.00 ENST00000429687.3
 PARP2
 poly (ADP-ribose) polymerase 2
chr1_+_202789394 0.00 ENST00000330493.5
 RP11-480I12.4
 Putative inactive alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein LOC641515
chr7_-_92848858 0.00 ENST00000440868.1
 HEPACAM2
 HEPACAM family member 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0001808 negative regulation of type IV hypersensitivity(GO:0001808)
0.1 0.3 GO:0032690 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.1 0.2 GO:0018352 protein-pyridoxal-5-phosphate linkage(GO:0018352)
0.0 0.1 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.0 0.1 GO:0071051 polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.0 0.1 GO:0051758 homologous chromosome movement towards spindle pole involved in homologous chromosome segregation(GO:0051758)
0.0 0.1 GO:0034344 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.0 0.1 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.0 0.4 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.0 0.1 GO:0071934 thiamine transmembrane transport(GO:0071934)
0.0 0.2 GO:0003344 pericardium morphogenesis(GO:0003344)
0.0 0.1 GO:0042256 mature ribosome assembly(GO:0042256)
0.0 0.0 GO:0032289 central nervous system myelin formation(GO:0032289) detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340)
0.0 0.2 GO:0042340 keratan sulfate catabolic process(GO:0042340)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0097433 dense body(GO:0097433)
0.0 0.0 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0042015 interleukin-20 binding(GO:0042015)
0.1 0.3 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.0 0.6 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.1 GO:0015439 heme-transporting ATPase activity(GO:0015439)
0.0 0.1 GO:0046848 hydroxyapatite binding(GO:0046848)
0.0 0.1 GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383)
0.0 0.2 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 0.1 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0 0.1 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.0 0.0 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.0 0.1 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.0 GO:0019862 IgA binding(GO:0019862)
0.0 0.0 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0 0.1 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 0.2 GO:0045499 chemorepellent activity(GO:0045499)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation