Project

Epithelial-Mesenchymal Transition, human (Scheel, 2011): : averaged replicates

Navigation
Downloads

Results for SREBF2

Z-value: 0.64

Motif logo

logo of

Transcription factors associated with SREBF2

Gene Symbol Gene ID Gene Info
SREBF2
ENSG00000198911.7 SREBF2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SREBF2hg19_v2_chr22_+_42229100_42229146-0.049.2e-01Click!

Activity profile of SREBF2 motif

Sorted Z-values of SREBF2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SREBF2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:

Promoter Score Transcript Gene Gene Info
chr5_-_149535421 0.69 ENST00000261799.4
 PDGFRB
 platelet-derived growth factor receptor, beta polypeptide
chr15_+_33010175 0.65 ENST00000300177.4
ENST00000560677.1
ENST00000560830.1
 GREM1
 gremlin 1, DAN family BMP antagonist
chr19_-_11308190 0.37 ENST00000586659.1
ENST00000592903.1
ENST00000589359.1
ENST00000588724.1
ENST00000432929.2
 KANK2
 KN motif and ankyrin repeat domains 2
chr6_+_151561085 0.29 ENST00000402676.2
 AKAP12
 A kinase (PRKA) anchor protein 12
chr20_+_33464238 0.25 ENST00000360596.2
 ACSS2
 acyl-CoA synthetase short-chain family member 2
chr5_-_39425068 0.25 ENST00000515700.1
ENST00000339788.6
 DAB2
 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr20_+_33464407 0.22 ENST00000253382.5
 ACSS2
 acyl-CoA synthetase short-chain family member 2
chr17_-_15168624 0.22 ENST00000312280.3
ENST00000494511.1
ENST00000580584.1
 PMP22
 peripheral myelin protein 22
chr12_-_91505608 0.16 ENST00000266718.4
 LUM
 lumican
chr8_+_26435359 0.15 ENST00000311151.5
 DPYSL2
 dihydropyrimidinase-like 2
chr19_-_46285646 0.15 ENST00000458663.2
 DMPK
 dystrophia myotonica-protein kinase
chr3_-_171528227 0.15 ENST00000356327.5
ENST00000342215.6
ENST00000340989.4
ENST00000351298.4
 PLD1
 phospholipase D1, phosphatidylcholine-specific
chr19_-_46285736 0.14 ENST00000291270.4
ENST00000447742.2
ENST00000354227.5
 DMPK
 dystrophia myotonica-protein kinase
chr10_-_3827371 0.14 ENST00000469435.1
 KLF6
 Kruppel-like factor 6
chr19_-_18392422 0.14 ENST00000252818.3
 JUND
 jun D proto-oncogene
chr5_+_137774706 0.14 ENST00000378339.2
ENST00000254901.5
ENST00000506158.1
 REEP2
 receptor accessory protein 2
chrX_-_103087136 0.12 ENST00000243298.2
 RAB9B
 RAB9B, member RAS oncogene family
chr6_-_52860171 0.11 ENST00000370963.4
 GSTA4
 glutathione S-transferase alpha 4
chr11_+_65479702 0.11 ENST00000530446.1
ENST00000534104.1
ENST00000530605.1
ENST00000528198.1
ENST00000531880.1
ENST00000534650.1
 KAT5
 K(lysine) acetyltransferase 5
chr10_-_3827417 0.10 ENST00000497571.1
ENST00000542957.1
 KLF6
 Kruppel-like factor 6
chr11_+_65479462 0.10 ENST00000377046.3
ENST00000352980.4
ENST00000341318.4
 KAT5
 K(lysine) acetyltransferase 5
chr17_-_40075219 0.10 ENST00000537919.1
ENST00000352035.2
ENST00000353196.1
ENST00000393896.2
 ACLY
 ATP citrate lyase
chr14_-_35183886 0.09 ENST00000298159.6
 CFL2
 cofilin 2 (muscle)
chr1_-_42384343 0.09 ENST00000372584.1
 HIVEP3
 human immunodeficiency virus type I enhancer binding protein 3
chr11_+_2923423 0.08 ENST00000312221.5
 SLC22A18
 solute carrier family 22, member 18
chr16_+_2083265 0.08 ENST00000565855.1
ENST00000566198.1
 SLC9A3R2
 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
chr4_+_75230853 0.08 ENST00000244869.2
 EREG
 epiregulin
chr2_-_219925189 0.08 ENST00000295731.6
 IHH
 indian hedgehog
chr11_-_73309228 0.07 ENST00000356467.4
ENST00000064778.4
 FAM168A
 family with sequence similarity 168, member A
chr15_+_47476275 0.07 ENST00000558014.1
 SEMA6D
 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr11_+_2923619 0.07 ENST00000380574.1
 SLC22A18
 solute carrier family 22, member 18
chr3_-_171527560 0.07 ENST00000331659.2
 PP13439
 PP13439
chr11_+_2923499 0.07 ENST00000449793.2
 SLC22A18
 solute carrier family 22, member 18
chr19_+_36266433 0.06 ENST00000314737.5
 ARHGAP33
 Rho GTPase activating protein 33
chr6_-_52859968 0.06 ENST00000370959.1
 GSTA4
 glutathione S-transferase alpha 4
chr17_-_40075197 0.06 ENST00000590770.1
ENST00000590151.1
 ACLY
 ATP citrate lyase
chr17_-_56065484 0.06 ENST00000581208.1
 VEZF1
 vascular endothelial zinc finger 1
chr5_-_107703556 0.06 ENST00000496714.1
 FBXL17
 F-box and leucine-rich repeat protein 17
chr19_+_36266417 0.06 ENST00000378944.5
ENST00000007510.4
 ARHGAP33
 Rho GTPase activating protein 33
chr3_+_5020801 0.06 ENST00000256495.3
 BHLHE40
 basic helix-loop-helix family, member e40
chr10_-_74856608 0.06 ENST00000307116.2
ENST00000373008.2
ENST00000412021.2
ENST00000394890.2
ENST00000263556.3
ENST00000440381.1
 P4HA1
 prolyl 4-hydroxylase, alpha polypeptide I
chr15_-_73075964 0.06 ENST00000563907.1
 ADPGK
 ADP-dependent glucokinase
chr1_+_39796810 0.05 ENST00000289893.4
 MACF1
 microtubule-actin crosslinking factor 1
chr6_-_31926208 0.05 ENST00000454913.1
ENST00000436289.2
 NELFE
 negative elongation factor complex member E
chr14_-_74959994 0.04 ENST00000238633.2
ENST00000434013.2
 NPC2
 Niemann-Pick disease, type C2
chr3_-_160117301 0.04 ENST00000326448.7
ENST00000498409.1
ENST00000475677.1
ENST00000478536.1
 IFT80
 intraflagellar transport 80 homolog (Chlamydomonas)
chr16_+_31225337 0.04 ENST00000322122.3
 TRIM72
 tripartite motif containing 72
chr19_+_11200038 0.04 ENST00000558518.1
ENST00000557933.1
ENST00000455727.2
ENST00000535915.1
ENST00000545707.1
ENST00000558013.1
 LDLR
 low density lipoprotein receptor
chr14_-_74960030 0.04 ENST00000553490.1
ENST00000557510.1
 NPC2
 Niemann-Pick disease, type C2
chr6_-_39902160 0.04 ENST00000340692.5
 MOCS1
 molybdenum cofactor synthesis 1
chr14_-_74959978 0.03 ENST00000541064.1
 NPC2
 Niemann-Pick disease, type C2
chr11_+_22688150 0.03 ENST00000454584.2
 GAS2
 growth arrest-specific 2
chr9_+_131452239 0.03 ENST00000372688.4
ENST00000372686.5
 SET
 SET nuclear oncogene
chrX_-_112084043 0.03 ENST00000304758.1
 AMOT
 angiomotin
chr12_+_50344516 0.03 ENST00000199280.3
ENST00000550862.1
 AQP2
 aquaporin 2 (collecting duct)
chr6_-_42713792 0.02 ENST00000372876.1
 TBCC
 tubulin folding cofactor C
chr3_+_160117418 0.02 ENST00000465903.1
ENST00000485645.1
ENST00000360111.2
ENST00000472991.1
ENST00000467468.1
ENST00000469762.1
ENST00000489573.1
ENST00000462787.1
ENST00000490207.1
ENST00000485867.1
 SMC4
 structural maintenance of chromosomes 4
chr15_-_73076030 0.02 ENST00000311669.8
 ADPGK
 ADP-dependent glucokinase
chr14_+_74960423 0.02 ENST00000556816.1
ENST00000298818.8
ENST00000554924.1
 ISCA2
 iron-sulfur cluster assembly 2
chr5_+_159656437 0.02 ENST00000402432.3
 FABP6
 fatty acid binding protein 6, ileal
chr1_-_155232047 0.02 ENST00000302631.3
 SCAMP3
 secretory carrier membrane protein 3
chr6_+_43968306 0.02 ENST00000442114.2
ENST00000336600.5
ENST00000439969.2
 C6orf223
 chromosome 6 open reading frame 223
chr6_-_53213780 0.02 ENST00000304434.6
ENST00000370918.4
 ELOVL5
 ELOVL fatty acid elongase 5
chr11_+_65383227 0.02 ENST00000355703.3
 PCNXL3
 pecanex-like 3 (Drosophila)
chr8_+_21882244 0.02 ENST00000289820.6
ENST00000381530.5
 NPM2
 nucleophosmin/nucleoplasmin 2
chr15_-_66858298 0.02 ENST00000537670.1
 LCTL
 lactase-like
chr1_-_155232221 0.02 ENST00000355379.3
 SCAMP3
 secretory carrier membrane protein 3
chr22_+_42229100 0.01 ENST00000361204.4
 SREBF2
 sterol regulatory element binding transcription factor 2
chr18_-_21166841 0.01 ENST00000269228.5
 NPC1
 Niemann-Pick disease, type C1
chr1_+_206643787 0.01 ENST00000367120.3
 IKBKE
 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr6_+_69942298 0.01 ENST00000238918.8
 BAI3
 brain-specific angiogenesis inhibitor 3
chr5_-_43313574 0.01 ENST00000325110.6
ENST00000433297.2
 HMGCS1
 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr16_+_22103828 0.01 ENST00000567131.1
ENST00000568328.1
ENST00000389398.5
ENST00000389397.4
 VWA3A
 von Willebrand factor A domain containing 3A
chrX_+_27826107 0.01 ENST00000356790.2
 MAGEB10
 melanoma antigen family B, 10
chr13_+_24844819 0.00 ENST00000399949.2
 SPATA13
 spermatogenesis associated 13

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:1900158 negative regulation of osteoclast proliferation(GO:0090291) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.2 0.7 GO:0035441 cell migration involved in vasculogenesis(GO:0035441) metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
0.1 0.4 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.1 0.5 GO:0019427 acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate metabolic process(GO:0019541) propionate biosynthetic process(GO:0019542)
0.1 0.3 GO:0035026 leading edge cell differentiation(GO:0035026)
0.0 0.1 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.0 0.1 GO:0016539 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.0 0.2 GO:0046618 drug export(GO:0046618)
0.0 0.3 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.0 0.1 GO:0019747 regulation of isoprenoid metabolic process(GO:0019747)
0.0 0.2 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0 0.3 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.1 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.1 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.3 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.1 GO:0035976 AP1 complex(GO:0035976)
0.0 0.1 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0 0.0 GO:0019008 molybdopterin synthase complex(GO:0019008)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.1 0.5 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.1 0.7 GO:0016015 morphogen activity(GO:0016015)
0.1 0.2 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.2 GO:0015307 drug:proton antiporter activity(GO:0015307)
0.0 0.2 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.1 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.3 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.3 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 0.5 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.3 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation