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Epithelial-Mesenchymal Transition, human (Scheel, 2011): : averaged replicates

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Results for TP73

Z-value: 0.34

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Transcription factors associated with TP73

Gene Symbol Gene ID Gene Info
TP73
ENSG00000078900.10 TP73

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TP73hg19_v2_chr1_+_3614591_36146220.344.1e-01Click!

Activity profile of TP73 motif

Sorted Z-values of TP73 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TP73

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr10_-_105212141 0.33 ENST00000369788.3
 CALHM2
 calcium homeostasis modulator 2
chr10_-_105212059 0.32 ENST00000260743.5
 CALHM2
 calcium homeostasis modulator 2
chr3_+_136676851 0.32 ENST00000309741.5
 IL20RB
 interleukin 20 receptor beta
chr3_+_136676707 0.32 ENST00000329582.4
 IL20RB
 interleukin 20 receptor beta
chr18_-_28681950 0.28 ENST00000251081.6
 DSC2
 desmocollin 2
chr19_+_45281118 0.27 ENST00000270279.3
ENST00000341505.4
 CBLC
 Cbl proto-oncogene C, E3 ubiquitin protein ligase
chr14_+_75746340 0.26 ENST00000555686.1
ENST00000555672.1
 FOS
 FBJ murine osteosarcoma viral oncogene homolog
chr10_+_47746929 0.24 ENST00000340243.6
ENST00000374277.5
ENST00000449464.2
ENST00000538825.1
ENST00000335083.5
 ANXA8L2
AL603965.1
 annexin A8-like 2
Protein LOC100996760
chr15_+_41136586 0.24 ENST00000431806.1
 SPINT1
 serine peptidase inhibitor, Kunitz type 1
chr14_+_75745477 0.22 ENST00000303562.4
ENST00000554617.1
ENST00000554212.1
ENST00000535987.1
ENST00000555242.1
 FOS
 FBJ murine osteosarcoma viral oncogene homolog
chr3_+_100120441 0.21 ENST00000489752.1
 LNP1
 leukemia NUP98 fusion partner 1
chr11_-_17035943 0.20 ENST00000355661.3
ENST00000532079.1
ENST00000448080.2
ENST00000531066.1
 PLEKHA7
 pleckstrin homology domain containing, family A member 7
chr18_-_53253323 0.18 ENST00000540999.1
ENST00000563888.2
 TCF4
 transcription factor 4
chr18_-_53253112 0.17 ENST00000568673.1
ENST00000562847.1
ENST00000568147.1
 TCF4
 transcription factor 4
chr15_+_41136216 0.17 ENST00000562057.1
ENST00000344051.4
 SPINT1
 serine peptidase inhibitor, Kunitz type 1
chr11_+_60197069 0.16 ENST00000528905.1
ENST00000528093.1
 MS4A5
 membrane-spanning 4-domains, subfamily A, member 5
chr2_+_95940186 0.14 ENST00000403131.2
ENST00000317668.4
ENST00000317620.9
 PROM2
 prominin 2
chr10_-_47173994 0.14 ENST00000414655.2
ENST00000545298.1
ENST00000359178.4
ENST00000358140.4
ENST00000503031.1
 ANXA8L1
LINC00842
 annexin A8-like 1
long intergenic non-protein coding RNA 842
chr22_-_20255212 0.13 ENST00000416372.1
 RTN4R
 reticulon 4 receptor
chr6_-_46703069 0.13 ENST00000538237.1
ENST00000274793.7
 PLA2G7
 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr2_+_95940220 0.13 ENST00000542147.1
 PROM2
 prominin 2
chr17_+_73750699 0.12 ENST00000584939.1
 ITGB4
 integrin, beta 4
chr11_+_60197040 0.11 ENST00000300190.2
 MS4A5
 membrane-spanning 4-domains, subfamily A, member 5
chr1_-_182641367 0.10 ENST00000508450.1
 RGS8
 regulator of G-protein signaling 8
chr7_-_27213893 0.10 ENST00000283921.4
 HOXA10
 homeobox A10
chr17_-_42200996 0.10 ENST00000587135.1
ENST00000225983.6
ENST00000393622.2
ENST00000588703.1
 HDAC5
 histone deacetylase 5
chr7_-_100171270 0.09 ENST00000538735.1
 SAP25
 Sin3A-associated protein, 25kDa
chr8_+_120885949 0.09 ENST00000523492.1
ENST00000286234.5
 DEPTOR
 DEP domain containing MTOR-interacting protein
chr14_+_103566665 0.08 ENST00000559116.1
 EXOC3L4
 exocyst complex component 3-like 4
chr19_-_35981358 0.08 ENST00000484218.2
ENST00000338897.3
 KRTDAP
 keratinocyte differentiation-associated protein
chr14_+_105190514 0.08 ENST00000330877.2
 ADSSL1
 adenylosuccinate synthase like 1
chr6_-_46703430 0.08 ENST00000537365.1
 PLA2G7
 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr19_-_19626838 0.07 ENST00000360913.3
 TSSK6
 testis-specific serine kinase 6
chr19_+_44037546 0.07 ENST00000601282.1
 ZNF575
 zinc finger protein 575
chr17_+_78388959 0.07 ENST00000518137.1
ENST00000520367.1
ENST00000523999.1
ENST00000323854.5
ENST00000522751.1
 ENDOV
 endonuclease V
chr3_-_185538849 0.07 ENST00000421047.2
 IGF2BP2
 insulin-like growth factor 2 mRNA binding protein 2
chr16_+_222846 0.06 ENST00000251595.6
ENST00000397806.1
 HBA2
 hemoglobin, alpha 2
chr11_+_75479850 0.06 ENST00000376262.3
ENST00000604733.1
 DGAT2
 diacylglycerol O-acyltransferase 2
chr12_-_57505121 0.06 ENST00000538913.2
ENST00000537215.2
ENST00000454075.3
ENST00000554825.1
ENST00000553275.1
ENST00000300134.3
 STAT6
 signal transducer and activator of transcription 6, interleukin-4 induced
chr1_-_203055129 0.06 ENST00000241651.4
 MYOG
 myogenin (myogenic factor 4)
chr16_+_84178874 0.06 ENST00000378553.5
 DNAAF1
 dynein, axonemal, assembly factor 1
chr2_-_73511559 0.06 ENST00000521871.1
 FBXO41
 F-box protein 41
chr3_-_50340996 0.06 ENST00000266031.4
ENST00000395143.2
ENST00000457214.2
ENST00000447605.2
ENST00000418723.1
ENST00000395144.2
 HYAL1
 hyaluronoglucosaminidase 1
chr20_-_52790055 0.05 ENST00000395955.3
 CYP24A1
 cytochrome P450, family 24, subfamily A, polypeptide 1
chr17_-_42452063 0.05 ENST00000588098.1
 ITGA2B
 integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
chr14_-_25045446 0.05 ENST00000216336.2
 CTSG
 cathepsin G
chr16_-_20367584 0.05 ENST00000570689.1
 UMOD
 uromodulin
chr13_-_48877795 0.05 ENST00000436963.1
ENST00000433480.2
 LINC00441
 long intergenic non-protein coding RNA 441
chr16_+_75032901 0.05 ENST00000335325.4
ENST00000320619.6
 ZNRF1
 zinc and ring finger 1, E3 ubiquitin protein ligase
chr11_-_75062829 0.05 ENST00000393505.4
 ARRB1
 arrestin, beta 1
chr1_-_111148241 0.05 ENST00000440270.1
 KCNA2
 potassium voltage-gated channel, shaker-related subfamily, member 2
chr11_+_236540 0.05 ENST00000532097.1
 PSMD13
 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
chr11_+_236959 0.05 ENST00000431206.2
ENST00000528906.1
 PSMD13
 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
chr2_-_26864228 0.04 ENST00000288861.4
 CIB4
 calcium and integrin binding family member 4
chr11_+_237016 0.04 ENST00000352303.5
 PSMD13
 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
chr14_-_105531759 0.04 ENST00000329797.3
ENST00000539291.2
ENST00000392585.2
 GPR132
 G protein-coupled receptor 132
chr17_+_37356528 0.04 ENST00000225430.4
 RPL19
 ribosomal protein L19
chr1_+_110082487 0.04 ENST00000527748.1
 GPR61
 G protein-coupled receptor 61
chr22_+_29168652 0.04 ENST00000249064.4
ENST00000444523.1
ENST00000448492.2
ENST00000421503.2
 CCDC117
 coiled-coil domain containing 117
chr17_+_21191341 0.04 ENST00000526076.2
ENST00000361818.5
ENST00000316920.6
 MAP2K3
 mitogen-activated protein kinase kinase 3
chr17_+_37356586 0.04 ENST00000579260.1
ENST00000582193.1
 RPL19
 ribosomal protein L19
chr1_-_78444738 0.04 ENST00000436586.2
ENST00000370768.2
 FUBP1
 far upstream element (FUSE) binding protein 1
chr7_-_128045984 0.04 ENST00000470772.1
ENST00000480861.1
ENST00000496200.1
 IMPDH1
 IMP (inosine 5'-monophosphate) dehydrogenase 1
chr19_-_39226045 0.04 ENST00000597987.1
ENST00000595177.1
 CAPN12
 calpain 12
chr17_+_37356555 0.03 ENST00000579374.1
 RPL19
 ribosomal protein L19
chr17_-_39023462 0.03 ENST00000251643.4
 KRT12
 keratin 12
chr20_+_48807351 0.03 ENST00000303004.3
 CEBPB
 CCAAT/enhancer binding protein (C/EBP), beta
chr21_+_43442100 0.03 ENST00000455701.1
ENST00000596595.1
 ZNF295-AS1
 ZNF295 antisense RNA 1
chr1_-_78444776 0.03 ENST00000370767.1
ENST00000421641.1
 FUBP1
 far upstream element (FUSE) binding protein 1
chr19_+_19627026 0.03 ENST00000608404.1
ENST00000555938.1
ENST00000503283.1
ENST00000512771.3
ENST00000428459.2
 YJEFN3
CTC-260F20.3
NDUFA13
 YjeF N-terminal domain containing 3
Uncharacterized protein
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
chr17_+_7792101 0.03 ENST00000358181.4
ENST00000330494.7
 CHD3
 chromodomain helicase DNA binding protein 3
chr16_+_8891670 0.03 ENST00000268261.4
ENST00000539622.1
ENST00000569958.1
ENST00000537352.1
 PMM2
 phosphomannomutase 2
chr2_+_128293323 0.03 ENST00000389524.4
ENST00000428314.1
 MYO7B
 myosin VIIB
chr16_-_8891481 0.03 ENST00000333050.6
 TMEM186
 transmembrane protein 186
chr20_-_52790512 0.03 ENST00000216862.3
 CYP24A1
 cytochrome P450, family 24, subfamily A, polypeptide 1
chr15_+_75498355 0.03 ENST00000567617.1
 C15orf39
 chromosome 15 open reading frame 39
chr14_+_105935396 0.03 ENST00000494981.1
 MTA1
 metastasis associated 1
chr12_-_117319236 0.03 ENST00000257572.5
 HRK
 harakiri, BCL2 interacting protein (contains only BH3 domain)
chrX_-_131228291 0.03 ENST00000370879.1
 FRMD7
 FERM domain containing 7
chr5_+_38258511 0.02 ENST00000354891.3
ENST00000322350.5
 EGFLAM
 EGF-like, fibronectin type III and laminin G domains
chr3_-_100120223 0.02 ENST00000284320.5
 TOMM70A
 translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
chr5_+_78532003 0.02 ENST00000396137.4
 JMY
 junction mediating and regulatory protein, p53 cofactor
chr20_-_62203808 0.02 ENST00000467148.1
 HELZ2
 helicase with zinc finger 2, transcriptional coactivator
chr10_-_79686284 0.02 ENST00000372391.2
ENST00000372388.2
 DLG5
 discs, large homolog 5 (Drosophila)
chr11_+_66234216 0.02 ENST00000349459.6
ENST00000320740.7
ENST00000524466.1
ENST00000526296.1
 PELI3
 pellino E3 ubiquitin protein ligase family member 3
chr3_+_42201653 0.02 ENST00000341421.3
ENST00000396175.1
 TRAK1
 trafficking protein, kinesin binding 1
chr6_+_31515337 0.02 ENST00000376148.4
ENST00000376145.4
 NFKBIL1
 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr17_-_2614927 0.02 ENST00000435359.1
 CLUH
 clustered mitochondria (cluA/CLU1) homolog
chr14_+_103566481 0.02 ENST00000380069.3
 EXOC3L4
 exocyst complex component 3-like 4
chr5_-_135528822 0.02 ENST00000607574.1
 AC009014.3
 AC009014.3
chr19_+_41856816 0.02 ENST00000539627.1
 TMEM91
 transmembrane protein 91
chr1_-_220220000 0.02 ENST00000366923.3
 EPRS
 glutamyl-prolyl-tRNA synthetase
chr10_+_70661014 0.01 ENST00000373585.3
 DDX50
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
chr1_-_26197744 0.01 ENST00000374296.3
 PAQR7
 progestin and adipoQ receptor family member VII
chr18_-_4455260 0.01 ENST00000581527.1
 DLGAP1
 discs, large (Drosophila) homolog-associated protein 1
chr2_+_114163945 0.01 ENST00000453673.3
 IGKV1OR2-108
 immunoglobulin kappa variable 1/OR2-108 (non-functional)
chr20_+_35504522 0.01 ENST00000602922.1
ENST00000217320.3
 TLDC2
 TBC/LysM-associated domain containing 2
chr6_-_112194484 0.01 ENST00000518295.1
ENST00000484067.2
ENST00000229470.5
ENST00000356013.2
ENST00000368678.4
ENST00000523238.1
ENST00000354650.3
 FYN
 FYN oncogene related to SRC, FGR, YES
chr22_-_37976082 0.01 ENST00000215886.4
 LGALS2
 lectin, galactoside-binding, soluble, 2
chr2_-_27357479 0.01 ENST00000406567.3
ENST00000260643.2
 PREB
 prolactin regulatory element binding
chr9_+_87285257 0.01 ENST00000323115.4
 NTRK2
 neurotrophic tyrosine kinase, receptor, type 2
chr5_-_156593273 0.01 ENST00000302938.4
 FAM71B
 family with sequence similarity 71, member B
chr1_+_26485511 0.01 ENST00000374268.3
 FAM110D
 family with sequence similarity 110, member D
chr8_-_70745575 0.01 ENST00000524945.1
 SLCO5A1
 solute carrier organic anion transporter family, member 5A1
chr11_-_65686496 0.01 ENST00000449692.3
 C11orf68
 chromosome 11 open reading frame 68
chr19_+_17326521 0.01 ENST00000593597.1
 USE1
 unconventional SNARE in the ER 1 homolog (S. cerevisiae)
chr11_+_65154070 0.01 ENST00000317568.5
ENST00000531296.1
ENST00000533782.1
ENST00000355991.5
ENST00000416776.2
ENST00000526201.1
 FRMD8
 FERM domain containing 8
chr17_-_79818354 0.01 ENST00000576541.1
ENST00000576380.1
ENST00000571617.1
ENST00000576052.1
ENST00000576390.1
ENST00000573778.2
ENST00000439918.2
ENST00000574914.1
ENST00000331483.4
 P4HB
 prolyl 4-hydroxylase, beta polypeptide
chr19_+_49622646 0.01 ENST00000334186.4
 PPFIA3
 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr9_+_6757634 0.01 ENST00000543771.1
ENST00000401787.3
ENST00000381306.3
ENST00000381309.3
 KDM4C
 lysine (K)-specific demethylase 4C
chr14_+_22554680 0.01 ENST00000390451.2
 TRAV23DV6
 T cell receptor alpha variable 23/delta variable 6
chr12_-_82752565 0.00 ENST00000256151.7
 CCDC59
 coiled-coil domain containing 59
chr17_-_40835076 0.00 ENST00000591765.1
 CCR10
 chemokine (C-C motif) receptor 10
chr7_+_116502527 0.00 ENST00000361183.3
 CAPZA2
 capping protein (actin filament) muscle Z-line, alpha 2
chr16_-_2581409 0.00 ENST00000567119.1
ENST00000565480.1
ENST00000382350.1
 CEMP1
 cementum protein 1
chr12_+_82752275 0.00 ENST00000248306.3
 METTL25
 methyltransferase like 25
chr17_-_47492236 0.00 ENST00000434917.2
ENST00000300408.3
ENST00000511832.1
ENST00000419140.2
 PHB
 prohibitin
chr17_-_47492164 0.00 ENST00000512041.2
ENST00000446735.1
ENST00000504124.1
 PHB
 prohibitin
chrX_-_138724677 0.00 ENST00000370573.4
ENST00000338585.6
ENST00000370576.4
 MCF2
 MCF.2 cell line derived transforming sequence
chr14_+_96858433 0.00 ENST00000267584.4
 AK7
 adenylate kinase 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0001808 negative regulation of type IV hypersensitivity(GO:0001808)
0.1 0.3 GO:2001287 negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.1 0.5 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.2 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.0 0.2 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.3 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.0 0.1 GO:0042369 vitamin D catabolic process(GO:0042369)
0.0 0.4 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0 0.1 GO:0071400 cellular response to oleic acid(GO:0071400)
0.0 0.1 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.0 0.1 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.0 0.1 GO:1900106 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.0 0.3 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.1 GO:1903862 regulation of muscle atrophy(GO:0014735) response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878) positive regulation of oxidative phosphorylation(GO:1903862)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0035976 AP1 complex(GO:0035976)
0.1 0.3 GO:0044393 microspike(GO:0044393)
0.0 0.2 GO:0005915 zonula adherens(GO:0005915)
0.0 0.1 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.1 GO:0038131 neuregulin receptor activity(GO:0038131)
0.0 0.3 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.0 0.1 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.0 0.3 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.1 GO:0004019 adenylosuccinate synthase activity(GO:0004019)
0.0 0.2 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.2 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0 0.1 GO:0050252 retinol O-fatty-acyltransferase activity(GO:0050252)
0.0 0.1 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.0 0.1 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.0 0.0 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.1 GO:0070051 fibrinogen binding(GO:0070051)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors