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Epithelial-Mesenchymal Transition, human (Scheel, 2011): : averaged replicates

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Results for VAX2_RHOXF2

Z-value: 0.25

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Transcription factors associated with VAX2_RHOXF2

Gene Symbol Gene ID Gene Info
VAX2
ENSG00000116035.2 VAX2
RHOXF2
ENSG00000131721.4 RHOXF2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
VAX2hg19_v2_chr2_+_71127699_71127744-0.413.1e-01Click!
RHOXF2hg19_v2_chrX_+_119292467_1192924670.117.9e-01Click!

Activity profile of VAX2_RHOXF2 motif

Sorted Z-values of VAX2_RHOXF2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of VAX2_RHOXF2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr1_-_57045228 0.54 ENST00000371250.3
 PPAP2B
 phosphatidic acid phosphatase type 2B
chr5_-_20575959 0.46 ENST00000507958.1
 CDH18
 cadherin 18, type 2
chr3_+_157154578 0.40 ENST00000295927.3
 PTX3
 pentraxin 3, long
chr4_-_186696425 0.32 ENST00000430503.1
ENST00000319454.6
ENST00000450341.1
 SORBS2
 sorbin and SH3 domain containing 2
chr16_+_53133070 0.27 ENST00000565832.1
 CHD9
 chromodomain helicase DNA binding protein 9
chr9_-_95166841 0.23 ENST00000262551.4
 OGN
 osteoglycin
chr4_-_138453606 0.19 ENST00000412923.2
ENST00000344876.4
ENST00000507846.1
ENST00000510305.1
 PCDH18
 protocadherin 18
chr3_-_191000172 0.14 ENST00000427544.2
 UTS2B
 urotensin 2B
chr4_-_66536057 0.14 ENST00000273854.3
 EPHA5
 EPH receptor A5
chr4_-_138453559 0.14 ENST00000511115.1
 PCDH18
 protocadherin 18
chr11_-_111794446 0.11 ENST00000527950.1
 CRYAB
 crystallin, alpha B
chr19_+_50016610 0.11 ENST00000596975.1
 FCGRT
 Fc fragment of IgG, receptor, transporter, alpha
chr7_-_92777606 0.10 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
 SAMD9L
 sterile alpha motif domain containing 9-like
chr12_+_26348246 0.10 ENST00000422622.2
 SSPN
 sarcospan
chr9_-_95166884 0.09 ENST00000375561.5
 OGN
 osteoglycin
chr7_+_99717230 0.09 ENST00000262932.3
 CNPY4
 canopy FGF signaling regulator 4
chr14_+_74034310 0.08 ENST00000538782.1
 ACOT2
 acyl-CoA thioesterase 2
chr17_-_33390667 0.08 ENST00000378516.2
ENST00000268850.7
ENST00000394597.2
 RFFL
 ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
chr6_+_26440700 0.08 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
 BTN3A3
 butyrophilin, subfamily 3, member A3
chrX_+_7137475 0.07 ENST00000217961.4
 STS
 steroid sulfatase (microsomal), isozyme S
chr10_-_92681033 0.07 ENST00000371697.3
 ANKRD1
 ankyrin repeat domain 1 (cardiac muscle)
chr15_+_74218787 0.07 ENST00000261921.7
 LOXL1
 lysyl oxidase-like 1
chr2_-_74618964 0.07 ENST00000417090.1
ENST00000409868.1
 DCTN1
 dynactin 1
chr17_-_40337470 0.06 ENST00000293330.1
 HCRT
 hypocretin (orexin) neuropeptide precursor
chr3_-_141747950 0.06 ENST00000497579.1
 TFDP2
 transcription factor Dp-2 (E2F dimerization partner 2)
chr20_+_15177480 0.06 ENST00000402914.1
 MACROD2
 MACRO domain containing 2
chr20_-_33735070 0.06 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
 EDEM2
 ER degradation enhancer, mannosidase alpha-like 2
chr8_-_42623747 0.05 ENST00000534622.1
 CHRNA6
 cholinergic receptor, nicotinic, alpha 6 (neuronal)
chr15_-_37393406 0.05 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
 MEIS2
 Meis homeobox 2
chr2_-_74619152 0.05 ENST00000440727.1
ENST00000409240.1
 DCTN1
 dynactin 1
chr21_+_17442799 0.05 ENST00000602580.1
ENST00000458468.1
ENST00000602935.1
 LINC00478
 long intergenic non-protein coding RNA 478
chr7_+_138145076 0.05 ENST00000343526.4
 TRIM24
 tripartite motif containing 24
chr10_-_27529486 0.05 ENST00000375888.1
 ACBD5
 acyl-CoA binding domain containing 5
chr8_-_7243080 0.05 ENST00000400156.4
 ZNF705G
 zinc finger protein 705G
chr12_-_78753496 0.05 ENST00000548512.1
 RP11-38F22.1
 RP11-38F22.1
chr1_-_211307404 0.05 ENST00000367007.4
 KCNH1
 potassium voltage-gated channel, subfamily H (eag-related), member 1
chr9_+_125133315 0.05 ENST00000223423.4
ENST00000362012.2
 PTGS1
 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chrX_+_43515467 0.05 ENST00000338702.3
ENST00000542639.1
 MAOA
 monoamine oxidase A
chr12_+_26348429 0.05 ENST00000242729.2
 SSPN
 sarcospan
chr2_+_169926047 0.04 ENST00000428522.1
ENST00000450153.1
ENST00000421653.1
 DHRS9
 dehydrogenase/reductase (SDR family) member 9
chr11_+_33061543 0.04 ENST00000432887.1
ENST00000528898.1
ENST00000531632.2
 TCP11L1
 t-complex 11, testis-specific-like 1
chr7_+_12727250 0.04 ENST00000404894.1
 ARL4A
 ADP-ribosylation factor-like 4A
chr11_-_62521614 0.04 ENST00000527994.1
ENST00000394807.3
 ZBTB3
 zinc finger and BTB domain containing 3
chr10_+_90660832 0.04 ENST00000371924.1
 STAMBPL1
 STAM binding protein-like 1
chr12_+_131438443 0.04 ENST00000261654.5
 GPR133
 G protein-coupled receptor 133
chr21_+_17443434 0.04 ENST00000400178.2
 LINC00478
 long intergenic non-protein coding RNA 478
chr7_+_120628731 0.04 ENST00000310396.5
 CPED1
 cadherin-like and PC-esterase domain containing 1
chr6_+_26402517 0.03 ENST00000414912.2
 BTN3A1
 butyrophilin, subfamily 3, member A1
chr21_+_17443521 0.03 ENST00000456342.1
 LINC00478
 long intergenic non-protein coding RNA 478
chr1_+_225600404 0.03 ENST00000366845.2
 AC092811.1
 AC092811.1
chr1_+_35258592 0.03 ENST00000342280.4
ENST00000450137.1
 GJA4
 gap junction protein, alpha 4, 37kDa
chr14_-_53258314 0.03 ENST00000216410.3
ENST00000557604.1
 GNPNAT1
 glucosamine-phosphate N-acetyltransferase 1
chr11_-_121986923 0.03 ENST00000560104.1
 BLID
 BH3-like motif containing, cell death inducer
chr8_-_101661887 0.03 ENST00000311812.2
 SNX31
 sorting nexin 31
chr17_+_66511540 0.03 ENST00000588188.2
 PRKAR1A
 protein kinase, cAMP-dependent, regulatory, type I, alpha
chr1_+_205682497 0.03 ENST00000598338.1
 AC119673.1
 AC119673.1
chr1_-_24151903 0.03 ENST00000436439.2
ENST00000374490.3
 HMGCL
 3-hydroxymethyl-3-methylglutaryl-CoA lyase
chr8_+_7783859 0.03 ENST00000400120.3
 ZNF705B
 zinc finger protein 705B
chr2_-_85555385 0.03 ENST00000377386.3
 TGOLN2
 trans-golgi network protein 2
chr10_-_50396407 0.03 ENST00000374153.2
ENST00000374151.3
 C10orf128
 chromosome 10 open reading frame 128
chr11_+_71900572 0.03 ENST00000312293.4
 FOLR1
 folate receptor 1 (adult)
chr15_-_98417780 0.03 ENST00000503874.3
 LINC00923
 long intergenic non-protein coding RNA 923
chr11_+_60383204 0.03 ENST00000412599.1
ENST00000320202.4
 LINC00301
 long intergenic non-protein coding RNA 301
chr12_+_31812121 0.03 ENST00000395763.3
 METTL20
 methyltransferase like 20
chr7_-_99716952 0.02 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
 TAF6
 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr7_-_99717463 0.02 ENST00000437822.2
 TAF6
 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr5_+_140557371 0.02 ENST00000239444.2
 PCDHB8
 protocadherin beta 8
chr7_+_100860949 0.02 ENST00000305105.2
 ZNHIT1
 zinc finger, HIT-type containing 1
chrX_+_72783026 0.02 ENST00000373504.6
ENST00000373502.5
 CHIC1
 cysteine-rich hydrophobic domain 1
chr11_+_71900703 0.02 ENST00000393681.2
 FOLR1
 folate receptor 1 (adult)
chr5_+_174151536 0.02 ENST00000239243.6
ENST00000507785.1
 MSX2
 msh homeobox 2
chr4_+_169418255 0.02 ENST00000505667.1
ENST00000511948.1
 PALLD
 palladin, cytoskeletal associated protein
chr20_-_29978286 0.02 ENST00000376315.2
 DEFB119
 defensin, beta 119
chr2_-_40680578 0.02 ENST00000455476.1
 SLC8A1
 solute carrier family 8 (sodium/calcium exchanger), member 1
chr21_-_37914898 0.02 ENST00000399136.1
 CLDN14
 claudin 14
chr14_-_20923195 0.02 ENST00000206542.4
 OSGEP
 O-sialoglycoprotein endopeptidase
chrX_+_36254051 0.02 ENST00000378657.4
 CXorf30
 chromosome X open reading frame 30
chr1_+_54569968 0.02 ENST00000391366.1
 AL161915.1
 Uncharacterized protein
chrX_+_135730297 0.02 ENST00000370629.2
 CD40LG
 CD40 ligand
chr6_+_26402465 0.02 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
 BTN3A1
 butyrophilin, subfamily 3, member A1
chr14_+_20923350 0.02 ENST00000555414.1
ENST00000216714.3
ENST00000553681.1
ENST00000557344.1
ENST00000398030.4
ENST00000557181.1
ENST00000555839.1
ENST00000553368.1
ENST00000556054.1
ENST00000557054.1
ENST00000557592.1
ENST00000557150.1
 APEX1
 APEX nuclease (multifunctional DNA repair enzyme) 1
chr5_-_149829294 0.02 ENST00000401695.3
 RPS14
 ribosomal protein S14
chr1_+_212965170 0.02 ENST00000532324.1
ENST00000366974.4
ENST00000530441.1
ENST00000526641.1
ENST00000531963.1
ENST00000366973.4
ENST00000526997.1
ENST00000488246.2
 TATDN3
 TatD DNase domain containing 3
chr10_-_17171817 0.02 ENST00000377833.4
 CUBN
 cubilin (intrinsic factor-cobalamin receptor)
chrX_+_135730373 0.02 ENST00000370628.2
 CD40LG
 CD40 ligand
chr5_-_149829244 0.02 ENST00000312037.5
 RPS14
 ribosomal protein S14
chr7_+_6655225 0.01 ENST00000457543.3
 ZNF853
 zinc finger protein 853
chr1_-_169429690 0.01 ENST00000445428.1
 RP1-206D15.3
 RP1-206D15.3
chr19_+_12175504 0.01 ENST00000439326.3
 ZNF844
 zinc finger protein 844
chr5_-_149829314 0.01 ENST00000407193.1
 RPS14
 ribosomal protein S14
chr4_+_169418195 0.01 ENST00000261509.6
ENST00000335742.7
 PALLD
 palladin, cytoskeletal associated protein
chr17_-_39191107 0.01 ENST00000344363.5
 KRTAP1-3
 keratin associated protein 1-3
chr1_-_212965104 0.01 ENST00000422588.2
ENST00000366975.6
ENST00000366977.3
ENST00000366976.1
 NSL1
 NSL1, MIS12 kinetochore complex component
chr14_-_39639523 0.01 ENST00000330149.5
ENST00000554018.1
ENST00000347691.5
 TRAPPC6B
 trafficking protein particle complex 6B
chr12_-_50643664 0.01 ENST00000550592.1
 LIMA1
 LIM domain and actin binding 1
chr4_+_159727272 0.01 ENST00000379346.3
 FNIP2
 folliculin interacting protein 2
chr19_-_46088068 0.01 ENST00000263275.4
ENST00000323060.3
 OPA3
 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr16_+_12059050 0.01 ENST00000396495.3
 TNFRSF17
 tumor necrosis factor receptor superfamily, member 17
chr15_+_58430368 0.01 ENST00000558772.1
ENST00000219919.4
 AQP9
 aquaporin 9
chr15_+_58430567 0.01 ENST00000536493.1
 AQP9
 aquaporin 9
chr16_+_69345243 0.01 ENST00000254950.11
 VPS4A
 vacuolar protein sorting 4 homolog A (S. cerevisiae)
chr1_-_190446759 0.01 ENST00000367462.3
 BRINP3
 bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr13_+_36050881 0.01 ENST00000537702.1
 NBEA
 neurobeachin
chr6_+_29079668 0.01 ENST00000377169.1
 OR2J3
 olfactory receptor, family 2, subfamily J, member 3
chr12_-_118796910 0.01 ENST00000541186.1
ENST00000539872.1
 TAOK3
 TAO kinase 3
chr17_-_39203519 0.01 ENST00000542137.1
ENST00000391419.3
 KRTAP2-1
 keratin associated protein 2-1
chr15_+_80351977 0.01 ENST00000559157.1
ENST00000561012.1
ENST00000564367.1
ENST00000558494.1
 ZFAND6
 zinc finger, AN1-type domain 6
chr9_+_131062367 0.01 ENST00000601297.1
 AL359091.2
 CDNA: FLJ21673 fis, clone COL09042; HCG2036511; Uncharacterized protein
chr3_+_152552685 0.01 ENST00000305097.3
 P2RY1
 purinergic receptor P2Y, G-protein coupled, 1
chr17_+_43238438 0.01 ENST00000593138.1
ENST00000586681.1
 HEXIM2
 hexamethylene bis-acetamide inducible 2
chr15_+_80351910 0.01 ENST00000261749.6
ENST00000561060.1
 ZFAND6
 zinc finger, AN1-type domain 6
chr14_+_22465771 0.01 ENST00000390445.2
 TRAV17
 T cell receptor alpha variable 17
chr12_+_81110684 0.01 ENST00000228644.3
 MYF5
 myogenic factor 5
chrX_-_77225135 0.01 ENST00000458128.1
 PGAM4
 phosphoglycerate mutase family member 4
chr4_-_69111401 0.01 ENST00000332644.5
 TMPRSS11B
 transmembrane protease, serine 11B
chr20_-_29978383 0.01 ENST00000339144.3
ENST00000376321.3
 DEFB119
 defensin, beta 119
chr5_+_176811431 0.01 ENST00000512593.1
ENST00000324417.5
 SLC34A1
 solute carrier family 34 (type II sodium/phosphate contransporter), member 1
chr12_+_82347498 0.01 ENST00000550506.1
 RP11-362A1.1
 RP11-362A1.1
chr16_+_72088376 0.01 ENST00000570083.1
ENST00000355906.5
ENST00000398131.2
ENST00000569639.1
ENST00000564499.1
ENST00000357763.4
ENST00000562526.1
ENST00000565574.1
ENST00000568417.2
ENST00000356967.5
 HP
HPR
 haptoglobin
haptoglobin-related protein
chr10_-_99205607 0.01 ENST00000477692.2
ENST00000485122.2
ENST00000370886.5
ENST00000370885.4
ENST00000370902.3
ENST00000370884.5
 EXOSC1
 exosome component 1
chr18_-_67624160 0.01 ENST00000581982.1
ENST00000280200.4
 CD226
 CD226 molecule
chr7_+_148936732 0.00 ENST00000335870.2
 ZNF212
 zinc finger protein 212
chr9_-_21202204 0.00 ENST00000239347.3
 IFNA7
 interferon, alpha 7
chr8_-_10512569 0.00 ENST00000382483.3
 RP1L1
 retinitis pigmentosa 1-like 1
chr1_+_46972668 0.00 ENST00000371956.4
ENST00000360032.3
 DMBX1
 diencephalon/mesencephalon homeobox 1
chr2_-_214016314 0.00 ENST00000434687.1
ENST00000374319.4
 IKZF2
 IKAROS family zinc finger 2 (Helios)
chr6_-_82957433 0.00 ENST00000306270.7
 IBTK
 inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr3_+_186353756 0.00 ENST00000431018.1
ENST00000450521.1
ENST00000539949.1
 FETUB
 fetuin B
chr3_+_158519654 0.00 ENST00000415822.2
ENST00000392813.4
ENST00000264266.8
 MFSD1
 major facilitator superfamily domain containing 1
chr16_-_28608424 0.00 ENST00000335715.4
 SULT1A2
 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr5_+_129083772 0.00 ENST00000564719.1
 KIAA1024L
 KIAA1024-like
chr7_-_44122063 0.00 ENST00000335195.6
ENST00000395831.3
ENST00000414235.1
ENST00000452049.1
ENST00000242248.5
 POLM
 polymerase (DNA directed), mu
chr17_-_10372875 0.00 ENST00000255381.2
 MYH4
 myosin, heavy chain 4, skeletal muscle
chr17_+_48823975 0.00 ENST00000513969.1
ENST00000503728.1
 LUC7L3
 LUC7-like 3 (S. cerevisiae)
chr3_+_115342349 0.00 ENST00000393780.3
 GAP43
 growth associated protein 43
chr17_+_4692230 0.00 ENST00000331264.7
 GLTPD2
 glycolipid transfer protein domain containing 2
chr20_+_43990576 0.00 ENST00000372727.1
ENST00000414310.1
 SYS1
 SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.0 0.1 GO:0036512 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.0 0.3 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 0.0 GO:0003147 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713)
0.0 0.1 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 0.1 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.0 0.1 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.0 0.1 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.1 GO:0019770 IgG receptor activity(GO:0019770)
0.0 0.1 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0 0.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.0 GO:0061714 folic acid receptor activity(GO:0061714)
0.0 0.0 GO:0005174 CD40 receptor binding(GO:0005174)
0.0 0.3 GO:0008093 cytoskeletal adaptor activity(GO:0008093)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.5 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis