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Epithelial-Mesenchymal Transition, human (Scheel, 2011): : averaged replicates

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Results for ZFHX3

Z-value: 0.37

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Transcription factors associated with ZFHX3

Gene Symbol Gene ID Gene Info
ZFHX3
ENSG00000140836.10 ZFHX3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZFHX3hg19_v2_chr16_-_73082274_73082274,
hg19_v2_chr16_-_73093597_73093597		0.601.2e-01Click!

Activity profile of ZFHX3 motif

Sorted Z-values of ZFHX3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ZFHX3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr12_-_91546926 0.69 ENST00000550758.1
 DCN
 decorin
chr5_+_95066823 0.47 ENST00000506817.1
ENST00000379982.3
 RHOBTB3
 Rho-related BTB domain containing 3
chr3_-_114477787 0.29 ENST00000464560.1
 ZBTB20
 zinc finger and BTB domain containing 20
chr9_-_123812542 0.27 ENST00000223642.1
 C5
 complement component 5
chr3_+_69915385 0.23 ENST00000314589.5
 MITF
 microphthalmia-associated transcription factor
chr3_+_69812701 0.23 ENST00000472437.1
 MITF
 microphthalmia-associated transcription factor
chr5_+_140625147 0.23 ENST00000231173.3
 PCDHB15
 protocadherin beta 15
chr19_+_50016610 0.19 ENST00000596975.1
 FCGRT
 Fc fragment of IgG, receptor, transporter, alpha
chr4_+_74347400 0.19 ENST00000226355.3
 AFM
 afamin
chr20_-_33735070 0.15 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
 EDEM2
 ER degradation enhancer, mannosidase alpha-like 2
chr2_+_88047606 0.14 ENST00000359481.4
 PLGLB2
 plasminogen-like B2
chr3_-_164796269 0.13 ENST00000264382.3
 SI
 sucrase-isomaltase (alpha-glucosidase)
chrX_+_9431324 0.13 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
 TBL1X
 transducin (beta)-like 1X-linked
chr19_-_58864848 0.12 ENST00000263100.3
 A1BG
 alpha-1-B glycoprotein
chr19_+_926000 0.11 ENST00000263620.3
 ARID3A
 AT rich interactive domain 3A (BRIGHT-like)
chr12_+_59989918 0.11 ENST00000547379.1
ENST00000549465.1
 SLC16A7
 solute carrier family 16 (monocarboxylate transporter), member 7
chr8_-_70745575 0.10 ENST00000524945.1
 SLCO5A1
 solute carrier organic anion transporter family, member 5A1
chr12_+_53835508 0.09 ENST00000551003.1
ENST00000549068.1
ENST00000549740.1
ENST00000546581.1
ENST00000549581.1
ENST00000541275.1
 PRR13
PCBP2
 proline rich 13
poly(rC) binding protein 2
chr7_-_7575477 0.09 ENST00000399429.3
 COL28A1
 collagen, type XXVIII, alpha 1
chr2_-_87248975 0.08 ENST00000409310.2
ENST00000355705.3
 PLGLB1
 plasminogen-like B1
chr2_-_40680578 0.08 ENST00000455476.1
 SLC8A1
 solute carrier family 8 (sodium/calcium exchanger), member 1
chr9_-_95298314 0.08 ENST00000344604.5
ENST00000375540.1
 ECM2
 extracellular matrix protein 2, female organ and adipocyte specific
chr12_+_59989791 0.08 ENST00000552432.1
 SLC16A7
 solute carrier family 16 (monocarboxylate transporter), member 7
chr7_+_130126165 0.08 ENST00000427521.1
ENST00000416162.2
ENST00000378576.4
 MEST
 mesoderm specific transcript
chr12_-_101801505 0.08 ENST00000539055.1
ENST00000551688.1
ENST00000551671.1
ENST00000261636.8
 ARL1
 ADP-ribosylation factor-like 1
chr21_+_40824003 0.08 ENST00000452550.1
 SH3BGR
 SH3 domain binding glutamic acid-rich protein
chrX_+_16668278 0.08 ENST00000380200.3
 S100G
 S100 calcium binding protein G
chr18_+_5748793 0.07 ENST00000566533.1
ENST00000562452.2
 RP11-945C19.1
 RP11-945C19.1
chr7_+_130126012 0.07 ENST00000341441.5
 MEST
 mesoderm specific transcript
chr12_+_131438443 0.07 ENST00000261654.5
 GPR133
 G protein-coupled receptor 133
chr5_-_125930929 0.07 ENST00000553117.1
ENST00000447989.2
ENST00000409134.3
 ALDH7A1
 aldehyde dehydrogenase 7 family, member A1
chr1_-_227505289 0.07 ENST00000366765.3
 CDC42BPA
 CDC42 binding protein kinase alpha (DMPK-like)
chr22_-_30722912 0.07 ENST00000215790.7
 TBC1D10A
 TBC1 domain family, member 10A
chr9_-_215744 0.07 ENST00000382387.2
 C9orf66
 chromosome 9 open reading frame 66
chr16_-_15474904 0.06 ENST00000534094.1
 NPIPA5
 nuclear pore complex interacting protein family, member A5
chr20_+_42187682 0.06 ENST00000373092.3
ENST00000373077.1
 SGK2
 serum/glucocorticoid regulated kinase 2
chr20_+_42187608 0.06 ENST00000373100.1
 SGK2
 serum/glucocorticoid regulated kinase 2
chr12_-_7818474 0.06 ENST00000229304.4
 APOBEC1
 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
chr8_-_145754428 0.06 ENST00000527462.1
ENST00000313465.5
ENST00000524821.1
 C8orf82
 chromosome 8 open reading frame 82
chr5_+_118690466 0.06 ENST00000503646.1
 TNFAIP8
 tumor necrosis factor, alpha-induced protein 8
chr11_+_5410607 0.06 ENST00000328611.3
 OR51M1
 olfactory receptor, family 51, subfamily M, member 1
chr15_+_58724184 0.05 ENST00000433326.2
 LIPC
 lipase, hepatic
chr6_+_47749718 0.05 ENST00000489301.2
ENST00000371211.2
ENST00000393699.2
 OPN5
 opsin 5
chr12_+_80750134 0.04 ENST00000546620.1
 OTOGL
 otogelin-like
chr20_-_21494654 0.04 ENST00000377142.4
 NKX2-2
 NK2 homeobox 2
chr12_+_53835383 0.04 ENST00000429243.2
 PRR13
 proline rich 13
chr1_+_159557607 0.04 ENST00000255040.2
 APCS
 amyloid P component, serum
chr5_-_35195338 0.04 ENST00000509839.1
 PRLR
 prolactin receptor
chr6_-_32374900 0.04 ENST00000374995.3
ENST00000374993.1
ENST00000414363.1
ENST00000540315.1
ENST00000544175.1
ENST00000429232.2
ENST00000454136.3
ENST00000446536.2
 BTNL2
 butyrophilin-like 2 (MHC class II associated)
chr12_+_53835539 0.04 ENST00000547368.1
ENST00000379786.4
ENST00000551945.1
 PRR13
 proline rich 13
chr2_+_105050794 0.04 ENST00000429464.1
ENST00000414442.1
ENST00000447380.1
 AC013402.2
 long intergenic non-protein coding RNA 1102
chr4_+_100495864 0.03 ENST00000265517.5
ENST00000422897.2
 MTTP
 microsomal triglyceride transfer protein
chr4_-_152149033 0.03 ENST00000514152.1
 SH3D19
 SH3 domain containing 19
chr1_-_159684371 0.03 ENST00000255030.5
ENST00000437342.1
ENST00000368112.1
ENST00000368111.1
ENST00000368110.1
ENST00000343919.2
 CRP
 C-reactive protein, pentraxin-related
chr8_+_70850403 0.03 ENST00000602248.1
 AC090574.1
 Uncharacterized protein
chr6_+_28317685 0.03 ENST00000252211.2
ENST00000341464.5
ENST00000377255.3
 ZKSCAN3
 zinc finger with KRAB and SCAN domains 3
chr13_-_30881134 0.03 ENST00000380617.3
ENST00000441394.1
 KATNAL1
 katanin p60 subunit A-like 1
chr7_-_100026280 0.02 ENST00000360951.4
ENST00000398027.2
ENST00000324725.6
ENST00000472716.1
 ZCWPW1
 zinc finger, CW type with PWWP domain 1
chr4_-_100356291 0.02 ENST00000476959.1
ENST00000482593.1
 ADH7
 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr6_+_161123270 0.02 ENST00000366924.2
ENST00000308192.9
ENST00000418964.1
 PLG
 plasminogen
chr1_-_153585539 0.02 ENST00000368706.4
 S100A16
 S100 calcium binding protein A16
chr11_+_8040739 0.02 ENST00000534099.1
 TUB
 tubby bipartite transcription factor
chr4_+_3443614 0.02 ENST00000382774.3
ENST00000511533.1
 HGFAC
 HGF activator
chr2_+_185463093 0.02 ENST00000302277.6
 ZNF804A
 zinc finger protein 804A
chr2_+_190541153 0.02 ENST00000313581.4
ENST00000438402.2
ENST00000431575.2
ENST00000281412.6
 ANKAR
 ankyrin and armadillo repeat containing
chr17_-_26697304 0.02 ENST00000536498.1
 VTN
 vitronectin
chr6_+_126070726 0.02 ENST00000368364.3
 HEY2
 hes-related family bHLH transcription factor with YRPW motif 2
chr2_-_68052694 0.02 ENST00000457448.1
 AC010987.6
 AC010987.6
chr6_-_31681839 0.02 ENST00000409239.1
ENST00000461287.1
 LY6G6E
XXbac-BPG32J3.20
 lymphocyte antigen 6 complex, locus G6E (pseudogene)
Uncharacterized protein
chr11_-_111649015 0.02 ENST00000529841.1
 RP11-108O10.2
 RP11-108O10.2
chr11_-_102576537 0.01 ENST00000260229.4
 MMP27
 matrix metallopeptidase 27
chr14_+_95027772 0.01 ENST00000555095.1
ENST00000298841.5
ENST00000554220.1
ENST00000553780.1
 SERPINA4
SERPINA5
 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr4_-_69111401 0.01 ENST00000332644.5
 TMPRSS11B
 transmembrane protease, serine 11B
chr1_-_160549235 0.01 ENST00000368054.3
ENST00000368048.3
ENST00000311224.4
ENST00000368051.3
ENST00000534968.1
 CD84
 CD84 molecule
chr9_+_44868935 0.01 ENST00000448436.2
 RP11-160N1.10
 RP11-160N1.10
chr8_-_18541603 0.01 ENST00000428502.2
 PSD3
 pleckstrin and Sec7 domain containing 3
chr3_+_46919235 0.01 ENST00000449590.1
 PTH1R
 parathyroid hormone 1 receptor
chr11_+_22696314 0.01 ENST00000532398.1
ENST00000433790.1
 GAS2
 growth arrest-specific 2
chr17_-_39156138 0.00 ENST00000391587.1
 KRTAP3-2
 keratin associated protein 3-2
chr4_-_149365827 0.00 ENST00000344721.4
 NR3C2
 nuclear receptor subfamily 3, group C, member 2
chr3_-_49066811 0.00 ENST00000442157.1
ENST00000326739.4
 IMPDH2
 IMP (inosine 5'-monophosphate) dehydrogenase 2
chr6_-_30899924 0.00 ENST00000359086.3
 SFTA2
 surfactant associated 2
chr1_-_168464875 0.00 ENST00000422253.1
 RP5-968D22.3
 RP5-968D22.3
chr6_+_50061315 0.00 ENST00000415106.1
 RP11-397G17.1
 RP11-397G17.1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.0 0.1 GO:0036511 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.0 0.7 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 0.2 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.1 GO:0031456 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.0 0.2 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.0 0.1 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.0 0.1 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.0 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0 0.0 GO:0046373 arabinose metabolic process(GO:0019566) L-arabinose metabolic process(GO:0046373)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.3 GO:0005579 membrane attack complex(GO:0005579)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0019770 IgG receptor activity(GO:0019770)
0.0 0.2 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.2 GO:0008431 vitamin E binding(GO:0008431)
0.0 0.1 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.0 0.1 GO:0070052 collagen V binding(GO:0070052)
0.0 0.1 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.0 0.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.1 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.1 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.0 GO:0046556 alpha-L-arabinofuranosidase activity(GO:0046556)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 NABA PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.1 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters