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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for AGCACCA
Z-value: 1.66
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miRNA associated with seed AGCACCA
Network of associatons between targets according to the STRING database.
First level regulatory network of AGCACCA
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_189839046 | 4.51 |
ENST00000304636.3 ENST00000317840.5 |
COL3A1 |
collagen, type III, alpha 1 |
| chr15_-_48937982 | 3.65 |
ENST00000316623.5 |
FBN1 |
fibrillin 1 |
| chr7_+_94023873 | 3.59 |
ENST00000297268.6 |
COL1A2 |
collagen, type I, alpha 2 |
| chrX_+_16964794 | 2.82 |
ENST00000357277.3 |
REPS2 |
RALBP1 associated Eps domain containing 2 |
| chr2_-_238323007 | 2.61 |
ENST00000295550.4 |
COL6A3 |
collagen, type VI, alpha 3 |
| chr1_-_236228403 | 2.49 |
ENST00000366595.3 |
NID1 |
nidogen 1 |
| chr1_-_72748417 | 2.47 |
ENST00000357731.5 |
NEGR1 |
neuronal growth regulator 1 |
| chr3_+_99357319 | 2.44 |
ENST00000452013.1 ENST00000261037.3 ENST00000273342.4 |
COL8A1 |
collagen, type VIII, alpha 1 |
| chr5_-_111093406 | 2.19 |
ENST00000379671.3 |
NREP |
neuronal regeneration related protein |
| chr17_-_48278983 | 2.07 |
ENST00000225964.5 |
COL1A1 |
collagen, type I, alpha 1 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.7 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.5 | 4.5 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.6 | 3.7 | GO:0035582 | sequestering of BMP in extracellular matrix(GO:0035582) |
| 0.2 | 3.6 | GO:0043589 | skin morphogenesis(GO:0043589) |
| 0.0 | 3.2 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 0.2 | 2.9 | GO:0032836 | glomerular basement membrane development(GO:0032836) |
| 0.9 | 2.7 | GO:0044691 | tooth eruption(GO:0044691) |
| 0.1 | 2.7 | GO:2001275 | positive regulation of glucose import in response to insulin stimulus(GO:2001275) |
| 0.8 | 2.4 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 0.5 | 2.0 | GO:0035441 | cell migration involved in vasculogenesis(GO:0035441) metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 9.1 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.6 | 5.7 | GO:0098651 | basement membrane collagen trimer(GO:0098651) |
| 0.2 | 4.8 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.2 | 3.3 | GO:0098644 | complex of collagen trimers(GO:0098644) |
| 1.0 | 3.0 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.0 | 2.7 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 2.6 | GO:0005605 | basal lamina(GO:0005605) |
| 0.0 | 2.4 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 2.3 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 1.9 | GO:0005801 | cis-Golgi network(GO:0005801) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 11.6 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.1 | 5.1 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 5.0 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.5 | 3.7 | GO:0030023 | extracellular matrix constituent conferring elasticity(GO:0030023) |
| 0.0 | 3.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.2 | 2.6 | GO:0035014 | phosphatidylinositol 3-kinase regulator activity(GO:0035014) |
| 0.3 | 2.5 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 0.0 | 2.1 | GO:0045182 | translation regulator activity(GO:0045182) |
| 0.1 | 1.8 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.3 | 1.6 | GO:0004949 | cannabinoid receptor activity(GO:0004949) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 19.9 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 4.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 3.7 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 3.6 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 2.2 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.0 | 2.2 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.0 | 2.1 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 1.5 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 1.2 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.0 | 1.2 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.6 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.3 | 5.7 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.0 | 4.6 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 2.7 | REACTOME SIGNALING BY PDGF | Genes involved in Signaling by PDGF |
| 0.0 | 2.5 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 2.2 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.1 | 2.0 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 2.0 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.0 | 1.9 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 1.4 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |