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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for ATF4

Z-value: 1.65

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Transcription factors associated with ATF4

Gene Symbol Gene ID Gene Info
ATF4
ENSG00000128272.10 ATF4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ATF4hg19_v2_chr22_+_39916558_399165790.657.9e-02Click!

Activity profile of ATF4 motif

Sorted Z-values of ATF4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF4

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr15_+_41245160 1.82 ENST00000444189.2
ENST00000446533.3
 CHAC1
 ChaC, cation transport regulator homolog 1 (E. coli)
chr16_-_28550320 1.79 ENST00000395641.2
 NUPR1
 nuclear protein, transcriptional regulator, 1
chr16_-_28550348 1.72 ENST00000324873.6
 NUPR1
 nuclear protein, transcriptional regulator, 1
chr21_-_44495919 1.28 ENST00000398158.1
 CBS
 cystathionine-beta-synthase
chr21_-_44495964 1.28 ENST00000398168.1
ENST00000398165.3
 CBS
 cystathionine-beta-synthase
chr7_-_56101826 1.12 ENST00000421626.1
 PSPH
 phosphoserine phosphatase
chr17_+_1665345 1.11 ENST00000576406.1
ENST00000571149.1
 SERPINF1
 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr14_-_92413353 0.96 ENST00000556154.1
 FBLN5
 fibulin 5
chr4_-_70725856 0.95 ENST00000226444.3
 SULT1E1
 sulfotransferase family 1E, estrogen-preferring, member 1
chr3_+_148415571 0.90 ENST00000497524.1
ENST00000349243.3
ENST00000542281.1
ENST00000418473.2
ENST00000404754.2
 AGTR1
 angiotensin II receptor, type 1
chr1_+_162602244 0.88 ENST00000367922.3
ENST00000367921.3
 DDR2
 discoidin domain receptor tyrosine kinase 2
chr17_+_1665253 0.83 ENST00000254722.4
 SERPINF1
 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr12_-_25101920 0.78 ENST00000539780.1
ENST00000546285.1
ENST00000342945.5
 BCAT1
 branched chain amino-acid transaminase 1, cytosolic
chr14_-_92413727 0.76 ENST00000267620.10
 FBLN5
 fibulin 5
chr12_-_25102252 0.72 ENST00000261192.7
 BCAT1
 branched chain amino-acid transaminase 1, cytosolic
chr14_+_24563510 0.68 ENST00000545054.2
ENST00000561286.1
ENST00000558096.1
 PCK2
 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr14_+_24563262 0.61 ENST00000559250.1
ENST00000216780.4
ENST00000560736.1
ENST00000396973.4
ENST00000559837.1
 PCK2
 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr15_+_89182178 0.57 ENST00000559876.1
 ISG20
 interferon stimulated exonuclease gene 20kDa
chr12_-_50298000 0.55 ENST00000550635.2
 FAIM2
 Fas apoptotic inhibitory molecule 2
chr14_-_100841670 0.52 ENST00000557297.1
ENST00000555813.1
ENST00000557135.1
ENST00000556698.1
ENST00000554509.1
ENST00000555410.1
 WARS
 tryptophanyl-tRNA synthetase
chr9_+_80912059 0.51 ENST00000347159.2
ENST00000376588.3
 PSAT1
 phosphoserine aminotransferase 1
chr1_-_44497118 0.50 ENST00000537678.1
ENST00000466926.1
 SLC6A9
 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr15_+_89182156 0.47 ENST00000379224.5
 ISG20
 interferon stimulated exonuclease gene 20kDa
chr17_-_79895097 0.41 ENST00000402252.2
ENST00000583564.1
ENST00000585244.1
ENST00000337943.5
ENST00000579698.1
 PYCR1
 pyrroline-5-carboxylate reductase 1
chr7_+_48211048 0.41 ENST00000435803.1
 ABCA13
 ATP-binding cassette, sub-family A (ABC1), member 13
chr1_-_38412683 0.40 ENST00000373024.3
ENST00000373023.2
 INPP5B
 inositol polyphosphate-5-phosphatase, 75kDa
chr16_+_46918235 0.40 ENST00000340124.4
 GPT2
 glutamic pyruvate transaminase (alanine aminotransferase) 2
chr4_+_77870960 0.40 ENST00000505788.1
ENST00000510515.1
ENST00000504637.1
 SEPT11
 septin 11
chr15_+_89181974 0.39 ENST00000306072.5
 ISG20
 interferon stimulated exonuclease gene 20kDa
chr8_-_116680833 0.39 ENST00000220888.5
 TRPS1
 trichorhinophalangeal syndrome I
chr17_-_79895154 0.39 ENST00000405481.4
ENST00000585215.1
ENST00000577624.1
ENST00000403172.4
 PYCR1
 pyrroline-5-carboxylate reductase 1
chr22_-_43485381 0.38 ENST00000331018.7
ENST00000266254.7
ENST00000445824.1
 TTLL1
 tubulin tyrosine ligase-like family, member 1
chr14_-_100841930 0.37 ENST00000555031.1
ENST00000553395.1
ENST00000553545.1
ENST00000344102.5
ENST00000556338.1
ENST00000392882.2
ENST00000553934.1
 WARS
 tryptophanyl-tRNA synthetase
chrX_-_15332665 0.36 ENST00000537676.1
ENST00000344384.4
 ASB11
 ankyrin repeat and SOCS box containing 11
chr12_+_57624085 0.36 ENST00000553474.1
 SHMT2
 serine hydroxymethyltransferase 2 (mitochondrial)
chr6_+_73076432 0.32 ENST00000414192.2
 RIMS1
 regulating synaptic membrane exocytosis 1
chr1_-_44497024 0.31 ENST00000372306.3
ENST00000372310.3
ENST00000475075.2
 SLC6A9
 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr6_+_126102292 0.31 ENST00000368357.3
 NCOA7
 nuclear receptor coactivator 7
chr4_+_77870856 0.30 ENST00000264893.6
ENST00000502584.1
ENST00000510641.1
 SEPT11
 septin 11
chr7_+_30634297 0.29 ENST00000389266.3
 GARS
 glycyl-tRNA synthetase
chr19_+_33865218 0.29 ENST00000585933.2
 CEBPG
 CCAAT/enhancer binding protein (C/EBP), gamma
chr11_-_3078616 0.29 ENST00000401769.3
ENST00000278224.9
ENST00000397114.3
ENST00000380525.4
 CARS
 cysteinyl-tRNA synthetase
chr10_+_111765562 0.29 ENST00000360162.3
 ADD3
 adducin 3 (gamma)
chr12_+_57849048 0.28 ENST00000266646.2
 INHBE
 inhibin, beta E
chr12_+_57624119 0.28 ENST00000555773.1
ENST00000554975.1
ENST00000449049.3
ENST00000393827.4
 SHMT2
 serine hydroxymethyltransferase 2 (mitochondrial)
chr10_+_95848824 0.28 ENST00000371385.3
ENST00000371375.1
 PLCE1
 phospholipase C, epsilon 1
chr11_-_3078838 0.28 ENST00000397111.5
 CARS
 cysteinyl-tRNA synthetase
chr16_+_67694849 0.27 ENST00000602551.1
ENST00000458121.2
ENST00000219255.3
 PARD6A
 par-6 family cell polarity regulator alpha
chr17_-_40829026 0.27 ENST00000412503.1
 PLEKHH3
 pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr12_-_92539614 0.27 ENST00000256015.3
 BTG1
 B-cell translocation gene 1, anti-proliferative
chr12_-_117318788 0.27 ENST00000550505.1
 HRK
 harakiri, BCL2 interacting protein (contains only BH3 domain)
chr12_+_56862301 0.25 ENST00000338146.5
 SPRYD4
 SPRY domain containing 4
chr12_+_57623869 0.24 ENST00000414700.3
ENST00000557703.1
 SHMT2
 serine hydroxymethyltransferase 2 (mitochondrial)
chr8_-_11324273 0.23 ENST00000284486.4
 FAM167A
 family with sequence similarity 167, member A
chr12_-_57914275 0.22 ENST00000547303.1
ENST00000552740.1
ENST00000547526.1
ENST00000551116.1
ENST00000346473.3
 DDIT3
 DNA-damage-inducible transcript 3
chr16_-_70323422 0.22 ENST00000261772.8
 AARS
 alanyl-tRNA synthetase
chr12_+_57623477 0.22 ENST00000557487.1
ENST00000555634.1
ENST00000556689.1
 SHMT2
 serine hydroxymethyltransferase 2 (mitochondrial)
chr1_+_154244987 0.22 ENST00000328703.7
ENST00000457918.2
ENST00000483970.2
ENST00000435087.1
ENST00000532105.1
 HAX1
 HCLS1 associated protein X-1
chr2_+_46769798 0.22 ENST00000238738.4
 RHOQ
 ras homolog family member Q
chr11_-_33913708 0.22 ENST00000257818.2
 LMO2
 LIM domain only 2 (rhombotin-like 1)
chr17_-_40828969 0.21 ENST00000591022.1
ENST00000587627.1
ENST00000293349.6
 PLEKHH3
 pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chrX_+_48398053 0.21 ENST00000537536.1
ENST00000418627.1
 TBC1D25
 TBC1 domain family, member 25
chr22_+_50919944 0.18 ENST00000395738.2
 ADM2
 adrenomedullin 2
chr17_-_77813186 0.18 ENST00000448310.1
ENST00000269397.4
 CBX4
 chromobox homolog 4
chr5_+_67586465 0.17 ENST00000336483.5
 PIK3R1
 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr22_+_50919995 0.17 ENST00000362068.2
ENST00000395737.1
 ADM2
 adrenomedullin 2
chr7_+_99006232 0.14 ENST00000403633.2
 BUD31
 BUD31 homolog (S. cerevisiae)
chr1_-_207143802 0.13 ENST00000324852.4
ENST00000400962.3
 FCAMR
 Fc receptor, IgA, IgM, high affinity
chrX_-_71792477 0.13 ENST00000421523.1
ENST00000415409.1
ENST00000373559.4
ENST00000373556.3
ENST00000373560.2
ENST00000373583.1
ENST00000429103.2
ENST00000373571.1
ENST00000373554.1
 HDAC8
 histone deacetylase 8
chr1_+_212782012 0.12 ENST00000341491.4
ENST00000366985.1
 ATF3
 activating transcription factor 3
chr7_-_50860565 0.12 ENST00000403097.1
 GRB10
 growth factor receptor-bound protein 10
chr19_+_11350278 0.12 ENST00000252453.8
 C19orf80
 chromosome 19 open reading frame 80
chr1_+_52521928 0.11 ENST00000489308.2
 BTF3L4
 basic transcription factor 3-like 4
chr9_-_95055956 0.11 ENST00000375629.3
ENST00000447699.2
ENST00000375643.3
ENST00000395554.3
 IARS
 isoleucyl-tRNA synthetase
chr10_+_63661053 0.10 ENST00000279873.7
 ARID5B
 AT rich interactive domain 5B (MRF1-like)
chr20_+_8112824 0.10 ENST00000378641.3
 PLCB1
 phospholipase C, beta 1 (phosphoinositide-specific)
chr7_+_99006550 0.10 ENST00000222969.5
 BUD31
 BUD31 homolog (S. cerevisiae)
chr9_-_34665983 0.10 ENST00000416454.1
ENST00000544078.2
ENST00000421828.2
ENST00000423809.1
 RP11-195F19.5
 HCG2040265, isoform CRA_a; Uncharacterized protein; cDNA FLJ50015
chr3_-_48130707 0.10 ENST00000360240.6
ENST00000383737.4
 MAP4
 microtubule-associated protein 4
chr1_-_220219775 0.08 ENST00000609181.1
 EPRS
 glutamyl-prolyl-tRNA synthetase
chr5_+_174151536 0.08 ENST00000239243.6
ENST00000507785.1
 MSX2
 msh homeobox 2
chr3_-_48130314 0.08 ENST00000439356.1
ENST00000395734.3
ENST00000426837.2
 MAP4
 microtubule-associated protein 4
chr14_-_25045446 0.08 ENST00000216336.2
 CTSG
 cathepsin G
chr3_-_99594948 0.08 ENST00000471562.1
ENST00000495625.2
 FILIP1L
 filamin A interacting protein 1-like
chr1_+_52521797 0.08 ENST00000313334.8
 BTF3L4
 basic transcription factor 3-like 4
chr7_-_93633684 0.08 ENST00000222547.3
ENST00000425626.1
 BET1
 Bet1 golgi vesicular membrane trafficking protein
chr7_-_93633658 0.08 ENST00000433727.1
 BET1
 Bet1 golgi vesicular membrane trafficking protein
chr1_-_167883353 0.07 ENST00000545172.1
 ADCY10
 adenylate cyclase 10 (soluble)
chr1_-_167883327 0.07 ENST00000476818.2
ENST00000367851.4
ENST00000367848.1
 ADCY10
 adenylate cyclase 10 (soluble)
chr12_+_93963590 0.06 ENST00000340600.2
 SOCS2
 suppressor of cytokine signaling 2
chr5_+_167956121 0.06 ENST00000338333.4
 FBLL1
 fibrillarin-like 1
chr2_-_46769694 0.06 ENST00000522587.1
 ATP6V1E2
 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2
chr1_-_20250110 0.06 ENST00000375116.3
 PLA2G2E
 phospholipase A2, group IIE
chr19_-_47288162 0.06 ENST00000594991.1
 SLC1A5
 solute carrier family 1 (neutral amino acid transporter), member 5
chr5_+_33440802 0.05 ENST00000502553.1
ENST00000514259.1
ENST00000265112.3
 TARS
 threonyl-tRNA synthetase
chr2_-_98280383 0.04 ENST00000289228.5
 ACTR1B
 ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
chr5_+_33441053 0.04 ENST00000541634.1
ENST00000455217.2
ENST00000414361.2
 TARS
 threonyl-tRNA synthetase
chr12_-_10324716 0.03 ENST00000545927.1
ENST00000432556.2
ENST00000309539.3
ENST00000544577.1
 OLR1
 oxidized low density lipoprotein (lectin-like) receptor 1
chr19_-_51014345 0.03 ENST00000391815.3
ENST00000594350.1
ENST00000601423.1
 JOSD2
 Josephin domain containing 2
chr1_-_220220000 0.03 ENST00000366923.3
 EPRS
 glutamyl-prolyl-tRNA synthetase
chr9_+_100745615 0.03 ENST00000339399.4
 ANP32B
 acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr9_+_36169380 0.03 ENST00000335119.2
 CCIN
 calicin
chr6_+_151187074 0.03 ENST00000367308.4
 MTHFD1L
 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr19_-_51014588 0.03 ENST00000598418.1
 JOSD2
 Josephin domain containing 2
chr7_-_99006443 0.03 ENST00000350498.3
 PDAP1
 PDGFA associated protein 1
chr19_-_47287990 0.02 ENST00000593713.1
ENST00000598022.1
ENST00000434726.2
 SLC1A5
 solute carrier family 1 (neutral amino acid transporter), member 5
chr1_+_162351503 0.02 ENST00000458626.2
 C1orf226
 chromosome 1 open reading frame 226
chrX_-_80457385 0.02 ENST00000451455.1
ENST00000436386.1
ENST00000358130.2
 HMGN5
 high mobility group nucleosome binding domain 5
chr19_-_51014460 0.01 ENST00000595669.1
 JOSD2
 Josephin domain containing 2
chr10_-_101190202 0.01 ENST00000543866.1
ENST00000370508.5
 GOT1
 glutamic-oxaloacetic transaminase 1, soluble
chr2_+_65663812 0.01 ENST00000606978.1
ENST00000377977.3
ENST00000536804.1
 AC074391.1
 AC074391.1
chr7_-_115670804 0.01 ENST00000320239.7
 TFEC
 transcription factor EC
chr12_+_6493406 0.00 ENST00000543190.1
 LTBR
 lymphotoxin beta receptor (TNFR superfamily, member 3)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0006535 cysteine biosynthetic process from serine(GO:0006535)
0.4 1.9 GO:0071279 cellular response to cobalt ion(GO:0071279)
0.3 0.9 GO:0006711 estrogen catabolic process(GO:0006711)
0.3 1.4 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.3 0.8 GO:0061536 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.2 1.5 GO:0009099 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.2 0.9 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.2 2.7 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.2 3.5 GO:2000194 regulation of female gonad development(GO:2000194)
0.2 0.6 GO:0006423 cysteinyl-tRNA aminoacylation(GO:0006423)
0.2 0.9 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.2 1.3 GO:0006116 NADH oxidation(GO:0006116)
0.1 1.7 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 0.8 GO:0055129 L-proline biosynthetic process(GO:0055129)
0.1 0.4 GO:0042853 L-alanine metabolic process(GO:0042851) L-alanine catabolic process(GO:0042853)
0.1 1.8 GO:0006751 glutathione catabolic process(GO:0006751)
0.1 0.3 GO:0015960 diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966)
0.1 0.2 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.1 0.9 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.1 0.3 GO:0032792 negative regulation of CREB transcription factor activity(GO:0032792)
0.0 0.1 GO:0090427 activation of meiosis(GO:0090427)
0.0 0.3 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.1 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 0.3 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.1 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.0 0.1 GO:0006433 glutamyl-tRNA aminoacylation(GO:0006424) prolyl-tRNA aminoacylation(GO:0006433)
0.0 0.4 GO:0018095 sperm axoneme assembly(GO:0007288) protein polyglutamylation(GO:0018095)
0.0 0.1 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.0 0.2 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.5 GO:0021694 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.0 0.3 GO:1904781 positive regulation of protein localization to centrosome(GO:1904781)
0.0 0.2 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
0.0 0.1 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
0.0 0.1 GO:0033967 box C/D snoRNA 3'-end processing(GO:0000494) box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963) histone glutamine methylation(GO:1990258)
0.0 0.3 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.0 0.1 GO:0010585 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
0.0 0.2 GO:1901096 regulation of autophagosome maturation(GO:1901096)
0.0 0.3 GO:0097151 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0 0.3 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.2 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.3 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.2 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.4 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.1 GO:0070943 neutrophil mediated cytotoxicity(GO:0070942) neutrophil mediated killing of symbiont cell(GO:0070943) neutrophil mediated killing of bacterium(GO:0070944)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.7 GO:0071953 elastic fiber(GO:0071953)
0.1 1.9 GO:0043203 axon hillock(GO:0043203)
0.1 1.1 GO:0070552 BRISC complex(GO:0070552)
0.1 0.3 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.0 0.2 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 1.5 GO:0015030 Cajal body(GO:0015030)
0.0 0.1 GO:0097452 GAIT complex(GO:0097452)
0.0 3.5 GO:0032993 protein-DNA complex(GO:0032993)
0.0 0.2 GO:0035102 PRC1 complex(GO:0035102)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0004122 cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809)
0.6 1.8 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.5 1.4 GO:0008859 exoribonuclease II activity(GO:0008859)
0.4 1.3 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.3 0.9 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.2 1.5 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.2 0.8 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.2 0.6 GO:0004817 cysteine-tRNA ligase activity(GO:0004817)
0.2 1.1 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.2 0.9 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.2 0.9 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.2 0.9 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.2 1.1 GO:0004372 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.1 0.8 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.1 0.2 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.1 0.2 GO:0032427 GBD domain binding(GO:0032427)
0.0 0.4 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.0 0.9 GO:0008483 transaminase activity(GO:0008483)
0.0 0.1 GO:0004827 glutamate-tRNA ligase activity(GO:0004818) proline-tRNA ligase activity(GO:0004827)
0.0 0.1 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.0 0.4 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.0 0.1 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
0.0 0.2 GO:0043559 insulin binding(GO:0043559)
0.0 0.1 GO:0036009 protein-glutamine N-methyltransferase activity(GO:0036009) histone-glutamine methyltransferase activity(GO:1990259)
0.0 0.3 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.0 0.2 GO:0019966 interleukin-1 binding(GO:0019966)
0.0 1.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.2 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.1 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.0 0.1 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.8 PID INSULIN PATHWAY Insulin Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.8 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 2.6 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 2.2 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 1.5 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.9 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.8 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.3 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.3 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 1.2 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 1.4 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.3 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)