ISMARA results: ATF4

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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for ATF4

Z-value: 1.65

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Transcription factors associated with ATF4

Gene Symbol	Gene ID	Gene Info
ATF4 Ensembl NCBI GeneCards UniProt	ENSG00000128272.10	ATF4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ATF4	hg19_v2_chr22_+_39916558_39916579	0.65	7.9e-02	Click!

Activity profile of ATF4 motif

Sorted Z-values of ATF4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF4

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr15_+_41245160	1.82	ENST00000444189.2 ENST00000446533.3	CHAC1	ChaC, cation transport regulator homolog 1 (E. coli)
chr16_-_28550320	1.79	ENST00000395641.2	NUPR1	nuclear protein, transcriptional regulator, 1
chr16_-_28550348	1.72	ENST00000324873.6	NUPR1	nuclear protein, transcriptional regulator, 1
chr21_-_44495919	1.28	ENST00000398158.1	CBS	cystathionine-beta-synthase
chr21_-_44495964	1.28	ENST00000398168.1 ENST00000398165.3	CBS	cystathionine-beta-synthase
chr7_-_56101826	1.12	ENST00000421626.1	PSPH	phosphoserine phosphatase
chr17_+_1665345	1.11	ENST00000576406.1 ENST00000571149.1	SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr14_-_92413353	0.96	ENST00000556154.1	FBLN5	fibulin 5
chr4_-_70725856	0.95	ENST00000226444.3	SULT1E1	sulfotransferase family 1E, estrogen-preferring, member 1
chr3_+_148415571	0.90	ENST00000497524.1 ENST00000349243.3 ENST00000542281.1 ENST00000418473.2 ENST00000404754.2	AGTR1	angiotensin II receptor, type 1

Showing 1 to 10 of 113 entries

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.5	GO:2000194	regulation of female gonad development(GO:2000194)
0.2	2.7	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.9	2.6	GO:0006535	cysteine biosynthetic process from serine(GO:0006535)
0.4	1.9	GO:0071279	cellular response to cobalt ion(GO:0071279)
0.1	1.8	GO:0006751	glutathione catabolic process(GO:0006751)
0.1	1.7	GO:0048251	elastic fiber assembly(GO:0048251)
0.2	1.5	GO:0009099	branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.3	1.4	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
0.2	1.3	GO:0006116	NADH oxidation(GO:0006116)
0.3	0.9	GO:0006711	estrogen catabolic process(GO:0006711)

Showing 1 to 10 of 44 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.5	GO:0032993	protein-DNA complex(GO:0032993)
0.1	1.9	GO:0043203	axon hillock(GO:0043203)
0.2	1.7	GO:0071953	elastic fiber(GO:0071953)
0.0	1.5	GO:0015030	Cajal body(GO:0015030)
0.1	1.1	GO:0070552	BRISC complex(GO:0070552)
0.1	0.3	GO:1990622	CHOP-ATF3 complex(GO:1990622)
0.0	0.2	GO:1990578	perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0	0.2	GO:0035102	PRC1 complex(GO:0035102)
0.0	0.1	GO:0097452	GAIT complex(GO:0097452)

Showing 1 to 9 of 9 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	2.6	GO:0004122	cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809)
0.0	1.9	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.6	1.8	GO:0003839	gamma-glutamylcyclotransferase activity(GO:0003839)
0.2	1.5	GO:0052654	branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.5	1.4	GO:0008859	exoribonuclease II activity(GO:0008859)
0.4	1.3	GO:0004613	phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.2	1.1	GO:0004647	phosphoserine phosphatase activity(GO:0004647)
0.2	1.1	GO:0004372	glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.3	0.9	GO:0001596	angiotensin type I receptor activity(GO:0001596)
0.2	0.9	GO:0004830	tryptophan-tRNA ligase activity(GO:0004830)

Showing 1 to 10 of 30 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.9	PID ARF6 PATHWAY	Arf6 signaling events
0.0	0.8	PID INSULIN PATHWAY	Insulin Pathway

Showing 1 to 2 of 2 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.8	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.1	2.6	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.1	2.2	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.1	1.5	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.0	1.4	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.0	1.2	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.0	0.9	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.0	0.8	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0	0.3	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.0	0.3	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle

Showing 1 to 10 of 12 entries

Results for ATF4

Z-value: 1.65

Motif logo

Transcription factors associated with ATF4

Activity-expression correlation:

Activity profile of ATF4 motif

Sorted Z-values of ATF4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF4

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: