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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for ATF6
Z-value: 1.59
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Transcription factors associated with ATF6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ATF6 | hg19_v2_chr1_+_161736072_161736093 | -0.51 | 2.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ATF6
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_+_45067659 | 2.47 |
ENST00000296130.4 |
CLEC3B |
C-type lectin domain family 3, member B |
| chr4_+_145567173 | 2.31 |
ENST00000296575.3 |
HHIP |
hedgehog interacting protein |
| chr11_-_35547572 | 2.22 |
ENST00000378880.2 |
PAMR1 |
peptidase domain containing associated with muscle regeneration 1 |
| chr11_+_113930291 | 2.10 |
ENST00000335953.4 |
ZBTB16 |
zinc finger and BTB domain containing 16 |
| chr11_-_35547151 | 2.09 |
ENST00000378878.3 ENST00000529303.1 ENST00000278360.3 |
PAMR1 |
peptidase domain containing associated with muscle regeneration 1 |
| chr9_-_79520989 | 2.04 |
ENST00000376713.3 ENST00000376718.3 ENST00000428286.1 |
PRUNE2 |
prune homolog 2 (Drosophila) |
| chr20_-_34042558 | 1.95 |
ENST00000374372.1 |
GDF5 |
growth differentiation factor 5 |
| chr5_+_156712372 | 1.86 |
ENST00000541131.1 |
CYFIP2 |
cytoplasmic FMR1 interacting protein 2 |
| chr4_+_145567297 | 1.83 |
ENST00000434550.2 |
HHIP |
hedgehog interacting protein |
| chr17_-_66951474 | 1.79 |
ENST00000269080.2 |
ABCA8 |
ATP-binding cassette, sub-family A (ABC1), member 8 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.1 | GO:0040036 | regulation of fibroblast growth factor receptor signaling pathway(GO:0040036) |
| 0.4 | 2.5 | GO:0010756 | positive regulation of plasminogen activation(GO:0010756) |
| 0.4 | 2.1 | GO:0048133 | germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) positive regulation of NK T cell differentiation(GO:0051138) germline stem cell asymmetric division(GO:0098728) |
| 0.3 | 2.0 | GO:0043932 | ossification involved in bone remodeling(GO:0043932) |
| 0.0 | 2.0 | GO:0071173 | mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173) |
| 0.2 | 1.9 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 0.1 | 1.8 | GO:0042908 | xenobiotic transport(GO:0042908) |
| 0.1 | 1.8 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
| 0.3 | 1.7 | GO:0010732 | protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734) |
| 0.2 | 1.7 | GO:0045602 | negative regulation of endothelial cell differentiation(GO:0045602) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.9 | GO:0060170 | ciliary membrane(GO:0060170) |
| 0.0 | 2.6 | GO:0016605 | PML body(GO:0016605) |
| 0.4 | 2.5 | GO:0001652 | granular component(GO:0001652) |
| 0.2 | 2.0 | GO:0005827 | polar microtubule(GO:0005827) |
| 0.1 | 1.7 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.0 | 1.7 | GO:0030133 | transport vesicle(GO:0030133) |
| 0.0 | 1.3 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
| 0.3 | 1.2 | GO:0043293 | apoptosome(GO:0043293) |
| 0.1 | 1.2 | GO:0030991 | intraciliary transport particle A(GO:0030991) |
| 0.1 | 1.1 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 4.1 | GO:0097108 | hedgehog family protein binding(GO:0097108) |
| 0.0 | 2.7 | GO:0008201 | heparin binding(GO:0008201) |
| 0.1 | 2.1 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.0 | 1.9 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.2 | 1.8 | GO:0008559 | xenobiotic-transporting ATPase activity(GO:0008559) |
| 0.2 | 1.8 | GO:0046923 | ER retention sequence binding(GO:0046923) |
| 0.1 | 1.7 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
| 0.0 | 1.7 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.1 | 1.5 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 1.5 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 5.1 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 3.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 2.1 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.1 | 1.9 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.0 | 1.9 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 1.7 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.5 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 1.5 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 1.1 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.3 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 1.9 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 1.8 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.1 | 1.2 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.0 | 1.2 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 1.0 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.0 | 0.9 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.0 | 0.9 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.1 | 0.8 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.0 | 0.7 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |