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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for ATF7
Z-value: 0.47
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Transcription factors associated with ATF7
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ATF7 | hg19_v2_chr12_-_54019755_54019804 | -0.69 | 6.0e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ATF7
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_156030937 | 0.90 |
ENST00000361084.5 |
RAB25 |
RAB25, member RAS oncogene family |
| chr14_+_68086515 | 0.85 |
ENST00000261783.3 |
ARG2 |
arginase 2 |
| chr6_+_28048753 | 0.58 |
ENST00000377325.1 |
ZNF165 |
zinc finger protein 165 |
| chr14_+_96671016 | 0.53 |
ENST00000542454.2 ENST00000554311.1 ENST00000306005.3 ENST00000539359.1 ENST00000553811.1 |
BDKRB2 RP11-404P21.8 |
bradykinin receptor B2 Uncharacterized protein |
| chr4_+_75310851 | 0.50 |
ENST00000395748.3 ENST00000264487.2 |
AREG |
amphiregulin |
| chr4_+_75311019 | 0.50 |
ENST00000502307.1 |
AREG |
amphiregulin |
| chr4_+_85504075 | 0.48 |
ENST00000295887.5 |
CDS1 |
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 |
| chr11_-_118122996 | 0.41 |
ENST00000525386.1 ENST00000527472.1 ENST00000278949.4 |
MPZL3 |
myelin protein zero-like 3 |
| chr12_-_12715266 | 0.41 |
ENST00000228862.2 |
DUSP16 |
dual specificity phosphatase 16 |
| chr1_+_2004901 | 0.39 |
ENST00000400921.2 |
PRKCZ |
protein kinase C, zeta |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | GO:0042695 | thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744) |
| 0.1 | 0.9 | GO:0000050 | urea cycle(GO:0000050) |
| 0.0 | 0.9 | GO:0031268 | pseudopodium organization(GO:0031268) |
| 0.1 | 0.8 | GO:2001181 | positive regulation of interleukin-10 secretion(GO:2001181) |
| 0.1 | 0.5 | GO:0002943 | tRNA dihydrouridine synthesis(GO:0002943) |
| 0.1 | 0.5 | GO:0002318 | myeloid progenitor cell differentiation(GO:0002318) |
| 0.1 | 0.5 | GO:1902219 | negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219) |
| 0.0 | 0.5 | GO:0006657 | CDP-choline pathway(GO:0006657) |
| 0.0 | 0.5 | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) |
| 0.1 | 0.4 | GO:0045204 | MAPK export from nucleus(GO:0045204) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.1 | 0.8 | GO:0045179 | apical cortex(GO:0045179) |
| 0.0 | 0.8 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.1 | 0.4 | GO:0071595 | Nem1-Spo7 phosphatase complex(GO:0071595) |
| 0.0 | 0.4 | GO:0071437 | invadopodium(GO:0071437) |
| 0.0 | 0.3 | GO:0098560 | cytoplasmic side of late endosome membrane(GO:0098560) |
| 0.0 | 0.2 | GO:0098536 | deuterosome(GO:0098536) |
| 0.0 | 0.2 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.0 | 0.2 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 0.2 | GO:0005828 | kinetochore microtubule(GO:0005828) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.3 | 1.0 | GO:0004947 | bradykinin receptor activity(GO:0004947) |
| 0.0 | 1.0 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.1 | 0.9 | GO:0016813 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813) |
| 0.0 | 0.9 | GO:0043560 | insulin receptor substrate binding(GO:0043560) |
| 0.1 | 0.5 | GO:0004142 | diacylglycerol cholinephosphotransferase activity(GO:0004142) phosphatidate cytidylyltransferase activity(GO:0004605) |
| 0.1 | 0.5 | GO:0017150 | tRNA dihydrouridine synthase activity(GO:0017150) |
| 0.1 | 0.4 | GO:0015018 | galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018) |
| 0.1 | 0.4 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549) |
| 0.0 | 0.4 | GO:0036374 | glutathione hydrolase activity(GO:0036374) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.9 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.5 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.0 | 0.4 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.0 | 0.2 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 0.4 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 0.0 | 0.3 | REACTOME SPRY REGULATION OF FGF SIGNALING | Genes involved in Spry regulation of FGF signaling |
| 0.0 | 0.3 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |