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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for BRCA1

Z-value: 0.37

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Transcription factors associated with BRCA1

Gene Symbol Gene ID Gene Info
BRCA1
ENSG00000012048.15 BRCA1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BRCA1hg19_v2_chr17_-_41277370_412774190.432.9e-01Click!

Activity profile of BRCA1 motif

Sorted Z-values of BRCA1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of BRCA1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr1_+_159141397 0.42 ENST00000368124.4
ENST00000368125.4
ENST00000416746.1
 CADM3
 cell adhesion molecule 3
chr14_-_60097524 0.17 ENST00000342503.4
 RTN1
 reticulon 1
chr7_-_23510086 0.16 ENST00000258729.3
 IGF2BP3
 insulin-like growth factor 2 mRNA binding protein 3
chr14_-_60097297 0.16 ENST00000395090.1
 RTN1
 reticulon 1
chr1_-_232598163 0.16 ENST00000308942.4
 SIPA1L2
 signal-induced proliferation-associated 1 like 2
chr2_+_108994466 0.13 ENST00000272452.2
 SULT1C4
 sulfotransferase family, cytosolic, 1C, member 4
chr2_+_108994633 0.13 ENST00000409309.3
 SULT1C4
 sulfotransferase family, cytosolic, 1C, member 4
chr11_-_27722021 0.12 ENST00000356660.4
ENST00000418212.1
ENST00000533246.1
 BDNF
 brain-derived neurotrophic factor
chr6_+_12717892 0.11 ENST00000379350.1
 PHACTR1
 phosphatase and actin regulator 1
chrX_+_10124977 0.09 ENST00000380833.4
 CLCN4
 chloride channel, voltage-sensitive 4
chr20_-_34025999 0.09 ENST00000374369.3
 GDF5
 growth differentiation factor 5
chr1_+_10271674 0.09 ENST00000377086.1
 KIF1B
 kinesin family member 1B
chr3_-_127455200 0.08 ENST00000398101.3
 MGLL
 monoglyceride lipase
chr1_-_227505289 0.08 ENST00000366765.3
 CDC42BPA
 CDC42 binding protein kinase alpha (DMPK-like)
chr12_-_12491608 0.06 ENST00000545735.1
 MANSC1
 MANSC domain containing 1
chr12_-_122879969 0.06 ENST00000540304.1
 CLIP1
 CAP-GLY domain containing linker protein 1
chr8_+_37553261 0.05 ENST00000331569.4
 ZNF703
 zinc finger protein 703
chr17_-_56296580 0.05 ENST00000313863.6
ENST00000546108.1
ENST00000337050.7
ENST00000393119.2
 MKS1
 Meckel syndrome, type 1
chr15_-_58358607 0.05 ENST00000249750.4
 ALDH1A2
 aldehyde dehydrogenase 1 family, member A2
chr7_+_44646162 0.05 ENST00000439616.2
 OGDH
 oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr10_+_92631709 0.04 ENST00000413330.1
ENST00000277882.3
 RPP30
 ribonuclease P/MRP 30kDa subunit
chr17_-_8702667 0.04 ENST00000329805.4
 MFSD6L
 major facilitator superfamily domain containing 6-like
chr13_-_31038370 0.04 ENST00000399489.1
ENST00000339872.4
 HMGB1
 high mobility group box 1
chr3_-_176914238 0.03 ENST00000430069.1
ENST00000428970.1
 TBL1XR1
 transducin (beta)-like 1 X-linked receptor 1
chr4_-_48782259 0.03 ENST00000507711.1
ENST00000358350.4
ENST00000537810.1
ENST00000264319.7
 FRYL
 FRY-like
chr10_+_104404644 0.03 ENST00000462202.2
 TRIM8
 tripartite motif containing 8
chr5_+_145583107 0.03 ENST00000506502.1
 RBM27
 RNA binding motif protein 27
chr17_-_60142609 0.03 ENST00000397786.2
 MED13
 mediator complex subunit 13
chr13_-_99910673 0.03 ENST00000397473.2
ENST00000397470.2
 GPR18
 G protein-coupled receptor 18
chr14_-_94942527 0.03 ENST00000448305.2
 SERPINA9
 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9
chr21_+_46066331 0.03 ENST00000334670.8
 KRTAP10-11
 keratin associated protein 10-11
chr14_-_94942548 0.03 ENST00000298845.7
 SERPINA9
 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9
chr4_+_185570767 0.03 ENST00000314970.6
ENST00000515774.1
ENST00000503752.1
 PRIMPOL
 primase and polymerase (DNA-directed)
chr9_-_86593238 0.03 ENST00000351839.3
 HNRNPK
 heterogeneous nuclear ribonucleoprotein K
chr12_+_122880045 0.03 ENST00000539034.1
ENST00000535976.1
 RP11-450K4.1
 RP11-450K4.1
chr18_-_23671139 0.03 ENST00000579061.1
ENST00000542420.2
 SS18
 synovial sarcoma translocation, chromosome 18
chr9_-_43133544 0.03 ENST00000254835.2
 ANKRD20A3
 ankyrin repeat domain 20 family, member A3
chr13_+_30002846 0.03 ENST00000542829.1
 MTUS2
 microtubule associated tumor suppressor candidate 2
chr17_+_36584662 0.03 ENST00000431231.2
ENST00000437668.3
 ARHGAP23
 Rho GTPase activating protein 23
chr3_+_185303962 0.03 ENST00000296257.5
 SENP2
 SUMO1/sentrin/SMT3 specific peptidase 2
chr12_-_49449107 0.03 ENST00000301067.7
 KMT2D
 lysine (K)-specific methyltransferase 2D
chr4_+_619386 0.03 ENST00000496514.1
 PDE6B
 phosphodiesterase 6B, cGMP-specific, rod, beta
chr7_+_44646177 0.03 ENST00000443864.2
ENST00000447398.1
ENST00000449767.1
ENST00000419661.1
 OGDH
 oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr14_-_69261310 0.03 ENST00000336440.3
 ZFP36L1
 ZFP36 ring finger protein-like 1
chr12_-_49418407 0.03 ENST00000526209.1
 KMT2D
 lysine (K)-specific methyltransferase 2D
chr19_+_46850251 0.03 ENST00000012443.4
 PPP5C
 protein phosphatase 5, catalytic subunit
chr6_+_16129308 0.02 ENST00000356840.3
ENST00000349606.4
 MYLIP
 myosin regulatory light chain interacting protein
chr7_+_99717230 0.02 ENST00000262932.3
 CNPY4
 canopy FGF signaling regulator 4
chr16_-_790982 0.02 ENST00000301694.5
ENST00000251588.2
 NARFL
 nuclear prelamin A recognition factor-like
chr19_+_46850320 0.02 ENST00000391919.1
 PPP5C
 protein phosphatase 5, catalytic subunit
chr16_-_790887 0.02 ENST00000540986.1
 NARFL
 nuclear prelamin A recognition factor-like
chr2_-_158182410 0.02 ENST00000419116.2
ENST00000410096.1
 ERMN
 ermin, ERM-like protein
chr2_+_223725652 0.02 ENST00000357430.3
ENST00000392066.3
 ACSL3
 acyl-CoA synthetase long-chain family member 3
chr2_-_152118352 0.02 ENST00000331426.5
 RBM43
 RNA binding motif protein 43
chr10_+_122610687 0.02 ENST00000263461.6
 WDR11
 WD repeat domain 11
chr1_-_173020056 0.02 ENST00000239468.2
ENST00000404377.3
 TNFSF18
 tumor necrosis factor (ligand) superfamily, member 18
chr11_+_47291645 0.02 ENST00000395336.3
ENST00000402192.2
 MADD
 MAP-kinase activating death domain
chr2_+_203879568 0.02 ENST00000449802.1
 NBEAL1
 neurobeachin-like 1
chr5_+_140079919 0.02 ENST00000274712.3
 ZMAT2
 zinc finger, matrin-type 2
chr17_-_7082861 0.02 ENST00000269299.3
 ASGR1
 asialoglycoprotein receptor 1
chr17_+_74372662 0.02 ENST00000591651.1
ENST00000545180.1
 SPHK1
 sphingosine kinase 1
chr11_+_47291193 0.02 ENST00000428807.1
ENST00000402799.1
ENST00000406482.1
ENST00000349238.3
ENST00000311027.5
ENST00000407859.3
ENST00000395344.3
ENST00000444117.1
 MADD
 MAP-kinase activating death domain
chr5_+_145583156 0.02 ENST00000265271.5
 RBM27
 RNA binding motif protein 27
chr10_-_36813162 0.02 ENST00000440465.1
 NAMPTL
 nicotinamide phosphoribosyltransferase-like
chr6_-_110797799 0.02 ENST00000456137.2
ENST00000368919.3
ENST00000439654.1
 SLC22A16
 solute carrier family 22 (organic cation/carnitine transporter), member 16
chr1_+_160147176 0.02 ENST00000470705.1
 ATP1A4
 ATPase, Na+/K+ transporting, alpha 4 polypeptide
chr9_-_124976154 0.02 ENST00000482062.1
 LHX6
 LIM homeobox 6
chr17_+_21730180 0.01 ENST00000584398.1
 UBBP4
 ubiquitin B pseudogene 4
chr1_-_160232197 0.01 ENST00000419626.1
ENST00000610139.1
ENST00000475733.1
ENST00000407642.2
ENST00000368073.3
ENST00000326837.2
 DCAF8
 DDB1 and CUL4 associated factor 8
chr19_+_45394477 0.01 ENST00000252487.5
ENST00000405636.2
ENST00000592434.1
ENST00000426677.2
ENST00000589649.1
 TOMM40
 translocase of outer mitochondrial membrane 40 homolog (yeast)
chr8_+_22462532 0.01 ENST00000389279.3
 CCAR2
 cell cycle and apoptosis regulator 2
chr10_-_69597828 0.01 ENST00000339758.7
 DNAJC12
 DnaJ (Hsp40) homolog, subfamily C, member 12
chr8_-_116681221 0.01 ENST00000395715.3
 TRPS1
 trichorhinophalangeal syndrome I
chr7_-_121944491 0.01 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
 FEZF1
 FEZ family zinc finger 1
chr12_+_510742 0.01 ENST00000239830.4
 CCDC77
 coiled-coil domain containing 77
chr10_-_61900762 0.01 ENST00000355288.2
 ANK3
 ankyrin 3, node of Ranvier (ankyrin G)
chr12_+_510795 0.01 ENST00000412006.2
 CCDC77
 coiled-coil domain containing 77
chrX_-_46187069 0.01 ENST00000446884.1
 RP1-30G7.2
 RP1-30G7.2
chr6_-_25832254 0.01 ENST00000476801.1
ENST00000244527.4
ENST00000427328.1
 SLC17A1
 solute carrier family 17 (organic anion transporter), member 1
chr5_-_68665084 0.01 ENST00000509462.1
 TAF9
 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
chr10_+_93683519 0.01 ENST00000265990.6
 BTAF1
 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa
chr5_-_68665469 0.01 ENST00000217893.5
 TAF9
 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
chr15_-_88799948 0.01 ENST00000394480.2
 NTRK3
 neurotrophic tyrosine kinase, receptor, type 3
chr7_-_99716952 0.01 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
 TAF6
 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr3_-_27410847 0.01 ENST00000429845.2
ENST00000341435.5
ENST00000435750.1
 NEK10
 NIMA-related kinase 10
chr5_-_68665296 0.01 ENST00000512152.1
ENST00000503245.1
ENST00000512561.1
ENST00000380822.4
 TAF9
 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
chr2_+_61404624 0.01 ENST00000394457.3
 AHSA2
 AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast)
chr10_+_28822636 0.01 ENST00000442148.1
ENST00000448193.1
 WAC
 WW domain containing adaptor with coiled-coil
chr7_-_6010263 0.01 ENST00000455618.2
ENST00000405415.1
ENST00000404406.1
ENST00000542644.1
 RSPH10B
 radial spoke head 10 homolog B (Chlamydomonas)
chr1_-_217250231 0.00 ENST00000493748.1
ENST00000463665.1
 ESRRG
 estrogen-related receptor gamma
chr11_-_71823266 0.00 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
 ANAPC15
 anaphase promoting complex subunit 15
chr1_+_161736072 0.00 ENST00000367942.3
 ATF6
 activating transcription factor 6
chr15_+_67430339 0.00 ENST00000439724.3
 SMAD3
 SMAD family member 3
chrX_-_70288234 0.00 ENST00000276105.3
ENST00000374274.3
 SNX12
 sorting nexin 12
chrX_+_49644470 0.00 ENST00000508866.2
 USP27X
 ubiquitin specific peptidase 27, X-linked
chr6_-_42981651 0.00 ENST00000244711.3
 MEA1
 male-enhanced antigen 1
chr19_-_40324767 0.00 ENST00000601972.1
ENST00000430012.2
ENST00000323039.5
ENST00000348817.3
 DYRK1B
 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
chr9_+_35792151 0.00 ENST00000342694.2
 NPR2
 natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr19_+_45971246 0.00 ENST00000585836.1
ENST00000417353.2
ENST00000353609.3
ENST00000591858.1
ENST00000443841.2
ENST00000590335.1
 FOSB
 FBJ murine osteosarcoma viral oncogene homolog B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
0.0 0.1 GO:1904647 response to rotenone(GO:1904647)
0.0 0.1 GO:0061034 olfactory bulb mitral cell layer development(GO:0061034)
0.0 0.1 GO:0043932 ossification involved in bone remodeling(GO:0043932)
0.0 0.1 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.0 0.1 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.0 0.1 GO:0001555 oocyte growth(GO:0001555)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.0 0.1 GO:0034602 oxoglutarate dehydrogenase (NAD+) activity(GO:0034602)
0.0 0.3 GO:0004062 aryl sulfotransferase activity(GO:0004062)