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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for CEBPA
Z-value: 1.85
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Transcription factors associated with CEBPA
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CEBPA | hg19_v2_chr19_-_33793430_33793470 | 0.54 | 1.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CEBPA
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_-_43883197 | 5.63 |
ENST00000338380.2 |
SLPI |
secretory leukocyte peptidase inhibitor |
| chr11_-_102668879 | 5.27 |
ENST00000315274.6 |
MMP1 |
matrix metallopeptidase 1 (interstitial collagenase) |
| chr20_+_58630972 | 4.37 |
ENST00000313426.1 |
C20orf197 |
chromosome 20 open reading frame 197 |
| chr18_+_61554932 | 3.55 |
ENST00000299502.4 ENST00000457692.1 ENST00000413956.1 |
SERPINB2 |
serpin peptidase inhibitor, clade B (ovalbumin), member 2 |
| chr19_-_35992780 | 3.14 |
ENST00000593342.1 ENST00000601650.1 ENST00000408915.2 |
DMKN |
dermokine |
| chr19_-_36004543 | 2.92 |
ENST00000339686.3 ENST00000447113.2 ENST00000440396.1 |
DMKN |
dermokine |
| chr11_-_18270182 | 2.87 |
ENST00000528349.1 ENST00000526900.1 ENST00000529528.1 ENST00000414546.2 ENST00000256733.4 |
SAA2 |
serum amyloid A2 |
| chr10_+_118187379 | 2.76 |
ENST00000369230.3 |
PNLIPRP3 |
pancreatic lipase-related protein 3 |
| chr11_+_18287721 | 2.74 |
ENST00000356524.4 |
SAA1 |
serum amyloid A1 |
| chr2_-_113594279 | 2.74 |
ENST00000416750.1 ENST00000418817.1 ENST00000263341.2 |
IL1B |
interleukin 1, beta |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 6.1 | GO:1903575 | cornified envelope assembly(GO:1903575) |
| 0.2 | 5.8 | GO:0050716 | positive regulation of interleukin-1 secretion(GO:0050716) |
| 0.0 | 5.7 | GO:0070268 | cornification(GO:0070268) |
| 0.1 | 5.3 | GO:0019731 | antibacterial humoral response(GO:0019731) |
| 0.1 | 5.1 | GO:0032461 | positive regulation of protein oligomerization(GO:0032461) |
| 0.6 | 3.9 | GO:0010025 | wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166) |
| 0.7 | 3.7 | GO:0015688 | iron chelate transport(GO:0015688) siderophore transport(GO:0015891) |
| 1.1 | 3.4 | GO:0032499 | positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) positive regulation of antigen processing and presentation of peptide antigen(GO:0002585) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588) detection of peptidoglycan(GO:0032499) |
| 0.1 | 3.4 | GO:1902475 | L-alpha-amino acid transmembrane transport(GO:1902475) |
| 0.9 | 2.7 | GO:0060557 | positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.8 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.1 | 4.8 | GO:0030057 | desmosome(GO:0030057) |
| 0.1 | 3.9 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.0 | 3.8 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 3.2 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.1 | 3.1 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 2.9 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.0 | 2.8 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 2.2 | GO:0005922 | connexon complex(GO:0005922) |
| 0.1 | 2.2 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.3 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.1 | 7.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 4.9 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.8 | 3.9 | GO:0080019 | fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019) |
| 0.5 | 3.4 | GO:0070891 | lipoteichoic acid binding(GO:0070891) |
| 0.0 | 3.4 | GO:0005506 | iron ion binding(GO:0005506) |
| 0.0 | 3.1 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 2.7 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.1 | 2.7 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.4 | 2.5 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.3 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.1 | 5.1 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 4.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 4.0 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 2.6 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 1.5 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.0 | 1.0 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 1.0 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.8 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.0 | 0.7 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.6 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.0 | 5.5 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.2 | 5.3 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 4.8 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 3.9 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.1 | 3.4 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.1 | 3.4 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 2.5 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 2.2 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.1 | 2.1 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |