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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for CTCF_CTCFL
Z-value: 0.91
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Transcription factors associated with CTCF_CTCFL
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CTCFL | hg19_v2_chr20_-_56100155_56100163 | -0.87 | 5.3e-03 | Click! |
| CTCF | hg19_v2_chr16_+_67596310_67596353 | -0.76 | 2.9e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CTCF_CTCFL
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_+_111985713 | 0.70 |
ENST00000239007.7 |
MXI1 |
MAX interactor 1, dimerization protein |
| chr14_+_105190514 | 0.66 |
ENST00000330877.2 |
ADSSL1 |
adenylosuccinate synthase like 1 |
| chr11_-_57335280 | 0.65 |
ENST00000287156.4 |
UBE2L6 |
ubiquitin-conjugating enzyme E2L 6 |
| chr1_-_156675535 | 0.65 |
ENST00000368221.1 |
CRABP2 |
cellular retinoic acid binding protein 2 |
| chr8_-_48651648 | 0.64 |
ENST00000408965.3 |
CEBPD |
CCAAT/enhancer binding protein (C/EBP), delta |
| chr11_-_72504681 | 0.57 |
ENST00000538536.1 ENST00000543304.1 ENST00000540587.1 ENST00000334805.6 |
STARD10 |
StAR-related lipid transfer (START) domain containing 10 |
| chr19_+_5823813 | 0.56 |
ENST00000303212.2 |
NRTN |
neurturin |
| chr7_+_302918 | 0.56 |
ENST00000599994.1 |
AC187652.1 |
Protein LOC100996433 |
| chr11_+_64781575 | 0.54 |
ENST00000246747.4 ENST00000529384.1 |
ARL2 |
ADP-ribosylation factor-like 2 |
| chr6_+_32821924 | 0.51 |
ENST00000374859.2 ENST00000453265.2 |
PSMB9 |
proteasome (prosome, macropain) subunit, beta type, 9 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 0.9 | GO:0016185 | synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185) |
| 0.1 | 0.9 | GO:0031444 | slow-twitch skeletal muscle fiber contraction(GO:0031444) |
| 0.1 | 0.9 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.1 | 0.9 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.0 | 0.9 | GO:0033617 | mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034) |
| 0.1 | 0.8 | GO:0032782 | bile acid secretion(GO:0032782) |
| 0.1 | 0.7 | GO:1902164 | regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164) |
| 0.1 | 0.7 | GO:0044208 | 'de novo' AMP biosynthetic process(GO:0044208) |
| 0.0 | 0.7 | GO:0042994 | cytoplasmic sequestering of transcription factor(GO:0042994) |
| 0.2 | 0.6 | GO:0090290 | positive regulation of osteoclast proliferation(GO:0090290) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 1.4 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 1.0 | GO:0008274 | gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274) |
| 0.0 | 0.9 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 0.9 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.1 | 0.8 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.1 | 0.8 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.0 | 0.8 | GO:0036038 | MKS complex(GO:0036038) |
| 0.0 | 0.8 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.1 | 0.7 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 1.2 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.1 | 0.9 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 0.1 | 0.9 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.2 | 0.8 | GO:0004427 | inorganic diphosphatase activity(GO:0004427) |
| 0.1 | 0.8 | GO:0008158 | hedgehog receptor activity(GO:0008158) |
| 0.0 | 0.8 | GO:0004407 | histone deacetylase activity(GO:0004407) |
| 0.2 | 0.7 | GO:0004019 | adenylosuccinate synthase activity(GO:0004019) |
| 0.0 | 0.7 | GO:0016918 | retinal binding(GO:0016918) |
| 0.2 | 0.6 | GO:0004574 | oligo-1,6-glucosidase activity(GO:0004574) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.3 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 0.8 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 0.6 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 0.5 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.0 | 0.3 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 0.2 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 0.1 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 0.9 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 0.7 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.0 | 0.7 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 0.6 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.0 | 0.6 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.0 | 0.6 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.0 | 0.5 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.0 | 0.5 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 0.5 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |