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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for CUX2
Z-value: 1.24
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Transcription factors associated with CUX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CUX2 | hg19_v2_chr12_+_111471828_111471975 | 0.73 | 3.8e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CUX2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_-_120651020 | 2.90 |
ENST00000522826.1 ENST00000520066.1 ENST00000259486.6 ENST00000075322.6 |
ENPP2 |
ectonucleotide pyrophosphatase/phosphodiesterase 2 |
| chr12_-_91573132 | 2.50 |
ENST00000550563.1 ENST00000546370.1 |
DCN |
decorin |
| chr12_-_91546926 | 2.25 |
ENST00000550758.1 |
DCN |
decorin |
| chr11_-_35547151 | 1.94 |
ENST00000378878.3 ENST00000529303.1 ENST00000278360.3 |
PAMR1 |
peptidase domain containing associated with muscle regeneration 1 |
| chr6_+_73076432 | 1.94 |
ENST00000414192.2 |
RIMS1 |
regulating synaptic membrane exocytosis 1 |
| chr8_+_77593448 | 1.74 |
ENST00000521891.2 |
ZFHX4 |
zinc finger homeobox 4 |
| chr4_+_70916119 | 1.71 |
ENST00000246896.3 ENST00000511674.1 |
HTN1 |
histatin 1 |
| chr8_+_77593474 | 1.66 |
ENST00000455469.2 ENST00000050961.6 |
ZFHX4 |
zinc finger homeobox 4 |
| chr10_+_31610064 | 1.44 |
ENST00000446923.2 ENST00000559476.1 |
ZEB1 |
zinc finger E-box binding homeobox 1 |
| chr17_-_53809473 | 1.43 |
ENST00000575734.1 |
TMEM100 |
transmembrane protein 100 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.2 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.2 | 2.9 | GO:0034638 | phosphatidylcholine catabolic process(GO:0034638) |
| 0.4 | 2.6 | GO:0036343 | psychomotor behavior(GO:0036343) |
| 0.1 | 2.5 | GO:0050832 | defense response to fungus(GO:0050832) |
| 0.1 | 1.5 | GO:0097151 | positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828) |
| 0.2 | 1.4 | GO:0044245 | polysaccharide digestion(GO:0044245) |
| 0.2 | 1.4 | GO:0045602 | negative regulation of endothelial cell differentiation(GO:0045602) |
| 0.2 | 1.4 | GO:0060842 | arterial endothelial cell differentiation(GO:0060842) |
| 0.1 | 1.4 | GO:0034465 | response to carbon monoxide(GO:0034465) |
| 0.1 | 1.4 | GO:0034058 | endosomal vesicle fusion(GO:0034058) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 5.2 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.0 | 2.0 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 1.5 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 1.1 | GO:0008305 | integrin complex(GO:0008305) |
| 0.0 | 1.0 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 0.9 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.1 | 0.8 | GO:0098839 | postsynaptic density membrane(GO:0098839) |
| 0.1 | 0.7 | GO:0061574 | ASAP complex(GO:0061574) |
| 0.0 | 0.7 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.0 | 0.7 | GO:0005669 | transcription factor TFIID complex(GO:0005669) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.4 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.7 | 2.9 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
| 0.5 | 1.9 | GO:0016160 | amylase activity(GO:0016160) |
| 0.3 | 1.6 | GO:0047961 | glycine N-acyltransferase activity(GO:0047961) |
| 0.2 | 1.5 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 0.0 | 1.3 | GO:0070888 | E-box binding(GO:0070888) |
| 0.2 | 1.2 | GO:0023024 | MHC class I protein complex binding(GO:0023024) |
| 0.0 | 1.2 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.0 | 1.1 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.3 | 1.0 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.4 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 1.1 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.0 | 1.0 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 1.0 | PID IFNG PATHWAY | IFN-gamma pathway |
| 0.0 | 0.9 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.0 | 0.8 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.0 | 0.7 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.0 | 0.4 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 0.2 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.2 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.3 | 3.5 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.1 | 2.1 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.1 | 1.1 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.1 | 1.0 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.0 | 1.0 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 0.9 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.0 | 0.9 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 0.9 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.0 | 0.7 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |