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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for CXXC1
Z-value: 1.30
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Transcription factors associated with CXXC1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CXXC1 | hg19_v2_chr18_-_47813940_47814021 | 0.81 | 1.4e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CXXC1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_-_79397391 | 2.02 |
ENST00000286628.8 ENST00000406533.3 ENST00000354353.5 ENST00000404857.1 |
KCNMA1 |
potassium large conductance calcium-activated channel, subfamily M, alpha member 1 |
| chr10_-_79397202 | 2.02 |
ENST00000372437.1 ENST00000372408.2 ENST00000372403.4 |
KCNMA1 |
potassium large conductance calcium-activated channel, subfamily M, alpha member 1 |
| chr10_-_79397316 | 1.68 |
ENST00000372421.5 ENST00000457953.1 |
KCNMA1 |
potassium large conductance calcium-activated channel, subfamily M, alpha member 1 |
| chr2_+_33172012 | 1.64 |
ENST00000404816.2 |
LTBP1 |
latent transforming growth factor beta binding protein 1 |
| chr22_+_45898712 | 1.43 |
ENST00000455233.1 ENST00000348697.2 ENST00000402984.3 ENST00000262722.7 ENST00000327858.6 ENST00000442170.2 ENST00000340923.5 ENST00000439835.1 |
FBLN1 |
fibulin 1 |
| chr17_-_46507567 | 1.35 |
ENST00000584924.1 |
SKAP1 |
src kinase associated phosphoprotein 1 |
| chr15_-_48937982 | 1.25 |
ENST00000316623.5 |
FBN1 |
fibrillin 1 |
| chr13_-_33112823 | 1.23 |
ENST00000504114.1 |
N4BP2L2 |
NEDD4 binding protein 2-like 2 |
| chr8_-_120685608 | 1.17 |
ENST00000427067.2 |
ENPP2 |
ectonucleotide pyrophosphatase/phosphodiesterase 2 |
| chr5_-_178054014 | 1.17 |
ENST00000520957.1 |
CLK4 |
CDC-like kinase 4 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 6.7 | GO:0034465 | response to carbon monoxide(GO:0034465) |
| 0.3 | 2.9 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) |
| 0.0 | 2.2 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.1 | 1.8 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.2 | 1.4 | GO:1902037 | negative regulation of hematopoietic stem cell differentiation(GO:1902037) |
| 0.1 | 1.4 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 0.1 | 1.4 | GO:1900025 | negative regulation of substrate adhesion-dependent cell spreading(GO:1900025) |
| 0.2 | 1.2 | GO:0051387 | negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387) |
| 0.1 | 1.2 | GO:0034638 | phosphatidylcholine catabolic process(GO:0034638) |
| 0.1 | 1.2 | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.4 | GO:0005901 | caveola(GO:0005901) |
| 0.1 | 2.9 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.1 | 2.0 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.0 | 2.0 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 1.4 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.1 | 1.4 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.0 | 1.3 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 1.3 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 1.2 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.1 | 1.1 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 6.8 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 0.1 | 2.8 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.3 | 1.6 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.1 | 1.6 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.0 | 1.5 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.4 | 1.4 | GO:0070051 | fibrinogen binding(GO:0070051) |
| 0.1 | 1.4 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.3 | 1.2 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
| 0.1 | 1.2 | GO:0030023 | extracellular matrix constituent conferring elasticity(GO:0030023) |
| 0.1 | 1.2 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 1.7 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 1.4 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 1.2 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 0.9 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 0.7 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.0 | 0.6 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 0.6 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 0.6 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.0 | 0.6 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.6 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 1.8 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.0 | 1.6 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 1.6 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.0 | 1.5 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.1 | 1.3 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 1.2 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 1.1 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 0.9 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.1 | 0.8 | REACTOME SIGNALING BY FGFR3 MUTANTS | Genes involved in Signaling by FGFR3 mutants |