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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for DLX5

Z-value: 0.52

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Transcription factors associated with DLX5

Gene Symbol Gene ID Gene Info
DLX5
ENSG00000105880.4 DLX5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DLX5hg19_v2_chr7_-_96654133_96654409-0.686.4e-02Click!

Activity profile of DLX5 motif

Sorted Z-values of DLX5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of DLX5

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr16_+_53133070 0.86 ENST00000565832.1
 CHD9
 chromodomain helicase DNA binding protein 9
chr15_+_89631381 0.71 ENST00000352732.5
 ABHD2
 abhydrolase domain containing 2
chr3_+_186560462 0.51 ENST00000412955.2
 ADIPOQ
 adiponectin, C1Q and collagen domain containing
chr3_+_186560476 0.51 ENST00000320741.2
ENST00000444204.2
 ADIPOQ
 adiponectin, C1Q and collagen domain containing
chr15_+_89631647 0.51 ENST00000569550.1
ENST00000565066.1
ENST00000565973.1
 ABHD2
 abhydrolase domain containing 2
chr5_-_20575959 0.44 ENST00000507958.1
 CDH18
 cadherin 18, type 2
chr12_-_10151773 0.32 ENST00000298527.6
ENST00000348658.4
 CLEC1B
 C-type lectin domain family 1, member B
chr3_-_105588231 0.32 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
 CBLB
 Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr17_+_42264556 0.31 ENST00000319511.6
ENST00000589785.1
ENST00000592825.1
ENST00000589184.1
 TMUB2
 transmembrane and ubiquitin-like domain containing 2
chr7_+_100770328 0.31 ENST00000223095.4
ENST00000445463.2
 SERPINE1
 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
chr15_+_41913690 0.30 ENST00000563576.1
 MGA
 MGA, MAX dimerization protein
chr7_+_99717230 0.23 ENST00000262932.3
 CNPY4
 canopy FGF signaling regulator 4
chr7_+_70597109 0.23 ENST00000333538.5
 WBSCR17
 Williams-Beuren syndrome chromosome region 17
chr3_-_105587879 0.21 ENST00000264122.4
ENST00000403724.1
ENST00000405772.1
 CBLB
 Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr12_+_51818749 0.21 ENST00000514353.3
 SLC4A8
 solute carrier family 4, sodium bicarbonate cotransporter, member 8
chr1_+_160160283 0.20 ENST00000368079.3
 CASQ1
 calsequestrin 1 (fast-twitch, skeletal muscle)
chr1_+_160160346 0.19 ENST00000368078.3
 CASQ1
 calsequestrin 1 (fast-twitch, skeletal muscle)
chr3_+_11178779 0.18 ENST00000438284.2
 HRH1
 histamine receptor H1
chr17_+_59489112 0.17 ENST00000335108.2
 C17orf82
 chromosome 17 open reading frame 82
chr3_+_158519654 0.17 ENST00000415822.2
ENST00000392813.4
ENST00000264266.8
 MFSD1
 major facilitator superfamily domain containing 1
chr4_-_74853897 0.17 ENST00000296028.3
 PPBP
 pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
chr6_-_78173490 0.17 ENST00000369947.2
 HTR1B
 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
chr8_-_124553437 0.15 ENST00000517956.1
ENST00000443022.2
 FBXO32
 F-box protein 32
chr2_-_183387430 0.15 ENST00000410103.1
 PDE1A
 phosphodiesterase 1A, calmodulin-dependent
chr5_-_160279207 0.13 ENST00000327245.5
 ATP10B
 ATPase, class V, type 10B
chr13_+_36050881 0.13 ENST00000537702.1
 NBEA
 neurobeachin
chr10_+_99205959 0.13 ENST00000352634.4
ENST00000353979.3
ENST00000370842.2
ENST00000345745.5
 ZDHHC16
 zinc finger, DHHC-type containing 16
chr1_+_202317855 0.12 ENST00000356764.2
 PPP1R12B
 protein phosphatase 1, regulatory subunit 12B
chr5_-_42811986 0.12 ENST00000511224.1
ENST00000507920.1
ENST00000510965.1
 SEPP1
 selenoprotein P, plasma, 1
chr10_+_99205894 0.12 ENST00000370854.3
ENST00000393760.1
ENST00000414567.1
ENST00000370846.4
 ZDHHC16
 zinc finger, DHHC-type containing 16
chr11_-_33913708 0.11 ENST00000257818.2
 LMO2
 LIM domain only 2 (rhombotin-like 1)
chrX_-_16887963 0.11 ENST00000380084.4
 RBBP7
 retinoblastoma binding protein 7
chr6_+_123038689 0.11 ENST00000354275.2
ENST00000368446.1
 PKIB
 protein kinase (cAMP-dependent, catalytic) inhibitor beta
chr4_-_138453559 0.11 ENST00000511115.1
 PCDH18
 protocadherin 18
chr2_+_95963052 0.11 ENST00000295225.5
 KCNIP3
 Kv channel interacting protein 3, calsenilin
chr1_-_114447412 0.11 ENST00000369567.1
ENST00000369566.3
 AP4B1
 adaptor-related protein complex 4, beta 1 subunit
chr17_+_28268623 0.11 ENST00000394835.3
ENST00000320856.5
ENST00000394832.2
ENST00000378738.3
 EFCAB5
 EF-hand calcium binding domain 5
chr7_-_14028488 0.11 ENST00000405358.4
 ETV1
 ets variant 1
chr7_-_14029283 0.10 ENST00000433547.1
ENST00000405192.2
 ETV1
 ets variant 1
chr7_-_7575477 0.10 ENST00000399429.3
 COL28A1
 collagen, type XXVIII, alpha 1
chr1_-_150669604 0.10 ENST00000427665.1
ENST00000540514.1
 GOLPH3L
 golgi phosphoprotein 3-like
chr19_-_14785674 0.10 ENST00000253673.5
 EMR3
 egf-like module containing, mucin-like, hormone receptor-like 3
chr19_-_14785622 0.09 ENST00000443157.2
 EMR3
 egf-like module containing, mucin-like, hormone receptor-like 3
chr14_+_22739823 0.09 ENST00000390464.2
 TRAV38-1
 T cell receptor alpha variable 38-1
chr2_+_105050794 0.09 ENST00000429464.1
ENST00000414442.1
ENST00000447380.1
 AC013402.2
 long intergenic non-protein coding RNA 1102
chr18_-_33709268 0.09 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
 SLC39A6
 solute carrier family 39 (zinc transporter), member 6
chr14_-_68283291 0.08 ENST00000555452.1
ENST00000347230.4
 ZFYVE26
 zinc finger, FYVE domain containing 26
chr2_+_196313239 0.08 ENST00000413290.1
 AC064834.1
 AC064834.1
chr11_-_26593779 0.08 ENST00000529533.1
 MUC15
 mucin 15, cell surface associated
chr19_-_14785698 0.08 ENST00000344373.4
ENST00000595472.1
 EMR3
 egf-like module containing, mucin-like, hormone receptor-like 3
chr17_-_47785504 0.08 ENST00000514907.1
ENST00000503334.1
ENST00000508520.1
 SLC35B1
 solute carrier family 35, member B1
chr19_+_58570605 0.08 ENST00000359978.6
ENST00000401053.4
ENST00000439855.2
ENST00000313434.5
ENST00000511556.1
ENST00000506786.1
 ZNF135
 zinc finger protein 135
chr11_-_26593677 0.08 ENST00000527569.1
 MUC15
 mucin 15, cell surface associated
chr22_-_32860427 0.07 ENST00000534972.1
ENST00000397450.1
ENST00000397452.1
 BPIFC
 BPI fold containing family C
chr3_+_186288454 0.07 ENST00000265028.3
 DNAJB11
 DnaJ (Hsp40) homolog, subfamily B, member 11
chr6_-_27860956 0.07 ENST00000359611.2
 HIST1H2AM
 histone cluster 1, H2am
chr4_-_66536057 0.07 ENST00000273854.3
 EPHA5
 EPH receptor A5
chr2_+_228736321 0.07 ENST00000309931.2
 DAW1
 dynein assembly factor with WDR repeat domains 1
chr13_-_36050819 0.07 ENST00000379919.4
 MAB21L1
 mab-21-like 1 (C. elegans)
chr2_+_228736335 0.06 ENST00000440997.1
ENST00000545118.1
 DAW1
 dynein assembly factor with WDR repeat domains 1
chr11_+_76092353 0.06 ENST00000530460.1
ENST00000321844.4
 RP11-111M22.2
 Homo sapiens putative uncharacterized protein FLJ37770-like (LOC100506127), mRNA.
chr2_+_169757750 0.06 ENST00000375363.3
ENST00000429379.2
ENST00000421979.1
 G6PC2
 glucose-6-phosphatase, catalytic, 2
chr1_-_197115818 0.05 ENST00000367409.4
ENST00000294732.7
 ASPM
 asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr2_+_228735763 0.05 ENST00000373666.2
 DAW1
 dynein assembly factor with WDR repeat domains 1
chr3_+_2933893 0.05 ENST00000397459.2
 CNTN4
 contactin 4
chr11_-_26743546 0.05 ENST00000280467.6
ENST00000396005.3
 SLC5A12
 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
chr12_-_10978957 0.05 ENST00000240619.2
 TAS2R10
 taste receptor, type 2, member 10
chr3_-_186288097 0.05 ENST00000446782.1
 TBCCD1
 TBCC domain containing 1
chr1_-_23670813 0.05 ENST00000374612.1
 HNRNPR
 heterogeneous nuclear ribonucleoprotein R
chr15_+_63188009 0.05 ENST00000557900.1
 RP11-1069G10.2
 RP11-1069G10.2
chr14_+_24540046 0.05 ENST00000397016.2
ENST00000537691.1
ENST00000560356.1
ENST00000558450.1
 CPNE6
 copine VI (neuronal)
chr11_-_102651343 0.04 ENST00000279441.4
ENST00000539681.1
 MMP10
 matrix metallopeptidase 10 (stromelysin 2)
chr19_-_19302931 0.04 ENST00000444486.3
ENST00000514819.3
ENST00000585679.1
ENST00000162023.5
 MEF2BNB-MEF2B
MEF2BNB
MEF2B
 MEF2BNB-MEF2B readthrough
MEF2B neighbor
myocyte enhancer factor 2B
chr15_+_89164520 0.04 ENST00000332810.3
 AEN
 apoptosis enhancing nuclease
chr8_-_7332604 0.04 ENST00000316169.2
 DEFB104B
 defensin, beta 104B
chr2_-_183387064 0.04 ENST00000536095.1
ENST00000331935.6
ENST00000358139.2
ENST00000456212.1
 PDE1A
 phosphodiesterase 1A, calmodulin-dependent
chr11_-_26593649 0.04 ENST00000455601.2
 MUC15
 mucin 15, cell surface associated
chr11_+_818902 0.04 ENST00000336615.4
 PNPLA2
 patatin-like phospholipase domain containing 2
chr1_-_23670752 0.04 ENST00000302271.6
ENST00000426846.2
ENST00000427764.2
ENST00000606561.1
ENST00000374616.3
 HNRNPR
 heterogeneous nuclear ribonucleoprotein R
chr1_+_202317815 0.04 ENST00000608999.1
ENST00000336894.4
ENST00000480184.1
 PPP1R12B
 protein phosphatase 1, regulatory subunit 12B
chr21_-_32253874 0.03 ENST00000332378.4
 KRTAP11-1
 keratin associated protein 11-1
chr2_-_183387283 0.03 ENST00000435564.1
 PDE1A
 phosphodiesterase 1A, calmodulin-dependent
chr21_-_15918618 0.03 ENST00000400564.1
ENST00000400566.1
 SAMSN1
 SAM domain, SH3 domain and nuclear localization signals 1
chr6_-_33160231 0.03 ENST00000395194.1
ENST00000457788.1
ENST00000341947.2
ENST00000357486.1
ENST00000374714.1
ENST00000374713.1
ENST00000395197.1
ENST00000374712.1
ENST00000361917.1
ENST00000374708.4
 COL11A2
 collagen, type XI, alpha 2
chr13_-_36788718 0.03 ENST00000317764.6
ENST00000379881.3
 SOHLH2
 spermatogenesis and oogenesis specific basic helix-loop-helix 2
chr17_-_39324424 0.03 ENST00000391356.2
 KRTAP4-3
 keratin associated protein 4-3
chr8_+_32579341 0.02 ENST00000519240.1
ENST00000539990.1
 NRG1
 neuregulin 1
chr19_+_36606354 0.02 ENST00000589996.1
ENST00000591296.1
 TBCB
 tubulin folding cofactor B
chr7_-_99716952 0.02 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
 TAF6
 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr5_+_63802109 0.02 ENST00000334025.2
 RGS7BP
 regulator of G-protein signaling 7 binding protein
chr4_-_105416039 0.01 ENST00000394767.2
 CXXC4
 CXXC finger protein 4
chr1_-_201140673 0.01 ENST00000367333.2
 TMEM9
 transmembrane protein 9
chr22_-_30960876 0.01 ENST00000401975.1
ENST00000428682.1
ENST00000423299.1
 GAL3ST1
 galactose-3-O-sulfotransferase 1
chr7_-_86849883 0.01 ENST00000433078.1
 TMEM243
 transmembrane protein 243, mitochondrial
chr12_+_52695617 0.01 ENST00000293525.5
 KRT86
 keratin 86
chr4_-_8873531 0.01 ENST00000400677.3
 HMX1
 H6 family homeobox 1
chr1_-_150669500 0.01 ENST00000271732.3
 GOLPH3L
 golgi phosphoprotein 3-like
chr19_+_36605850 0.00 ENST00000221855.3
 TBCB
 tubulin folding cofactor B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:2000532 renal albumin absorption(GO:0097018) regulation of renal albumin absorption(GO:2000532) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.1 0.3 GO:2000097 chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.0 0.5 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.2 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.0 1.2 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.5 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.1 GO:0015785 UDP-galactose transport(GO:0015785) UDP-galactose transmembrane transport(GO:0072334)
0.0 0.1 GO:0010286 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.0 0.2 GO:0032962 positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)
0.0 0.1 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.0 0.2 GO:0046069 cGMP catabolic process(GO:0046069)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.4 GO:0014802 terminal cisterna(GO:0014802)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0033691 sialic acid binding(GO:0033691)
0.1 1.2 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.2 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.1 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.0 0.2 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.1 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.2 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.2 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.2 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID CD40 PATHWAY CD40/CD40L signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors