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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for DPRX
Z-value: 1.32
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Transcription factors associated with DPRX
Network of associatons between targets according to the STRING database.
First level regulatory network of DPRX
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_-_105845674 | 1.66 |
ENST00000353479.5 ENST00000369733.3 |
COL17A1 |
collagen, type XVII, alpha 1 |
| chr1_+_35220613 | 1.56 |
ENST00000338513.1 |
GJB5 |
gap junction protein, beta 5, 31.1kDa |
| chr10_+_118187379 | 1.52 |
ENST00000369230.3 |
PNLIPRP3 |
pancreatic lipase-related protein 3 |
| chr18_-_28681950 | 1.44 |
ENST00000251081.6 |
DSC2 |
desmocollin 2 |
| chr5_-_150948414 | 1.33 |
ENST00000261800.5 |
FAT2 |
FAT atypical cadherin 2 |
| chr9_-_23821273 | 1.21 |
ENST00000380110.4 |
ELAVL2 |
ELAV like neuron-specific RNA binding protein 2 |
| chr18_-_28682374 | 1.15 |
ENST00000280904.6 |
DSC2 |
desmocollin 2 |
| chr3_+_136676851 | 1.08 |
ENST00000309741.5 |
IL20RB |
interleukin 20 receptor beta |
| chr17_-_4643114 | 1.04 |
ENST00000293778.6 |
CXCL16 |
chemokine (C-X-C motif) ligand 16 |
| chr3_+_136676707 | 1.01 |
ENST00000329582.4 |
IL20RB |
interleukin 20 receptor beta |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.6 | GO:0086073 | bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073) |
| 0.0 | 2.6 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 2.4 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.5 | 2.1 | GO:0001808 | negative regulation of type IV hypersensitivity(GO:0001808) |
| 0.1 | 1.7 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.4 | 1.6 | GO:0060708 | spongiotrophoblast differentiation(GO:0060708) |
| 0.0 | 1.1 | GO:0032456 | endocytic recycling(GO:0032456) |
| 0.2 | 0.9 | GO:0035627 | ceramide transport(GO:0035627) |
| 0.2 | 0.9 | GO:0050717 | positive regulation of interleukin-1 alpha secretion(GO:0050717) |
| 0.0 | 0.9 | GO:0010818 | T cell chemotaxis(GO:0010818) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.6 | GO:0030057 | desmosome(GO:0030057) |
| 0.1 | 2.3 | GO:0090545 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.1 | 1.7 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.1 | 1.6 | GO:0005922 | connexon complex(GO:0005922) |
| 0.2 | 1.4 | GO:0097179 | protease inhibitor complex(GO:0097179) |
| 0.0 | 1.4 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.1 | 0.9 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.1 | 0.8 | GO:0045179 | apical cortex(GO:0045179) |
| 0.1 | 0.7 | GO:0016013 | syntrophin complex(GO:0016013) |
| 0.0 | 0.6 | GO:0042613 | MHC class II protein complex(GO:0042613) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.6 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
| 0.3 | 2.1 | GO:0042015 | interleukin-20 binding(GO:0042015) |
| 0.1 | 1.9 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.2 | 1.7 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.1 | 1.5 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.1 | 1.1 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.0 | 1.0 | GO:0005041 | low-density lipoprotein receptor activity(GO:0005041) |
| 0.2 | 0.9 | GO:0034040 | lipid-transporting ATPase activity(GO:0034040) |
| 0.0 | 0.9 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.0 | 0.8 | GO:0000146 | microfilament motor activity(GO:0000146) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 0.9 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.4 | PID CONE PATHWAY | Visual signal transduction: Cones |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 1.6 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.0 | 1.1 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 1.1 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 1.0 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.0 | 0.9 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 0.9 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.8 | REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS | Genes involved in Regulation of Water Balance by Renal Aquaporins |
| 0.0 | 0.7 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 0.6 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |