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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for E2F2_E2F5
Z-value: 2.44
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Transcription factors associated with E2F2_E2F5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F2 | hg19_v2_chr1_-_23857698_23857733 | 0.64 | 8.8e-02 | Click! |
| E2F5 | hg19_v2_chr8_+_86121448_86121494 | -0.50 | 2.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F2_E2F5
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_36235529 | 2.27 |
ENST00000318121.3 ENST00000373220.3 ENST00000520551.1 |
CLSPN |
claspin |
| chr8_-_124408652 | 2.22 |
ENST00000287394.5 |
ATAD2 |
ATPase family, AAA domain containing 2 |
| chr11_-_19263145 | 1.63 |
ENST00000532666.1 ENST00000527884.1 |
E2F8 |
E2F transcription factor 8 |
| chr1_-_36235559 | 1.61 |
ENST00000251195.5 |
CLSPN |
claspin |
| chr16_-_3030283 | 1.50 |
ENST00000572619.1 ENST00000574415.1 ENST00000440027.2 ENST00000572059.1 |
PKMYT1 |
protein kinase, membrane associated tyrosine/threonine 1 |
| chr11_-_19262486 | 1.49 |
ENST00000250024.4 |
E2F8 |
E2F transcription factor 8 |
| chr2_+_27498289 | 1.45 |
ENST00000296097.3 ENST00000420191.1 |
DNAJC5G |
DnaJ (Hsp40) homolog, subfamily C, member 5 gamma |
| chr16_-_3030407 | 1.40 |
ENST00000431515.2 ENST00000574385.1 ENST00000576268.1 ENST00000574730.1 ENST00000575632.1 ENST00000573944.1 ENST00000262300.8 |
PKMYT1 |
protein kinase, membrane associated tyrosine/threonine 1 |
| chr2_+_27498331 | 1.30 |
ENST00000402462.1 ENST00000404433.1 ENST00000406962.1 |
DNAJC5G |
DnaJ (Hsp40) homolog, subfamily C, member 5 gamma |
| chr4_+_55524085 | 1.20 |
ENST00000412167.2 ENST00000288135.5 |
KIT |
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.2 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) |
| 0.3 | 4.1 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 1.2 | 3.6 | GO:0032877 | positive regulation of DNA endoreduplication(GO:0032877) |
| 0.1 | 3.2 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.6 | 2.9 | GO:0060356 | leucine import(GO:0060356) |
| 0.2 | 2.2 | GO:0031936 | negative regulation of chromatin silencing(GO:0031936) |
| 0.1 | 1.8 | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) |
| 0.0 | 1.8 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.5 | 1.6 | GO:0071139 | resolution of recombination intermediates(GO:0071139) resolution of mitotic recombination intermediates(GO:0071140) |
| 0.2 | 1.5 | GO:0048478 | replication fork protection(GO:0048478) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.9 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 2.6 | GO:0000800 | lateral element(GO:0000800) |
| 0.2 | 1.9 | GO:0042555 | MCM complex(GO:0042555) |
| 0.3 | 1.6 | GO:0031515 | tRNA (m1A) methyltransferase complex(GO:0031515) |
| 0.0 | 1.5 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.3 | 1.4 | GO:0097362 | MCM8-MCM9 complex(GO:0097362) |
| 0.1 | 1.4 | GO:0031298 | replication fork protection complex(GO:0031298) |
| 0.0 | 1.4 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.3 | 1.3 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 0.1 | 1.3 | GO:0016012 | sarcoglycan complex(GO:0016012) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.6 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.0 | 3.8 | GO:0042393 | histone binding(GO:0042393) |
| 0.5 | 3.7 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 0.2 | 2.9 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 0.0 | 2.0 | GO:0004386 | helicase activity(GO:0004386) |
| 0.3 | 1.8 | GO:0004741 | [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
| 0.2 | 1.6 | GO:0008821 | crossover junction endodeoxyribonuclease activity(GO:0008821) |
| 0.1 | 1.6 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.1 | 1.3 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.1 | 1.3 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.3 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 2.6 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.2 | 2.5 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 2.1 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 2.0 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 1.5 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 1.3 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 1.2 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 0.9 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 0.9 | PID AURORA B PATHWAY | Aurora B signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.5 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.1 | 2.9 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.1 | 2.8 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.1 | 2.6 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.4 | 2.5 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.1 | 2.4 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.1 | 2.0 | REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.1 | 1.8 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.0 | 1.4 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 1.2 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |