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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for E2F3
Z-value: 1.56
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Transcription factors associated with E2F3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F3 | hg19_v2_chr6_+_20403997_20404034 | 0.45 | 2.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F3
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_-_79397391 | 3.08 |
ENST00000286628.8 ENST00000406533.3 ENST00000354353.5 ENST00000404857.1 |
KCNMA1 |
potassium large conductance calcium-activated channel, subfamily M, alpha member 1 |
| chr5_-_111093759 | 2.20 |
ENST00000509979.1 ENST00000513100.1 ENST00000508161.1 ENST00000455559.2 |
NREP |
neuronal regeneration related protein |
| chr5_-_111093406 | 2.00 |
ENST00000379671.3 |
NREP |
neuronal regeneration related protein |
| chr5_-_111092873 | 1.49 |
ENST00000509025.1 ENST00000515855.1 |
NREP |
neuronal regeneration related protein |
| chr14_-_30396802 | 1.48 |
ENST00000415220.2 |
PRKD1 |
protein kinase D1 |
| chr14_-_53417732 | 1.38 |
ENST00000399304.3 ENST00000395631.2 ENST00000341590.3 ENST00000343279.4 |
FERMT2 |
fermitin family member 2 |
| chr5_+_92919043 | 1.31 |
ENST00000327111.3 |
NR2F1 |
nuclear receptor subfamily 2, group F, member 1 |
| chr5_-_111092930 | 1.24 |
ENST00000257435.7 |
NREP |
neuronal regeneration related protein |
| chr3_-_33260707 | 1.23 |
ENST00000309558.3 |
SUSD5 |
sushi domain containing 5 |
| chr20_-_34042558 | 1.21 |
ENST00000374372.1 |
GDF5 |
growth differentiation factor 5 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.1 | GO:0034465 | response to carbon monoxide(GO:0034465) |
| 0.4 | 2.6 | GO:0089700 | protein kinase D signaling(GO:0089700) |
| 0.2 | 2.3 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 0.0 | 2.1 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.3 | 2.0 | GO:0043932 | ossification involved in bone remodeling(GO:0043932) |
| 0.0 | 1.9 | GO:1904837 | beta-catenin-TCF complex assembly(GO:1904837) |
| 0.0 | 1.9 | GO:1902036 | regulation of hematopoietic stem cell differentiation(GO:1902036) |
| 0.4 | 1.7 | GO:0009183 | purine deoxyribonucleoside diphosphate biosynthetic process(GO:0009183) |
| 0.3 | 1.3 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
| 0.2 | 1.2 | GO:0000720 | pyrimidine dimer repair by nucleotide-excision repair(GO:0000720) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.0 | GO:0005901 | caveola(GO:0005901) |
| 0.1 | 3.2 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.0 | 2.2 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 2.1 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 1.6 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 1.5 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.0 | 1.4 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 1.4 | GO:0005814 | centriole(GO:0005814) |
| 0.1 | 1.3 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.0 | 1.3 | GO:0031201 | SNARE complex(GO:0031201) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 3.1 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 0.1 | 2.4 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.0 | 2.1 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.4 | 1.8 | GO:0004306 | ethanolamine-phosphate cytidylyltransferase activity(GO:0004306) |
| 0.1 | 1.8 | GO:0019206 | nucleoside kinase activity(GO:0019206) |
| 0.0 | 1.7 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.3 | 1.4 | GO:0004957 | prostaglandin E receptor activity(GO:0004957) |
| 0.0 | 1.4 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.0 | 1.4 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.1 | 1.3 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.6 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.0 | 2.0 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 1.5 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 1.4 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.1 | 1.3 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 1.3 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.0 | 1.2 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 1.2 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.0 | 1.2 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.2 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.1 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.2 | 2.6 | REACTOME PROSTANOID LIGAND RECEPTORS | Genes involved in Prostanoid ligand receptors |
| 0.0 | 2.6 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 2.1 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 1.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.6 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 1.6 | REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 | Genes involved in Autodegradation of the E3 ubiquitin ligase COP1 |
| 0.0 | 1.6 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 1.4 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.1 | 1.3 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |