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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for E2F7_E2F1
Z-value: 2.82
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Transcription factors associated with E2F7_E2F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F7 | hg19_v2_chr12_-_77459306_77459365 | 0.90 | 2.2e-03 | Click! |
| E2F1 | hg19_v2_chr20_-_32274179_32274213 | 0.67 | 6.9e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F7_E2F1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_36235529 | 1.67 |
ENST00000318121.3 ENST00000373220.3 ENST00000520551.1 |
CLSPN |
claspin |
| chr13_-_110438914 | 1.16 |
ENST00000375856.3 |
IRS2 |
insulin receptor substrate 2 |
| chr8_-_95907423 | 1.12 |
ENST00000396133.3 ENST00000308108.4 |
CCNE2 |
cyclin E2 |
| chr12_-_77459306 | 1.06 |
ENST00000547316.1 ENST00000416496.2 ENST00000550669.1 ENST00000322886.7 |
E2F7 |
E2F transcription factor 7 |
| chr5_+_126112794 | 1.06 |
ENST00000261366.5 ENST00000395354.1 |
LMNB1 |
lamin B1 |
| chr6_+_31707725 | 1.01 |
ENST00000375755.3 ENST00000375742.3 ENST00000375750.3 ENST00000425703.1 ENST00000534153.4 ENST00000375703.3 ENST00000375740.3 |
MSH5 |
mutS homolog 5 |
| chr11_-_108369101 | 1.01 |
ENST00000323468.5 |
KDELC2 |
KDEL (Lys-Asp-Glu-Leu) containing 2 |
| chr13_+_32889605 | 0.99 |
ENST00000380152.3 ENST00000544455.1 ENST00000530893.2 |
BRCA2 |
breast cancer 2, early onset |
| chr7_-_72936608 | 0.97 |
ENST00000404251.1 |
BAZ1B |
bromodomain adjacent to zinc finger domain, 1B |
| chr11_-_19263145 | 0.95 |
ENST00000532666.1 ENST00000527884.1 |
E2F8 |
E2F transcription factor 8 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.0 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.9 | 2.8 | GO:0032877 | positive regulation of DNA endoreduplication(GO:0032877) |
| 0.1 | 2.8 | GO:0034080 | CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.2 | 2.3 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 0.4 | 2.0 | GO:0033567 | DNA replication, Okazaki fragment processing(GO:0033567) |
| 0.3 | 2.0 | GO:1900262 | regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264) |
| 0.6 | 1.9 | GO:0070512 | regulation of histone H4-K20 methylation(GO:0070510) positive regulation of histone H4-K20 methylation(GO:0070512) |
| 0.2 | 1.8 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.0 | 1.8 | GO:0071349 | interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349) |
| 0.2 | 1.5 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.3 | GO:0000793 | condensed chromosome(GO:0000793) |
| 0.2 | 2.7 | GO:0042555 | MCM complex(GO:0042555) |
| 0.1 | 2.6 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.3 | 2.5 | GO:0031390 | Ctf18 RFC-like complex(GO:0031390) |
| 0.2 | 2.4 | GO:0000796 | condensin complex(GO:0000796) |
| 0.6 | 2.2 | GO:0031436 | BRCA1-BARD1 complex(GO:0031436) |
| 0.0 | 2.0 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.5 | 1.8 | GO:0097135 | cyclin E2-CDK2 complex(GO:0097135) |
| 0.2 | 1.8 | GO:0005664 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.0 | 1.5 | GO:0005814 | centriole(GO:0005814) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.3 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.0 | 3.3 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.1 | 2.7 | GO:0035173 | histone kinase activity(GO:0035173) |
| 0.3 | 2.5 | GO:0003910 | DNA ligase (ATP) activity(GO:0003910) |
| 0.0 | 2.2 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.3 | 2.1 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 0.2 | 2.1 | GO:0033170 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
| 0.1 | 1.7 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.0 | 1.5 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.3 | 1.4 | GO:0004748 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.7 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 6.6 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 3.6 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 2.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 1.9 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 1.7 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 1.4 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.0 | 1.4 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.3 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 1.0 | PID ATM PATHWAY | ATM pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.7 | REACTOME LAGGING STRAND SYNTHESIS | Genes involved in Lagging Strand Synthesis |
| 0.2 | 3.5 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.2 | 3.4 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.1 | 3.3 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.0 | 3.3 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 2.0 | REACTOME APOPTOTIC EXECUTION PHASE | Genes involved in Apoptotic execution phase |
| 0.1 | 1.8 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.0 | 1.6 | REACTOME LATE PHASE OF HIV LIFE CYCLE | Genes involved in Late Phase of HIV Life Cycle |
| 0.0 | 1.5 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 0.1 | 1.4 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |