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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for EBF1
Z-value: 1.94
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Transcription factors associated with EBF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EBF1 | hg19_v2_chr5_-_158526756_158526797 | 0.06 | 8.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of EBF1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_22005018 | 2.02 |
ENST00000546363.1 |
SALL2 |
spalt-like transcription factor 2 |
| chr19_-_51456198 | 1.76 |
ENST00000594846.1 |
KLK5 |
kallikrein-related peptidase 5 |
| chr19_-_51456321 | 1.45 |
ENST00000391809.2 |
KLK5 |
kallikrein-related peptidase 5 |
| chr14_-_22005062 | 1.35 |
ENST00000317492.5 |
SALL2 |
spalt-like transcription factor 2 |
| chr19_-_51456344 | 1.24 |
ENST00000336334.3 ENST00000593428.1 |
KLK5 |
kallikrein-related peptidase 5 |
| chr8_+_22436248 | 1.23 |
ENST00000308354.7 |
PDLIM2 |
PDZ and LIM domain 2 (mystique) |
| chr19_+_35606692 | 1.19 |
ENST00000406242.3 ENST00000454903.2 |
FXYD3 |
FXYD domain containing ion transport regulator 3 |
| chr15_+_41136586 | 1.14 |
ENST00000431806.1 |
SPINT1 |
serine peptidase inhibitor, Kunitz type 1 |
| chr16_-_68269971 | 1.13 |
ENST00000565858.1 |
ESRP2 |
epithelial splicing regulatory protein 2 |
| chr19_+_35739897 | 1.12 |
ENST00000605618.1 ENST00000427250.1 ENST00000601623.1 |
LSR |
lipolysis stimulated lipoprotein receptor |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 5.1 | GO:0002225 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803) |
| 0.8 | 4.0 | GO:1904274 | tricellular tight junction assembly(GO:1904274) |
| 0.0 | 3.0 | GO:0070268 | cornification(GO:0070268) |
| 0.0 | 2.8 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 0.0 | 2.3 | GO:0038095 | Fc-epsilon receptor signaling pathway(GO:0038095) |
| 0.4 | 2.2 | GO:1903282 | negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470) |
| 0.2 | 2.1 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.3 | 1.9 | GO:0070995 | NADPH oxidation(GO:0070995) |
| 0.0 | 1.8 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 0.0 | 1.7 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 5.1 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.1 | 4.2 | GO:0090545 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.4 | 4.0 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.1 | 2.5 | GO:0005861 | troponin complex(GO:0005861) |
| 0.1 | 2.1 | GO:0030057 | desmosome(GO:0030057) |
| 0.1 | 2.1 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.5 | 1.9 | GO:1990031 | pinceau fiber(GO:1990031) |
| 0.1 | 1.6 | GO:0045179 | apical cortex(GO:0045179) |
| 0.0 | 1.4 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 1.4 | GO:0036064 | ciliary basal body(GO:0036064) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 3.3 | GO:0097110 | scaffold protein binding(GO:0097110) |
| 0.2 | 2.6 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.0 | 2.5 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.4 | 2.2 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.4 | 1.9 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.1 | 1.9 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.1 | 1.8 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.2 | 1.6 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
| 0.1 | 1.6 | GO:0002162 | dystroglycan binding(GO:0002162) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 2.2 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 2.2 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 2.1 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 2.0 | PID EPO PATHWAY | EPO signaling pathway |
| 0.0 | 1.8 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 1.6 | PID P73PATHWAY | p73 transcription factor network |
| 0.0 | 1.3 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 1.2 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 1.2 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.2 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 2.0 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 1.8 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 1.7 | REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION | Genes involved in Cyclin E associated events during G1/S transition |
| 0.1 | 1.5 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.1 | 1.4 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 0.0 | 1.4 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.1 | 1.3 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.0 | 1.3 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 1.3 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |