Project
Epithelial-Mesenchymal Transition, human (Scheel, 2011)
Navigation
Downloads
Results for EGR3_EGR2
Z-value: 0.77
Motif logo
Transcription factors associated with EGR3_EGR2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EGR3 | hg19_v2_chr8_-_22550815_22550844 | 0.65 | 7.8e-02 | Click! |
| EGR2 | hg19_v2_chr10_-_64576105_64576133 | 0.43 | 2.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of EGR3_EGR2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_100199800 | 0.62 |
ENST00000223061.5 |
PCOLCE |
procollagen C-endopeptidase enhancer |
| chrX_+_16964794 | 0.58 |
ENST00000357277.3 |
REPS2 |
RALBP1 associated Eps domain containing 2 |
| chr6_+_72596406 | 0.55 |
ENST00000491071.2 |
RIMS1 |
regulating synaptic membrane exocytosis 1 |
| chrX_+_16964985 | 0.51 |
ENST00000303843.7 |
REPS2 |
RALBP1 associated Eps domain containing 2 |
| chr6_+_72596604 | 0.49 |
ENST00000348717.5 ENST00000517960.1 ENST00000518273.1 ENST00000522291.1 ENST00000521978.1 ENST00000520567.1 ENST00000264839.7 |
RIMS1 |
regulating synaptic membrane exocytosis 1 |
| chr18_-_500692 | 0.48 |
ENST00000400256.3 |
COLEC12 |
collectin sub-family member 12 |
| chr1_+_215256467 | 0.41 |
ENST00000391894.2 ENST00000444842.2 |
KCNK2 |
potassium channel, subfamily K, member 2 |
| chrX_-_142722897 | 0.40 |
ENST00000338017.4 |
SLITRK4 |
SLIT and NTRK-like family, member 4 |
| chr20_-_3996165 | 0.39 |
ENST00000545616.2 ENST00000358395.6 |
RNF24 |
ring finger protein 24 |
| chr7_-_100493482 | 0.39 |
ENST00000411582.1 ENST00000419336.2 ENST00000241069.5 ENST00000302913.4 |
ACHE |
acetylcholinesterase (Yt blood group) |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | GO:0097151 | positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828) |
| 0.1 | 0.9 | GO:0021842 | directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) |
| 0.0 | 0.8 | GO:0040036 | regulation of fibroblast growth factor receptor signaling pathway(GO:0040036) |
| 0.0 | 0.8 | GO:0033120 | positive regulation of RNA splicing(GO:0033120) |
| 0.2 | 0.7 | GO:0045212 | negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212) |
| 0.2 | 0.6 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 0.1 | 0.6 | GO:1903361 | protein localization to basolateral plasma membrane(GO:1903361) |
| 0.2 | 0.5 | GO:0044691 | tooth eruption(GO:0044691) |
| 0.1 | 0.5 | GO:0060355 | positive regulation of cell adhesion molecule production(GO:0060355) |
| 0.1 | 0.5 | GO:2001300 | lipoxin metabolic process(GO:2001300) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 0.9 | GO:0030673 | axolemma(GO:0030673) |
| 0.1 | 0.8 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.1 | 0.6 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.0 | 0.6 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.1 | 0.4 | GO:0044305 | calyx of Held(GO:0044305) |
| 0.0 | 0.4 | GO:0043190 | ATP-binding cassette (ABC) transporter complex(GO:0043190) |
| 0.0 | 0.4 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
| 0.0 | 0.4 | GO:0010369 | chromocenter(GO:0010369) |
| 0.1 | 0.3 | GO:1990578 | perinuclear endoplasmic reticulum membrane(GO:1990578) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
| 0.1 | 0.8 | GO:0097108 | hedgehog family protein binding(GO:0097108) |
| 0.0 | 0.8 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.2 | 0.7 | GO:0003990 | acetylcholinesterase activity(GO:0003990) |
| 0.1 | 0.6 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.1 | 0.6 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.0 | 0.6 | GO:0015271 | outward rectifier potassium channel activity(GO:0015271) |
| 0.1 | 0.5 | GO:0016404 | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404) |
| 0.1 | 0.5 | GO:0005534 | galactose binding(GO:0005534) |
| 0.0 | 0.5 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 0.9 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.2 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.0 | 0.1 | PID ALK2 PATHWAY | ALK2 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.7 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.0 | 0.9 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.0 | 0.8 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.6 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.0 | 0.6 | REACTOME CD28 DEPENDENT PI3K AKT SIGNALING | Genes involved in CD28 dependent PI3K/Akt signaling |
| 0.0 | 0.4 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 0.3 | REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.0 | 0.3 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.0 | 0.3 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 0.3 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |