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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for ELF2_GABPA_ELF5
Z-value: 2.30
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Transcription factors associated with ELF2_GABPA_ELF5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ELF2 | hg19_v2_chr4_-_140098339_140098392, hg19_v2_chr4_-_140005341_140005411 | -0.87 | 4.9e-03 | Click! |
| ELF5 | hg19_v2_chr11_-_34535297_34535317 | 0.38 | 3.5e-01 | Click! |
| GABPA | hg19_v2_chr21_+_27107672_27107698 | 0.10 | 8.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ELF2_GABPA_ELF5
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_+_48610074 | 1.82 |
ENST00000503690.1 ENST00000514874.1 ENST00000537145.1 ENST00000541226.1 |
EPN3 |
epsin 3 |
| chr11_-_118122996 | 1.67 |
ENST00000525386.1 ENST00000527472.1 ENST00000278949.4 |
MPZL3 |
myelin protein zero-like 3 |
| chr15_+_91260552 | 1.46 |
ENST00000355112.3 ENST00000560509.1 |
BLM |
Bloom syndrome, RecQ helicase-like |
| chr1_-_52870059 | 1.46 |
ENST00000371566.1 |
ORC1 |
origin recognition complex, subunit 1 |
| chr11_-_62389449 | 1.39 |
ENST00000534026.1 |
B3GAT3 |
beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I) |
| chr2_-_238499337 | 1.38 |
ENST00000411462.1 ENST00000409822.1 |
RAB17 |
RAB17, member RAS oncogene family |
| chr15_+_90744533 | 1.37 |
ENST00000411539.2 |
SEMA4B |
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B |
| chr15_+_41136586 | 1.32 |
ENST00000431806.1 |
SPINT1 |
serine peptidase inhibitor, Kunitz type 1 |
| chr1_-_38273840 | 1.32 |
ENST00000373044.2 |
YRDC |
yrdC N(6)-threonylcarbamoyltransferase domain containing |
| chr15_+_74833518 | 1.30 |
ENST00000346246.5 |
ARID3B |
AT rich interactive domain 3B (BRIGHT-like) |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.9 | GO:0000398 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 0.1 | 6.6 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 0.1 | 6.0 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.1 | 4.5 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.1 | 4.2 | GO:0006409 | tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
| 0.0 | 3.9 | GO:0070268 | cornification(GO:0070268) |
| 0.1 | 3.8 | GO:0006363 | termination of RNA polymerase I transcription(GO:0006363) |
| 0.0 | 3.3 | GO:0006415 | translational termination(GO:0006415) |
| 0.1 | 3.1 | GO:0098534 | centriole assembly(GO:0098534) |
| 0.1 | 2.9 | GO:0030490 | maturation of SSU-rRNA(GO:0030490) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.0 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 4.9 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 4.8 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.2 | 4.6 | GO:0032040 | small-subunit processome(GO:0032040) |
| 0.0 | 4.3 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.0 | 4.0 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 3.4 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 3.2 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 3.2 | GO:0005814 | centriole(GO:0005814) |
| 0.1 | 3.1 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.1 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.1 | 7.4 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186) |
| 0.2 | 5.9 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.0 | 5.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 5.5 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 5.2 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.1 | 4.3 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 0.1 | 2.8 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.0 | 2.8 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.1 | 2.6 | GO:0070628 | proteasome binding(GO:0070628) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.7 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 7.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 5.5 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 4.1 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.1 | 4.0 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 3.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 3.2 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 2.9 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.0 | 2.7 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.0 | 2.5 | PID LKB1 PATHWAY | LKB1 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.4 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 8.1 | REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | Genes involved in Processing of Capped Intron-Containing Pre-mRNA |
| 0.2 | 6.0 | REACTOME DOUBLE STRAND BREAK REPAIR | Genes involved in Double-Strand Break Repair |
| 0.1 | 4.6 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 4.2 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 0.1 | 4.0 | REACTOME RNA POL I TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.1 | 3.9 | REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 0.1 | 3.7 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.2 | 3.3 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.0 | 3.3 | REACTOME HEPARAN SULFATE HEPARIN HS GAG METABOLISM | Genes involved in Heparan sulfate/heparin (HS-GAG) metabolism |