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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for EPAS1_BCL3
Z-value: 2.21
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Transcription factors associated with EPAS1_BCL3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EPAS1 | hg19_v2_chr2_+_46524537_46524553 | 0.83 | 1.0e-02 | Click! |
| BCL3 | hg19_v2_chr19_+_45251804_45251840 | 0.61 | 1.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of EPAS1_BCL3
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_+_57662419 | 4.91 |
ENST00000388812.4 ENST00000538815.1 ENST00000456916.1 ENST00000567154.1 ENST00000388813.5 ENST00000562558.1 ENST00000566271.2 |
GPR56 |
G protein-coupled receptor 56 |
| chr5_+_52776228 | 4.78 |
ENST00000256759.3 |
FST |
follistatin |
| chr5_+_52776449 | 3.48 |
ENST00000396947.3 |
FST |
follistatin |
| chr20_+_44637526 | 3.23 |
ENST00000372330.3 |
MMP9 |
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) |
| chr18_+_61254534 | 3.07 |
ENST00000269489.5 |
SERPINB13 |
serpin peptidase inhibitor, clade B (ovalbumin), member 13 |
| chr3_-_116163830 | 2.79 |
ENST00000333617.4 |
LSAMP |
limbic system-associated membrane protein |
| chr16_+_22825475 | 2.73 |
ENST00000261374.3 |
HS3ST2 |
heparan sulfate (glucosamine) 3-O-sulfotransferase 2 |
| chr6_-_40555176 | 2.73 |
ENST00000338305.6 |
LRFN2 |
leucine rich repeat and fibronectin type III domain containing 2 |
| chr18_+_61254570 | 2.54 |
ENST00000344731.5 |
SERPINB13 |
serpin peptidase inhibitor, clade B (ovalbumin), member 13 |
| chr2_+_102618428 | 2.50 |
ENST00000457817.1 |
IL1R2 |
interleukin 1 receptor, type II |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 9.0 | GO:0032926 | negative regulation of activin receptor signaling pathway(GO:0032926) |
| 0.0 | 6.0 | GO:0007266 | Rho protein signal transduction(GO:0007266) |
| 1.1 | 5.6 | GO:0002415 | immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415) |
| 0.4 | 5.4 | GO:0097283 | keratinocyte apoptotic process(GO:0097283) regulation of keratinocyte apoptotic process(GO:1902172) |
| 0.2 | 4.8 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.0 | 3.6 | GO:0006970 | response to osmotic stress(GO:0006970) |
| 0.4 | 3.2 | GO:2001268 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268) |
| 0.5 | 3.0 | GO:0006196 | AMP catabolic process(GO:0006196) |
| 0.2 | 2.8 | GO:0035641 | locomotory exploration behavior(GO:0035641) |
| 0.2 | 2.7 | GO:1902414 | protein localization to cell junction(GO:1902414) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.6 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 5.6 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 3.4 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 3.1 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 3.0 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.3 | 2.5 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.1 | 2.4 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 0.1 | 2.4 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
| 0.0 | 2.4 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.1 | 2.3 | GO:0030056 | hemidesmosome(GO:0030056) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 8.3 | GO:0048185 | activin binding(GO:0048185) |
| 0.1 | 7.2 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.1 | 5.8 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.1 | 5.0 | GO:0019003 | GDP binding(GO:0019003) |
| 0.3 | 3.3 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.3 | 2.9 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.3 | 2.7 | GO:0008467 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467) |
| 0.5 | 2.5 | GO:0004910 | interleukin-1, Type II, blocking receptor activity(GO:0004910) |
| 0.4 | 2.5 | GO:0042577 | lipid phosphatase activity(GO:0042577) |
| 0.1 | 2.5 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.4 | PID BMP PATHWAY | BMP receptor signaling |
| 0.2 | 4.6 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 4.5 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 3.5 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 3.4 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 3.2 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 2.7 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 2.1 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 2.1 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 2.1 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.7 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.0 | 4.5 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.1 | 3.6 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.1 | 3.4 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 2.9 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.0 | 2.8 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 2.4 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.1 | 2.3 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 2.2 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.0 | 2.2 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |