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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for ESRRA_ESR2
Z-value: 2.42
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Transcription factors associated with ESRRA_ESR2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ESRRA | hg19_v2_chr11_+_64073699_64073918 | 0.89 | 3.1e-03 | Click! |
| ESR2 | hg19_v2_chr14_-_64804814_64804842 | -0.75 | 3.1e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ESRRA_ESR2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_52845910 | 5.61 |
ENST00000252252.3 |
KRT6B |
keratin 6B |
| chr20_+_58251716 | 4.51 |
ENST00000355648.4 |
PHACTR3 |
phosphatase and actin regulator 3 |
| chr17_-_39677971 | 3.86 |
ENST00000393976.2 |
KRT15 |
keratin 15 |
| chr20_+_58152524 | 3.36 |
ENST00000359926.3 |
PHACTR3 |
phosphatase and actin regulator 3 |
| chr2_-_238499303 | 3.35 |
ENST00000409576.1 |
RAB17 |
RAB17, member RAS oncogene family |
| chr14_+_21525981 | 3.32 |
ENST00000308227.2 |
RNASE8 |
ribonuclease, RNase A family, 8 |
| chr19_+_35606692 | 3.00 |
ENST00000406242.3 ENST00000454903.2 |
FXYD3 |
FXYD domain containing ion transport regulator 3 |
| chr18_+_21529811 | 2.92 |
ENST00000588004.1 |
LAMA3 |
laminin, alpha 3 |
| chr19_-_16045665 | 2.83 |
ENST00000248041.8 |
CYP4F11 |
cytochrome P450, family 4, subfamily F, polypeptide 11 |
| chr19_-_6690723 | 2.77 |
ENST00000601008.1 |
C3 |
complement component 3 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.5 | GO:0070268 | cornification(GO:0070268) |
| 2.1 | 10.3 | GO:0002415 | immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415) |
| 0.1 | 9.3 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.3 | 9.1 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 1.6 | 6.6 | GO:0042377 | menaquinone catabolic process(GO:0042361) vitamin K catabolic process(GO:0042377) |
| 0.2 | 6.5 | GO:0007398 | ectoderm development(GO:0007398) |
| 1.1 | 5.4 | GO:1902162 | regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164) |
| 0.9 | 5.4 | GO:0002803 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803) |
| 0.4 | 5.2 | GO:0038203 | TORC2 signaling(GO:0038203) |
| 0.4 | 4.9 | GO:0070257 | positive regulation of mucus secretion(GO:0070257) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.4 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.1 | 9.2 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.4 | 8.7 | GO:0005861 | troponin complex(GO:0005861) |
| 0.1 | 8.3 | GO:0045095 | keratin filament(GO:0045095) |
| 0.2 | 8.1 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 8.1 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 7.9 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 7.4 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.9 | 6.8 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.2 | 6.7 | GO:0030057 | desmosome(GO:0030057) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 14.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.3 | 11.4 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.1 | 9.6 | GO:0019003 | GDP binding(GO:0019003) |
| 0.6 | 8.3 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.1 | 7.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 6.8 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.0 | 6.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 5.9 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.1 | 5.7 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
| 0.1 | 5.6 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.0 | PID P73PATHWAY | p73 transcription factor network |
| 0.0 | 10.1 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.4 | 8.6 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 7.3 | PID TXA2PATHWAY | Thromboxane A2 receptor signaling |
| 0.1 | 5.9 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 5.6 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 4.1 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 3.5 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.1 | 3.4 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 3.0 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.6 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.1 | 8.7 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 7.9 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.1 | 7.5 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.1 | 7.4 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.2 | 6.1 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.2 | 5.4 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.2 | 5.4 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.2 | 5.4 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.3 | 4.8 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |