Project
Epithelial-Mesenchymal Transition, human (Scheel, 2011)
Navigation
Downloads
Results for FOSB
Z-value: 1.23
Motif logo
Transcription factors associated with FOSB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOSB | hg19_v2_chr19_+_45973120_45973171 | -0.35 | 3.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOSB
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr18_+_21452964 | 7.29 |
ENST00000587184.1 |
LAMA3 |
laminin, alpha 3 |
| chr18_+_21452804 | 7.06 |
ENST00000269217.6 |
LAMA3 |
laminin, alpha 3 |
| chr19_-_36004543 | 2.42 |
ENST00000339686.3 ENST00000447113.2 ENST00000440396.1 |
DMKN |
dermokine |
| chr6_+_125540951 | 2.14 |
ENST00000524679.1 |
TPD52L1 |
tumor protein D52-like 1 |
| chr3_-_151034734 | 2.10 |
ENST00000260843.4 |
GPR87 |
G protein-coupled receptor 87 |
| chr11_-_102668879 | 1.90 |
ENST00000315274.6 |
MMP1 |
matrix metallopeptidase 1 (interstitial collagenase) |
| chr1_-_21059029 | 1.89 |
ENST00000444387.2 ENST00000375031.1 ENST00000518294.1 |
SH2D5 |
SH2 domain containing 5 |
| chr11_-_108408895 | 1.86 |
ENST00000443411.1 ENST00000533052.1 |
EXPH5 |
exophilin 5 |
| chr15_+_40531243 | 1.79 |
ENST00000558055.1 ENST00000455577.2 |
PAK6 |
p21 protein (Cdc42/Rac)-activated kinase 6 |
| chr18_+_61442629 | 1.75 |
ENST00000398019.2 ENST00000540675.1 |
SERPINB7 |
serpin peptidase inhibitor, clade B (ovalbumin), member 7 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 16.3 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.0 | 5.6 | GO:0031098 | stress-activated protein kinase signaling cascade(GO:0031098) |
| 0.7 | 4.0 | GO:1903575 | cornified envelope assembly(GO:1903575) |
| 0.0 | 2.4 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.5 | 2.3 | GO:0002159 | desmosome assembly(GO:0002159) |
| 0.5 | 2.3 | GO:0002415 | immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415) |
| 0.5 | 2.1 | GO:0038195 | urokinase plasminogen activator signaling pathway(GO:0038195) |
| 0.1 | 2.1 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.1 | 2.1 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
| 0.4 | 1.8 | GO:0090362 | positive regulation of platelet-derived growth factor production(GO:0090362) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 14.4 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.0 | 3.5 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.1 | 2.8 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.2 | 2.3 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.0 | 2.2 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 1.5 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 1.4 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.1 | 0.9 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.0 | 0.8 | GO:0030315 | T-tubule(GO:0030315) |
| 0.1 | 0.6 | GO:1990796 | photoreceptor cell terminal bouton(GO:1990796) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.7 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.0 | 3.3 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.0 | 2.4 | GO:0019003 | GDP binding(GO:0019003) |
| 0.8 | 2.3 | GO:0030377 | urokinase plasminogen activator receptor activity(GO:0030377) |
| 0.2 | 2.3 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.0 | 2.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 2.1 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.1 | 2.1 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 2.0 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 1.9 | GO:0038132 | neuregulin binding(GO:0038132) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 16.3 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 7.0 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 3.5 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 1.6 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 1.1 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.0 | 1.1 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 1.1 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.0 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 0.6 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 0.4 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.1 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.1 | 3.5 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.1 | 2.3 | REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 0.0 | 2.1 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 1.9 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 1.9 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.0 | 1.7 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 1.0 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.1 | 0.9 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.0 | 0.9 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |