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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for FOSL1
Z-value: 1.79
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Transcription factors associated with FOSL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOSL1 | hg19_v2_chr11_-_65667884_65667895 | 0.47 | 2.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOSL1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr18_+_21452964 | 9.09 |
ENST00000587184.1 |
LAMA3 |
laminin, alpha 3 |
| chr18_+_21452804 | 8.86 |
ENST00000269217.6 |
LAMA3 |
laminin, alpha 3 |
| chr3_-_151034734 | 6.56 |
ENST00000260843.4 |
GPR87 |
G protein-coupled receptor 87 |
| chr1_+_183155373 | 6.05 |
ENST00000493293.1 ENST00000264144.4 |
LAMC2 |
laminin, gamma 2 |
| chr1_+_153003671 | 4.43 |
ENST00000307098.4 |
SPRR1B |
small proline-rich protein 1B |
| chr18_+_61554932 | 4.25 |
ENST00000299502.4 ENST00000457692.1 ENST00000413956.1 |
SERPINB2 |
serpin peptidase inhibitor, clade B (ovalbumin), member 2 |
| chr19_-_36004543 | 4.15 |
ENST00000339686.3 ENST00000447113.2 ENST00000440396.1 |
DMKN |
dermokine |
| chr19_-_35992780 | 4.05 |
ENST00000593342.1 ENST00000601650.1 ENST00000408915.2 |
DMKN |
dermokine |
| chr11_+_394196 | 3.84 |
ENST00000331563.2 ENST00000531857.1 |
PKP3 |
plakophilin 3 |
| chr17_-_39769005 | 3.81 |
ENST00000301653.4 ENST00000593067.1 |
KRT16 |
keratin 16 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 28.9 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.1 | 16.1 | GO:0070268 | cornification(GO:0070268) |
| 0.4 | 11.7 | GO:0061436 | establishment of skin barrier(GO:0061436) |
| 1.4 | 8.2 | GO:1903575 | cornified envelope assembly(GO:1903575) |
| 0.3 | 6.6 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
| 0.0 | 5.7 | GO:0031098 | stress-activated protein kinase signaling cascade(GO:0031098) |
| 0.9 | 4.7 | GO:0002159 | desmosome assembly(GO:0002159) |
| 0.2 | 4.4 | GO:0060670 | branching involved in labyrinthine layer morphogenesis(GO:0060670) |
| 0.1 | 3.9 | GO:0042730 | fibrinolysis(GO:0042730) |
| 1.2 | 3.7 | GO:1904300 | positive regulation of neutrophil degranulation(GO:0043315) cellular response to gravity(GO:0071258) positive regulation of neutrophil activation(GO:1902565) regulation of transcytosis(GO:1904298) positive regulation of transcytosis(GO:1904300) regulation of maternal process involved in parturition(GO:1904301) positive regulation of maternal process involved in parturition(GO:1904303) response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904316) cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904317) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 21.2 | GO:0001533 | cornified envelope(GO:0001533) |
| 2.4 | 19.6 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.0 | 8.3 | GO:0001650 | fibrillar center(GO:0001650) |
| 2.0 | 6.0 | GO:0005607 | laminin-2 complex(GO:0005607) |
| 0.1 | 4.2 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.1 | 3.9 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 3.2 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.1 | 3.1 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 3.0 | GO:0015030 | Cajal body(GO:0015030) |
| 0.1 | 2.9 | GO:0031932 | TORC2 complex(GO:0031932) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 26.8 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.1 | 17.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 10.3 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.4 | 10.2 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.0 | 7.2 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.0 | 4.6 | GO:0008201 | heparin binding(GO:0008201) |
| 0.0 | 4.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.3 | 3.8 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.3 | 3.5 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.2 | 3.3 | GO:0045294 | alpha-catenin binding(GO:0045294) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 27.8 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 9.5 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 4.4 | PID P73PATHWAY | p73 transcription factor network |
| 0.0 | 4.1 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 3.9 | PID AVB3 OPN PATHWAY | Osteopontin-mediated events |
| 0.0 | 3.9 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 2.7 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 2.6 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.1 | 2.5 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.3 | 2.1 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 32.2 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.4 | 9.7 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.1 | 3.6 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.0 | 3.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 3.1 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.0 | 3.1 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.1 | 2.7 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 2.4 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 1.9 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.1 | 1.9 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |