ISMARA results: FOXD3_FOXI1

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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for FOXD3_FOXI1_FOXF1

Z-value: 1.09

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Transcription factors associated with FOXD3_FOXI1_FOXF1

Gene Symbol	Gene ID	Gene Info
FOXD3 Ensembl NCBI GeneCards UniProt	ENSG00000187140.4	FOXD3
FOXI1 Ensembl NCBI GeneCards UniProt	ENSG00000168269.7	FOXI1
FOXF1 Ensembl NCBI GeneCards UniProt	ENSG00000103241.5	FOXF1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
FOXI1	hg19_v2_chr5_+_169532896_169532917	0.86	6.3e-03	Click!
FOXF1	hg19_v2_chr16_+_86544113_86544145	-0.67	7.2e-02	Click!
FOXD3	hg19_v2_chr1_+_63788730_63788730	-0.35	3.9e-01	Click!

Activity profile of FOXD3_FOXI1_FOXF1 motif

Sorted Z-values of FOXD3_FOXI1_FOXF1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXD3_FOXI1_FOXF1

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr8_+_97597148	2.27	ENST00000521590.1	SDC2	syndecan 2
chr8_-_108510224	1.87	ENST00000517746.1 ENST00000297450.3	ANGPT1	angiopoietin 1
chr12_-_15038779	1.70	ENST00000228938.5 ENST00000539261.1	MGP	matrix Gla protein
chr17_-_19290483	1.50	ENST00000395592.2 ENST00000299610.4	MFAP4	microfibrillar-associated protein 4
chr1_-_57045228	1.32	ENST00000371250.3	PPAP2B	phosphatidic acid phosphatase type 2B
chr18_-_52626622	1.21	ENST00000591504.1	CCDC68	coiled-coil domain containing 68
chr14_-_92414055	1.17	ENST00000342058.4	FBLN5	fibulin 5
chr4_-_186696425	1.11	ENST00000430503.1 ENST00000319454.6 ENST00000450341.1	SORBS2	sorbin and SH3 domain containing 2
chr9_-_95244781	0.96	ENST00000375544.3 ENST00000375543.1 ENST00000395538.3 ENST00000450139.2	ASPN	asporin
chr8_+_104384616	0.93	ENST00000520337.1	CTHRC1	collagen triple helix repeat containing 1

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	2.6	GO:0008218	bioluminescence(GO:0008218)
0.2	2.5	GO:0048251	elastic fiber assembly(GO:0048251)
0.1	2.2	GO:0007021	tubulin complex assembly(GO:0007021)
0.2	1.6	GO:0048014	Tie signaling pathway(GO:0048014)
0.2	1.6	GO:0043932	ossification involved in bone remodeling(GO:0043932)
0.1	1.6	GO:0001502	cartilage condensation(GO:0001502)
0.1	1.4	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1	1.1	GO:0035583	sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.1	1.1	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.2	1.0	GO:0070171	negative regulation of tooth mineralization(GO:0070171)

Showing 1 to 10 of 205 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.0	GO:0005796	Golgi lumen(GO:0005796)
0.3	2.7	GO:0071953	elastic fiber(GO:0071953)
0.1	2.1	GO:0097512	cardiac myofibril(GO:0097512)
0.1	1.4	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	1.3	GO:0005902	microvillus(GO:0005902)
0.0	1.1	GO:0001527	microfibril(GO:0001527) fibril(GO:0043205)
0.0	1.0	GO:1904724	tertiary granule lumen(GO:1904724)
0.0	0.9	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.1	0.8	GO:0030478	actin cap(GO:0030478)
0.0	0.8	GO:0032839	dendrite cytoplasm(GO:0032839)

Showing 1 to 10 of 62 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.0	GO:0030165	PDZ domain binding(GO:0030165)
0.0	2.8	GO:0005518	collagen binding(GO:0005518)
0.1	2.3	GO:0005212	structural constituent of eye lens(GO:0005212)
0.0	2.0	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.1	1.5	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	1.4	GO:0017147	Wnt-protein binding(GO:0017147)
0.3	1.1	GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.0	0.9	GO:1905030	voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.2	0.8	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404)
0.2	0.8	GO:0050436	microfibril binding(GO:0050436)

Showing 1 to 10 of 126 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
3.4	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
3.0	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
2.8	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
1.5	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
1.4	PID WNT SIGNALING PATHWAY	Wnt signaling network
1.1	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
1.0	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.9	PID HIV NEF PATHWAY	HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.8	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.7	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling

Showing 1 to 10 of 20 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.8	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.1	1.4	REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0	1.4	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.0	1.3	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0	1.1	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.9	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	0.9	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.0	0.8	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.0	0.7	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.0	0.7	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation

Showing 1 to 10 of 24 entries

Results for FOXD3_FOXI1_FOXF1

Z-value: 1.09

Motif logo

Transcription factors associated with FOXD3_FOXI1_FOXF1

Activity-expression correlation:

Activity profile of FOXD3_FOXI1_FOXF1 motif

Sorted Z-values of FOXD3_FOXI1_FOXF1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXD3_FOXI1_FOXF1

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: