ISMARA results: GATA2

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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for GATA2

Z-value: 1.53

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Transcription factors associated with GATA2

Gene Symbol	Gene ID	Gene Info
GATA2 Ensembl NCBI GeneCards UniProt	ENSG00000179348.7	GATA2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
GATA2	hg19_v2_chr3_-_128206759_128206781	-0.64	8.9e-02	Click!

Activity profile of GATA2 motif

Sorted Z-values of GATA2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA2

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr12_-_91546926	3.67	ENST00000550758.1	DCN	decorin
chr12_-_91573132	2.96	ENST00000550563.1 ENST00000546370.1	DCN	decorin
chr1_+_78956651	2.44	ENST00000370757.3 ENST00000370756.3	PTGFR	prostaglandin F receptor (FP)
chr13_+_102142296	2.38	ENST00000376162.3	ITGBL1	integrin, beta-like 1 (with EGF-like repeat domains)
chr2_-_202562774	1.96	ENST00000396886.3 ENST00000409143.1	MPP4	membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr1_+_114522049	1.78	ENST00000369551.1 ENST00000320334.4	OLFML3	olfactomedin-like 3
chr5_-_20575959	1.70	ENST00000507958.1	CDH18	cadherin 18, type 2
chr10_+_69865866	1.66	ENST00000354393.2	MYPN	myopalladin
chr20_+_34802295	1.64	ENST00000432603.1	EPB41L1	erythrocyte membrane protein band 4.1-like 1
chr12_-_91572278	1.57	ENST00000425043.1 ENST00000420120.2 ENST00000441303.2 ENST00000456569.2	DCN	decorin

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	8.8	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.3	3.6	GO:0034465	response to carbon monoxide(GO:0034465)
0.4	2.8	GO:0036072	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1	2.7	GO:0048739	cardiac muscle fiber development(GO:0048739)
0.0	2.6	GO:0034332	adherens junction organization(GO:0034332)
0.3	2.4	GO:0071798	response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.0	2.1	GO:0030866	cortical actin cytoskeleton organization(GO:0030866)
0.2	2.0	GO:1903944	regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.0	1.8	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.1	1.7	GO:0070208	protein heterotrimerization(GO:0070208)

Showing 1 to 10 of 248 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	9.0	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	3.4	GO:0005901	caveola(GO:0005901)
0.2	2.2	GO:0005583	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	2.2	GO:1904724	tertiary granule lumen(GO:1904724)
0.0	2.2	GO:0044309	neuron spine(GO:0044309)
0.1	2.0	GO:0031265	CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342)
0.0	1.7	GO:0097610	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1	1.5	GO:0071565	nBAF complex(GO:0071565)
0.0	1.5	GO:0035577	azurophil granule membrane(GO:0035577)
0.0	1.0	GO:0043218	compact myelin(GO:0043218)

Showing 1 to 10 of 109 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	9.2	GO:0050840	extracellular matrix binding(GO:0050840)
0.5	3.6	GO:0060072	large conductance calcium-activated potassium channel activity(GO:0060072)
0.8	2.4	GO:0004958	prostaglandin F receptor activity(GO:0004958)
0.1	2.2	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.3	2.1	GO:0015057	thrombin receptor activity(GO:0015057)
0.1	2.0	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.1	1.8	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	1.8	GO:0005178	integrin binding(GO:0005178)
0.3	1.6	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	1.4	GO:0005179	hormone activity(GO:0005179)

Showing 1 to 10 of 160 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	11.5	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1	2.1	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.1	2.1	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	2.0	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.0	1.9	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.0	1.9	NABA COLLAGENS	Genes encoding collagen proteins
0.0	1.9	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.0	1.7	PID E2F PATHWAY	E2F transcription factor network
0.0	1.4	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.0	1.3	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)

Showing 1 to 10 of 26 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	8.9	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.2	2.4	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.1	2.4	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	2.1	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.1	2.0	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.1	2.0	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.1	1.7	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.0	1.7	REACTOME TRAFFICKING OF AMPA RECEPTORS	Genes involved in Trafficking of AMPA receptors
0.0	1.6	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	1.5	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions

Showing 1 to 10 of 41 entries

Results for GATA2

Z-value: 1.53

Motif logo

Transcription factors associated with GATA2

Activity-expression correlation:

Activity profile of GATA2 motif

Sorted Z-values of GATA2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA2

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: