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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for GATA3
Z-value: 1.22
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Transcription factors associated with GATA3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GATA3 | hg19_v2_chr10_+_8096631_8096660 | 0.58 | 1.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of GATA3
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr22_-_30866564 | 0.90 |
ENST00000435069.1 ENST00000415957.2 ENST00000540910.1 |
SEC14L3 |
SEC14-like 3 (S. cerevisiae) |
| chr1_+_171060018 | 0.86 |
ENST00000367755.4 ENST00000392085.2 ENST00000542847.1 ENST00000538429.1 ENST00000479749.1 |
FMO3 |
flavin containing monooxygenase 3 |
| chr2_+_128177458 | 0.80 |
ENST00000409048.1 ENST00000422777.3 |
PROC |
protein C (inactivator of coagulation factors Va and VIIIa) |
| chr9_+_90112117 | 0.77 |
ENST00000358077.5 |
DAPK1 |
death-associated protein kinase 1 |
| chr8_-_93029865 | 0.76 |
ENST00000422361.2 |
RUNX1T1 |
runt-related transcription factor 1; translocated to, 1 (cyclin D-related) |
| chr16_+_55512742 | 0.75 |
ENST00000568715.1 ENST00000219070.4 |
MMP2 |
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) |
| chr11_-_35547151 | 0.72 |
ENST00000378878.3 ENST00000529303.1 ENST00000278360.3 |
PAMR1 |
peptidase domain containing associated with muscle regeneration 1 |
| chr3_-_121379739 | 0.69 |
ENST00000428394.2 ENST00000314583.3 |
HCLS1 |
hematopoietic cell-specific Lyn substrate 1 |
| chr20_+_12989596 | 0.68 |
ENST00000434210.1 ENST00000399002.2 |
SPTLC3 |
serine palmitoyltransferase, long chain base subunit 3 |
| chr12_+_56075330 | 0.65 |
ENST00000394252.3 |
METTL7B |
methyltransferase like 7B |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.7 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.1 | 2.0 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.1 | 1.7 | GO:0071447 | cellular response to hydroperoxide(GO:0071447) |
| 0.1 | 1.5 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.0 | 1.5 | GO:2001275 | positive regulation of glucose import in response to insulin stimulus(GO:2001275) |
| 0.0 | 1.5 | GO:0045599 | negative regulation of fat cell differentiation(GO:0045599) |
| 0.1 | 1.4 | GO:0097151 | positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828) |
| 0.0 | 1.4 | GO:0070126 | mitochondrial translational termination(GO:0070126) |
| 0.4 | 1.3 | GO:0044537 | regulation of circulating fibrinogen levels(GO:0044537) |
| 0.1 | 1.3 | GO:1901748 | leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 2.2 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.1 | 2.0 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.0 | 2.0 | GO:0030018 | Z disc(GO:0030018) |
| 0.1 | 1.9 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.0 | 1.6 | GO:0033176 | proton-transporting V-type ATPase complex(GO:0033176) |
| 0.0 | 1.4 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.0 | 1.3 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.1 | 1.1 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.0 | 1.1 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.8 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 4.1 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 2.1 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.1 | 1.9 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 1.6 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.1 | 1.4 | GO:1990459 | transferrin receptor binding(GO:1990459) |
| 0.1 | 1.3 | GO:0036374 | glutathione hydrolase activity(GO:0036374) |
| 0.0 | 1.3 | GO:0005527 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.0 | 1.3 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.2 | 1.2 | GO:0018479 | benzaldehyde dehydrogenase (NAD+) activity(GO:0018479) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.8 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.8 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.0 | 1.8 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 1.6 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 1.4 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 1.4 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.0 | 1.3 | PID FOXO PATHWAY | FoxO family signaling |
| 0.0 | 1.1 | ST GA13 PATHWAY | G alpha 13 Pathway |
| 0.0 | 0.9 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 0.9 | PID BMP PATHWAY | BMP receptor signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.4 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 2.3 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 2.1 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.0 | 2.1 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 2.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 1.8 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 1.7 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.0 | 1.7 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 1.7 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 1.4 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |