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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for GGAAUGU
Z-value: 1.08
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miRNA associated with seed GGAAUGU
Network of associatons between targets according to the STRING database.
First level regulatory network of GGAAUGU
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_-_172756506 | 1.86 |
ENST00000265087.4 |
STC2 |
stanniocalcin 2 |
| chr1_-_92351769 | 1.32 |
ENST00000212355.4 |
TGFBR3 |
transforming growth factor, beta receptor III |
| chr6_-_139695757 | 1.07 |
ENST00000367651.2 |
CITED2 |
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 |
| chr17_+_38599693 | 1.02 |
ENST00000542955.1 ENST00000269593.4 |
IGFBP4 |
insulin-like growth factor binding protein 4 |
| chr4_-_39640700 | 1.02 |
ENST00000295958.5 |
SMIM14 |
small integral membrane protein 14 |
| chr2_+_201170703 | 0.99 |
ENST00000358677.5 |
SPATS2L |
spermatogenesis associated, serine-rich 2-like |
| chr8_+_17354587 | 0.97 |
ENST00000494857.1 ENST00000522656.1 |
SLC7A2 |
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 |
| chr7_+_120628731 | 0.95 |
ENST00000310396.5 |
CPED1 |
cadherin-like and PC-esterase domain containing 1 |
| chr5_-_9546180 | 0.92 |
ENST00000382496.5 |
SEMA5A |
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A |
| chr18_-_70535177 | 0.83 |
ENST00000327305.6 |
NETO1 |
neuropilin (NRP) and tolloid (TLL)-like 1 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.9 | GO:2001256 | regulation of store-operated calcium entry(GO:2001256) |
| 0.0 | 1.6 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.1 | 1.5 | GO:0048843 | negative regulation of axon extension involved in axon guidance(GO:0048843) |
| 0.3 | 1.3 | GO:0034699 | transforming growth factor beta receptor complex assembly(GO:0007181) response to luteinizing hormone(GO:0034699) |
| 0.0 | 1.2 | GO:0016601 | Rac protein signal transduction(GO:0016601) |
| 0.3 | 1.1 | GO:0061428 | negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428) |
| 0.3 | 1.0 | GO:0034226 | lysine import(GO:0034226) L-lysine import(GO:0061461) L-lysine import into cell(GO:1903410) |
| 0.0 | 1.0 | GO:0070884 | regulation of calcineurin-NFAT signaling cascade(GO:0070884) |
| 0.0 | 0.9 | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568) |
| 0.3 | 0.8 | GO:0009051 | pentose-phosphate shunt, oxidative branch(GO:0009051) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.3 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
| 0.1 | 0.8 | GO:0098839 | postsynaptic density membrane(GO:0098839) |
| 0.0 | 0.8 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.2 | 0.6 | GO:0042585 | germinal vesicle(GO:0042585) |
| 0.1 | 0.6 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.0 | 0.5 | GO:0097524 | sperm plasma membrane(GO:0097524) |
| 0.0 | 0.5 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 0.5 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 0.1 | 0.4 | GO:0060201 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.0 | 0.4 | GO:0017059 | serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | GO:0005179 | hormone activity(GO:0005179) |
| 0.1 | 1.3 | GO:0005114 | type II transforming growth factor beta receptor binding(GO:0005114) |
| 0.1 | 1.1 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.1 | 1.1 | GO:0050693 | LBD domain binding(GO:0050693) |
| 0.2 | 1.0 | GO:0005287 | high-affinity basic amino acid transmembrane transporter activity(GO:0005287) high-affinity arginine transmembrane transporter activity(GO:0005289) high-affinity lysine transmembrane transporter activity(GO:0005292) |
| 0.0 | 1.0 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.2 | 0.9 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
| 0.0 | 0.9 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.0 | 0.8 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.1 | 0.7 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 0.8 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.6 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 0.5 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 0.3 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.0 | 0.3 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.2 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 0.2 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 0.1 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.0 | 0.1 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 0.9 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 0.9 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 0.7 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 0.6 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.0 | 0.6 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.0 | 0.6 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 0.6 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 0.6 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 0.5 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |