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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for GLI2
Z-value: 1.41
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Transcription factors associated with GLI2
Network of associatons between targets according to the STRING database.
First level regulatory network of GLI2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_118550346 | 2.91 |
ENST00000530256.1 |
TREH |
trehalase (brush-border membrane glycoprotein) |
| chr11_-_118550375 | 2.55 |
ENST00000525958.1 ENST00000264029.4 ENST00000397925.1 ENST00000529101.1 |
TREH |
trehalase (brush-border membrane glycoprotein) |
| chr3_+_45067659 | 2.15 |
ENST00000296130.4 |
CLEC3B |
C-type lectin domain family 3, member B |
| chr5_-_9546180 | 1.89 |
ENST00000382496.5 |
SEMA5A |
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A |
| chr9_+_90112767 | 1.56 |
ENST00000408954.3 |
DAPK1 |
death-associated protein kinase 1 |
| chr21_-_45079341 | 1.55 |
ENST00000443485.1 ENST00000291560.2 |
HSF2BP |
heat shock transcription factor 2 binding protein |
| chr9_+_90112741 | 1.44 |
ENST00000469640.2 |
DAPK1 |
death-associated protein kinase 1 |
| chr4_-_57524061 | 1.42 |
ENST00000508121.1 |
HOPX |
HOP homeobox |
| chrX_-_51812268 | 1.40 |
ENST00000486010.1 ENST00000497164.1 ENST00000360134.6 ENST00000485287.1 ENST00000335504.5 ENST00000431659.1 |
MAGED4B |
melanoma antigen family D, 4B |
| chr12_-_56101647 | 1.39 |
ENST00000347027.6 ENST00000257879.6 ENST00000257880.7 ENST00000394230.2 ENST00000394229.2 |
ITGA7 |
integrin, alpha 7 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 5.5 | GO:0005984 | disaccharide metabolic process(GO:0005984) |
| 0.1 | 4.8 | GO:0001895 | retina homeostasis(GO:0001895) |
| 0.1 | 3.0 | GO:0071447 | cellular response to hydroperoxide(GO:0071447) |
| 0.3 | 2.2 | GO:0010756 | positive regulation of plasminogen activation(GO:0010756) |
| 0.6 | 1.9 | GO:0044537 | regulation of circulating fibrinogen levels(GO:0044537) |
| 0.1 | 1.9 | GO:0048843 | negative regulation of axon extension involved in axon guidance(GO:0048843) |
| 0.2 | 1.8 | GO:0070236 | negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.1 | 1.7 | GO:0098828 | positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828) |
| 0.0 | 1.5 | GO:0061014 | positive regulation of mRNA catabolic process(GO:0061014) |
| 0.2 | 1.4 | GO:0060154 | cellular process regulating host cell cycle in response to virus(GO:0060154) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.7 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.0 | 2.5 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.4 | 2.2 | GO:0001652 | granular component(GO:0001652) |
| 0.2 | 1.6 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
| 0.0 | 1.6 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 0.1 | 1.4 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.0 | 1.4 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.1 | 1.2 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
| 0.1 | 1.2 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
| 0.0 | 1.2 | GO:0043198 | dendritic shaft(GO:0043198) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.1 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.0 | 4.6 | GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553) |
| 0.1 | 3.2 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.0 | 2.2 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.2 | 2.0 | GO:0043426 | MRF binding(GO:0043426) |
| 0.5 | 1.9 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
| 0.2 | 1.9 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.1 | 1.6 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.1 | 1.3 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
| 0.0 | 1.3 | GO:0070300 | phosphatidic acid binding(GO:0070300) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.2 | PID IFNG PATHWAY | IFN-gamma pathway |
| 0.0 | 2.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.2 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 1.9 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 1.8 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 1.3 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.0 | 1.2 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 0.8 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 0.8 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 0.8 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 5.8 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.3 | 3.8 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.1 | 2.9 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.1 | 2.0 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.1 | 1.9 | REACTOME INFLAMMASOMES | Genes involved in Inflammasomes |
| 0.0 | 1.4 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 1.3 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.0 | 1.0 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 0.9 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 0.9 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |