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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for HAND1

Z-value: 0.25

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Transcription factors associated with HAND1

Gene Symbol Gene ID Gene Info
HAND1
ENSG00000113196.2 HAND1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HAND1hg19_v2_chr5_-_153857819_1538578240.029.5e-01Click!

Activity profile of HAND1 motif

Sorted Z-values of HAND1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HAND1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr3_+_141103634 0.16 ENST00000507722.1
 ZBTB38
 zinc finger and BTB domain containing 38
chr19_+_12862604 0.16 ENST00000553030.1
 BEST2
 bestrophin 2
chr19_+_12862486 0.15 ENST00000549706.1
 BEST2
 bestrophin 2
chr19_+_36359341 0.15 ENST00000221891.4
 APLP1
 amyloid beta (A4) precursor-like protein 1
chr10_+_99344071 0.14 ENST00000370647.4
ENST00000370646.4
 HOGA1
 4-hydroxy-2-oxoglutarate aldolase 1
chr3_+_148415571 0.13 ENST00000497524.1
ENST00000349243.3
ENST00000542281.1
ENST00000418473.2
ENST00000404754.2
 AGTR1
 angiotensin II receptor, type 1
chr14_-_53331239 0.11 ENST00000553663.1
 FERMT2
 fermitin family member 2
chr5_-_147286065 0.11 ENST00000318315.4
ENST00000515291.1
 C5orf46
 chromosome 5 open reading frame 46
chr2_+_210444142 0.10 ENST00000360351.4
ENST00000361559.4
 MAP2
 microtubule-associated protein 2
chr20_-_56285595 0.10 ENST00000395816.3
ENST00000347215.4
 PMEPA1
 prostate transmembrane protein, androgen induced 1
chr20_-_56286479 0.10 ENST00000265626.4
 PMEPA1
 prostate transmembrane protein, androgen induced 1
chr20_-_1165117 0.10 ENST00000381894.3
 TMEM74B
 transmembrane protein 74B
chr17_-_64216748 0.09 ENST00000585162.1
 APOH
 apolipoprotein H (beta-2-glycoprotein I)
chr6_-_39282221 0.09 ENST00000453413.2
 KCNK17
 potassium channel, subfamily K, member 17
chr6_-_39282329 0.08 ENST00000373231.4
 KCNK17
 potassium channel, subfamily K, member 17
chr1_+_110036728 0.08 ENST00000369868.3
ENST00000430195.2
 CYB561D1
 cytochrome b561 family, member D1
chrX_+_149531524 0.08 ENST00000370401.2
 MAMLD1
 mastermind-like domain containing 1
chr6_+_6588902 0.08 ENST00000230568.4
 LY86
 lymphocyte antigen 86
chrX_+_49832231 0.08 ENST00000376108.3
 CLCN5
 chloride channel, voltage-sensitive 5
chr1_+_164528866 0.07 ENST00000420696.2
 PBX1
 pre-B-cell leukemia homeobox 1
chr12_+_110338063 0.07 ENST00000405876.4
 TCHP
 trichoplein, keratin filament binding
chr1_+_65775204 0.07 ENST00000371069.4
 DNAJC6
 DnaJ (Hsp40) homolog, subfamily C, member 6
chrX_-_34675391 0.07 ENST00000275954.3
 TMEM47
 transmembrane protein 47
chr6_+_124125286 0.07 ENST00000368416.1
ENST00000368417.1
ENST00000546092.1
 NKAIN2
 Na+/K+ transporting ATPase interacting 2
chr2_+_228678550 0.07 ENST00000409189.3
ENST00000358813.4
 CCL20
 chemokine (C-C motif) ligand 20
chr1_+_110036699 0.06 ENST00000496961.1
ENST00000533024.1
ENST00000310611.4
ENST00000527072.1
ENST00000420578.2
ENST00000528785.1
 CYB561D1
 cytochrome b561 family, member D1
chr8_+_79428539 0.06 ENST00000352966.5
 PKIA
 protein kinase (cAMP-dependent, catalytic) inhibitor alpha
chr7_-_142207004 0.06 ENST00000426318.2
 TRBV10-2
 T cell receptor beta variable 10-2
chr1_-_32210275 0.06 ENST00000440175.2
 BAI2
 brain-specific angiogenesis inhibitor 2
chr6_-_87804815 0.06 ENST00000369582.2
 CGA
 glycoprotein hormones, alpha polypeptide
chr2_-_197791441 0.06 ENST00000409475.1
ENST00000354764.4
ENST00000374738.3
 PGAP1
 post-GPI attachment to proteins 1
chr10_+_72972281 0.06 ENST00000335350.6
 UNC5B
 unc-5 homolog B (C. elegans)
chr16_-_10652993 0.06 ENST00000536829.1
 EMP2
 epithelial membrane protein 2
chr2_+_201997676 0.06 ENST00000462763.1
ENST00000479953.2
 CFLAR
 CASP8 and FADD-like apoptosis regulator
chr11_+_67171358 0.05 ENST00000526387.1
 TBC1D10C
 TBC1 domain family, member 10C
chr11_+_67171391 0.05 ENST00000312390.5
 TBC1D10C
 TBC1 domain family, member 10C
chr5_-_41870621 0.05 ENST00000196371.5
 OXCT1
 3-oxoacid CoA transferase 1
chr11_+_67171548 0.05 ENST00000542590.1
 TBC1D10C
 TBC1 domain family, member 10C
chr12_+_121131970 0.05 ENST00000535656.1
 MLEC
 malectin
chr16_-_89556942 0.05 ENST00000301030.4
 ANKRD11
 ankyrin repeat domain 11
chr7_-_81399411 0.05 ENST00000423064.2
 HGF
 hepatocyte growth factor (hepapoietin A; scatter factor)
chr11_-_2323290 0.05 ENST00000381153.3
 C11orf21
 chromosome 11 open reading frame 21
chr19_-_10213335 0.05 ENST00000592641.1
ENST00000253109.4
 ANGPTL6
 angiopoietin-like 6
chr3_-_114035026 0.05 ENST00000570269.1
 RP11-553L6.5
 RP11-553L6.5
chr6_+_134210243 0.05 ENST00000367882.4
 TCF21
 transcription factor 21
chr20_+_29956369 0.05 ENST00000253381.2
 DEFB118
 defensin, beta 118
chr9_+_72658490 0.04 ENST00000377182.4
 MAMDC2
 MAM domain containing 2
chr9_-_35828576 0.04 ENST00000377984.2
ENST00000423537.2
ENST00000472182.1
 FAM221B
 family with sequence similarity 221, member B
chr7_-_116963334 0.04 ENST00000265441.3
 WNT2
 wingless-type MMTV integration site family member 2
chr22_+_31518938 0.04 ENST00000412985.1
ENST00000331075.5
ENST00000412277.2
ENST00000420017.1
ENST00000400294.2
ENST00000405300.1
ENST00000404390.3
 INPP5J
 inositol polyphosphate-5-phosphatase J
chr5_+_167913450 0.04 ENST00000231572.3
ENST00000538719.1
 RARS
 arginyl-tRNA synthetase
chr9_-_25678856 0.04 ENST00000358022.3
 TUSC1
 tumor suppressor candidate 1
chr11_+_101785727 0.04 ENST00000263468.8
 KIAA1377
 KIAA1377
chr12_+_26111823 0.04 ENST00000381352.3
ENST00000535907.1
ENST00000405154.2
 RASSF8
 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr1_-_11007927 0.04 ENST00000468348.1
 C1orf127
 chromosome 1 open reading frame 127
chr4_+_41614720 0.04 ENST00000509277.1
 LIMCH1
 LIM and calponin homology domains 1
chr1_-_214638146 0.04 ENST00000543945.1
 PTPN14
 protein tyrosine phosphatase, non-receptor type 14
chr11_-_64527425 0.03 ENST00000377432.3
 PYGM
 phosphorylase, glycogen, muscle
chr1_-_155904187 0.03 ENST00000368321.3
ENST00000368320.3
 KIAA0907
 KIAA0907
chr2_+_231860830 0.03 ENST00000424440.1
ENST00000452881.1
ENST00000433428.2
ENST00000455816.1
ENST00000440792.1
ENST00000423134.1
 SPATA3
 spermatogenesis associated 3
chr14_+_74083548 0.03 ENST00000381139.1
 ACOT6
 acyl-CoA thioesterase 6
chr8_-_93029520 0.03 ENST00000521553.1
 RUNX1T1
 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr7_-_2883928 0.03 ENST00000275364.3
 GNA12
 guanine nucleotide binding protein (G protein) alpha 12
chr12_-_57630873 0.03 ENST00000556732.1
 NDUFA4L2
 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr3_-_157251383 0.03 ENST00000487753.1
ENST00000489602.1
ENST00000461299.1
ENST00000479987.1
 VEPH1
 ventricular zone expressed PH domain-containing 1
chr1_+_27719148 0.03 ENST00000374024.3
 GPR3
 G protein-coupled receptor 3
chr5_+_143584814 0.03 ENST00000507359.3
 KCTD16
 potassium channel tetramerization domain containing 16
chr10_+_118350468 0.03 ENST00000358834.4
ENST00000528052.1
ENST00000442761.1
 PNLIPRP1
 pancreatic lipase-related protein 1
chr10_+_118350522 0.03 ENST00000530319.1
ENST00000527980.1
ENST00000471549.1
ENST00000534537.1
 PNLIPRP1
 pancreatic lipase-related protein 1
chr7_+_76139833 0.03 ENST00000257632.5
 UPK3B
 uroplakin 3B
chr6_+_44191507 0.03 ENST00000371724.1
ENST00000371713.1
 SLC29A1
 solute carrier family 29 (equilibrative nucleoside transporter), member 1
chr14_-_106642049 0.03 ENST00000390605.2
 IGHV1-18
 immunoglobulin heavy variable 1-18
chr2_+_201997492 0.02 ENST00000494258.1
 CFLAR
 CASP8 and FADD-like apoptosis regulator
chr8_-_93029865 0.02 ENST00000422361.2
 RUNX1T1
 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr12_-_7261772 0.02 ENST00000545280.1
ENST00000543933.1
ENST00000545337.1
ENST00000544702.1
ENST00000266542.4
 C1RL
 complement component 1, r subcomponent-like
chr11_-_26743546 0.02 ENST00000280467.6
ENST00000396005.3
 SLC5A12
 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
chr19_-_55866061 0.02 ENST00000588572.2
ENST00000593184.1
ENST00000589467.1
 COX6B2
 cytochrome c oxidase subunit VIb polypeptide 2 (testis)
chr2_+_201997595 0.02 ENST00000470178.2
 CFLAR
 CASP8 and FADD-like apoptosis regulator
chr3_-_20227619 0.02 ENST00000425061.1
ENST00000443724.1
ENST00000421451.1
ENST00000452020.1
ENST00000417364.1
ENST00000306698.2
ENST00000419233.2
ENST00000263753.4
ENST00000383774.1
ENST00000437051.1
ENST00000412868.1
ENST00000429446.3
ENST00000442720.1
 SGOL1
 shugoshin-like 1 (S. pombe)
chr17_-_36358166 0.02 ENST00000537432.1
 TBC1D3
 TBC1 domain family, member 3
chr17_+_45908974 0.02 ENST00000269025.4
 LRRC46
 leucine rich repeat containing 46
chr2_-_128784846 0.02 ENST00000259235.3
ENST00000357702.5
ENST00000424298.1
 SAP130
 Sin3A-associated protein, 130kDa
chr17_+_53342311 0.02 ENST00000226067.5
 HLF
 hepatic leukemia factor
chr10_+_82297658 0.02 ENST00000339284.2
 SH2D4B
 SH2 domain containing 4B
chr10_-_118032697 0.02 ENST00000439649.3
 GFRA1
 GDNF family receptor alpha 1
chr2_-_159237472 0.02 ENST00000409187.1
 CCDC148
 coiled-coil domain containing 148
chrX_+_70364667 0.02 ENST00000536169.1
ENST00000395855.2
ENST00000374051.3
ENST00000358741.3
 NLGN3
 neuroligin 3
chr11_+_2323349 0.02 ENST00000381121.3
 TSPAN32
 tetraspanin 32
chr20_+_22034809 0.02 ENST00000449427.1
 RP11-125P18.1
 RP11-125P18.1
chr14_-_74892805 0.02 ENST00000331628.3
ENST00000554953.1
 SYNDIG1L
 synapse differentiation inducing 1-like
chr20_+_123010 0.02 ENST00000382398.3
 DEFB126
 defensin, beta 126
chr1_+_202091980 0.02 ENST00000367282.5
 GPR37L1
 G protein-coupled receptor 37 like 1
chr6_+_6588316 0.02 ENST00000379953.2
 LY86
 lymphocyte antigen 86
chr7_+_140378955 0.02 ENST00000473512.1
 ADCK2
 aarF domain containing kinase 2
chr19_+_47421933 0.02 ENST00000404338.3
 ARHGAP35
 Rho GTPase activating protein 35
chr21_+_34602377 0.01 ENST00000342101.3
ENST00000413881.1
ENST00000443073.1
 IFNAR2
 interferon (alpha, beta and omega) receptor 2
chr1_-_52344471 0.01 ENST00000352171.7
ENST00000354831.7
 NRD1
 nardilysin (N-arginine dibasic convertase)
chr6_-_53013620 0.01 ENST00000259803.7
 GCM1
 glial cells missing homolog 1 (Drosophila)
chr12_+_68042517 0.01 ENST00000393555.3
 DYRK2
 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr15_-_31393910 0.01 ENST00000397795.2
ENST00000256552.6
ENST00000559179.1
 TRPM1
 transient receptor potential cation channel, subfamily M, member 1
chr1_+_215747118 0.01 ENST00000448333.1
 KCTD3
 potassium channel tetramerization domain containing 3
chr12_+_68042495 0.01 ENST00000344096.3
 DYRK2
 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr4_-_40632605 0.01 ENST00000514014.1
 RBM47
 RNA binding motif protein 47
chr16_+_6069664 0.01 ENST00000422070.4
 RBFOX1
 RNA binding protein, fox-1 homolog (C. elegans) 1
chr12_-_53730147 0.01 ENST00000536324.2
 SP7
 Sp7 transcription factor
chr16_+_70328680 0.01 ENST00000563206.1
ENST00000451014.3
ENST00000568625.1
 DDX19B
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B
chr17_+_7836398 0.01 ENST00000565740.1
 CNTROB
 centrobin, centrosomal BRCA2 interacting protein
chr17_+_6347761 0.01 ENST00000250056.8
ENST00000571373.1
ENST00000570337.2
ENST00000572595.2
ENST00000576056.1
 FAM64A
 family with sequence similarity 64, member A
chr7_-_141957847 0.01 ENST00000552471.1
ENST00000547058.2
 PRSS58
 protease, serine, 58
chr17_+_6347729 0.01 ENST00000572447.1
 FAM64A
 family with sequence similarity 64, member A
chr2_-_89597542 0.01 ENST00000465170.1
 IGKV1-37
 immunoglobulin kappa variable 1-37 (non-functional)
chr12_+_53848505 0.01 ENST00000552819.1
ENST00000455667.3
 PCBP2
 poly(rC) binding protein 2
chr22_-_24093267 0.01 ENST00000341976.3
 ZNF70
 zinc finger protein 70
chr12_-_53729525 0.01 ENST00000303846.3
 SP7
 Sp7 transcription factor
chr17_-_43025005 0.01 ENST00000587309.1
ENST00000593135.1
ENST00000339151.4
 KIF18B
 kinesin family member 18B
chr16_-_28608424 0.01 ENST00000335715.4
 SULT1A2
 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr1_-_54405773 0.01 ENST00000371376.1
 HSPB11
 heat shock protein family B (small), member 11
chr2_+_204732487 0.01 ENST00000302823.3
 CTLA4
 cytotoxic T-lymphocyte-associated protein 4
chr19_-_37701386 0.01 ENST00000527838.1
ENST00000591492.1
ENST00000532828.2
 ZNF585B
 zinc finger protein 585B
chr6_-_117923610 0.01 ENST00000535237.1
ENST00000052569.6
 GOPC
 golgi-associated PDZ and coiled-coil motif containing
chrX_-_133930285 0.01 ENST00000486347.1
ENST00000343004.5
 FAM122B
 family with sequence similarity 122B
chr4_-_25161996 0.01 ENST00000513285.1
ENST00000382103.2
 SEPSECS
 Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
chr3_+_112051994 0.01 ENST00000473539.1
ENST00000315711.8
ENST00000383681.3
 CD200
 CD200 molecule
chr10_+_103113802 0.01 ENST00000370187.3
 BTRC
 beta-transducin repeat containing E3 ubiquitin protein ligase
chr18_+_12407895 0.01 ENST00000590956.1
ENST00000336990.4
ENST00000440960.1
ENST00000588729.1
 SLMO1
 slowmo homolog 1 (Drosophila)
chr12_-_25801478 0.01 ENST00000540106.1
ENST00000445693.1
ENST00000545543.1
ENST00000542224.1
 IFLTD1
 intermediate filament tail domain containing 1
chr3_-_15382875 0.01 ENST00000408919.3
 SH3BP5
 SH3-domain binding protein 5 (BTK-associated)
chr2_+_204732666 0.01 ENST00000295854.6
ENST00000472206.1
 CTLA4
 cytotoxic T-lymphocyte-associated protein 4
chr16_+_56969284 0.01 ENST00000568358.1
 HERPUD1
 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr14_-_93673353 0.01 ENST00000556566.1
ENST00000306954.4
 C14orf142
 chromosome 14 open reading frame 142
chr12_+_67663056 0.01 ENST00000545606.1
 CAND1
 cullin-associated and neddylation-dissociated 1
chr11_+_118826999 0.01 ENST00000264031.2
 UPK2
 uroplakin 2
chr2_+_90153696 0.01 ENST00000417279.2
 IGKV3D-15
 immunoglobulin kappa variable 3D-15 (gene/pseudogene)
chr20_+_3713314 0.00 ENST00000254963.2
ENST00000542646.1
ENST00000399701.1
 HSPA12B
 heat shock 70kD protein 12B
chr21_+_34602200 0.00 ENST00000382264.3
ENST00000382241.3
ENST00000404220.3
ENST00000342136.4
 IFNAR2
 interferon (alpha, beta and omega) receptor 2
chr12_-_68647281 0.00 ENST00000328087.4
ENST00000538666.1
 IL22
 interleukin 22
chr3_+_123813509 0.00 ENST00000460856.1
ENST00000240874.3
 KALRN
 kalirin, RhoGEF kinase
chr15_+_45028753 0.00 ENST00000338264.4
 TRIM69
 tripartite motif containing 69
chr1_-_102462565 0.00 ENST00000370103.4
 OLFM3
 olfactomedin 3
chr3_+_46919235 0.00 ENST00000449590.1
 PTH1R
 parathyroid hormone 1 receptor
chr11_+_369804 0.00 ENST00000329962.6
 B4GALNT4
 beta-1,4-N-acetyl-galactosaminyl transferase 4
chr2_-_208031943 0.00 ENST00000421199.1
ENST00000457962.1
 KLF7
 Kruppel-like factor 7 (ubiquitous)
chr7_+_96634850 0.00 ENST00000518156.2
 DLX6
 distal-less homeobox 6
chr4_-_25162188 0.00 ENST00000302922.3
 SEPSECS
 Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
chr10_+_103113840 0.00 ENST00000393441.4
ENST00000408038.2
 BTRC
 beta-transducin repeat containing E3 ubiquitin protein ligase
chr7_-_81399329 0.00 ENST00000453411.1
ENST00000444829.2
 HGF
 hepatocyte growth factor (hepapoietin A; scatter factor)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0009436 glyoxylate catabolic process(GO:0009436)
0.0 0.1 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.0 0.1 GO:0071874 cellular response to norepinephrine stimulus(GO:0071874)
0.0 0.2 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0 0.1 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.0 0.2 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.0 GO:0060435 branchiomeric skeletal muscle development(GO:0014707) bronchiole development(GO:0060435)
0.0 0.1 GO:0046952 ketone body catabolic process(GO:0046952)
0.0 0.1 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.0 0.1 GO:1903944 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.0 0.1 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.0 0.1 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.0 0.1 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.0 0.1 GO:0008410 CoA-transferase activity(GO:0008410)
0.0 0.1 GO:0060230 lipoprotein lipase activator activity(GO:0060230)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels