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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for HIC1
Z-value: 1.57
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Transcription factors associated with HIC1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HIC1 | hg19_v2_chr17_+_1959369_1959604, hg19_v2_chr17_+_1958388_1958404 | 0.39 | 3.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HIC1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_176237478 | 1.32 |
ENST00000329542.4 |
UNC5A |
unc-5 homolog A (C. elegans) |
| chr2_+_7057523 | 1.29 |
ENST00000320892.6 |
RNF144A |
ring finger protein 144A |
| chr6_+_56819773 | 0.88 |
ENST00000370750.2 |
BEND6 |
BEN domain containing 6 |
| chr11_-_2160611 | 0.84 |
ENST00000416167.2 |
IGF2 |
insulin-like growth factor 2 (somatomedin A) |
| chr2_+_241938255 | 0.81 |
ENST00000401884.1 ENST00000405547.3 ENST00000310397.8 ENST00000342631.6 |
SNED1 |
sushi, nidogen and EGF-like domains 1 |
| chr11_+_65779283 | 0.72 |
ENST00000312134.2 |
CST6 |
cystatin E/M |
| chr6_-_46459099 | 0.71 |
ENST00000371374.1 |
RCAN2 |
regulator of calcineurin 2 |
| chr1_-_184006611 | 0.70 |
ENST00000546159.1 |
COLGALT2 |
collagen beta(1-O)galactosyltransferase 2 |
| chr20_-_62462566 | 0.67 |
ENST00000245663.4 ENST00000302995.2 |
ZBTB46 |
zinc finger and BTB domain containing 46 |
| chrX_-_142722897 | 0.67 |
ENST00000338017.4 |
SLITRK4 |
SLIT and NTRK-like family, member 4 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | GO:0045746 | negative regulation of Notch signaling pathway(GO:0045746) |
| 0.2 | 1.3 | GO:0033564 | anterior/posterior axon guidance(GO:0033564) |
| 0.1 | 1.1 | GO:2001300 | lipoxin metabolic process(GO:2001300) |
| 0.1 | 1.1 | GO:0098828 | positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828) |
| 0.2 | 1.0 | GO:0021834 | chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration(GO:0021834) |
| 0.1 | 1.0 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
| 0.0 | 0.9 | GO:0001829 | trophectodermal cell differentiation(GO:0001829) |
| 0.1 | 0.8 | GO:0030853 | negative regulation of granulocyte differentiation(GO:0030853) |
| 0.2 | 0.7 | GO:0021966 | corticospinal neuron axon guidance(GO:0021966) |
| 0.2 | 0.7 | GO:2000230 | negative regulation of pancreatic stellate cell proliferation(GO:2000230) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | GO:0043679 | axon terminus(GO:0043679) |
| 0.0 | 1.4 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 1.1 | GO:0032809 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.0 | 1.0 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 1.0 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 0.8 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 0.7 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 0.7 | GO:0005605 | basal lamina(GO:0005605) |
| 0.0 | 0.6 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.1 | 0.5 | GO:0098845 | postsynaptic endosome(GO:0098845) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.0 | 1.4 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.3 | 1.2 | GO:0016404 | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404) |
| 0.1 | 1.0 | GO:0048495 | Roundabout binding(GO:0048495) |
| 0.1 | 0.9 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.1 | 0.9 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.2 | 0.8 | GO:0050211 | procollagen galactosyltransferase activity(GO:0050211) |
| 0.2 | 0.7 | GO:0086062 | voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062) |
| 0.2 | 0.7 | GO:0098782 | mechanically-gated potassium channel activity(GO:0098782) |
| 0.1 | 0.7 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 1.5 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 1.1 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 1.0 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.8 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.7 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 0.5 | PID AVB3 OPN PATHWAY | Osteopontin-mediated events |
| 0.0 | 0.4 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 0.2 | PID FOXO PATHWAY | FoxO family signaling |
| 0.0 | 0.2 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.3 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.1 | 1.3 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 1.1 | REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.0 | 1.0 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 0.9 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.0 | 0.9 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.0 | 0.7 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 0.0 | 0.6 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 0.6 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 0.5 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |