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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for HMGA2

Z-value: 0.28

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Transcription factors associated with HMGA2

Gene Symbol Gene ID Gene Info
HMGA2
ENSG00000149948.9 HMGA2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HMGA2hg19_v2_chr12_+_66218212_662182440.521.9e-01Click!

Activity profile of HMGA2 motif

Sorted Z-values of HMGA2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HMGA2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr15_+_43885252 0.46 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
 CKMT1B
 creatine kinase, mitochondrial 1B
chr15_+_43985084 0.45 ENST00000434505.1
ENST00000411750.1
 CKMT1A
 creatine kinase, mitochondrial 1A
chr5_+_36608422 0.21 ENST00000381918.3
 SLC1A3
 solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr10_-_129691195 0.14 ENST00000368671.3
 CLRN3
 clarin 3
chr19_-_43099070 0.13 ENST00000244336.5
 CEACAM8
 carcinoembryonic antigen-related cell adhesion molecule 8
chr15_+_30375158 0.12 ENST00000341650.6
ENST00000567927.1
 GOLGA8J
 golgin A8 family, member J
chr6_+_111580508 0.12 ENST00000368847.4
 KIAA1919
 KIAA1919
chr2_-_130031335 0.11 ENST00000375987.3
 AC079586.1
 AC079586.1
chr17_-_76220740 0.11 ENST00000600484.1
 AC087645.1
 Uncharacterized protein
chr3_+_193853927 0.11 ENST00000232424.3
 HES1
 hes family bHLH transcription factor 1
chrX_+_135614293 0.10 ENST00000370634.3
 VGLL1
 vestigial like 1 (Drosophila)
chr3_+_121774202 0.08 ENST00000469710.1
ENST00000493101.1
ENST00000330540.2
ENST00000264468.5
 CD86
 CD86 molecule
chr15_+_88120158 0.08 ENST00000560153.1
 LINC00052
 long intergenic non-protein coding RNA 52
chr15_-_82939157 0.08 ENST00000559949.1
 RP13-996F3.5
 golgin A6 family-like 18
chr15_+_30427352 0.07 ENST00000569052.1
 GOLGA8T
 golgin A8 family, member T
chr11_+_73661364 0.06 ENST00000339764.1
 DNAJB13
 DnaJ (Hsp40) homolog, subfamily B, member 13
chr9_-_86955598 0.06 ENST00000376238.4
 SLC28A3
 solute carrier family 28 (concentrative nucleoside transporter), member 3
chr6_-_136571400 0.06 ENST00000418509.2
ENST00000420702.1
ENST00000451457.2
 MTFR2
 mitochondrial fission regulator 2
chr15_-_83018198 0.06 ENST00000557886.1
 RP13-996F3.4
 golgin A6 family-like 19
chr9_-_34397800 0.06 ENST00000297623.2
 C9orf24
 chromosome 9 open reading frame 24
chr19_-_36297632 0.06 ENST00000588266.2
 PRODH2
 proline dehydrogenase (oxidase) 2
chr10_-_5046042 0.06 ENST00000421196.3
ENST00000455190.1
 AKR1C2
 aldo-keto reductase family 1, member C2
chr15_+_84904525 0.05 ENST00000510439.2
 GOLGA6L4
 golgin A6 family-like 4
chrX_+_117480036 0.05 ENST00000371822.5
ENST00000254029.3
ENST00000371825.3
 WDR44
 WD repeat domain 44
chr14_+_50291993 0.05 ENST00000595378.1
 AL627171.2
 HCG1786899; PRO2610; Uncharacterized protein
chr2_-_287299 0.05 ENST00000405290.1
 FAM150B
 family with sequence similarity 150, member B
chr9_+_108463234 0.05 ENST00000374688.1
 TMEM38B
 transmembrane protein 38B
chrX_-_77150911 0.05 ENST00000373336.3
 MAGT1
 magnesium transporter 1
chr12_+_21207503 0.04 ENST00000545916.1
 SLCO1B7
 solute carrier organic anion transporter family, member 1B7 (non-functional)
chr2_+_177134134 0.04 ENST00000249442.6
ENST00000392529.2
ENST00000443241.1
 MTX2
 metaxin 2
chr2_+_120436733 0.04 ENST00000401466.1
ENST00000424086.1
ENST00000272521.6
 TMEM177
 transmembrane protein 177
chr22_+_22676808 0.04 ENST00000390290.2
 IGLV1-51
 immunoglobulin lambda variable 1-51
chr2_+_177134201 0.04 ENST00000452865.1
 MTX2
 metaxin 2
chr6_-_29324054 0.04 ENST00000543825.1
 OR5V1
 olfactory receptor, family 5, subfamily V, member 1
chr6_-_32908792 0.04 ENST00000418107.2
 HLA-DMB
 major histocompatibility complex, class II, DM beta
chr5_-_135290705 0.03 ENST00000274507.1
 LECT2
 leukocyte cell-derived chemotaxin 2
chr6_+_123110302 0.03 ENST00000368440.4
 SMPDL3A
 sphingomyelin phosphodiesterase, acid-like 3A
chr10_-_36813162 0.03 ENST00000440465.1
 NAMPTL
 nicotinamide phosphoribosyltransferase-like
chr12_+_69979113 0.03 ENST00000299300.6
 CCT2
 chaperonin containing TCP1, subunit 2 (beta)
chr15_+_83098710 0.03 ENST00000561062.1
ENST00000358583.3
 GOLGA6L9
 golgin A6 family-like 20
chr10_-_62332357 0.03 ENST00000503366.1
 ANK3
 ankyrin 3, node of Ranvier (ankyrin G)
chr17_-_48785216 0.03 ENST00000285243.6
 ANKRD40
 ankyrin repeat domain 40
chr2_-_287320 0.03 ENST00000401503.1
 FAM150B
 family with sequence similarity 150, member B
chr2_+_1417228 0.03 ENST00000382269.3
ENST00000337415.3
ENST00000345913.4
ENST00000346956.3
ENST00000349624.3
ENST00000539820.1
ENST00000329066.4
ENST00000382201.3
 TPO
 thyroid peroxidase
chr18_-_21017817 0.03 ENST00000542162.1
ENST00000383233.3
ENST00000582336.1
ENST00000450466.2
ENST00000578520.1
ENST00000399707.1
 TMEM241
 transmembrane protein 241
chr15_+_82722225 0.03 ENST00000300515.8
 GOLGA6L9
 golgin A6 family-like 9
chr4_+_184826418 0.03 ENST00000308497.4
ENST00000438269.1
 STOX2
 storkhead box 2
chrX_+_1710484 0.03 ENST00000313871.3
ENST00000381261.3
 AKAP17A
 A kinase (PRKA) anchor protein 17A
chr5_+_150827143 0.03 ENST00000243389.3
ENST00000517945.1
ENST00000521925.1
 SLC36A1
 solute carrier family 36 (proton/amino acid symporter), member 1
chr12_+_69979210 0.03 ENST00000544368.2
 CCT2
 chaperonin containing TCP1, subunit 2 (beta)
chrX_-_23926004 0.03 ENST00000379226.4
ENST00000379220.3
 APOO
 apolipoprotein O
chr12_-_21757774 0.02 ENST00000261195.2
 GYS2
 glycogen synthase 2 (liver)
chr3_-_106959424 0.02 ENST00000607801.1
ENST00000479612.2
ENST00000484698.1
ENST00000477210.2
ENST00000473636.1
 LINC00882
 long intergenic non-protein coding RNA 882
chr7_-_102985288 0.02 ENST00000379263.3
 DNAJC2
 DnaJ (Hsp40) homolog, subfamily C, member 2
chr2_-_239140011 0.02 ENST00000409376.1
ENST00000409070.1
ENST00000409942.1
 AC016757.3
 Protein LOC151174
chr1_-_43638168 0.02 ENST00000431635.2
 EBNA1BP2
 EBNA1 binding protein 2
chr6_-_52705641 0.02 ENST00000370989.2
 GSTA5
 glutathione S-transferase alpha 5
chr6_-_32908765 0.02 ENST00000416244.2
 HLA-DMB
 major histocompatibility complex, class II, DM beta
chr17_-_38911580 0.02 ENST00000312150.4
 KRT25
 keratin 25
chr19_-_1650666 0.02 ENST00000588136.1
 TCF3
 transcription factor 3
chr14_-_65409502 0.02 ENST00000389614.5
 GPX2
 glutathione peroxidase 2 (gastrointestinal)
chr10_+_96305535 0.02 ENST00000419900.1
ENST00000348459.5
ENST00000394045.1
ENST00000394044.1
ENST00000394036.1
 HELLS
 helicase, lymphoid-specific
chr11_+_60163775 0.02 ENST00000300187.6
ENST00000395005.2
 MS4A14
 membrane-spanning 4-domains, subfamily A, member 14
chr20_-_31989307 0.02 ENST00000473997.1
ENST00000544843.1
ENST00000346416.2
ENST00000357886.4
ENST00000339269.5
 CDK5RAP1
 CDK5 regulatory subunit associated protein 1
chr20_+_48884002 0.02 ENST00000425497.1
ENST00000445003.1
 RP11-290F20.3
 RP11-290F20.3
chr15_+_58702742 0.02 ENST00000356113.6
ENST00000414170.3
 LIPC
 lipase, hepatic
chr14_+_45553296 0.02 ENST00000355765.6
ENST00000553605.1
 PRPF39
 pre-mRNA processing factor 39
chr19_-_11456935 0.01 ENST00000590788.1
ENST00000586590.1
ENST00000589555.1
ENST00000586956.1
ENST00000593256.2
ENST00000447337.1
ENST00000591677.1
ENST00000586701.1
ENST00000589655.1
 TMEM205
RAB3D
 transmembrane protein 205
RAB3D, member RAS oncogene family
chr15_+_28623784 0.01 ENST00000526619.2
ENST00000337838.7
ENST00000532622.2
 GOLGA8F
 golgin A8 family, member F
chr1_+_64014588 0.01 ENST00000371086.2
ENST00000340052.3
 DLEU2L
 deleted in lymphocytic leukemia 2-like
chr2_-_89266286 0.01 ENST00000464162.1
 IGKV1-6
 immunoglobulin kappa variable 1-6
chr19_+_44455368 0.01 ENST00000591168.1
ENST00000587682.1
ENST00000251269.5
 ZNF221
 zinc finger protein 221
chr18_-_14132422 0.01 ENST00000589498.1
ENST00000590202.1
 ZNF519
 zinc finger protein 519
chrX_-_77150985 0.01 ENST00000358075.6
 MAGT1
 magnesium transporter 1
chr15_-_70994612 0.01 ENST00000558758.1
ENST00000379983.2
ENST00000560441.1
 UACA
 uveal autoantigen with coiled-coil domains and ankyrin repeats
chr14_+_99947715 0.01 ENST00000389879.5
ENST00000557441.1
ENST00000555049.1
ENST00000555842.1
 CCNK
 cyclin K
chr6_+_88106840 0.01 ENST00000369570.4
 C6orf164
 chromosome 6 open reading frame 164
chr12_+_113587558 0.01 ENST00000335621.6
 CCDC42B
 coiled-coil domain containing 42B
chr14_-_94759361 0.01 ENST00000393096.1
 SERPINA10
 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr14_-_94759408 0.01 ENST00000554723.1
 SERPINA10
 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr12_-_122750957 0.01 ENST00000451053.2
 VPS33A
 vacuolar protein sorting 33 homolog A (S. cerevisiae)
chr4_+_25378912 0.00 ENST00000510092.1
ENST00000505991.1
 ANAPC4
 anaphase promoting complex subunit 4
chr12_-_8765446 0.00 ENST00000537228.1
ENST00000229335.6
 AICDA
 activation-induced cytidine deaminase
chr11_-_130786400 0.00 ENST00000265909.4
 SNX19
 sorting nexin 19
chr6_+_29426230 0.00 ENST00000442615.1
 OR2H1
 olfactory receptor, family 2, subfamily H, member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 GO:0006600 creatine metabolic process(GO:0006600)
0.0 0.1 GO:0042668 trochlear nerve development(GO:0021558) auditory receptor cell fate determination(GO:0042668) negative regulation of auditory receptor cell differentiation(GO:0045608) regulation of timing of neuron differentiation(GO:0060164) negative regulation of pro-B cell differentiation(GO:2000974)
0.0 0.2 GO:0006537 glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0 0.1 GO:0002644 negative regulation of tolerance induction(GO:0002644) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.0 0.1 GO:0051086 chaperone mediated protein folding independent of cofactor(GO:0051086)
0.0 0.1 GO:2001190 positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.0 0.1 GO:1904158 axonemal central apparatus assembly(GO:1904158)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.1 GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389)
0.0 0.1 GO:0004657 proline dehydrogenase activity(GO:0004657)