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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for HOXA2_HOXB1

Z-value: 0.47

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Transcription factors associated with HOXA2_HOXB1

Gene Symbol Gene ID Gene Info
HOXA2
ENSG00000105996.5 HOXA2
HOXB1
ENSG00000120094.6 HOXB1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXA2hg19_v2_chr7_-_27142290_271424300.865.9e-03Click!
HOXB1hg19_v2_chr17_-_46608272_46608385-0.423.0e-01Click!

Activity profile of HOXA2_HOXB1 motif

Sorted Z-values of HOXA2_HOXB1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA2_HOXB1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr15_-_93616340 0.76 ENST00000557420.1
ENST00000542321.2
 RGMA
 repulsive guidance molecule family member a
chr15_-_93616892 0.52 ENST00000556658.1
ENST00000538818.1
ENST00000425933.2
 RGMA
 repulsive guidance molecule family member a
chr2_-_190044480 0.49 ENST00000374866.3
 COL5A2
 collagen, type V, alpha 2
chr12_-_15038779 0.49 ENST00000228938.5
ENST00000539261.1
 MGP
 matrix Gla protein
chr1_-_182641367 0.31 ENST00000508450.1
 RGS8
 regulator of G-protein signaling 8
chr11_-_2162162 0.28 ENST00000381389.1
 IGF2
 insulin-like growth factor 2 (somatomedin A)
chr1_-_108507631 0.26 ENST00000527011.1
ENST00000370056.4
 VAV3
 vav 3 guanine nucleotide exchange factor
chr12_+_21679220 0.25 ENST00000256969.2
 C12orf39
 chromosome 12 open reading frame 39
chr11_-_111782484 0.25 ENST00000533971.1
 CRYAB
 crystallin, alpha B
chr5_+_147582348 0.25 ENST00000514389.1
 SPINK6
 serine peptidase inhibitor, Kazal type 6
chr11_-_111782696 0.24 ENST00000227251.3
ENST00000526180.1
 CRYAB
 crystallin, alpha B
chr1_-_92351769 0.22 ENST00000212355.4
 TGFBR3
 transforming growth factor, beta receptor III
chr2_-_45236540 0.20 ENST00000303077.6
 SIX2
 SIX homeobox 2
chr6_+_151561085 0.18 ENST00000402676.2
 AKAP12
 A kinase (PRKA) anchor protein 12
chr1_-_182642017 0.16 ENST00000367557.4
ENST00000258302.4
 RGS8
 regulator of G-protein signaling 8
chr10_+_95848824 0.16 ENST00000371385.3
ENST00000371375.1
 PLCE1
 phospholipase C, epsilon 1
chr16_+_15596123 0.16 ENST00000452191.2
 C16orf45
 chromosome 16 open reading frame 45
chr6_+_151561506 0.15 ENST00000253332.1
 AKAP12
 A kinase (PRKA) anchor protein 12
chr2_+_12857043 0.14 ENST00000381465.2
 TRIB2
 tribbles pseudokinase 2
chr2_-_145278475 0.14 ENST00000558170.2
 ZEB2
 zinc finger E-box binding homeobox 2
chr17_+_39975455 0.14 ENST00000455106.1
 FKBP10
 FK506 binding protein 10, 65 kDa
chr2_+_12857015 0.14 ENST00000155926.4
 TRIB2
 tribbles pseudokinase 2
chr17_+_39975544 0.13 ENST00000544340.1
 FKBP10
 FK506 binding protein 10, 65 kDa
chr7_-_150864635 0.13 ENST00000297537.4
 GBX1
 gastrulation brain homeobox 1
chr10_-_79397202 0.13 ENST00000372437.1
ENST00000372408.2
ENST00000372403.4
 KCNMA1
 potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr20_+_34802295 0.12 ENST00000432603.1
 EPB41L1
 erythrocyte membrane protein band 4.1-like 1
chr10_-_79397316 0.12 ENST00000372421.5
ENST00000457953.1
 KCNMA1
 potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr17_+_58755184 0.11 ENST00000589222.1
ENST00000407086.3
ENST00000390652.5
 BCAS3
 breast carcinoma amplified sequence 3
chr5_-_10761206 0.10 ENST00000432074.2
ENST00000230895.6
 DAP
 death-associated protein
chr5_+_162864575 0.10 ENST00000512163.1
ENST00000393929.1
ENST00000340828.2
ENST00000511683.2
ENST00000510097.1
ENST00000511490.2
ENST00000510664.1
 CCNG1
 cyclin G1
chr7_-_27142290 0.10 ENST00000222718.5
 HOXA2
 homeobox A2
chr19_-_45735138 0.10 ENST00000252482.3
 EXOC3L2
 exocyst complex component 3-like 2
chr10_-_79397479 0.09 ENST00000404771.3
 KCNMA1
 potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr10_-_98945677 0.09 ENST00000266058.4
ENST00000371041.3
 SLIT1
 slit homolog 1 (Drosophila)
chr16_+_85645007 0.09 ENST00000405402.2
 GSE1
 Gse1 coiled-coil protein
chr4_-_90757364 0.09 ENST00000508895.1
 SNCA
 synuclein, alpha (non A4 component of amyloid precursor)
chr10_-_75457554 0.09 ENST00000374094.4
ENST00000443782.2
 AGAP5
 ArfGAP with GTPase domain, ankyrin repeat and PH domain 5
chr16_-_49890016 0.09 ENST00000563137.2
 ZNF423
 zinc finger protein 423
chrX_+_99899180 0.09 ENST00000373004.3
 SRPX2
 sushi-repeat containing protein, X-linked 2
chr19_+_35849723 0.09 ENST00000594310.1
 FFAR3
 free fatty acid receptor 3
chr4_-_90756769 0.09 ENST00000345009.4
ENST00000505199.1
ENST00000502987.1
 SNCA
 synuclein, alpha (non A4 component of amyloid precursor)
chr2_-_154335300 0.08 ENST00000325926.3
 RPRM
 reprimo, TP53 dependent G2 arrest mediator candidate
chrX_-_13835147 0.08 ENST00000493677.1
ENST00000355135.2
 GPM6B
 glycoprotein M6B
chr9_-_73029540 0.08 ENST00000377126.2
 KLF9
 Kruppel-like factor 9
chr4_+_129732467 0.07 ENST00000413543.2
 PHF17
 jade family PHD finger 1
chr17_-_42277203 0.07 ENST00000587097.1
 ATXN7L3
 ataxin 7-like 3
chr2_-_200323414 0.07 ENST00000443023.1
 SATB2
 SATB homeobox 2
chr17_-_42276574 0.07 ENST00000589805.1
 ATXN7L3
 ataxin 7-like 3
chr2_+_26624775 0.07 ENST00000288710.2
 DRC1
 dynein regulatory complex subunit 1 homolog (Chlamydomonas)
chr2_-_200322723 0.06 ENST00000417098.1
 SATB2
 SATB homeobox 2
chr4_-_113437328 0.06 ENST00000313341.3
 NEUROG2
 neurogenin 2
chr5_-_125930929 0.06 ENST00000553117.1
ENST00000447989.2
ENST00000409134.3
 ALDH7A1
 aldehyde dehydrogenase 7 family, member A1
chr7_-_14029283 0.06 ENST00000433547.1
ENST00000405192.2
 ETV1
 ets variant 1
chr1_+_178062855 0.06 ENST00000448150.3
 RASAL2
 RAS protein activator like 2
chrX_-_13835461 0.06 ENST00000316715.4
ENST00000356942.5
 GPM6B
 glycoprotein M6B
chr20_+_34742650 0.06 ENST00000373945.1
ENST00000338074.2
 EPB41L1
 erythrocyte membrane protein band 4.1-like 1
chr2_-_145277882 0.06 ENST00000465070.1
ENST00000444559.1
 ZEB2
 zinc finger E-box binding homeobox 2
chr7_-_144107320 0.06 ENST00000483238.1
ENST00000467773.1
 NOBOX
 NOBOX oogenesis homeobox
chr1_-_67390474 0.06 ENST00000371023.3
ENST00000371022.3
ENST00000371026.3
ENST00000431318.1
 WDR78
 WD repeat domain 78
chr11_+_57365150 0.05 ENST00000457869.1
ENST00000340687.6
ENST00000378323.4
ENST00000378324.2
ENST00000403558.1
 SERPING1
 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr7_-_27170352 0.05 ENST00000428284.2
ENST00000360046.5
 HOXA4
 homeobox A4
chr7_-_14029515 0.05 ENST00000430479.1
ENST00000405218.2
ENST00000343495.5
 ETV1
 ets variant 1
chr7_+_26591441 0.05 ENST00000420912.1
ENST00000457000.1
ENST00000430426.1
 AC004947.2
 AC004947.2
chr7_-_100881041 0.05 ENST00000412417.1
ENST00000414035.1
 CLDN15
 claudin 15
chr6_-_112575687 0.05 ENST00000521398.1
ENST00000424408.2
ENST00000243219.3
 LAMA4
 laminin, alpha 4
chr19_+_44645700 0.05 ENST00000592437.1
 ZNF234
 zinc finger protein 234
chr9_-_73477826 0.05 ENST00000396285.1
ENST00000396292.4
ENST00000396280.5
ENST00000358082.3
ENST00000408909.2
ENST00000377097.3
 TRPM3
 transient receptor potential cation channel, subfamily M, member 3
chr6_+_32006042 0.05 ENST00000418967.2
 CYP21A2
 cytochrome P450, family 21, subfamily A, polypeptide 2
chr5_+_133861790 0.05 ENST00000395003.1
 PHF15
 jade family PHD finger 2
chr10_+_102891048 0.04 ENST00000467928.2
 TLX1
 T-cell leukemia homeobox 1
chr11_-_126870655 0.04 ENST00000525144.2
 KIRREL3
 kin of IRRE like 3 (Drosophila)
chr6_+_32006159 0.04 ENST00000478281.1
ENST00000471671.1
ENST00000435122.2
 CYP21A2
 cytochrome P450, family 21, subfamily A, polypeptide 2
chr2_-_197226875 0.04 ENST00000409111.1
 HECW2
 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chr9_+_44867571 0.04 ENST00000377548.2
 RP11-160N1.10
 RP11-160N1.10
chr10_-_65028817 0.04 ENST00000542921.1
 JMJD1C
 jumonji domain containing 1C
chr3_+_191046810 0.03 ENST00000392455.3
ENST00000392456.3
 CCDC50
 coiled-coil domain containing 50
chr8_-_143999259 0.03 ENST00000323110.2
 CYP11B2
 cytochrome P450, family 11, subfamily B, polypeptide 2
chr10_-_65028938 0.03 ENST00000402544.1
 JMJD1C
 jumonji domain containing 1C
chr10_-_98945515 0.03 ENST00000371070.4
 SLIT1
 slit homolog 1 (Drosophila)
chr12_+_57610562 0.03 ENST00000349394.5
 NXPH4
 neurexophilin 4
chr18_+_56887381 0.03 ENST00000256857.2
ENST00000529320.2
ENST00000420468.2
 GRP
 gastrin-releasing peptide
chr12_-_49393092 0.03 ENST00000421952.2
 DDN
 dendrin
chr10_-_46342921 0.03 ENST00000448048.2
 AGAP4
 ArfGAP with GTPase domain, ankyrin repeat and PH domain 4
chrX_+_48455866 0.03 ENST00000376729.5
ENST00000218056.5
 WDR13
 WD repeat domain 13
chrX_+_95939711 0.03 ENST00000373049.4
ENST00000324765.8
 DIAPH2
 diaphanous-related formin 2
chr12_-_58135903 0.03 ENST00000257897.3
 AGAP2
 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chrX_+_95939638 0.03 ENST00000373061.3
ENST00000373054.4
ENST00000355827.4
 DIAPH2
 diaphanous-related formin 2
chr2_+_242089833 0.03 ENST00000404405.3
ENST00000439916.1
ENST00000406106.3
ENST00000401987.1
 PPP1R7
 protein phosphatase 1, regulatory subunit 7
chr19_+_44645731 0.02 ENST00000426739.2
 ZNF234
 zinc finger protein 234
chr9_+_44868935 0.02 ENST00000448436.2
 RP11-160N1.10
 RP11-160N1.10
chr6_-_112575758 0.02 ENST00000431543.2
ENST00000453937.2
ENST00000368638.4
ENST00000389463.4
 LAMA4
 laminin, alpha 4
chr13_+_52586517 0.02 ENST00000523764.1
ENST00000521508.1
 ALG11
 ALG11, alpha-1,2-mannosyltransferase
chr21_-_43430440 0.02 ENST00000398505.3
ENST00000310826.5
ENST00000449949.1
ENST00000398499.1
ENST00000398497.2
ENST00000398511.3
 ZBTB21
 zinc finger and BTB domain containing 21
chr17_+_43239231 0.02 ENST00000591576.1
ENST00000591070.1
ENST00000592695.1
 HEXIM2
 hexamethylene bis-acetamide inducible 2
chr21_+_19617140 0.02 ENST00000299295.2
ENST00000338326.3
 CHODL
 chondrolectin
chr6_-_112575838 0.02 ENST00000455073.1
 LAMA4
 laminin, alpha 4
chr1_+_67390578 0.02 ENST00000371018.3
ENST00000355977.6
ENST00000357692.2
ENST00000401041.1
ENST00000371016.1
ENST00000371014.1
ENST00000371012.2
 MIER1
 mesoderm induction early response 1, transcriptional regulator
chr3_-_156877997 0.02 ENST00000295926.3
 CCNL1
 cyclin L1
chr11_-_128712362 0.02 ENST00000392664.2
 KCNJ1
 potassium inwardly-rectifying channel, subfamily J, member 1
chr10_-_100995603 0.02 ENST00000370552.3
ENST00000370549.1
 HPSE2
 heparanase 2
chr6_-_112575912 0.02 ENST00000522006.1
ENST00000230538.7
ENST00000519932.1
 LAMA4
 laminin, alpha 4
chr13_+_36050881 0.02 ENST00000537702.1
 NBEA
 neurobeachin
chr10_-_100995540 0.02 ENST00000370546.1
ENST00000404542.1
 HPSE2
 heparanase 2
chr8_-_67874805 0.02 ENST00000563496.1
 TCF24
 transcription factor 24
chr20_+_30467600 0.02 ENST00000375934.4
ENST00000375922.4
 TTLL9
 tubulin tyrosine ligase-like family, member 9
chr3_+_189507460 0.01 ENST00000434928.1
 TP63
 tumor protein p63
chr19_+_52074502 0.01 ENST00000545217.1
ENST00000262259.2
ENST00000596504.1
 ZNF175
 zinc finger protein 175
chr6_+_29426230 0.01 ENST00000442615.1
 OR2H1
 olfactory receptor, family 2, subfamily H, member 1
chr2_-_44588679 0.01 ENST00000409411.1
 PREPL
 prolyl endopeptidase-like
chr6_-_159065741 0.01 ENST00000367085.3
ENST00000367089.3
 DYNLT1
 dynein, light chain, Tctex-type 1
chr12_+_56414795 0.01 ENST00000431367.2
 IKZF4
 IKAROS family zinc finger 4 (Eos)
chr19_+_47421933 0.01 ENST00000404338.3
 ARHGAP35
 Rho GTPase activating protein 35
chr12_+_57482877 0.01 ENST00000342556.6
ENST00000357680.4
 NAB2
 NGFI-A binding protein 2 (EGR1 binding protein 2)
chr3_-_150264272 0.01 ENST00000491660.1
ENST00000487153.1
ENST00000239944.2
 SERP1
 stress-associated endoplasmic reticulum protein 1
chr11_+_47430133 0.01 ENST00000531974.1
ENST00000531419.1
ENST00000531865.1
ENST00000362021.4
ENST00000354884.4
 SLC39A13
 solute carrier family 39 (zinc transporter), member 13
chr2_-_44588694 0.01 ENST00000409957.1
 PREPL
 prolyl endopeptidase-like
chr15_-_64673630 0.01 ENST00000558008.1
ENST00000559519.1
ENST00000380258.2
 KIAA0101
 KIAA0101
chr3_-_187388173 0.01 ENST00000287641.3
 SST
 somatostatin
chr15_+_75335604 0.01 ENST00000563393.1
 PPCDC
 phosphopantothenoylcysteine decarboxylase
chr15_-_95870310 0.01 ENST00000508732.2
 CTD-2536I1.1
 CTD-2536I1.1
chr18_-_53070913 0.01 ENST00000568186.1
ENST00000564228.1
 TCF4
 transcription factor 4
chr6_+_33387868 0.01 ENST00000418600.2
 SYNGAP1
 synaptic Ras GTPase activating protein 1
chr8_+_143530791 0.00 ENST00000517894.1
 BAI1
 brain-specific angiogenesis inhibitor 1
chr13_-_110438914 0.00 ENST00000375856.3
 IRS2
 insulin receptor substrate 2
chr1_+_52082751 0.00 ENST00000447887.1
ENST00000435686.2
ENST00000428468.1
ENST00000453295.1
 OSBPL9
 oxysterol binding protein-like 9
chr8_-_79717750 0.00 ENST00000263851.4
ENST00000379113.2
 IL7
 interleukin 7
chr8_-_143961236 0.00 ENST00000377675.3
ENST00000517471.1
ENST00000292427.4
 CYP11B1
 cytochrome P450, family 11, subfamily B, polypeptide 1
chr17_+_37824411 0.00 ENST00000269582.2
 PNMT
 phenylethanolamine N-methyltransferase
chr8_+_23386305 0.00 ENST00000519973.1
 SLC25A37
 solute carrier family 25 (mitochondrial iron transporter), member 37
chr1_-_109584716 0.00 ENST00000531337.1
ENST00000529074.1
ENST00000369965.4
 WDR47
 WD repeat domain 47
chr1_+_12524965 0.00 ENST00000471923.1
 VPS13D
 vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr1_-_109584768 0.00 ENST00000357672.3
 WDR47
 WD repeat domain 47
chr1_-_109584608 0.00 ENST00000400794.3
ENST00000528747.1
ENST00000369962.3
ENST00000361054.3
 WDR47
 WD repeat domain 47
chrX_+_125953746 0.00 ENST00000371125.3
 CXorf64
 chromosome X open reading frame 64
chr7_-_120497178 0.00 ENST00000441017.1
ENST00000424710.1
ENST00000433758.1
 TSPAN12
 tetraspanin 12

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 0.3 GO:0000412 histone peptidyl-prolyl isomerization(GO:0000412)
0.1 1.3 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.1 0.2 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.1 0.3 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.1 0.2 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.0 0.2 GO:1903976 negative regulation of glial cell migration(GO:1903976)
0.0 0.2 GO:0051585 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.0 0.1 GO:0035283 central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0 0.2 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 0.1 GO:0033563 dorsal/ventral axon guidance(GO:0033563)
0.0 0.3 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.0 0.3 GO:0034465 response to carbon monoxide(GO:0034465)
0.0 0.1 GO:0051581 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.5 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.2 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.1 GO:0019230 proprioception(GO:0019230)
0.0 0.5 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.1 GO:0002879 positive regulation of acute inflammatory response to non-antigenic stimulus(GO:0002879)
0.0 0.3 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.1 GO:0031456 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.0 0.5 GO:0001502 cartilage condensation(GO:0001502)
0.0 0.1 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.0 0.1 GO:0051414 response to cortisol(GO:0051414)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.2 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.5 GO:0097512 cardiac myofibril(GO:0097512)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 GO:1990459 transferrin receptor binding(GO:1990459)
0.0 0.3 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.0 0.1 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.0 0.2 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.0 0.2 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.3 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.5 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.3 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.1 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.0 GO:0004507 steroid 11-beta-monooxygenase activity(GO:0004507) corticosterone 18-monooxygenase activity(GO:0047783)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID BMP PATHWAY BMP receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)