ISMARA results: HOXD11

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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for HOXD11_HOXA11

Z-value: 0.62

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Transcription factors associated with HOXD11_HOXA11

Gene Symbol	Gene ID	Gene Info
HOXD11 Ensembl NCBI GeneCards UniProt	ENSG00000128713.11	HOXD11
HOXA11 Ensembl NCBI GeneCards UniProt	ENSG00000005073.5	HOXA11

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HOXD11	hg19_v2_chr2_+_176972000_176972025	-0.39	3.4e-01	Click!
HOXA11	hg19_v2_chr7_-_27224795_27224840, hg19_v2_chr7_-_27224842_27224872	0.29	4.9e-01	Click!

Activity profile of HOXD11_HOXA11 motif

Sorted Z-values of HOXD11_HOXA11 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD11_HOXA11

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Promoter	Score	Transcript	Gene	Gene Info
chr1_+_183774240	0.74	ENST00000360851.3	RGL1	ral guanine nucleotide dissociation stimulator-like 1
chr8_+_97597148	0.60	ENST00000521590.1	SDC2	syndecan 2
chr5_+_148521381	0.52	ENST00000504238.1	ABLIM3	actin binding LIM protein family, member 3
chr3_-_18480260	0.49	ENST00000454909.2	SATB1	SATB homeobox 1
chr1_+_244515930	0.48	ENST00000366537.1 ENST00000308105.4	C1orf100	chromosome 1 open reading frame 100
chr5_-_111093167	0.47	ENST00000446294.2 ENST00000419114.2	NREP	neuronal regeneration related protein
chr5_-_20575959	0.45	ENST00000507958.1	CDH18	cadherin 18, type 2
chr6_+_32812568	0.42	ENST00000414474.1	PSMB9	proteasome (prosome, macropain) subunit, beta type, 9
chr12_-_91546926	0.37	ENST00000550758.1	DCN	decorin
chr19_+_46367518	0.37	ENST00000302177.2	FOXA3	forkhead box A3

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0008218	bioluminescence(GO:0008218)
0.0	0.6	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0	0.6	GO:0035493	SNARE complex assembly(GO:0035493)
0.0	0.5	GO:0043374	CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.5	GO:0071447	cellular response to hydroperoxide(GO:0071447)
0.1	0.4	GO:0007037	vacuolar phosphate transport(GO:0007037) positive regulation of mitotic cell cycle DNA replication(GO:1903465) positive regulation of parathyroid hormone secretion(GO:2000830)
0.1	0.4	GO:0090131	mesenchyme migration(GO:0090131)
0.0	0.4	GO:0035583	sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.0	0.4	GO:0000338	protein deneddylation(GO:0000338)
0.0	0.4	GO:0098828	positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)

Showing 1 to 10 of 90 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.6	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	0.6	GO:0005720	nuclear heterochromatin(GO:0005720)
0.1	0.4	GO:0030485	smooth muscle contractile fiber(GO:0030485)
0.0	0.4	GO:1990111	spermatoproteasome complex(GO:1990111)
0.0	0.4	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.4	GO:0043205	microfibril(GO:0001527) fibril(GO:0043205)
0.1	0.3	GO:1990578	perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0	0.3	GO:0000110	nucleotide-excision repair factor 1 complex(GO:0000110)
0.0	0.2	GO:1990131	Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0	0.2	GO:0071144	SMAD2-SMAD3 protein complex(GO:0071144)

Showing 1 to 10 of 27 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.7	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.7	GO:0005484	SNAP receptor activity(GO:0005484)
0.0	0.5	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.1	0.4	GO:0050436	microfibril binding(GO:0050436)
0.0	0.4	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.4	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1	0.3	GO:0004958	prostaglandin F receptor activity(GO:0004958)
0.1	0.3	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
0.0	0.3	GO:0001594	trace-amine receptor activity(GO:0001594)
0.0	0.3	GO:1990599	3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)

Showing 1 to 10 of 60 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.2	PID FGF PATHWAY	FGF signaling pathway

Showing 1 to 1 of 1 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
1.2	REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.9	REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	Genes involved in Regulation of ornithine decarboxylase (ODC)
0.6	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.6	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.5	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.4	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.4	REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1	Genes involved in Signaling by activated point mutants of FGFR1
0.4	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.4	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.4	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions

Showing 1 to 10 of 15 entries

Results for HOXD11_HOXA11

Z-value: 0.62

Motif logo

Transcription factors associated with HOXD11_HOXA11

Activity-expression correlation:

Activity profile of HOXD11_HOXA11 motif

Sorted Z-values of HOXD11_HOXA11 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD11_HOXA11

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: