ISMARA results: ID4_TCF4

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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for ID4_TCF4_SNAI2

Z-value: 3.13

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Transcription factors associated with ID4_TCF4_SNAI2

Gene Symbol	Gene ID	Gene Info
ID4 Ensembl NCBI GeneCards UniProt	ENSG00000172201.6	ID4
TCF4 Ensembl NCBI GeneCards UniProt	ENSG00000196628.9	TCF4
SNAI2 Ensembl NCBI GeneCards UniProt	ENSG00000019549.4	SNAI2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TCF4	hg19_v2_chr18_-_53303123_53303190	0.79	1.9e-02	Click!
SNAI2	hg19_v2_chr8_-_49833978_49833996, hg19_v2_chr8_-_49834299_49834446	0.48	2.3e-01	Click!
ID4	hg19_v2_chr6_+_19837592_19837621	0.36	3.8e-01	Click!

Activity profile of ID4_TCF4_SNAI2 motif

Sorted Z-values of ID4_TCF4_SNAI2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ID4_TCF4_SNAI2

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Promoter	Score	Transcript	Gene	Gene Info
chr1_+_60280458	12.43	ENST00000455990.1 ENST00000371208.3	HOOK1	hook microtubule-tethering protein 1
chr8_+_120220561	9.78	ENST00000276681.6	MAL2	mal, T-cell differentiation protein 2 (gene/pseudogene)
chr16_+_68771128	9.27	ENST00000261769.5 ENST00000422392.2	CDH1	cadherin 1, type 1, E-cadherin (epithelial)
chr19_+_38755203	8.80	ENST00000587090.1 ENST00000454580.3	SPINT2	serine peptidase inhibitor, Kunitz type, 2
chr19_+_38755042	8.63	ENST00000301244.7	SPINT2	serine peptidase inhibitor, Kunitz type, 2
chr2_+_47596287	7.85	ENST00000263735.4	EPCAM	epithelial cell adhesion molecule
chr1_-_209979465	6.92	ENST00000542854.1	IRF6	interferon regulatory factor 6
chr19_+_35739280	6.78	ENST00000602122.1	LSR	lipolysis stimulated lipoprotein receptor
chr8_+_95653427	6.72	ENST00000454170.2	ESRP1	epithelial splicing regulatory protein 1
chr17_-_39674668	6.50	ENST00000393981.3	KRT15	keratin 15

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	26.6	GO:0070268	cornification(GO:0070268)
5.2	25.8	GO:1904274	tricellular tight junction assembly(GO:1904274)
4.7	23.4	GO:0060672	epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.7	21.0	GO:0031581	hemidesmosome assembly(GO:0031581)
1.8	16.4	GO:0086073	bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.5	13.8	GO:0060644	mammary gland epithelial cell differentiation(GO:0060644)
0.1	13.8	GO:0008543	fibroblast growth factor receptor signaling pathway(GO:0008543)
0.3	13.3	GO:0098927	vesicle-mediated transport between endosomal compartments(GO:0098927)
1.9	13.1	GO:2001181	positive regulation of interleukin-10 secretion(GO:2001181)
0.7	12.7	GO:0090179	planar cell polarity pathway involved in neural tube closure(GO:0090179)

Showing 1 to 10 of 1,005 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	62.5	GO:0016021	integral component of membrane(GO:0016021)
3.0	26.6	GO:0061689	tricellular tight junction(GO:0061689)
0.1	25.4	GO:0016323	basolateral plasma membrane(GO:0016323)
0.7	23.8	GO:0016327	apicolateral plasma membrane(GO:0016327)
1.5	18.9	GO:0045179	apical cortex(GO:0045179)
0.2	16.9	GO:0016328	lateral plasma membrane(GO:0016328)
0.5	15.3	GO:0030057	desmosome(GO:0030057)
0.1	14.8	GO:0005923	bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
1.8	12.6	GO:0097209	epidermal lamellar body(GO:0097209)
0.5	12.6	GO:0005861	troponin complex(GO:0005861)

Showing 1 to 10 of 274 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	26.5	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
1.8	16.4	GO:0086083	cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.0	14.2	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	14.2	GO:0044822	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
1.1	13.9	GO:0038132	neuregulin binding(GO:0038132)
0.1	13.1	GO:0031490	chromatin DNA binding(GO:0031490)
0.6	12.5	GO:0043274	phospholipase binding(GO:0043274)
0.9	12.2	GO:0031014	troponin T binding(GO:0031014)
0.4	11.4	GO:0098641	cadherin binding involved in cell-cell adhesion(GO:0098641)
0.2	11.3	GO:0097110	scaffold protein binding(GO:0097110)

Showing 1 to 10 of 585 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	18.2	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.5	18.0	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.3	12.4	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.3	10.2	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.1	8.5	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.2	6.9	PID NECTIN PATHWAY	Nectin adhesion pathway
0.0	6.9	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.3	6.3	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.1	6.1	PID P73PATHWAY	p73 transcription factor network
0.2	6.0	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin

Showing 1 to 10 of 92 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	22.0	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.6	22.0	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.8	19.6	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.3	14.6	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.2	14.6	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.4	13.1	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.6	12.3	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.2	10.9	REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1	10.1	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
0.4	9.0	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling

Showing 1 to 10 of 148 entries

Results for ID4_TCF4_SNAI2

Z-value: 3.13

Motif logo

Transcription factors associated with ID4_TCF4_SNAI2

Activity-expression correlation:

Activity profile of ID4_TCF4_SNAI2 motif

Sorted Z-values of ID4_TCF4_SNAI2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ID4_TCF4_SNAI2

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: