ISMARA results: IRF2_STAT2_IRF8

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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for IRF2_STAT2_IRF8_IRF1

Z-value: 3.09

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Transcription factors associated with IRF2_STAT2_IRF8_IRF1

Gene Symbol	Gene ID	Gene Info
IRF2 Ensembl NCBI GeneCards UniProt	ENSG00000168310.6	IRF2
STAT2 Ensembl NCBI GeneCards UniProt	ENSG00000170581.9	STAT2
IRF8 Ensembl NCBI GeneCards UniProt	ENSG00000140968.6	IRF8
IRF1 Ensembl NCBI GeneCards UniProt	ENSG00000125347.9	IRF1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
STAT2	hg19_v2_chr12_-_56753858_56753930	0.77	2.6e-02	Click!
IRF1	hg19_v2_chr5_-_131826457_131826514	0.64	8.6e-02	Click!
IRF8	hg19_v2_chr16_+_85942594_85942635	-0.47	2.4e-01	Click!
IRF2	hg19_v2_chr4_-_185395672_185395734	0.42	3.0e-01	Click!

Activity profile of IRF2_STAT2_IRF8_IRF1 motif

Sorted Z-values of IRF2_STAT2_IRF8_IRF1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF2_STAT2_IRF8_IRF1

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Promoter	Score	Transcript	Gene	Gene Info
chr1_+_79086088	8.03	ENST00000370751.5 ENST00000342282.3	IFI44L	interferon-induced protein 44-like
chr1_+_948803	3.69	ENST00000379389.4	ISG15	ISG15 ubiquitin-like modifier
chr6_+_32821924	3.48	ENST00000374859.2 ENST00000453265.2	PSMB9	proteasome (prosome, macropain) subunit, beta type, 9
chr13_-_43566301	3.39	ENST00000398762.3 ENST00000313640.7 ENST00000313624.7	EPSTI1	epithelial stromal interaction 1 (breast)
chr11_-_104916034	2.99	ENST00000528513.1 ENST00000375706.2 ENST00000375704.3	CARD16	caspase recruitment domain family, member 16
chr11_-_57335280	2.82	ENST00000287156.4	UBE2L6	ubiquitin-conjugating enzyme E2L 6
chr5_+_32710736	2.64	ENST00000415685.2	NPR3	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr10_+_91152303	2.64	ENST00000371804.3	IFIT1	interferon-induced protein with tetratricopeptide repeats 1
chr1_+_79115503	2.63	ENST00000370747.4 ENST00000438486.1 ENST00000545124.1	IFI44	interferon-induced protein 44
chr12_-_91574142	2.34	ENST00000547937.1	DCN	decorin

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	9.2	GO:0006521	regulation of cellular amino acid metabolic process(GO:0006521)
0.8	7.9	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.1	5.8	GO:0032728	positive regulation of interferon-beta production(GO:0032728)
0.6	4.9	GO:0071494	cellular response to UV-C(GO:0071494)
0.1	4.3	GO:0060338	regulation of type I interferon-mediated signaling pathway(GO:0060338)
0.3	4.2	GO:0035457	cellular response to interferon-alpha(GO:0035457)
0.3	3.5	GO:0002158	osteoclast proliferation(GO:0002158)
0.1	3.3	GO:0072643	interferon-gamma secretion(GO:0072643)
0.3	3.2	GO:0070212	protein poly-ADP-ribosylation(GO:0070212)
0.1	3.2	GO:0035456	response to interferon-beta(GO:0035456)

Showing 1 to 10 of 244 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	7.9	GO:1990111	spermatoproteasome complex(GO:1990111)
1.1	6.4	GO:0097179	protease inhibitor complex(GO:0097179)
0.2	3.0	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	3.0	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	2.7	GO:0019897	extrinsic component of plasma membrane(GO:0019897)
0.0	2.6	GO:0015030	Cajal body(GO:0015030)
0.0	2.5	GO:0035577	azurophil granule membrane(GO:0035577)
0.0	2.3	GO:0005796	Golgi lumen(GO:0005796)
0.0	2.2	GO:0042734	presynaptic membrane(GO:0042734)
0.0	2.1	GO:0090575	RNA polymerase II transcription factor complex(GO:0090575)

Showing 1 to 10 of 94 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	8.2	GO:0005525	GTP binding(GO:0005525)
0.3	7.8	GO:0070003	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2	6.4	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0	5.9	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0	5.5	GO:0003714	transcription corepressor activity(GO:0003714)
0.3	4.7	GO:0089720	caspase binding(GO:0089720)
0.1	4.5	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.3	3.7	GO:0031386	protein tag(GO:0031386)
0.0	3.7	GO:0005518	collagen binding(GO:0005518)
0.2	2.8	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)

Showing 1 to 10 of 169 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.8	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	4.3	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	3.4	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.1	3.0	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.2	2.5	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.0	1.9	PID S1P S1P3 PATHWAY	S1P3 pathway
0.1	1.8	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0	1.8	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	1.5	PID MYC PATHWAY	C-MYC pathway
0.0	1.3	PID PDGFRB PATHWAY	PDGFR-beta signaling pathway

Showing 1 to 10 of 31 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	21.1	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.1	9.3	REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G	Genes involved in Vif-mediated degradation of APOBEC3G
0.1	5.1	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1	3.0	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.1	2.8	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1	2.7	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.1	2.6	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.1	2.3	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.1	1.9	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.1	1.9	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle

Showing 1 to 10 of 48 entries

Results for IRF2_STAT2_IRF8_IRF1

Z-value: 3.09

Motif logo

Transcription factors associated with IRF2_STAT2_IRF8_IRF1

Activity-expression correlation:

Activity profile of IRF2_STAT2_IRF8_IRF1 motif

Sorted Z-values of IRF2_STAT2_IRF8_IRF1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF2_STAT2_IRF8_IRF1

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: