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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for IRF2_STAT2_IRF8_IRF1

Z-value: 3.09

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Transcription factors associated with IRF2_STAT2_IRF8_IRF1

Gene Symbol Gene ID Gene Info
IRF2
ENSG00000168310.6 IRF2
STAT2
ENSG00000170581.9 STAT2
IRF8
ENSG00000140968.6 IRF8
IRF1
ENSG00000125347.9 IRF1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
STAT2hg19_v2_chr12_-_56753858_567539300.772.6e-02Click!
IRF1hg19_v2_chr5_-_131826457_1318265140.648.6e-02Click!
IRF8hg19_v2_chr16_+_85942594_85942635-0.472.4e-01Click!
IRF2hg19_v2_chr4_-_185395672_1853957340.423.0e-01Click!

Activity profile of IRF2_STAT2_IRF8_IRF1 motif

Sorted Z-values of IRF2_STAT2_IRF8_IRF1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF2_STAT2_IRF8_IRF1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr1_+_79086088 8.03 ENST00000370751.5
ENST00000342282.3
 IFI44L
 interferon-induced protein 44-like
chr1_+_948803 3.69 ENST00000379389.4
 ISG15
 ISG15 ubiquitin-like modifier
chr6_+_32821924 3.48 ENST00000374859.2
ENST00000453265.2
 PSMB9
 proteasome (prosome, macropain) subunit, beta type, 9
chr13_-_43566301 3.39 ENST00000398762.3
ENST00000313640.7
ENST00000313624.7
 EPSTI1
 epithelial stromal interaction 1 (breast)
chr11_-_104916034 2.99 ENST00000528513.1
ENST00000375706.2
ENST00000375704.3
 CARD16
 caspase recruitment domain family, member 16
chr11_-_57335280 2.82 ENST00000287156.4
 UBE2L6
 ubiquitin-conjugating enzyme E2L 6
chr5_+_32710736 2.64 ENST00000415685.2
 NPR3
 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr10_+_91152303 2.64 ENST00000371804.3
 IFIT1
 interferon-induced protein with tetratricopeptide repeats 1
chr1_+_79115503 2.63 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
 IFI44
 interferon-induced protein 44
chr12_-_91574142 2.34 ENST00000547937.1
 DCN
 decorin
chr11_+_5710919 2.25 ENST00000379965.3
ENST00000425490.1
 TRIM22
 tripartite motif containing 22
chr7_-_122526799 2.14 ENST00000334010.7
ENST00000313070.7
 CADPS2
 Ca++-dependent secretion activator 2
chr22_+_18632666 2.04 ENST00000215794.7
 USP18
 ubiquitin specific peptidase 18
chr16_-_67970990 2.01 ENST00000358514.4
 PSMB10
 proteasome (prosome, macropain) subunit, beta type, 10
chr17_+_6659153 2.00 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
 XAF1
 XIAP associated factor 1
chr3_-_114343039 1.98 ENST00000481632.1
 ZBTB20
 zinc finger and BTB domain containing 20
chr3_-_49851313 1.97 ENST00000333486.3
 UBA7
 ubiquitin-like modifier activating enzyme 7
chr3_-_114477962 1.96 ENST00000471418.1
 ZBTB20
 zinc finger and BTB domain containing 20
chr11_+_63304273 1.94 ENST00000439013.2
ENST00000255688.3
 RARRES3
 retinoic acid receptor responder (tazarotene induced) 3
chr3_-_114477787 1.90 ENST00000464560.1
 ZBTB20
 zinc finger and BTB domain containing 20
chr4_-_138453606 1.88 ENST00000412923.2
ENST00000344876.4
ENST00000507846.1
ENST00000510305.1
 PCDH18
 protocadherin 18
chr3_+_187086120 1.83 ENST00000259030.2
 RTP4
 receptor (chemosensory) transporter protein 4
chr6_+_26440700 1.81 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
 BTN3A3
 butyrophilin, subfamily 3, member A3
chr11_-_104972158 1.80 ENST00000598974.1
ENST00000593315.1
ENST00000594519.1
ENST00000415981.2
ENST00000525374.1
ENST00000375707.1
 CASP1
CARD16
CARD17
 caspase 1, apoptosis-related cysteine peptidase
caspase recruitment domain family, member 16
caspase recruitment domain family, member 17
chr5_-_95158375 1.76 ENST00000512469.2
ENST00000379979.4
ENST00000505427.1
ENST00000508780.1
 GLRX
 glutaredoxin (thioltransferase)
chr11_-_111794446 1.76 ENST00000527950.1
 CRYAB
 crystallin, alpha B
chr12_+_94542459 1.71 ENST00000258526.4
 PLXNC1
 plexin C1
chr7_-_92777606 1.65 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
 SAMD9L
 sterile alpha motif domain containing 9-like
chr11_-_104905840 1.64 ENST00000526568.1
ENST00000393136.4
ENST00000531166.1
ENST00000534497.1
ENST00000527979.1
ENST00000446369.1
ENST00000353247.5
ENST00000528974.1
ENST00000533400.1
ENST00000525825.1
ENST00000436863.3
 CASP1
 caspase 1, apoptosis-related cysteine peptidase
chr10_+_91061712 1.63 ENST00000371826.3
 IFIT2
 interferon-induced protein with tetratricopeptide repeats 2
chr9_-_21305312 1.55 ENST00000259555.4
 IFNA5
 interferon, alpha 5
chr1_-_151319710 1.53 ENST00000290524.4
ENST00000437327.1
ENST00000452513.2
ENST00000368870.2
ENST00000452671.2
 RFX5
 regulatory factor X, 5 (influences HLA class II expression)
chrX_+_22056165 1.53 ENST00000535894.1
 PHEX
 phosphate regulating endopeptidase homolog, X-linked
chr3_-_122283079 1.52 ENST00000471785.1
ENST00000466126.1
 PARP9
 poly (ADP-ribose) polymerase family, member 9
chr19_+_10196781 1.50 ENST00000253110.11
 C19orf66
 chromosome 19 open reading frame 66
chr6_+_32811885 1.49 ENST00000458296.1
ENST00000413039.1
ENST00000429600.1
ENST00000412095.1
ENST00000415067.1
ENST00000395330.1
 TAPSAR1
PSMB9
 TAP1 and PSMB8 antisense RNA 1
proteasome (prosome, macropain) subunit, beta type, 9
chr4_-_138453559 1.49 ENST00000511115.1
 PCDH18
 protocadherin 18
chr3_-_122283424 1.48 ENST00000477522.2
ENST00000360356.2
 PARP9
 poly (ADP-ribose) polymerase family, member 9
chrX_+_80457442 1.47 ENST00000373212.5
 SH3BGRL
 SH3 domain binding glutamic acid-rich protein like
chr1_-_146644036 1.44 ENST00000425272.2
 PRKAB2
 protein kinase, AMP-activated, beta 2 non-catalytic subunit
chr19_+_10196981 1.40 ENST00000591813.1
 C19orf66
 chromosome 19 open reading frame 66
chr19_-_17516449 1.39 ENST00000252593.6
 BST2
 bone marrow stromal cell antigen 2
chr20_-_48099182 1.39 ENST00000371741.4
 KCNB1
 potassium voltage-gated channel, Shab-related subfamily, member 1
chr5_-_149535421 1.36 ENST00000261799.4
 PDGFRB
 platelet-derived growth factor receptor, beta polypeptide
chr19_-_49371711 1.36 ENST00000355496.5
ENST00000263265.6
 PLEKHA4
 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
chr6_+_32811861 1.34 ENST00000453426.1
 TAPSAR1
 TAP1 and PSMB8 antisense RNA 1
chr4_+_186990298 1.32 ENST00000296795.3
ENST00000513189.1
 TLR3
 toll-like receptor 3
chr9_-_95298314 1.31 ENST00000344604.5
ENST00000375540.1
 ECM2
 extracellular matrix protein 2, female organ and adipocyte specific
chr4_-_156875003 1.29 ENST00000433477.3
 CTSO
 cathepsin O
chr10_+_91087651 1.29 ENST00000371818.4
 IFIT3
 interferon-induced protein with tetratricopeptide repeats 3
chr10_+_91092241 1.25 ENST00000371811.4
 IFIT3
 interferon-induced protein with tetratricopeptide repeats 3
chr10_-_90751038 1.23 ENST00000458159.1
ENST00000415557.1
ENST00000458208.1
 ACTA2
 actin, alpha 2, smooth muscle, aorta
chr11_+_1874200 1.19 ENST00000311604.3
 LSP1
 lymphocyte-specific protein 1
chr11_+_5646213 1.13 ENST00000429814.2
 TRIM34
 tripartite motif containing 34
chr9_+_4985016 1.11 ENST00000539801.1
 JAK2
 Janus kinase 2
chr6_+_26402465 1.08 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
 BTN3A1
 butyrophilin, subfamily 3, member A1
chr3_-_28390581 1.06 ENST00000479665.1
 AZI2
 5-azacytidine induced 2
chr19_+_49977818 1.05 ENST00000594009.1
ENST00000595510.1
 FLT3LG
 fms-related tyrosine kinase 3 ligand
chr5_-_95158644 1.04 ENST00000237858.6
 GLRX
 glutaredoxin (thioltransferase)
chr22_-_36556821 1.03 ENST00000531095.1
ENST00000397293.2
ENST00000349314.2
 APOL3
 apolipoprotein L, 3
chr6_-_121655593 1.03 ENST00000398212.2
 TBC1D32
 TBC1 domain family, member 32
chr14_+_24630465 0.99 ENST00000557894.1
ENST00000559284.1
ENST00000560275.1
 IRF9
 interferon regulatory factor 9
chr16_-_31214051 0.99 ENST00000350605.4
 PYCARD
 PYD and CARD domain containing
chr6_+_26402517 0.94 ENST00000414912.2
 BTN3A1
 butyrophilin, subfamily 3, member A1
chr6_-_32811771 0.94 ENST00000395339.3
ENST00000374882.3
 PSMB8
 proteasome (prosome, macropain) subunit, beta type, 8
chr12_+_94656297 0.93 ENST00000545312.1
 PLXNC1
 plexin C1
chr17_+_4643337 0.93 ENST00000592813.1
 ZMYND15
 zinc finger, MYND-type containing 15
chr1_-_27998689 0.93 ENST00000339145.4
ENST00000362020.4
ENST00000361157.6
 IFI6
 interferon, alpha-inducible protein 6
chr4_-_100242549 0.93 ENST00000305046.8
ENST00000394887.3
 ADH1B
 alcohol dehydrogenase 1B (class I), beta polypeptide
chr17_+_4643300 0.92 ENST00000433935.1
 ZMYND15
 zinc finger, MYND-type containing 15
chr2_+_210288760 0.92 ENST00000199940.6
 MAP2
 microtubule-associated protein 2
chr3_+_122399444 0.91 ENST00000474629.2
 PARP14
 poly (ADP-ribose) polymerase family, member 14
chr14_-_80677815 0.89 ENST00000557125.1
ENST00000555750.1
 DIO2
 deiodinase, iodothyronine, type II
chrX_+_102883620 0.87 ENST00000372626.3
 TCEAL1
 transcription elongation factor A (SII)-like 1
chr1_-_89531041 0.87 ENST00000370473.4
 GBP1
 guanylate binding protein 1, interferon-inducible
chr22_+_39436862 0.86 ENST00000381565.2
ENST00000452957.2
 APOBEC3F
APOBEC3G
 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
chr19_+_17516909 0.85 ENST00000601007.1
ENST00000594913.1
ENST00000599975.1
ENST00000600514.1
 CTD-2521M24.9
MVB12A
 CTD-2521M24.9
multivesicular body subunit 12A
chr1_+_221051699 0.84 ENST00000366903.6
 HLX
 H2.0-like homeobox
chr6_+_26365443 0.84 ENST00000527422.1
ENST00000356386.2
ENST00000396934.3
ENST00000377708.2
ENST00000396948.1
ENST00000508906.2
 BTN3A2
 butyrophilin, subfamily 3, member A2
chr10_+_111985713 0.83 ENST00000239007.7
 MXI1
 MAX interactor 1, dimerization protein
chr2_+_201980961 0.82 ENST00000342795.5
 CFLAR
 CASP8 and FADD-like apoptosis regulator
chr6_+_72922590 0.82 ENST00000523963.1
 RIMS1
 regulating synaptic membrane exocytosis 1
chr17_-_40264692 0.82 ENST00000591220.1
ENST00000251642.3
 DHX58
 DEXH (Asp-Glu-X-His) box polypeptide 58
chr6_+_72922505 0.81 ENST00000401910.3
 RIMS1
 regulating synaptic membrane exocytosis 1
chr2_-_163175133 0.78 ENST00000421365.2
ENST00000263642.2
 IFIH1
 interferon induced with helicase C domain 1
chr2_+_201981527 0.77 ENST00000441224.1
 CFLAR
 CASP8 and FADD-like apoptosis regulator
chr10_+_92980517 0.76 ENST00000336126.5
 PCGF5
 polycomb group ring finger 5
chr12_+_26348246 0.76 ENST00000422622.2
 SSPN
 sarcospan
chr12_+_26348429 0.75 ENST00000242729.2
 SSPN
 sarcospan
chr9_-_95166841 0.72 ENST00000262551.4
 OGN
 osteoglycin
chr19_+_17516531 0.71 ENST00000528911.1
ENST00000528604.1
ENST00000595892.1
ENST00000500836.2
ENST00000598546.1
ENST00000600369.1
ENST00000598356.1
ENST00000594426.1
 MVB12A
CTD-2521M24.9
 multivesicular body subunit 12A
CTD-2521M24.9
chr3_-_121379739 0.71 ENST00000428394.2
ENST00000314583.3
 HCLS1
 hematopoietic cell-specific Lyn substrate 1
chr9_-_95166884 0.71 ENST00000375561.5
 OGN
 osteoglycin
chr8_+_17434689 0.68 ENST00000398074.3
 PDGFRL
 platelet-derived growth factor receptor-like
chr22_-_30695471 0.68 ENST00000434291.1
 RP1-130H16.18
 Uncharacterized protein
chr22_-_50765489 0.68 ENST00000413817.3
 DENND6B
 DENN/MADD domain containing 6B
chr14_+_100531615 0.67 ENST00000392920.3
 EVL
 Enah/Vasp-like
chr6_+_25963020 0.67 ENST00000357085.3
 TRIM38
 tripartite motif containing 38
chrX_+_154113317 0.65 ENST00000354461.2
 H2AFB1
 H2A histone family, member B1
chrX_+_103031758 0.65 ENST00000303958.2
ENST00000361621.2
 PLP1
 proteolipid protein 1
chrX_+_103031421 0.64 ENST00000433491.1
ENST00000418604.1
ENST00000443502.1
 PLP1
 proteolipid protein 1
chr7_-_80551671 0.64 ENST00000419255.2
ENST00000544525.1
 SEMA3C
 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr19_-_3028354 0.64 ENST00000586422.1
 TLE2
 transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chr19_-_3029011 0.64 ENST00000590536.1
ENST00000587137.1
ENST00000455444.2
ENST00000262953.6
 TLE2
 transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chr10_+_115439282 0.63 ENST00000369321.2
ENST00000345633.4
 CASP7
 caspase 7, apoptosis-related cysteine peptidase
chr17_-_4643114 0.63 ENST00000293778.6
 CXCL16
 chemokine (C-X-C motif) ligand 16
chr5_-_111093081 0.63 ENST00000453526.2
ENST00000509427.1
 NREP
 neuronal regeneration related protein
chr3_-_28390298 0.63 ENST00000457172.1
 AZI2
 5-azacytidine induced 2
chr15_+_74287035 0.62 ENST00000395132.2
ENST00000268059.6
ENST00000354026.6
ENST00000268058.3
ENST00000565898.1
ENST00000569477.1
ENST00000569965.1
ENST00000567543.1
ENST00000436891.3
ENST00000435786.2
ENST00000564428.1
ENST00000359928.4
 PML
 promyelocytic leukemia
chr1_-_182558374 0.62 ENST00000367559.3
ENST00000539397.1
 RNASEL
 ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
chr4_-_39640513 0.62 ENST00000511809.1
ENST00000505729.1
 SMIM14
 small integral membrane protein 14
chr13_-_67802549 0.62 ENST00000328454.5
ENST00000377865.2
 PCDH9
 protocadherin 9
chr22_+_36649056 0.62 ENST00000397278.3
ENST00000422706.1
ENST00000426053.1
ENST00000319136.4
 APOL1
 apolipoprotein L, 1
chr2_+_201980827 0.62 ENST00000309955.3
ENST00000443227.1
ENST00000341222.6
ENST00000355558.4
ENST00000340870.5
ENST00000341582.6
 CFLAR
 CASP8 and FADD-like apoptosis regulator
chr12_-_91572278 0.62 ENST00000425043.1
ENST00000420120.2
ENST00000441303.2
ENST00000456569.2
 DCN
 decorin
chr14_+_24605389 0.61 ENST00000382708.3
ENST00000561435.1
 PSME1
 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr1_+_162602244 0.61 ENST00000367922.3
ENST00000367921.3
 DDR2
 discoidin domain receptor tyrosine kinase 2
chrX_+_102883887 0.61 ENST00000372625.3
ENST00000372624.3
 TCEAL1
 transcription elongation factor A (SII)-like 1
chr12_-_15374343 0.61 ENST00000256953.2
ENST00000546331.1
 RERG
 RAS-like, estrogen-regulated, growth inhibitor
chr1_-_151319283 0.61 ENST00000392746.3
 RFX5
 regulatory factor X, 5 (influences HLA class II expression)
chr6_+_16238786 0.60 ENST00000259727.4
 GMPR
 guanosine monophosphate reductase
chr20_+_388791 0.60 ENST00000441733.1
ENST00000353660.3
 RBCK1
 RanBP-type and C3HC4-type zinc finger containing 1
chr6_+_126240442 0.60 ENST00000448104.1
ENST00000438495.1
ENST00000444128.1
 NCOA7
 nuclear receptor coactivator 7
chr9_+_131684562 0.59 ENST00000421063.2
 PHYHD1
 phytanoyl-CoA dioxygenase domain containing 1
chr10_+_115439630 0.57 ENST00000369318.3
 CASP7
 caspase 7, apoptosis-related cysteine peptidase
chr3_-_141747439 0.57 ENST00000467667.1
 TFDP2
 transcription factor Dp-2 (E2F dimerization partner 2)
chr6_-_26056695 0.57 ENST00000343677.2
 HIST1H1C
 histone cluster 1, H1c
chr7_+_154720173 0.56 ENST00000397551.2
 PAXIP1-AS2
 PAXIP1 antisense RNA 2
chr11_+_313503 0.56 ENST00000528780.1
ENST00000328221.5
 IFITM1
 interferon induced transmembrane protein 1
chr19_+_30863271 0.56 ENST00000355537.3
 ZNF536
 zinc finger protein 536
chr8_+_97597148 0.55 ENST00000521590.1
 SDC2
 syndecan 2
chr1_+_27668505 0.55 ENST00000318074.5
 SYTL1
 synaptotagmin-like 1
chr6_-_82462425 0.55 ENST00000369754.3
ENST00000320172.6
ENST00000369756.3
 FAM46A
 family with sequence similarity 46, member A
chr2_+_205410516 0.54 ENST00000406610.2
ENST00000462231.1
 PARD3B
 par-3 family cell polarity regulator beta
chr17_+_46908350 0.54 ENST00000258947.3
ENST00000509507.1
ENST00000448105.2
ENST00000570513.1
ENST00000509415.1
ENST00000513119.1
ENST00000416445.2
ENST00000508679.1
ENST00000505071.1
 CALCOCO2
 calcium binding and coiled-coil domain 2
chr2_+_201994569 0.54 ENST00000457277.1
 CFLAR
 CASP8 and FADD-like apoptosis regulator
chr4_+_142557717 0.54 ENST00000320650.4
ENST00000296545.7
 IL15
 interleukin 15
chr11_-_321050 0.54 ENST00000399808.4
 IFITM3
 interferon induced transmembrane protein 3
chr2_-_175629135 0.54 ENST00000409542.1
ENST00000409219.1
 CHRNA1
 cholinergic receptor, nicotinic, alpha 1 (muscle)
chr11_-_2160180 0.54 ENST00000381406.4
 IGF2
 insulin-like growth factor 2 (somatomedin A)
chr7_+_18535893 0.53 ENST00000432645.2
ENST00000441542.2
 HDAC9
 histone deacetylase 9
chr16_+_31213206 0.53 ENST00000561916.2
 C16orf98
 chromosome 16 open reading frame 98
chr10_+_115439699 0.53 ENST00000369315.1
 CASP7
 caspase 7, apoptosis-related cysteine peptidase
chr2_-_231084659 0.53 ENST00000258381.6
ENST00000358662.4
ENST00000455674.1
ENST00000392048.3
 SP110
 SP110 nuclear body protein
chr9_-_21077939 0.53 ENST00000380232.2
 IFNB1
 interferon, beta 1, fibroblast
chr14_+_24605361 0.53 ENST00000206451.6
ENST00000559123.1
 PSME1
 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr1_+_241695424 0.52 ENST00000366558.3
ENST00000366559.4
 KMO
 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr12_+_43086018 0.52 ENST00000550177.1
 RP11-25I15.3
 RP11-25I15.3
chr12_-_63328817 0.51 ENST00000228705.6
 PPM1H
 protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr3_-_141747459 0.51 ENST00000477292.1
ENST00000478006.1
ENST00000495310.1
ENST00000486111.1
 TFDP2
 transcription factor Dp-2 (E2F dimerization partner 2)
chr19_+_49977466 0.50 ENST00000596435.1
ENST00000344019.3
ENST00000597551.1
ENST00000204637.2
ENST00000600429.1
 FLT3LG
 fms-related tyrosine kinase 3 ligand
chr5_-_111092930 0.50 ENST00000257435.7
 NREP
 neuronal regeneration related protein
chr5_-_111093167 0.50 ENST00000446294.2
ENST00000419114.2
 NREP
 neuronal regeneration related protein
chr11_-_2906979 0.50 ENST00000380725.1
ENST00000313407.6
ENST00000430149.2
ENST00000440480.2
ENST00000414822.3
 CDKN1C
 cyclin-dependent kinase inhibitor 1C (p57, Kip2)
chr9_-_95186739 0.50 ENST00000375550.4
 OMD
 osteomodulin
chr11_-_14358620 0.49 ENST00000531421.1
 RRAS2
 related RAS viral (r-ras) oncogene homolog 2
chr2_+_102686820 0.49 ENST00000409929.1
ENST00000424272.1
 IL1R1
 interleukin 1 receptor, type I
chr8_-_93107443 0.49 ENST00000360348.2
ENST00000520428.1
ENST00000518992.1
ENST00000520556.1
ENST00000518317.1
ENST00000521319.1
ENST00000521375.1
ENST00000518449.1
 RUNX1T1
 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr4_+_142557771 0.49 ENST00000514653.1
 IL15
 interleukin 15
chr3_-_114790179 0.48 ENST00000462705.1
 ZBTB20
 zinc finger and BTB domain containing 20
chr8_+_39770803 0.48 ENST00000518237.1
 IDO1
 indoleamine 2,3-dioxygenase 1
chr14_+_94577074 0.48 ENST00000444961.1
ENST00000448882.1
ENST00000557098.1
ENST00000554800.1
ENST00000556544.1
ENST00000298902.5
ENST00000555819.1
ENST00000557634.1
ENST00000555744.1
 IFI27
 interferon, alpha-inducible protein 27
chr6_-_167276033 0.47 ENST00000503859.1
ENST00000506565.1
 RPS6KA2
 ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr12_+_80730292 0.47 ENST00000298820.3
 OTOGL
 otogelin-like
chr12_+_26348582 0.47 ENST00000535504.1
 SSPN
 sarcospan
chr9_-_21995300 0.47 ENST00000498628.2
 CDKN2A
 cyclin-dependent kinase inhibitor 2A
chr11_-_102826434 0.46 ENST00000340273.4
ENST00000260302.3
 MMP13
 matrix metallopeptidase 13 (collagenase 3)
chr2_-_231084820 0.46 ENST00000258382.5
ENST00000338556.3
 SP110
 SP110 nuclear body protein
chr12_-_10324716 0.46 ENST00000545927.1
ENST00000432556.2
ENST00000309539.3
ENST00000544577.1
 OLR1
 oxidized low density lipoprotein (lectin-like) receptor 1
chr2_+_42104692 0.46 ENST00000398796.2
ENST00000442214.1
 AC104654.1
 AC104654.1
chr10_+_35415719 0.46 ENST00000474362.1
ENST00000374721.3
 CREM
 cAMP responsive element modulator
chr4_+_37892682 0.46 ENST00000508802.1
ENST00000261439.4
ENST00000402522.1
 TBC1D1
 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr1_+_221054584 0.46 ENST00000549319.1
 HLX
 H2.0-like homeobox
chr9_-_21995249 0.45 ENST00000494262.1
 CDKN2A
 cyclin-dependent kinase inhibitor 2A
chr17_+_18380051 0.45 ENST00000581545.1
ENST00000582333.1
ENST00000328114.6
ENST00000412421.2
ENST00000583322.1
ENST00000584941.1
 LGALS9C
 lectin, galactoside-binding, soluble, 9C
chr3_+_48507210 0.45 ENST00000433541.1
ENST00000422277.2
ENST00000436480.2
ENST00000444177.1
 TREX1
 three prime repair exonuclease 1
chr15_-_99789736 0.44 ENST00000560235.1
ENST00000394132.2
ENST00000560860.1
ENST00000558078.1
ENST00000394136.1
ENST00000262074.4
ENST00000558613.1
ENST00000394130.1
ENST00000560772.1
 TTC23
 tetratricopeptide repeat domain 23
chr3_+_150126101 0.44 ENST00000361875.3
ENST00000361136.2
 TSC22D2
 TSC22 domain family, member 2
chr16_+_28875126 0.43 ENST00000359285.5
ENST00000538342.1
 SH2B1
 SH2B adaptor protein 1
chr3_-_186080012 0.43 ENST00000544847.1
ENST00000265022.3
 DGKG
 diacylglycerol kinase, gamma 90kDa
chr15_+_89182178 0.43 ENST00000559876.1
 ISG20
 interferon stimulated exonuclease gene 20kDa
chr2_+_85811525 0.43 ENST00000306384.4
 VAMP5
 vesicle-associated membrane protein 5
chr1_-_146644122 0.43 ENST00000254101.3
 PRKAB2
 protein kinase, AMP-activated, beta 2 non-catalytic subunit
chr17_+_41158742 0.43 ENST00000415816.2
ENST00000438323.2
 IFI35
 interferon-induced protein 35
chr2_-_191878681 0.43 ENST00000409465.1
 STAT1
 signal transducer and activator of transcription 1, 91kDa
chr10_-_127505167 0.43 ENST00000368786.1
 UROS
 uroporphyrinogen III synthase
chrX_-_48937531 0.42 ENST00000473974.1
ENST00000475880.1
ENST00000396681.4
ENST00000553851.1
ENST00000471338.1
ENST00000476728.1
ENST00000376368.2
ENST00000485908.1
ENST00000376372.3
ENST00000376358.3
 WDR45
AF196779.12
 WD repeat domain 45
WD repeat domain phosphoinositide-interacting protein 4
chr4_+_142558078 0.42 ENST00000529613.1
 IL15
 interleukin 15
chr1_-_89488510 0.42 ENST00000564665.1
ENST00000370481.4
 GBP3
 guanylate binding protein 3
chr5_-_124080203 0.42 ENST00000504926.1
 ZNF608
 zinc finger protein 608
chr2_-_231084617 0.41 ENST00000409815.2
 SP110
 SP110 nuclear body protein
chr2_-_152118352 0.41 ENST00000331426.5
 RBM43
 RNA binding motif protein 43
chr17_+_25958174 0.41 ENST00000313648.6
ENST00000577392.1
ENST00000584661.1
ENST00000413914.2
 LGALS9
 lectin, galactoside-binding, soluble, 9
chr11_-_615570 0.41 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
 IRF7
 interferon regulatory factor 7
chr4_-_185395672 0.41 ENST00000393593.3
 IRF2
 interferon regulatory factor 2
chr11_-_96076334 0.40 ENST00000524717.1
 MAML2
 mastermind-like 2 (Drosophila)
chr12_+_25205446 0.40 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
 LRMP
 lymphoid-restricted membrane protein
chr1_+_229440129 0.40 ENST00000366688.3
 SPHAR
 S-phase response (cyclin related)
chr7_+_134551583 0.40 ENST00000435928.1
 CALD1
 caldesmon 1
chr19_+_11708229 0.40 ENST00000361113.5
 ZNF627
 zinc finger protein 627

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0051097 negative regulation of helicase activity(GO:0051097)
0.8 7.9 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.6 4.9 GO:0071494 cellular response to UV-C(GO:0071494)
0.5 1.6 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
0.5 2.0 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.5 1.4 GO:0045062 extrathymic T cell selection(GO:0045062)
0.5 2.3 GO:0044565 dendritic cell proliferation(GO:0044565)
0.5 1.4 GO:1901253 negative regulation of dendritic cell cytokine production(GO:0002731) negative regulation of intracellular transport of viral material(GO:1901253)
0.4 0.4 GO:0045357 interferon-beta biosynthetic process(GO:0045350) regulation of interferon-beta biosynthetic process(GO:0045357)
0.3 1.4 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.3 1.4 GO:0035441 cell migration involved in vasculogenesis(GO:0035441) metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
0.3 1.0 GO:0002277 myeloid dendritic cell activation involved in immune response(GO:0002277) positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) positive regulation of antigen processing and presentation of peptide antigen(GO:0002585) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588)
0.3 3.2 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.3 4.2 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.3 1.6 GO:0019075 virus maturation(GO:0019075)
0.3 3.1 GO:1903943 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.3 1.5 GO:1904383 response to sodium phosphate(GO:1904383)
0.3 2.1 GO:1990504 dense core granule exocytosis(GO:1990504)
0.3 3.5 GO:0002158 osteoclast proliferation(GO:0002158)
0.3 0.3 GO:0046668 regulation of retinal cell programmed cell death(GO:0046668)
0.2 2.0 GO:0070269 pyroptosis(GO:0070269)
0.2 1.1 GO:1902728 mineralocorticoid receptor signaling pathway(GO:0031959) positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
0.2 1.7 GO:0072734 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.2 0.2 GO:1903383 neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036482) positive regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902958) regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903383) negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903384)
0.2 1.2 GO:0090131 mesenchyme migration(GO:0090131)
0.2 3.0 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.2 1.0 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.2 0.7 GO:0072308 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308)
0.2 1.6 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.2 0.7 GO:0005986 sucrose biosynthetic process(GO:0005986)
0.2 0.5 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
0.2 1.3 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.1 1.8 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.1 2.8 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.1 0.7 GO:2000110 negative regulation of macrophage apoptotic process(GO:2000110)
0.1 3.3 GO:0072643 interferon-gamma secretion(GO:0072643)
0.1 0.4 GO:0071418 cellular response to amine stimulus(GO:0071418)
0.1 1.1 GO:0006216 cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.1 0.6 GO:0002636 positive regulation of germinal center formation(GO:0002636)
0.1 0.4 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 0.4 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.1 5.8 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 0.5 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.1 1.4 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.1 0.4 GO:0034238 macrophage fusion(GO:0034238) regulation of macrophage fusion(GO:0034239) positive regulation of macrophage fusion(GO:0034241)
0.1 0.4 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.1 1.0 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.1 0.5 GO:1902044 regulation of Fas signaling pathway(GO:1902044)
0.1 0.5 GO:0019566 arabinose metabolic process(GO:0019566) L-arabinose metabolic process(GO:0046373)
0.1 0.9 GO:0030578 PML body organization(GO:0030578)
0.1 0.3 GO:0014057 positive regulation of acetylcholine secretion, neurotransmission(GO:0014057)
0.1 3.2 GO:0035456 response to interferon-beta(GO:0035456)
0.1 0.7 GO:0030421 defecation(GO:0030421)
0.1 0.6 GO:0003350 pulmonary myocardium development(GO:0003350)
0.1 4.3 GO:0060338 regulation of type I interferon-mediated signaling pathway(GO:0060338)
0.1 1.0 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.1 0.3 GO:1990108 protein linear deubiquitination(GO:1990108)
0.1 0.2 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.1 1.9 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.1 0.9 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.1 1.8 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 1.5 GO:0001514 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.1 0.4 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.1 0.6 GO:0008218 bioluminescence(GO:0008218)
0.1 0.3 GO:0021816 lamellipodium assembly involved in ameboidal cell migration(GO:0003363) extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration(GO:0021816)
0.1 1.6 GO:0097151 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.1 9.2 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.1 0.8 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 0.2 GO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.1 0.3 GO:1905123 regulation of endosome organization(GO:1904978) regulation of glucosylceramidase activity(GO:1905123)
0.1 0.2 GO:1903422 negative regulation of synaptic vesicle recycling(GO:1903422) negative regulation of membrane invagination(GO:1905154) calcium ion regulated lysosome exocytosis(GO:1990927)
0.1 0.9 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
0.1 0.4 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.1 0.3 GO:2000230 negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.1 0.9 GO:0035986 senescence-associated heterochromatin focus assembly(GO:0035986)
0.1 0.2 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.1 0.2 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 0.4 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.1 1.3 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.1 0.2 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.1 1.4 GO:0006853 carnitine shuttle(GO:0006853)
0.1 0.2 GO:0006533 aspartate catabolic process(GO:0006533)
0.1 0.2 GO:0061551 trigeminal ganglion development(GO:0061551)
0.1 0.6 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.1 0.2 GO:0070541 response to platinum ion(GO:0070541)
0.1 2.6 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.1 0.2 GO:0072695 negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
0.1 0.4 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.1 0.2 GO:0033385 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.1 0.7 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.1 0.8 GO:0045651 positive regulation of macrophage differentiation(GO:0045651)
0.1 0.2 GO:1903976 negative regulation of glial cell migration(GO:1903976)
0.1 0.3 GO:1904977 lymphatic endothelial cell migration(GO:1904977)
0.1 0.4 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.1 0.2 GO:0060823 canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060823)
0.1 0.3 GO:0032962 positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)
0.1 0.2 GO:0006566 threonine metabolic process(GO:0006566)
0.1 2.0 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 0.2 GO:0036496 regulation of translational initiation by eIF2 alpha dephosphorylation(GO:0036496)
0.1 0.2 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.1 0.2 GO:0036371 protein localization to T-tubule(GO:0036371)
0.1 0.3 GO:2000354 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211) regulation of ovarian follicle development(GO:2000354)
0.1 0.7 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.1 0.2 GO:0061763 multivesicular body-lysosome fusion(GO:0061763)
0.0 0.5 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.0 0.4 GO:0021678 third ventricle development(GO:0021678)
0.0 0.7 GO:0035791 platelet-derived growth factor receptor-beta signaling pathway(GO:0035791)
0.0 0.1 GO:0006059 hexitol metabolic process(GO:0006059) inner medullary collecting duct development(GO:0072061)
0.0 0.1 GO:0050720 interleukin-1 beta biosynthetic process(GO:0050720)
0.0 0.2 GO:0046449 creatinine metabolic process(GO:0046449)
0.0 0.6 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.0 0.6 GO:0002349 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
0.0 0.7 GO:0032608 interferon-beta production(GO:0032608)
0.0 0.4 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 1.4 GO:0036152 phosphatidylethanolamine acyl-chain remodeling(GO:0036152)
0.0 0.3 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.2 GO:0006850 mitochondrial pyruvate transport(GO:0006850) mitochondrial pyruvate transmembrane transport(GO:1902361)
0.0 0.2 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.0 0.1 GO:1901069 guanosine-containing compound catabolic process(GO:1901069)
0.0 0.6 GO:0006069 ethanol oxidation(GO:0006069)
0.0 0.6 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.3 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.4 GO:0036150 phosphatidylserine acyl-chain remodeling(GO:0036150)
0.0 0.1 GO:0009443 pyridoxal 5'-phosphate salvage(GO:0009443)
0.0 0.2 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.5 GO:0060155 platelet dense granule organization(GO:0060155)
0.0 0.3 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.1 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.1 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
0.0 0.1 GO:1905244 regulation of modification of synaptic structure(GO:1905244)
0.0 0.1 GO:1903862 positive regulation of oxidative phosphorylation(GO:1903862)
0.0 0.1 GO:1903336 negative regulation of vacuolar transport(GO:1903336)
0.0 0.2 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 0.3 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.2 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.0 0.3 GO:0006527 arginine catabolic process(GO:0006527)
0.0 0.1 GO:0002384 hepatic immune response(GO:0002384)
0.0 0.2 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.0 0.1 GO:0060139 positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139)
0.0 0.3 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.1 GO:0045994 positive regulation of translational initiation by iron(GO:0045994)
0.0 0.4 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.1 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.0 0.0 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.0 0.4 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.2 GO:0045634 regulation of melanocyte differentiation(GO:0045634)
0.0 0.3 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.2 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 1.9 GO:0070206 protein trimerization(GO:0070206)
0.0 0.8 GO:0042994 cytoplasmic sequestering of transcription factor(GO:0042994)
0.0 0.3 GO:0001562 response to protozoan(GO:0001562) defense response to protozoan(GO:0042832)
0.0 0.1 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.0 1.2 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.0 0.2 GO:0051610 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.1 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
0.0 0.1 GO:0045626 negative regulation of T-helper 1 cell differentiation(GO:0045626) regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.0 0.0 GO:1902523 positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.0 0.6 GO:0043101 purine-containing compound salvage(GO:0043101)
0.0 0.4 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.0 0.3 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.0 1.4 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.0 0.4 GO:0034340 response to type I interferon(GO:0034340)
0.0 0.1 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.0 0.2 GO:1900227 positive regulation of NLRP3 inflammasome complex assembly(GO:1900227)
0.0 0.1 GO:0034670 chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.0 0.3 GO:0046149 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0 1.0 GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.0 0.1 GO:1900165 negative regulation of interleukin-6 secretion(GO:1900165)
0.0 0.4 GO:0010818 T cell chemotaxis(GO:0010818)
0.0 0.1 GO:0032474 otolith morphogenesis(GO:0032474)
0.0 0.2 GO:0002778 antimicrobial peptide production(GO:0002775) antibacterial peptide production(GO:0002778)
0.0 0.4 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.2 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 0.4 GO:0003417 growth plate cartilage development(GO:0003417)
0.0 0.3 GO:0045727 positive regulation of translation(GO:0045727)
0.0 0.1 GO:0021564 vagus nerve development(GO:0021564)
0.0 0.2 GO:0030091 protein repair(GO:0030091)
0.0 0.1 GO:0007525 somatic muscle development(GO:0007525)
0.0 0.2 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 0.3 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.0 0.1 GO:1902035 positive regulation of hematopoietic stem cell proliferation(GO:1902035)
0.0 0.3 GO:0007351 blastoderm segmentation(GO:0007350) tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595)
0.0 0.1 GO:2001012 mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.0 0.1 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.5 GO:0006293 nucleotide-excision repair, preincision complex stabilization(GO:0006293)
0.0 0.2 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.4 GO:0072189 ureter development(GO:0072189)
0.0 0.1 GO:0010609 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.0 0.1 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.1 GO:0010793 regulation of mRNA export from nucleus(GO:0010793)
0.0 0.2 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.2 GO:0003416 endochondral bone growth(GO:0003416)
0.0 0.1 GO:0001712 ectodermal cell fate commitment(GO:0001712)
0.0 0.1 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.0 0.2 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.0 0.1 GO:0032489 regulation of Cdc42 protein signal transduction(GO:0032489)
0.0 0.7 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.1 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 0.1 GO:0032480 negative regulation of type I interferon production(GO:0032480)
0.0 0.0 GO:0021986 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.0 0.2 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.3 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.0 GO:0046619 optic placode formation(GO:0001743) hepatocyte cell migration(GO:0002194) olfactory placode formation(GO:0030910) otic placode formation(GO:0043049) optic placode formation involved in camera-type eye formation(GO:0046619) branching involved in pancreas morphogenesis(GO:0061114) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.0 0.7 GO:0006536 glutamate metabolic process(GO:0006536)
0.0 0.1 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.0 0.5 GO:0006298 mismatch repair(GO:0006298)
0.0 0.1 GO:0071395 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.0 0.0 GO:0008217 regulation of blood pressure(GO:0008217)
0.0 0.0 GO:0002282 microglial cell activation involved in immune response(GO:0002282)
0.0 0.1 GO:0060351 cartilage development involved in endochondral bone morphogenesis(GO:0060351)
0.0 0.1 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
0.0 0.5 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.1 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.0 0.1 GO:0038161 prolactin signaling pathway(GO:0038161)
0.0 0.2 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.0 0.1 GO:0002115 store-operated calcium entry(GO:0002115)
0.0 0.1 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.0 0.1 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)
0.0 0.0 GO:1904603 regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904596) negative regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904597) regulation of advanced glycation end-product receptor activity(GO:1904603) negative regulation of advanced glycation end-product receptor activity(GO:1904604) negative regulation of connective tissue replacement(GO:1905204)
0.0 0.2 GO:0031953 negative regulation of protein autophosphorylation(GO:0031953)
0.0 0.1 GO:0003360 brainstem development(GO:0003360)
0.0 0.6 GO:0007340 acrosome reaction(GO:0007340)
0.0 0.1 GO:0051798 positive regulation of hair cycle(GO:0042635) positive regulation of hair follicle development(GO:0051798)
0.0 0.0 GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255)
0.0 0.2 GO:0030043 actin filament fragmentation(GO:0030043)
0.0 0.2 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.4 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 0.1 GO:0010529 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.0 0.3 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 0.3 GO:0046825 regulation of protein export from nucleus(GO:0046825)
0.0 0.3 GO:0016048 detection of temperature stimulus(GO:0016048)
0.0 0.1 GO:0019388 galactose catabolic process(GO:0019388)
0.0 0.2 GO:0000730 DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0 0.1 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.8 GO:0033275 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0 0.1 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0 0.1 GO:1901660 calcium ion export(GO:1901660) calcium ion export from cell(GO:1990034)
0.0 1.6 GO:0007286 spermatid development(GO:0007286)
0.0 0.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.2 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.4 GO:0019835 cytolysis(GO:0019835)
0.0 0.1 GO:0035634 response to stilbenoid(GO:0035634)
0.0 0.2 GO:0006554 lysine catabolic process(GO:0006554)
0.0 0.8 GO:0002456 T cell mediated immunity(GO:0002456)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 6.4 GO:0097179 protease inhibitor complex(GO:0097179)
0.9 7.9 GO:1990111 spermatoproteasome complex(GO:1990111)
0.3 0.9 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.3 1.7 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.3 1.6 GO:0008537 proteasome activator complex(GO:0008537)
0.2 1.0 GO:0072558 NLRP1 inflammasome complex(GO:0072558)
0.2 0.9 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.2 3.0 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.2 1.0 GO:0071797 LUBAC complex(GO:0071797)
0.1 0.9 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 3.0 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.1 0.9 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 1.6 GO:0000813 ESCRT I complex(GO:0000813)
0.1 0.6 GO:1902560 GMP reductase complex(GO:1902560)
0.1 1.7 GO:0097512 cardiac myofibril(GO:0097512)
0.1 0.3 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.1 0.7 GO:0030870 Mre11 complex(GO:0030870)
0.1 1.9 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 0.9 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 0.2 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.9 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.2 GO:0031084 BLOC-2 complex(GO:0031084)
0.1 0.2 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 0.5 GO:0030905 retromer, tubulation complex(GO:0030905)
0.1 1.3 GO:0036020 endolysosome membrane(GO:0036020)
0.1 1.3 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.2 GO:0020003 symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005)
0.0 0.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 1.7 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.5 GO:0000439 core TFIIH complex(GO:0000439)
0.0 0.2 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0 0.4 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.3 GO:0070552 BRISC complex(GO:0070552)
0.0 0.2 GO:0032798 Swi5-Sfr1 complex(GO:0032798)
0.0 0.1 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.0 0.6 GO:0030478 actin cap(GO:0030478)
0.0 0.3 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.7 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 0.4 GO:0071953 elastic fiber(GO:0071953)
0.0 0.3 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.4 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.0 1.0 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 0.4 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.1 GO:0071746 IgA immunoglobulin complex(GO:0071745) IgA immunoglobulin complex, circulating(GO:0071746) monomeric IgA immunoglobulin complex(GO:0071748) polymeric IgA immunoglobulin complex(GO:0071749) secretory IgA immunoglobulin complex(GO:0071751)
0.0 1.6 GO:0048786 presynaptic active zone(GO:0048786)
0.0 2.6 GO:0015030 Cajal body(GO:0015030)
0.0 1.4 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.2 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.1 GO:0071020 post-spliceosomal complex(GO:0071020)
0.0 0.2 GO:0061617 MICOS complex(GO:0061617)
0.0 0.6 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 0.1 GO:0097447 dendritic tree(GO:0097447)
0.0 2.5 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 2.2 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.6 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.4 GO:0000124 SAGA complex(GO:0000124)
0.0 0.2 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.1 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.0 0.1 GO:0071547 piP-body(GO:0071547)
0.0 0.5 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.1 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.3 GO:0031209 SCAR complex(GO:0031209)
0.0 1.8 GO:0043657 host(GO:0018995) host cell(GO:0043657)
0.0 0.3 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.1 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.0 0.5 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.4 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 2.3 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.1 GO:0032437 cuticular plate(GO:0032437)
0.0 0.1 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 0.9 GO:0031201 SNARE complex(GO:0031201)
0.0 0.5 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.2 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.1 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.1 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.1 GO:0097443 sorting endosome(GO:0097443)
0.0 0.1 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.0 0.2 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.3 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.1 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.1 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.0 0.3 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 2.1 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.4 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.1 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 0.1 GO:0033010 paranodal junction(GO:0033010)
0.0 0.8 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.2 GO:0000777 condensed chromosome kinetochore(GO:0000777) condensed chromosome, centromeric region(GO:0000779)
0.0 0.1 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.4 GO:0002080 acrosomal membrane(GO:0002080)
0.0 2.7 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.0 0.3 GO:0032839 dendrite cytoplasm(GO:0032839)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.5 1.9 GO:0031849 olfactory receptor binding(GO:0031849)
0.4 2.6 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.4 1.3 GO:0070052 collagen V binding(GO:0070052)
0.3 4.7 GO:0089720 caspase binding(GO:0089720)
0.3 1.0 GO:0032090 Pyrin domain binding(GO:0032090)
0.3 2.0 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.3 1.0 GO:0008859 exoribonuclease II activity(GO:0008859)
0.3 3.7 GO:0031386 protein tag(GO:0031386)
0.3 2.3 GO:0042296 ISG15 transferase activity(GO:0042296)
0.3 1.5 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.3 7.8 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2 2.8 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.2 6.4 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.2 1.6 GO:0061133 endopeptidase activator activity(GO:0061133)
0.2 0.7 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.2 0.5 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
0.1 0.4 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.1 0.7 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.1 0.7 GO:0047820 D-glutamate cyclase activity(GO:0047820)
0.1 2.6 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 0.1 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.1 0.5 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.1 0.6 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 0.5 GO:0046556 alpha-L-arabinofuranosidase activity(GO:0046556)
0.1 1.9 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 4.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 0.3 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.1 0.3 GO:0050698 proteoglycan sulfotransferase activity(GO:0050698)
0.1 0.8 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.1 0.4 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.1 0.6 GO:0016657 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.1 0.8 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 1.5 GO:0005132 type I interferon receptor binding(GO:0005132)
0.1 1.6 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 0.8 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.1 0.4 GO:0048030 disaccharide binding(GO:0048030)
0.1 0.3 GO:0004074 biliverdin reductase activity(GO:0004074)
0.1 1.3 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 0.3 GO:0016160 amylase activity(GO:0016160)
0.1 0.6 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.1 0.3 GO:0004995 tachykinin receptor activity(GO:0004995)
0.1 1.4 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 0.4 GO:0001515 opioid peptide activity(GO:0001515)
0.1 0.8 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.7 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.1 0.5 GO:0070087 chromo shadow domain binding(GO:0070087)
0.1 0.2 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.1 0.2 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 0.4 GO:0052739 phosphatidylserine 1-acylhydrolase activity(GO:0052739)
0.1 0.4 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.1 1.0 GO:0005522 profilin binding(GO:0005522)
0.1 0.8 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.1 0.2 GO:0009041 uridylate kinase activity(GO:0009041)
0.1 0.4 GO:0050692 DBD domain binding(GO:0050692)
0.1 1.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 1.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.4 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.0 0.3 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.0 0.3 GO:0016403 dimethylargininase activity(GO:0016403)
0.0 0.4 GO:1901612 cardiolipin binding(GO:1901612)
0.0 0.3 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.3 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.2 GO:0016402 pristanoyl-CoA oxidase activity(GO:0016402)
0.0 1.1 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.0 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.0 1.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 1.7 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 0.1 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.0 0.2 GO:0030348 syntaxin-3 binding(GO:0030348)
0.0 0.7 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.2 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.0 0.2 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.2 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 1.6 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.3 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 0.2 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 0.2 GO:0008035 high-density lipoprotein particle binding(GO:0008035)
0.0 0.1 GO:0008478 pyridoxal kinase activity(GO:0008478) lithium ion binding(GO:0031403)
0.0 0.3 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.6 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.2 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 3.7 GO:0005518 collagen binding(GO:0005518)
0.0 0.8 GO:0032183 SUMO binding(GO:0032183)
0.0 0.4 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 0.4 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.2 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.0 0.3 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.1 GO:0034584 piRNA binding(GO:0034584)
0.0 0.2 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 5.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.7 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.1 GO:0047374 methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.0 0.1 GO:0019981 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.0 0.7 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.4 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.6 GO:0042166 acetylcholine-gated cation channel activity(GO:0022848) acetylcholine binding(GO:0042166)
0.0 0.5 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.3 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.0 0.1 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.3 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.2 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 1.4 GO:0050699 WW domain binding(GO:0050699)
0.0 0.1 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.0 0.2 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.3 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 0.1 GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.0 0.2 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.0 0.3 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.1 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.1 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.0 0.2 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.0 0.2 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.3 GO:0034452 dynactin binding(GO:0034452)
0.0 0.7 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.2 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.0 0.1 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.0 0.2 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.2 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.1 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 0.1 GO:0016503 pheromone receptor activity(GO:0016503)
0.0 0.4 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0 0.8 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.2 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.3 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 1.5 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 5.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 2.4 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.4 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 1.3 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.9 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.2 GO:0003951 NAD+ kinase activity(GO:0003951)
0.0 0.2 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.0 GO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386)
0.0 0.1 GO:1990763 arrestin family protein binding(GO:1990763)
0.0 0.4 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.1 GO:0015288 porin activity(GO:0015288)
0.0 0.6 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 0.3 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.0 0.1 GO:0015254 glycerol channel activity(GO:0015254)
0.0 0.1 GO:0004925 prolactin receptor activity(GO:0004925)
0.0 0.5 GO:0030546 receptor activator activity(GO:0030546)
0.0 1.2 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 8.2 GO:0005525 GTP binding(GO:0005525)
0.0 0.1 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.0 1.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.5 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.0 GO:0016495 C-X3-C chemokine receptor activity(GO:0016495)
0.0 0.5 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.2 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.0 2.5 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.1 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.4 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.0 GO:1904599 advanced glycation end-product binding(GO:1904599)
0.0 1.5 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.1 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.1 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.2 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.3 GO:0035591 signaling adaptor activity(GO:0035591)
0.0 0.1 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 0.1 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.0 0.2 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.1 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.1 GO:0010340 carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
0.0 0.1 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 0.1 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.5 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 0.9 GO:0008307 structural constituent of muscle(GO:0008307)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.5 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.2 1.1 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.1 3.4 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 3.0 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 4.8 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.8 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.9 PID S1P S1P3 PATHWAY S1P3 pathway
0.0 1.8 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.5 PID MYC PATHWAY C-MYC pathway
0.0 0.8 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.6 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 0.4 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 4.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.5 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.8 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 0.4 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 1.1 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.4 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.5 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.6 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.3 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 1.3 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.0 0.5 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.1 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.8 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 1.2 PID E2F PATHWAY E2F transcription factor network
0.0 1.1 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.0 0.8 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.6 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.3 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.1 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 21.1 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 2.7 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.1 1.9 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 1.2 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.1 9.3 REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.1 1.3 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.1 5.1 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 3.0 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.1 2.6 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 1.9 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1 1.9 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 2.8 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 2.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 1.4 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 1.6 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 1.8 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.6 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.7 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.6 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.9 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.9 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.4 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 1.1 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.0 0.5 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 1.8 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.3 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.2 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 1.7 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.3 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.5 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 1.5 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.6 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.7 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS Genes involved in CREB phosphorylation through the activation of Ras
0.0 1.4 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.5 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 0.9 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.6 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.3 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.8 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.5 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.4 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.1 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.7 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.3 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.1 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN