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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for IRF7
Z-value: 1.69
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Transcription factors associated with IRF7
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF7 | hg19_v2_chr11_-_615570_615728 | 0.49 | 2.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF7
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_91574142 | 5.97 |
ENST00000547937.1 |
DCN |
decorin |
| chr13_+_102104980 | 3.96 |
ENST00000545560.2 |
ITGBL1 |
integrin, beta-like 1 (with EGF-like repeat domains) |
| chr8_+_97597148 | 3.65 |
ENST00000521590.1 |
SDC2 |
syndecan 2 |
| chr12_-_91572278 | 3.07 |
ENST00000425043.1 ENST00000420120.2 ENST00000441303.2 ENST00000456569.2 |
DCN |
decorin |
| chr9_-_95186739 | 2.90 |
ENST00000375550.4 |
OMD |
osteomodulin |
| chr5_+_92919043 | 2.71 |
ENST00000327111.3 |
NR2F1 |
nuclear receptor subfamily 2, group F, member 1 |
| chr12_-_91576750 | 2.62 |
ENST00000228329.5 ENST00000303320.3 ENST00000052754.5 |
DCN |
decorin |
| chr12_-_91576561 | 2.51 |
ENST00000547568.2 ENST00000552962.1 |
DCN |
decorin |
| chr1_+_155829286 | 2.44 |
ENST00000368324.4 |
SYT11 |
synaptotagmin XI |
| chr1_+_79086088 | 2.43 |
ENST00000370751.5 ENST00000342282.3 |
IFI44L |
interferon-induced protein 44-like |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 18.6 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.5 | 4.0 | GO:0045629 | negative regulation of T-helper 2 cell differentiation(GO:0045629) |
| 0.6 | 3.6 | GO:0008218 | bioluminescence(GO:0008218) |
| 0.6 | 3.3 | GO:1902748 | positive regulation of lens fiber cell differentiation(GO:1902748) |
| 0.4 | 3.1 | GO:0007598 | blood coagulation, extrinsic pathway(GO:0007598) |
| 0.2 | 2.9 | GO:0042340 | keratan sulfate catabolic process(GO:0042340) |
| 0.0 | 2.8 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.0 | 2.8 | GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418) |
| 0.1 | 2.6 | GO:0071447 | cellular response to hydroperoxide(GO:0071447) |
| 0.1 | 2.5 | GO:0098828 | positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 18.6 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.1 | 8.2 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.1 | 3.3 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 3.0 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.7 | 2.7 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.6 | 2.4 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 0.2 | 2.4 | GO:0016600 | flotillin complex(GO:0016600) |
| 0.1 | 2.4 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
| 0.1 | 2.4 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 2.4 | GO:0072562 | blood microparticle(GO:0072562) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.1 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 4.0 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 3.5 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.1 | 3.4 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.8 | 3.3 | GO:0005017 | platelet-derived growth factor-activated receptor activity(GO:0005017) |
| 0.1 | 3.3 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.4 | 3.1 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 0.1 | 3.1 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.1 | 2.7 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.1 | 2.6 | GO:0008327 | methyl-CpG binding(GO:0008327) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 21.5 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 4.0 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 3.7 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 2.4 | SIG BCR SIGNALING PATHWAY | Members of the BCR signaling pathway |
| 0.0 | 2.3 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.1 | 2.2 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 2.0 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 1.7 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.1 | 1.6 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.1 | 1.6 | PID S1P S1P1 PATHWAY | S1P1 pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 18.5 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.2 | 3.6 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.2 | 3.0 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.2 | 2.9 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.0 | 2.5 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.2 | 2.3 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.0 | 2.3 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 0.1 | 2.2 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.1 | 2.2 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.1 | 2.0 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |