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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for ISL2

Z-value: 0.24

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Transcription factors associated with ISL2

Gene Symbol Gene ID Gene Info
ENSG00000159556.5 ISL2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ISL2hg19_v2_chr15_+_76629064_76629073-0.117.9e-01Click!

Activity profile of ISL2 motif

Sorted Z-values of ISL2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ISL2

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr13_-_20806440 0.14 ENST00000400066.3
ENST00000400065.3
ENST00000356192.6
GJB6
gap junction protein, beta 6, 30kDa
chr6_-_155776966 0.14 ENST00000159060.2
NOX3
NADPH oxidase 3
chr19_-_36001113 0.14 ENST00000434389.1
DMKN
dermokine
chr7_-_111032971 0.13 ENST00000450877.1
IMMP2L
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr1_+_160370344 0.12 ENST00000368061.2
VANGL2
VANGL planar cell polarity protein 2
chr3_-_141747950 0.12 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr12_+_122356488 0.10 ENST00000397454.2
WDR66
WD repeat domain 66
chr4_-_90756769 0.09 ENST00000345009.4
ENST00000505199.1
ENST00000502987.1
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr9_+_12693336 0.08 ENST00000381137.2
ENST00000388918.5
TYRP1
tyrosinase-related protein 1
chr20_-_50722183 0.08 ENST00000371523.4
ZFP64
ZFP64 zinc finger protein
chr8_-_125577940 0.08 ENST00000519168.1
ENST00000395508.2
MTSS1
metastasis suppressor 1
chr1_+_77333117 0.08 ENST00000477717.1
ST6GALNAC5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chrX_-_32173579 0.07 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
DMD
dystrophin
chr12_-_12715266 0.06 ENST00000228862.2
DUSP16
dual specificity phosphatase 16
chr6_+_31105426 0.06 ENST00000547221.1
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr22_-_29107919 0.05 ENST00000434810.1
ENST00000456369.1
CHEK2
checkpoint kinase 2
chr4_+_128702969 0.05 ENST00000508776.1
ENST00000439123.2
HSPA4L
heat shock 70kDa protein 4-like
chr14_+_102276132 0.04 ENST00000350249.3
ENST00000557621.1
ENST00000556946.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr6_-_24358264 0.04 ENST00000378454.3
DCDC2
doublecortin domain containing 2
chr1_+_149871171 0.04 ENST00000369150.1
BOLA1
bolA family member 1
chr3_-_191000172 0.04 ENST00000427544.2
UTS2B
urotensin 2B
chr2_-_85108363 0.04 ENST00000335459.5
TRABD2A
TraB domain containing 2A
chr14_-_67878917 0.04 ENST00000216446.4
PLEK2
pleckstrin 2
chr17_-_10372875 0.04 ENST00000255381.2
MYH4
myosin, heavy chain 4, skeletal muscle
chr7_-_45151272 0.04 ENST00000461363.1
ENST00000495078.1
ENST00000494076.1
ENST00000478532.1
ENST00000258770.3
ENST00000361278.3
TBRG4
transforming growth factor beta regulator 4
chr2_+_113825547 0.04 ENST00000341010.2
ENST00000337569.3
IL1F10
interleukin 1 family, member 10 (theta)
chr11_-_13517565 0.03 ENST00000282091.1
ENST00000529816.1
PTH
parathyroid hormone
chr1_+_149871135 0.03 ENST00000369152.5
BOLA1
bolA family member 1
chr4_-_120243545 0.03 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chr11_-_5255861 0.03 ENST00000380299.3
HBD
hemoglobin, delta
chrX_-_84634737 0.03 ENST00000262753.4
POF1B
premature ovarian failure, 1B
chr18_-_3845293 0.03 ENST00000400145.2
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr12_-_95945246 0.03 ENST00000258499.3
USP44
ubiquitin specific peptidase 44
chr21_+_39644305 0.03 ENST00000398930.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr11_-_62609281 0.03 ENST00000525239.1
ENST00000538098.2
WDR74
WD repeat domain 74
chr11_+_86085778 0.03 ENST00000354755.1
ENST00000278487.3
ENST00000531271.1
ENST00000445632.2
CCDC81
coiled-coil domain containing 81
chr2_+_234668894 0.03 ENST00000305208.5
ENST00000608383.1
ENST00000360418.3
UGT1A8
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A1
UDP glucuronosyltransferase 1 family, polypeptide A8
chr13_-_46716969 0.03 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr2_+_86669118 0.03 ENST00000427678.1
ENST00000542128.1
KDM3A
lysine (K)-specific demethylase 3A
chr5_+_40909354 0.03 ENST00000313164.9
C7
complement component 7
chr4_+_88532028 0.03 ENST00000282478.7
DSPP
dentin sialophosphoprotein
chr1_-_17766198 0.03 ENST00000375436.4
RCC2
regulator of chromosome condensation 2
chr21_+_39644395 0.03 ENST00000398934.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr11_-_124190184 0.03 ENST00000357438.2
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr10_-_5046042 0.03 ENST00000421196.3
ENST00000455190.1
AKR1C2
aldo-keto reductase family 1, member C2
chr7_-_16844611 0.03 ENST00000401412.1
ENST00000419304.2
AGR2
anterior gradient 2
chr15_-_83378638 0.03 ENST00000261722.3
AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr18_-_64271316 0.03 ENST00000540086.1
ENST00000580157.1
CDH19
cadherin 19, type 2
chr17_+_3118915 0.03 ENST00000304094.1
OR1A1
olfactory receptor, family 1, subfamily A, member 1
chrX_+_65384182 0.02 ENST00000441993.2
ENST00000419594.1
HEPH
hephaestin
chr1_+_63063152 0.02 ENST00000371129.3
ANGPTL3
angiopoietin-like 3
chr9_+_35042205 0.02 ENST00000312292.5
ENST00000378745.3
C9orf131
chromosome 9 open reading frame 131
chr17_-_7307358 0.02 ENST00000576017.1
ENST00000302422.3
ENST00000535512.1
TMEM256
TMEM256-PLSCR3
transmembrane protein 256
TMEM256-PLSCR3 readthrough (NMD candidate)
chr17_-_48785216 0.02 ENST00000285243.6
ANKRD40
ankyrin repeat domain 40
chr7_-_37488834 0.02 ENST00000310758.4
ELMO1
engulfment and cell motility 1
chr2_-_163008903 0.02 ENST00000418842.2
ENST00000375497.3
GCG
glucagon
chrX_-_15332665 0.02 ENST00000537676.1
ENST00000344384.4
ASB11
ankyrin repeat and SOCS box containing 11
chr11_+_71544246 0.02 ENST00000328698.1
DEFB108B
defensin, beta 108B
chrX_-_84634708 0.02 ENST00000373145.3
POF1B
premature ovarian failure, 1B
chr4_+_169013666 0.02 ENST00000359299.3
ANXA10
annexin A10
chr6_+_130339710 0.02 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr11_-_327537 0.02 ENST00000602735.1
IFITM3
interferon induced transmembrane protein 3
chr17_-_4938712 0.02 ENST00000254853.5
ENST00000424747.1
SLC52A1
solute carrier family 52 (riboflavin transporter), member 1
chr11_+_73498898 0.02 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
MRPL48
mitochondrial ribosomal protein L48
chr14_-_106781017 0.02 ENST00000390612.2
IGHV4-28
immunoglobulin heavy variable 4-28
chr8_-_121457608 0.02 ENST00000306185.3
MRPL13
mitochondrial ribosomal protein L13
chr18_-_64271363 0.02 ENST00000262150.2
CDH19
cadherin 19, type 2
chr18_-_53303123 0.02 ENST00000569357.1
ENST00000565124.1
ENST00000398339.1
TCF4
transcription factor 4
chr11_+_28129795 0.02 ENST00000406787.3
ENST00000342303.5
ENST00000403099.1
ENST00000407364.3
METTL15
methyltransferase like 15
chr1_+_15668240 0.02 ENST00000444385.1
FHAD1
forkhead-associated (FHA) phosphopeptide binding domain 1
chr19_-_46234119 0.02 ENST00000317683.3
FBXO46
F-box protein 46
chr9_-_28670283 0.02 ENST00000379992.2
LINGO2
leucine rich repeat and Ig domain containing 2
chr11_+_101983176 0.02 ENST00000524575.1
YAP1
Yes-associated protein 1
chr5_+_140201183 0.02 ENST00000529619.1
ENST00000529859.1
ENST00000378126.3
PCDHA5
protocadherin alpha 5
chr17_+_4710391 0.02 ENST00000263088.6
ENST00000572940.1
PLD2
phospholipase D2
chr2_-_209010874 0.02 ENST00000260988.4
CRYGB
crystallin, gamma B
chrX_-_119077695 0.01 ENST00000371410.3
NKAP
NFKB activating protein
chr1_-_178840157 0.01 ENST00000367629.1
ENST00000234816.2
ANGPTL1
angiopoietin-like 1
chrX_+_11311533 0.01 ENST00000380714.3
ENST00000380712.3
ENST00000348912.4
AMELX
amelogenin, X-linked
chr19_+_29456034 0.01 ENST00000589921.1
LINC00906
long intergenic non-protein coding RNA 906
chr12_-_118628350 0.01 ENST00000537952.1
ENST00000537822.1
TAOK3
TAO kinase 3
chr2_+_234580525 0.01 ENST00000609637.1
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A8
chr5_-_139726181 0.01 ENST00000507104.1
ENST00000230990.6
HBEGF
heparin-binding EGF-like growth factor
chr14_+_92789498 0.01 ENST00000531433.1
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr5_+_110427983 0.01 ENST00000513710.2
ENST00000505303.1
WDR36
WD repeat domain 36
chr6_+_26440700 0.01 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
BTN3A3
butyrophilin, subfamily 3, member A3
chr17_+_7155819 0.01 ENST00000570322.1
ENST00000576496.1
ENST00000574841.2
ELP5
elongator acetyltransferase complex subunit 5
chr2_+_234580499 0.01 ENST00000354728.4
UGT1A9
UDP glucuronosyltransferase 1 family, polypeptide A9
chr4_+_15471489 0.01 ENST00000424120.1
ENST00000413206.1
ENST00000438599.2
ENST00000511544.1
ENST00000512702.1
ENST00000507954.1
ENST00000515124.1
ENST00000503292.1
ENST00000503658.1
CC2D2A
coiled-coil and C2 domain containing 2A
chr2_-_231860596 0.01 ENST00000441063.1
ENST00000434094.1
ENST00000418330.1
ENST00000457803.1
ENST00000414876.1
ENST00000446741.1
ENST00000426904.1
AC105344.2
SPATA3 antisense RNA 1 (head to head)
chr10_-_50396407 0.01 ENST00000374153.2
ENST00000374151.3
C10orf128
chromosome 10 open reading frame 128
chr17_-_64225508 0.01 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr2_-_169887827 0.01 ENST00000263817.6
ABCB11
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr3_+_139063372 0.01 ENST00000478464.1
MRPS22
mitochondrial ribosomal protein S22
chr1_-_174992544 0.01 ENST00000476371.1
MRPS14
mitochondrial ribosomal protein S14
chr11_-_107729887 0.01 ENST00000525815.1
SLC35F2
solute carrier family 35, member F2
chr16_+_28565230 0.01 ENST00000317058.3
CCDC101
coiled-coil domain containing 101
chrX_+_65382433 0.01 ENST00000374727.3
HEPH
hephaestin
chr15_-_75748115 0.01 ENST00000360439.4
SIN3A
SIN3 transcription regulator family member A
chr2_+_74685413 0.01 ENST00000233615.2
WBP1
WW domain binding protein 1
chr6_-_32095968 0.01 ENST00000375203.3
ENST00000375201.4
ATF6B
activating transcription factor 6 beta
chr19_+_4402659 0.01 ENST00000301280.5
ENST00000585854.1
CHAF1A
chromatin assembly factor 1, subunit A (p150)
chr21_-_30445886 0.01 ENST00000431234.1
ENST00000540844.1
ENST00000286788.4
CCT8
chaperonin containing TCP1, subunit 8 (theta)
chrX_+_96138907 0.01 ENST00000373040.3
RPA4
replication protein A4, 30kDa
chr1_-_168464875 0.01 ENST00000422253.1
RP5-968D22.3
RP5-968D22.3
chr4_-_185275104 0.01 ENST00000317596.3
RP11-290F5.2
RP11-290F5.2
chr6_+_26087509 0.01 ENST00000397022.3
ENST00000353147.5
ENST00000352392.4
ENST00000349999.4
ENST00000317896.7
ENST00000357618.5
ENST00000470149.1
ENST00000336625.8
ENST00000461397.1
ENST00000488199.1
HFE
hemochromatosis
chr2_+_234826016 0.01 ENST00000324695.4
ENST00000433712.2
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr17_-_3496171 0.01 ENST00000399756.4
TRPV1
transient receptor potential cation channel, subfamily V, member 1
chr8_-_116504448 0.01 ENST00000518018.1
TRPS1
trichorhinophalangeal syndrome I
chr3_+_136649311 0.01 ENST00000469404.1
ENST00000467911.1
NCK1
NCK adaptor protein 1
chr19_+_49199209 0.01 ENST00000522966.1
ENST00000425340.2
ENST00000391876.4
FUT2
fucosyltransferase 2 (secretor status included)
chr12_-_10282681 0.01 ENST00000533022.1
CLEC7A
C-type lectin domain family 7, member A
chr1_+_234765057 0.01 ENST00000429269.1
LINC00184
long intergenic non-protein coding RNA 184
chr10_-_128359074 0.00 ENST00000544758.1
C10orf90
chromosome 10 open reading frame 90
chr20_-_29978286 0.00 ENST00000376315.2
DEFB119
defensin, beta 119
chr1_-_202897724 0.00 ENST00000435533.3
ENST00000367258.1
KLHL12
kelch-like family member 12
chr18_-_3845321 0.00 ENST00000539435.1
ENST00000400147.2
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr3_-_193096600 0.00 ENST00000446087.1
ENST00000342358.4
ATP13A5
ATPase type 13A5
chr14_-_90798418 0.00 ENST00000354366.3
NRDE2
NRDE-2, necessary for RNA interference, domain containing
chr15_+_58702742 0.00 ENST00000356113.6
ENST00000414170.3
LIPC
lipase, hepatic
chr4_+_169418255 0.00 ENST00000505667.1
ENST00000511948.1
PALLD
palladin, cytoskeletal associated protein
chr1_+_13516066 0.00 ENST00000332192.6
PRAMEF21
PRAME family member 21
chr6_+_29555683 0.00 ENST00000383640.2
OR2H2
olfactory receptor, family 2, subfamily H, member 2
chr14_+_45605157 0.00 ENST00000542564.2
FANCM
Fanconi anemia, complementation group M
chr3_+_134514093 0.00 ENST00000398015.3
EPHB1
EPH receptor B1
chr10_-_29923893 0.00 ENST00000355867.4
SVIL
supervillin
chr3_-_20053741 0.00 ENST00000389050.4
PP2D1
protein phosphatase 2C-like domain containing 1
chr15_+_79166065 0.00 ENST00000559690.1
ENST00000559158.1
MORF4L1
mortality factor 4 like 1
chr10_+_35484793 0.00 ENST00000488741.1
ENST00000474931.1
ENST00000468236.1
ENST00000344351.5
ENST00000490511.1
CREM
cAMP responsive element modulator
chr12_+_104337515 0.00 ENST00000550595.1
HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr1_-_21377383 0.00 ENST00000374935.3
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr7_-_115670804 0.00 ENST00000320239.7
TFEC
transcription factor EC
chr3_-_157221380 0.00 ENST00000468233.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr4_+_169418195 0.00 ENST00000261509.6
ENST00000335742.7
PALLD
palladin, cytoskeletal associated protein
chr18_+_61575200 0.00 ENST00000238508.3
SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr15_-_72563585 0.00 ENST00000287196.9
ENST00000260376.7
PARP6
poly (ADP-ribose) polymerase family, member 6
chr1_-_13390765 0.00 ENST00000357367.2
PRAMEF8
PRAME family member 8
chr10_+_63422695 0.00 ENST00000330194.2
ENST00000389639.3
C10orf107
chromosome 10 open reading frame 107

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0061300 cerebellum vasculature development(GO:0061300)
0.0 0.1 GO:0061346 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.0 0.1 GO:1903575 cornified envelope assembly(GO:1903575)
0.0 0.1 GO:0051945 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.0 0.0 GO:1903926 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.0 0.1 GO:0048840 otolith development(GO:0048840)
0.0 0.0 GO:1904806 regulation of protein oxidation(GO:1904806) positive regulation of protein oxidation(GO:1904808)
0.0 0.1 GO:0030035 microspike assembly(GO:0030035)
0.0 0.1 GO:0045204 MAPK export from nucleus(GO:0045204)
0.0 0.0 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.1 GO:0001534 radial spoke(GO:0001534)
0.0 0.1 GO:0060187 cell pole(GO:0060187)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.0 0.1 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)