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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for KLF1
Z-value: 2.15
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Transcription factors associated with KLF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF1 | hg19_v2_chr19_-_12997995_12998021 | 0.51 | 1.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_+_43885252 | 7.07 |
ENST00000453782.1 ENST00000300283.6 ENST00000437924.1 ENST00000450086.2 |
CKMT1B |
creatine kinase, mitochondrial 1B |
| chr15_+_43985084 | 6.82 |
ENST00000434505.1 ENST00000411750.1 |
CKMT1A |
creatine kinase, mitochondrial 1A |
| chr19_-_51522955 | 5.69 |
ENST00000358789.3 |
KLK10 |
kallikrein-related peptidase 10 |
| chr19_-_36004543 | 4.53 |
ENST00000339686.3 ENST00000447113.2 ENST00000440396.1 |
DMKN |
dermokine |
| chr1_+_209602156 | 4.46 |
ENST00000429156.1 ENST00000366437.3 ENST00000603283.1 ENST00000431096.1 |
MIR205HG |
MIR205 host gene (non-protein coding) |
| chr18_+_29027696 | 4.44 |
ENST00000257189.4 |
DSG3 |
desmoglein 3 |
| chr1_+_44398943 | 3.48 |
ENST00000372359.5 ENST00000414809.3 |
ARTN |
artemin |
| chr19_-_51523412 | 3.47 |
ENST00000391805.1 ENST00000599077.1 |
KLK10 |
kallikrein-related peptidase 10 |
| chr18_+_21452964 | 3.41 |
ENST00000587184.1 |
LAMA3 |
laminin, alpha 3 |
| chr16_-_31147020 | 3.41 |
ENST00000568261.1 ENST00000567797.1 ENST00000317508.6 |
PRSS8 |
protease, serine, 8 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.2 | GO:0070268 | cornification(GO:0070268) |
| 0.4 | 11.9 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.2 | 10.2 | GO:0060216 | definitive hemopoiesis(GO:0060216) |
| 1.4 | 6.8 | GO:0061146 | Peyer's patch morphogenesis(GO:0061146) lymphocyte migration into lymphoid organs(GO:0097021) |
| 0.7 | 6.8 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 0.1 | 5.1 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.5 | 4.9 | GO:0086073 | bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073) |
| 0.1 | 4.7 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 0.8 | 4.5 | GO:1903575 | cornified envelope assembly(GO:1903575) |
| 0.4 | 3.0 | GO:0015820 | leucine transport(GO:0015820) proline transmembrane transport(GO:0035524) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 13.6 | GO:0030057 | desmosome(GO:0030057) |
| 0.4 | 10.5 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.0 | 7.2 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.8 | 6.7 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.2 | 5.1 | GO:0005861 | troponin complex(GO:0005861) |
| 0.1 | 5.1 | GO:0034707 | chloride channel complex(GO:0034707) |
| 1.7 | 5.0 | GO:0034676 | integrin alpha6-beta4 complex(GO:0034676) |
| 0.2 | 3.0 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.1 | 2.8 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
| 0.1 | 2.5 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.1 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 8.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 8.4 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 7.9 | GO:0008083 | growth factor activity(GO:0008083) |
| 1.1 | 7.4 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.4 | 5.2 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.4 | 5.1 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.5 | 4.9 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
| 0.2 | 3.2 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 1.0 | 3.0 | GO:0005298 | proline:sodium symporter activity(GO:0005298) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.9 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.5 | 11.7 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 9.3 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 4.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 3.5 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 3.1 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 3.0 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 1.9 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 1.6 | ST B CELL ANTIGEN RECEPTOR | B Cell Antigen Receptor |
| 0.0 | 1.4 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.5 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 10.8 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.1 | 6.3 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.3 | 6.0 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.1 | 4.8 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.2 | 4.3 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.1 | 3.0 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.0 | 2.9 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.2 | 2.7 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.0 | 2.6 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |