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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for KLF15
Z-value: 0.38
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Transcription factors associated with KLF15
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF15 | hg19_v2_chr3_-_126076264_126076305 | 0.53 | 1.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF15
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_39640513 | 0.26 |
ENST00000511809.1 ENST00000505729.1 |
SMIM14 |
small integral membrane protein 14 |
| chr19_+_11457232 | 0.26 |
ENST00000587531.1 |
CCDC159 |
coiled-coil domain containing 159 |
| chr16_-_30107491 | 0.25 |
ENST00000566134.1 ENST00000565110.1 ENST00000398841.1 ENST00000398838.4 |
YPEL3 |
yippee-like 3 (Drosophila) |
| chr5_-_111093081 | 0.24 |
ENST00000453526.2 ENST00000509427.1 |
NREP |
neuronal regeneration related protein |
| chr4_-_39640700 | 0.23 |
ENST00000295958.5 |
SMIM14 |
small integral membrane protein 14 |
| chr7_-_76256557 | 0.21 |
ENST00000275569.4 ENST00000310842.4 |
POMZP3 |
POM121 and ZP3 fusion |
| chr17_-_42276574 | 0.21 |
ENST00000589805.1 |
ATXN7L3 |
ataxin 7-like 3 |
| chr2_+_48757278 | 0.21 |
ENST00000404752.1 ENST00000406226.1 |
STON1 |
stonin 1 |
| chr17_-_19290483 | 0.20 |
ENST00000395592.2 ENST00000299610.4 |
MFAP4 |
microfibrillar-associated protein 4 |
| chr10_+_112631547 | 0.20 |
ENST00000280154.7 ENST00000393104.2 |
PDCD4 |
programmed cell death 4 (neoplastic transformation inhibitor) |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.0 | 0.3 | GO:2000774 | positive regulation of cellular senescence(GO:2000774) |
| 0.0 | 0.3 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 0.1 | 0.2 | GO:0036446 | myofibroblast differentiation(GO:0036446) epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940) regulation of myofibroblast differentiation(GO:1904760) |
| 0.0 | 0.2 | GO:0061289 | pro-T cell differentiation(GO:0002572) cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) negative regulation of DNA demethylation(GO:1901536) |
| 0.0 | 0.2 | GO:0035803 | egg coat formation(GO:0035803) |
| 0.0 | 0.2 | GO:0010748 | regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) |
| 0.0 | 0.2 | GO:0032487 | regulation of Rap protein signal transduction(GO:0032487) |
| 0.0 | 0.2 | GO:0018094 | protein polyglycylation(GO:0018094) |
| 0.0 | 0.2 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.0 | 0.3 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.0 | 0.2 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.0 | 0.2 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.0 | 0.2 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.0 | 0.1 | GO:1902937 | inward rectifier potassium channel complex(GO:1902937) |
| 0.0 | 0.1 | GO:0097629 | extrinsic component of omegasome membrane(GO:0097629) |
| 0.0 | 0.1 | GO:0016035 | zeta DNA polymerase complex(GO:0016035) |
| 0.0 | 0.1 | GO:0051286 | cell tip(GO:0051286) |
| 0.0 | 0.0 | GO:0070195 | growth hormone receptor complex(GO:0070195) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.0 | 0.2 | GO:0005219 | ryanodine-sensitive calcium-release channel activity(GO:0005219) |
| 0.0 | 0.2 | GO:0070735 | protein-glycine ligase activity(GO:0070735) |
| 0.0 | 0.2 | GO:0016403 | dimethylargininase activity(GO:0016403) |
| 0.0 | 0.2 | GO:0032190 | acrosin binding(GO:0032190) |
| 0.0 | 0.2 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 0.0 | 0.1 | GO:0098782 | mechanically-gated potassium channel activity(GO:0098782) |
| 0.0 | 0.1 | GO:0004800 | thyroxine 5'-deiodinase activity(GO:0004800) |
| 0.0 | 0.1 | GO:0005275 | amine transmembrane transporter activity(GO:0005275) |
| 0.0 | 0.1 | GO:0003990 | acetylcholinesterase activity(GO:0003990) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.3 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |