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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for MAFK
Z-value: 1.53
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Transcription factors associated with MAFK
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MAFK | hg19_v2_chr7_+_1570322_1570360 | 0.65 | 7.8e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAFK
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_+_118187379 | 4.54 |
ENST00000369230.3 |
PNLIPRP3 |
pancreatic lipase-related protein 3 |
| chr2_+_47596287 | 2.48 |
ENST00000263735.4 |
EPCAM |
epithelial cell adhesion molecule |
| chr20_+_58296265 | 2.08 |
ENST00000395636.2 ENST00000361300.4 |
PHACTR3 |
phosphatase and actin regulator 3 |
| chr1_+_156030937 | 1.93 |
ENST00000361084.5 |
RAB25 |
RAB25, member RAS oncogene family |
| chr19_+_35609380 | 1.65 |
ENST00000604621.1 |
FXYD3 |
FXYD domain containing ion transport regulator 3 |
| chr18_+_61445007 | 1.62 |
ENST00000447428.1 ENST00000546027.1 |
SERPINB7 |
serpin peptidase inhibitor, clade B (ovalbumin), member 7 |
| chr8_+_82644669 | 1.54 |
ENST00000297265.4 |
CHMP4C |
charged multivesicular body protein 4C |
| chr19_-_36001113 | 1.46 |
ENST00000434389.1 |
DMKN |
dermokine |
| chr1_+_153004800 | 1.34 |
ENST00000392661.3 |
SPRR1B |
small proline-rich protein 1B |
| chr19_-_10697895 | 1.32 |
ENST00000591240.1 ENST00000589684.1 ENST00000591676.1 ENST00000250244.6 ENST00000590923.1 |
AP1M2 |
adaptor-related protein complex 1, mu 2 subunit |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.7 | GO:0070268 | cornification(GO:0070268) |
| 0.0 | 3.1 | GO:0030449 | regulation of complement activation(GO:0030449) |
| 0.0 | 2.6 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.4 | 2.5 | GO:2000048 | negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048) |
| 0.6 | 2.4 | GO:0090362 | positive regulation of platelet-derived growth factor production(GO:0090362) |
| 0.0 | 2.4 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.2 | 2.3 | GO:1902172 | keratinocyte apoptotic process(GO:0097283) regulation of keratinocyte apoptotic process(GO:1902172) |
| 0.1 | 2.0 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
| 0.1 | 1.9 | GO:0031268 | pseudopodium organization(GO:0031268) |
| 0.4 | 1.8 | GO:0032227 | negative regulation of synaptic transmission, dopaminergic(GO:0032227) negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.4 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 3.5 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.0 | 2.2 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 1.9 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 0.1 | 1.8 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.1 | 1.7 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.1 | 1.7 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.0 | 1.6 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.1 | 1.5 | GO:0032982 | myosin filament(GO:0032982) |
| 0.0 | 1.4 | GO:0045095 | keratin filament(GO:0045095) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 3.8 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.2 | 2.6 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.1 | 2.4 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.1 | 2.4 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 2.3 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 2.1 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.1 | 2.0 | GO:0001608 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.1 | 1.9 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.4 | 1.8 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.6 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.0 | 1.5 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 1.0 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 0.9 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.8 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 0.8 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.0 | 0.5 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 0.5 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.0 | 0.5 | ST B CELL ANTIGEN RECEPTOR | B Cell Antigen Receptor |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.6 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 3.5 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 3.3 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 2.2 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 2.0 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 1.7 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.1 | 1.6 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.0 | 1.5 | REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS | Genes involved in Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds |
| 0.1 | 1.3 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.1 | 1.3 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |