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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for MAZ_ZNF281_GTF2F1
Z-value: 2.23
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Transcription factors associated with MAZ_ZNF281_GTF2F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF281 | hg19_v2_chr1_-_200379180_200379191 | -0.82 | 1.3e-02 | Click! |
| GTF2F1 | hg19_v2_chr19_-_6393216_6393229 | 0.63 | 9.3e-02 | Click! |
| MAZ | hg19_v2_chr16_+_29819096_29819250 | 0.47 | 2.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAZ_ZNF281_GTF2F1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrX_+_152760397 | 4.41 |
ENST00000331595.4 ENST00000431891.1 |
BGN |
biglycan |
| chr7_+_94023873 | 4.16 |
ENST00000297268.6 |
COL1A2 |
collagen, type I, alpha 2 |
| chr13_+_88324870 | 3.82 |
ENST00000325089.6 |
SLITRK5 |
SLIT and NTRK-like family, member 5 |
| chr5_+_92919043 | 3.77 |
ENST00000327111.3 |
NR2F1 |
nuclear receptor subfamily 2, group F, member 1 |
| chr12_+_56075330 | 3.68 |
ENST00000394252.3 |
METTL7B |
methyltransferase like 7B |
| chr5_-_111093340 | 3.42 |
ENST00000508870.1 |
NREP |
neuronal regeneration related protein |
| chr5_-_111092873 | 3.34 |
ENST00000509025.1 ENST00000515855.1 |
NREP |
neuronal regeneration related protein |
| chr5_-_111093081 | 3.29 |
ENST00000453526.2 ENST00000509427.1 |
NREP |
neuronal regeneration related protein |
| chr10_+_31608054 | 3.28 |
ENST00000320985.10 ENST00000361642.5 ENST00000560721.2 ENST00000558440.1 ENST00000424869.1 ENST00000542815.3 |
ZEB1 |
zinc finger E-box binding homeobox 1 |
| chr5_-_111092930 | 3.23 |
ENST00000257435.7 |
NREP |
neuronal regeneration related protein |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 10.9 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.1 | 9.2 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.6 | 8.3 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.4 | 7.9 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.3 | 7.7 | GO:0070208 | protein heterotrimerization(GO:0070208) |
| 1.2 | 7.4 | GO:1902748 | positive regulation of lens fiber cell differentiation(GO:1902748) |
| 0.6 | 6.4 | GO:0034465 | response to carbon monoxide(GO:0034465) |
| 0.7 | 6.1 | GO:0070236 | negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.1 | 5.2 | GO:0045599 | negative regulation of fat cell differentiation(GO:0045599) |
| 0.8 | 4.0 | GO:0046449 | creatinine metabolic process(GO:0046449) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 10.1 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.1 | 9.6 | GO:0016605 | PML body(GO:0016605) |
| 0.6 | 8.2 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.1 | 7.9 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.4 | 7.8 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.3 | 7.8 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.0 | 5.2 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.4 | 5.1 | GO:0005583 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.0 | 5.0 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 4.6 | GO:0044306 | neuron projection terminus(GO:0044306) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 22.0 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.3 | 8.4 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.5 | 8.1 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.1 | 6.9 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.8 | 6.4 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 0.1 | 6.3 | GO:0070888 | E-box binding(GO:0070888) |
| 0.8 | 5.6 | GO:0097108 | hedgehog family protein binding(GO:0097108) |
| 0.1 | 5.6 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.1 | 5.4 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.6 | 5.1 | GO:0043426 | MRF binding(GO:0043426) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 11.5 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 9.5 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.2 | 8.5 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.2 | 5.8 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 5.5 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 5.3 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 5.1 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.1 | 4.4 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 4.0 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 11.5 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.3 | 8.1 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 7.0 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 6.5 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 6.2 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS | Genes involved in CREB phosphorylation through the activation of Ras |
| 0.1 | 5.6 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 5.6 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.3 | 4.6 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.2 | 4.2 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 4.1 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |