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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for MECP2
Z-value: 1.42
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Transcription factors associated with MECP2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MECP2 | hg19_v2_chrX_-_153363125_153363182 | -0.48 | 2.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MECP2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_+_31608054 | 2.43 |
ENST00000320985.10 ENST00000361642.5 ENST00000560721.2 ENST00000558440.1 ENST00000424869.1 ENST00000542815.3 |
ZEB1 |
zinc finger E-box binding homeobox 1 |
| chr2_-_225907150 | 1.72 |
ENST00000258390.7 |
DOCK10 |
dedicator of cytokinesis 10 |
| chr15_-_48937982 | 1.60 |
ENST00000316623.5 |
FBN1 |
fibrillin 1 |
| chr21_+_47518011 | 1.38 |
ENST00000300527.4 ENST00000357838.4 ENST00000310645.5 |
COL6A2 |
collagen, type VI, alpha 2 |
| chr2_-_127864577 | 1.37 |
ENST00000376113.2 |
BIN1 |
bridging integrator 1 |
| chr8_-_38325219 | 1.33 |
ENST00000533668.1 ENST00000413133.2 ENST00000397108.4 ENST00000526742.1 ENST00000525001.1 ENST00000425967.3 ENST00000529552.1 ENST00000397113.2 |
FGFR1 |
fibroblast growth factor receptor 1 |
| chr2_-_127864839 | 1.28 |
ENST00000409400.1 ENST00000357970.3 ENST00000393040.3 ENST00000348750.4 ENST00000259238.4 ENST00000346226.3 ENST00000393041.3 ENST00000351659.3 ENST00000352848.3 ENST00000316724.5 |
BIN1 |
bridging integrator 1 |
| chr5_-_111093759 | 1.27 |
ENST00000509979.1 ENST00000513100.1 ENST00000508161.1 ENST00000455559.2 |
NREP |
neuronal regeneration related protein |
| chr2_+_33172221 | 1.26 |
ENST00000354476.3 |
LTBP1 |
latent transforming growth factor beta binding protein 1 |
| chr10_-_79397316 | 1.23 |
ENST00000372421.5 ENST00000457953.1 |
KCNMA1 |
potassium large conductance calcium-activated channel, subfamily M, alpha member 1 |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 5.9 | GO:0034465 | response to carbon monoxide(GO:0034465) |
| 0.4 | 4.0 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) |
| 0.4 | 3.2 | GO:0045602 | negative regulation of endothelial cell differentiation(GO:0045602) |
| 0.2 | 2.7 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.9 | 2.6 | GO:0060988 | lipid tube assembly(GO:0060988) |
| 0.1 | 2.6 | GO:0070208 | protein heterotrimerization(GO:0070208) |
| 0.8 | 2.4 | GO:0007037 | vacuolar phosphate transport(GO:0007037) positive regulation of mitotic cell cycle DNA replication(GO:1903465) positive regulation of parathyroid hormone secretion(GO:2000830) |
| 0.6 | 1.9 | GO:0034226 | lysine import(GO:0034226) L-lysine import(GO:0061461) L-lysine import into cell(GO:1903410) |
| 0.2 | 1.8 | GO:0021564 | vagus nerve development(GO:0021564) |
| 0.1 | 1.8 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.6 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 7.1 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.2 | 4.5 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.0 | 4.0 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 3.9 | GO:0030496 | midbody(GO:0030496) |
| 0.2 | 3.7 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.4 | 3.6 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.0 | 2.5 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.0 | 2.3 | GO:0005814 | centriole(GO:0005814) |
| 0.1 | 2.1 | GO:0000421 | autophagosome membrane(GO:0000421) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 5.9 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 0.0 | 3.0 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.1 | 2.3 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.0 | 2.3 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 2.3 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.0 | 2.3 | GO:0004386 | helicase activity(GO:0004386) |
| 0.2 | 2.2 | GO:0030023 | extracellular matrix constituent conferring elasticity(GO:0030023) |
| 0.1 | 2.2 | GO:0000030 | mannosyltransferase activity(GO:0000030) |
| 0.0 | 2.2 | GO:0005178 | integrin binding(GO:0005178) |
| 0.4 | 2.0 | GO:0050436 | microfibril binding(GO:0050436) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 4.2 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.1 | 4.1 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.1 | 3.9 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 3.8 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.0 | 2.8 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.0 | 2.6 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 2.2 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 2.0 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 1.9 | PID AURORA A PATHWAY | Aurora A signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.7 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 4.6 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 3.5 | REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES | Genes involved in Recruitment of mitotic centrosome proteins and complexes |
| 0.2 | 2.9 | REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 | Genes involved in Signaling by activated point mutants of FGFR1 |
| 0.0 | 2.8 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.0 | 2.1 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 2.1 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.0 | 2.0 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 1.8 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 1.8 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |